Aspirin

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64 Diseases Researched for Aspirin
NameACCKFocus
Cardiovascular Diseases771Locked
Cardiac Mortality 660Locked
Coronary Artery Disease560Locked
Drug-Induced Toxicity 434Locked
Gastric Ulcer534Locked
Aspirin-Induced Toxicity 831Locked
Diabetes: Cardiovascular Illness230Locked
Hearing Loss630Locked
Myocardial Infarction230Locked
Stroke330Locked
Gastroduodenal Ulcer322Locked
Gastrointestinal Hemorrhage321Locked
Cerebral Aneurysm220Locked
Cerebral Ischemia220Locked
Coronary Stenting 220Locked
Diabetes Mellitus: Type 2120Locked
Drug-Induced Toxicity: Gastrointestinal220Locked
Subarachnoid hemorrhage220Locked
Thromboembolism 120Locked
Inflammation313Locked
Duodenal Ulcer212Locked
Anemia: Hemolytic110Locked
Aspirin-Exacerbated Respiratory Disease (AERD) 110Locked
Brain Hemorrhage: Cerebral110Locked
Brain Injury: Traumatic110Locked
Brain Ischemia110Locked
Diverticular Disease110Locked
Diverticular Disease: Bleeding110Locked
Elderly: Age Specific Diseases110Locked
Glucose-6-phosphate-dehydrogenase-deficient (G-6-PD-deficient)110Locked
Glucosephosphate Dehydrogenase Deficiency110Locked
Heart Attack110Locked
Helicobacter Pylori Infection110Locked
Hemodialysis110Locked
Hypoxia110Locked
Intracranial Hemmorhage110Locked
Intraocular Hemorrhage110Locked
Macular Degeneration110Locked
Mortality: All-Cause110Locked
NSAID-induced toxicity 110Locked
Osteoporosis110Locked
Pain110Locked
Tinnitus59Locked
Wound Healing24Locked
Wound Healing: Delayed24Locked
Arthritis: Juvenile Rheumatoid13Locked
Esophageal Cancer13Locked
Rheumatoid Arthritis13Locked
Acetaminophen (Tylenol) Toxicity 12Locked
Cold and Flu: Infants & Children 12Locked
Fatty Acid Disorders/Imbalances: Arachidonic Acid12Locked
Febrile Seizures12Locked
Fever12Locked
Hypoglycemia12Locked
Influenza12Locked
Influenza: Mortality12Locked
Radiation-Induced Illness: Plutonium 12Locked
Vitamin E Deficiency12Locked
Anemia11Locked
Hypersensitivity11Locked
Immune Disorders: Low Immune Function11Locked
Reye Syndrome11Locked
Stroke: Prevention 11Locked
Thrombosis11Locked
8 Adverse Pharmacological Actions Researched for Aspirin
NameACCKFocus
Cardiotoxic450Locked
Ulcerogenic322Locked
Gastrotoxic220Locked
Bronchoconstriction110Locked
Hemolytic110Locked
Hemorrhagic 110Locked
Neurotoxic510Locked
Immunotoxic11Locked
Related Topics

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View the Evidence:
89 Abstracts with Aspirin Research

[+]

Aspirin does not prevent cardiovascular events in diabetes mellitus.Jun 01, 2010

Pubmed Data : Expert Opin Pharmacother. 2010 Jun;11(9):1459-66. PMID: 20429671
Article Published Date : Jun 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Cardiovascular Diseases, Diabetes: Cardiovascular Illness, Diabetes Mellitus: Type 2
Problem Substances : Aspirin
[+]

long-term, low-dose aspirin treatment has little effect on the prevention of venous thromboembolism in initially healthy women. Oct 16, 2007

Pubmed Data : Ann Intern Med. 2007 Oct 16;147(8):525-33. PMID: 17938390
Article Published Date : Oct 16, 2007
Study Type : Meta Analysis
Additional Links
Diseases : Thromboembolism
Problem Substances : Aspirin
[+]

Patients taking aspirin before an acute coronary syndrome (ACS) are at higher risk of recurrent heart attack.Oct 19, 2010

Pubmed Data : J Am Coll Cardiol. 2010 Oct 19;56(17):1376-85. PMID: 20946994
Article Published Date : Oct 19, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Coronary Artery Disease, Myocardial Infarction
Problem Substances : Aspirin
Adverse Pharmacological Actions : Cardiotoxic
[+]

Regular use of aspirin, NSAIDs, or acetaminophen increases the risk of hearing loss in men, and the impact is larger on younger individuals.Mar 01, 2010

Pubmed Data : Am J Med. 2010 Mar;123(3):231-7. PMID: 20193831
Article Published Date : Mar 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Drug-Induced Toxicity , Hearing Loss
Problem Substances : Aspirin , Ibuprofen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Tylenol
[+]

This analysis suggests Helicobacter pylori increases the risk of low-dose aspirin ulcers.Nov 07, 2018

Pubmed Data : J Gastroenterol Hepatol. 2018 Nov 8. Epub 2018 Nov 8. PMID: 30408229
Article Published Date : Nov 07, 2018
Study Type : Meta Analysis
Additional Links
Diseases : Aspirin-Induced Toxicity , Gastric Ulcers, Helicobacter Pylori Infection
Additional Keywords : Increased Risk
Problem Substances : Aspirin
[+]

Alendronate is associated with injury and ulceration of the gastric mucosa. Nov 01, 2000

Pubmed Data : Aliment Pharmacol Ther. 2000 Nov;14(11):1451-7. PMID: 11069316
Article Published Date : Nov 01, 2000
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity: Gastrointestinal, Gastric Ulcer, Osteoporosis
Problem Substances : Alendronate (trade name Fosamax) , Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Adverse Pharmacological Actions : Gastrotoxic, Ulcerogenic
[+]

Antiplatelet therapy does not appear to improve outcome in patients with cerebral aneurysm (subarachnoid hemorrhage).Jun 01, 2009

Pubmed Data : Stroke. 2009 Jun;40(6):1969-72. Epub 2009 Apr 23. PMID: 19390079
Article Published Date : Jun 01, 2009
Study Type : Human Study
Additional Links
Diseases : Cerebral Aneurysm, Subarachnoid hemorrhage
Problem Substances : Antiplatelet Drugs, Aspirin
[+]

Aspirin (Acetylsalicylic acid) may cause severe hemolytic anemia in some glucose-6-phosphate-dehydrogenase-deficient (G-6-PD-deficient) individuals. Jul 01, 1970

Pubmed Data : J Clin Invest. 1970 Jul;49(7):1334-40. PMID: 5432368
Article Published Date : Jul 01, 1970
Study Type : Human Study
Additional Links
Diseases : Anemia: Hemolytic, Glucose-6-phosphate-dehydrogenase-deficient (G-6-PD-deficient), Glucosephosphate Dehydrogenase Deficiency
Problem Substances : Aspirin
Adverse Pharmacological Actions : Hemolytic
[+]

Aspirin adversely effects cerebral blood flow in vivo, which may explain why research has shown it may increase the risk of ischemic stroke. Jul 01, 1999

Pubmed Data : Neurol Res. 1999 Jul;21(5):488-90. PMID: 10439430
Article Published Date : Jul 01, 1999
Study Type : Human Study
Additional Links
Diseases : Brain Ischemia, Cerebral Ischemia, Stroke
Problem Substances : Aspirin
[+]

Aspirin causes significant gastroduodenal damage even at the low doses used for cardiovascular protection. Nov 01, 2009

Pubmed Data : Curr Med Res Opin. 2009 Nov;25(11):2785-93. PMID: 19788350
Article Published Date : Nov 01, 2009
Study Type : Human Study
Additional Links
Diseases : Duodenal Ulcer, Gastric Ulcer, Gastroduodenal Ulcer
Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Aspirin given after aneurysm treatment does not appreciably reduce the occurrence of delayed ischemic neurological deficit.Sep 01, 2006

Pubmed Data : Stroke. 2006 Sep;37(9):2326-30. Epub 2006 Aug 3. PMID: 16888270
Article Published Date : Sep 01, 2006
Study Type : Human Study
Additional Links
Diseases : Cerebral Aneurysm, Cerebral Ischemia, Subarachnoid hemorrhage
Problem Substances : Aspirin
[+]

Aspirin increases mortality in diabetic patients without cardiovascular disease. Dec 01, 2009

Pubmed Data : Pharmacoepidemiol Drug Saf. 2009 Dec;18(12):1143-9. PMID: 19672841
Article Published Date : Dec 01, 2009
Study Type : Human Study
Additional Links
Diseases : Cardiac Mortality , Cardiovascular Diseases, Diabetes: Cardiovascular Illness
Problem Substances : Aspirin
[+]

Aspirin is a risk factor for colonic diverticular bleedingDec 24, 2012

Pubmed Data : Korean J Gastroenterol. 2012 Dec 25 ;60(6):349-54. PMID: 23242017
Article Published Date : Dec 24, 2012
Study Type : Human Study
Additional Links
Diseases : Diverticular Disease, Diverticular Disease: Bleeding
Problem Substances : Aspirin
Adverse Pharmacological Actions : Hemorrhagic
[+]

Aspirin may contribute to the development of CD in a middle-aged to elderly populationSep 01, 2011

Pubmed Data : Aliment Pharmacol Ther. 2011 Sep ;34(6):649-55. Epub 2011 Jul 26. PMID: 21790683
Article Published Date : Sep 01, 2011
Study Type : Human Study
Additional Links
Diseases : Elderly: Age Specific Diseases
Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Aspirin treatment reduces ischemic strokes while increasing hemorrhagic stroke. Jan 01, 2009

Pubmed Data : Curr Top Med Chem. 2009;9(14):1298-316. PMID: 19849660
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Diseases : Stroke
Problem Substances : Aspirin
[+]

Aspirin use was associated with increased risks of ischemic stroke in women and hemorrhagic stroke overall in the elderly.May 01, 1998

Pubmed Data : Stroke. 1998 May;29(5):887-94. PMID: 9596230
Article Published Date : May 01, 1998
Study Type : Human Study
Additional Links
Diseases : Stroke
Problem Substances : Aspirin
[+]

Aspirin use was not found to lower the risk of heart attack or death from cardiovascular causes. Mar 31, 2005

Pubmed Data : N Engl J Med. 2005 Mar 31;352(13):1293-304. Epub 2005 Mar 7. PMID: 15753114
Article Published Date : Mar 31, 2005
Study Type : Human Study
Additional Links
Diseases : Cardiovascular Diseases, Myocardial Infarction
Problem Substances : Aspirin
[+]

Aspirin with or without chronic oral anticoagulant treatment does not reduce mortality or reinfarction, reduces stroke, but is associated with significantly more major bleeding. Mar 01, 2010

Pubmed Data : Am J Med. 2010 Mar;123(3):250-8. PMID: 20193834
Article Published Date : Mar 01, 2010
Study Type : Human Study
Additional Links
Diseases : Cardiac Mortality , Heart Attack
Problem Substances : Anticoagulants, Antiplatelet Drugs, Aspirin
[+]

Bisphosphonates cause mucosal injury to the upper gastrointestinal tract similar to aspirin.Aug 01, 1997

Pubmed Data : Am J Gastroenterol. 1997 Aug;92(8):1322-5. PMID: 9260798
Article Published Date : Aug 01, 1997
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity: Gastrointestinal, Gastric Ulcer
Problem Substances : Alendronate (trade name Fosamax) , Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Pamidronate
Adverse Pharmacological Actions : Gastrotoxic, Ulcerogenic
[+]

Bronchoconstriction in asthmatics following the exposure to aspirin or other nonsteroidal anti-inflammatory drugs has been observed and labeled as Aspirin-exacerbated respiratory disease (AERD. Jan 01, 2012

Pubmed Data : J Allergy (Cairo). 2012 ;2012:794890. Epub 2011 Aug 7. PMID: 21837245
Article Published Date : Jan 01, 2012
Study Type : Human Study
Additional Links
Diseases : Aspirin-Exacerbated Respiratory Disease (AERD)
Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Adverse Pharmacological Actions : Bronchoconstriction
[+]

Combination therapy with aspirin, clopidogrel and warfarin following coronary stenting is associated with a significant risk of bleeding.Apr 01, 2006

Pubmed Data : J Invasive Cardiol. 2006 Apr;18(4):162-4. PMID: 16729401
Article Published Date : Apr 01, 2006
Study Type : Human Study
Additional Links
Diseases : Coronary Artery Disease, Coronary Stenting
Problem Substances : Anticoagulants, Antiplatelet Drugs, Aspirin , Clopidogrel, Warfarin
[+]

Decline of aspirin use is associated with a decreased incidence of Reye's syndrome.Jun 01, 1987

Pubmed Data : Pediatrics. 1987 Jun ;79(6):858-63. PMID: 3588140
Article Published Date : Jun 01, 1987
Study Type : Human Study
Additional Links
Diseases : Aspirin-Induced Toxicity , Encephalitis, Hepatitis
Problem Substances : Aspirin
[+]

In a population-based cohort, aspirin use was significantly associated with an increased risk of major gastrointestinal or cerebral bleeding episodes.Jun 06, 2012

Pubmed Data : JAMA. 2012 Jun 6 ;307(21):2286-94. PMID: 22706834.1
Article Published Date : Jun 06, 2012
Study Type : Human Study
Additional Links
Diseases : Brain Hemorrhage: Cerebral, Gastrointestinal Hemorrhage
Problem Substances : Aspirin
[+]

In healthy individuals using aspirin 80% experience small bowel mucosal injury. Jan 01, 2009

Pubmed Data : Digestion. 2009;79(1):44-51. Epub 2009 Feb 26. PMID: 19246922
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Problem Substances : Aspirin
[+]

In patients undergoing percutaneous coronary intervention with drug-eluting stents the use of proton pump inhibitors was associated with a greater rate of major adverse cardiac events.Mar 15, 2010

Pubmed Data : Am J Cardiol. 2010 Mar 15;105(6):833-8. PMID: 20211327
Article Published Date : Mar 15, 2010
Study Type : Human Study
Additional Links
Diseases : Cardiac Mortality , Cardiovascular Diseases, Coronary Stenting
Problem Substances : Aspirin
Adverse Pharmacological Actions : Cardiotoxic
[+]

Low-dose aspirin has been linked to gastroduodenal ulcer. Nov 20, 2009

Pubmed Data : Dig Dis Sci. 2009 Nov 20. Epub 2009 Nov 20. PMID: 19936921
Article Published Date : Nov 20, 2009
Study Type : Human Study
Additional Links
Diseases : Gastroduodenal Ulcer
Problem Substances : Aspirin
[+]

N-acetylcysteine could be associated with a reduction in depressive symptoms.Dec 03, 2018

Pubmed Data : J Clin Psychiatry. 2018 Dec 4 ;80(1). Epub 2018 Dec 4. PMID: 30549489
Article Published Date : Dec 03, 2018
Study Type : Human Study
Additional Links
Substances : Cysteine (see N-Acetylcysteine)
Diseases : Bipolar Disorder, Depression
Pharmacological Actions : Antidepressive Agents
Problem Substances : Aspirin
[+]

Patients taking aspirin plus ibuprofen have an increased risk of all-cause mortality.Feb 15, 2003

Pubmed Data : Lancet. 2003 Feb 15;361(9357):573-4. PMID: 12598144
Article Published Date : Feb 15, 2003
Study Type : Human Study
Additional Links
Diseases : Cardiac Mortality , Cardiovascular Diseases, Mortality: All-Cause
Problem Substances : Aspirin , Ibuprofen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Adverse Pharmacological Actions : Cardiotoxic
[+]

Patients with a bleeding peptic ulcer after NSAID/LD ASA consumption frequently have H. pylori infection.Oct 28, 2011

Pubmed Data : World J Gastroenterol. 2011 Oct 28 ;17(40):4509-16. PMID: 22110282
Article Published Date : Oct 28, 2011
Study Type : Human Study
Additional Links
Diseases : Helicobacter Pylori Infection
Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Patients with recurrent urticaria and angio-edema show significant improvement when they refrain from using aspirin, benzoates and azo dyes. Jul 01, 1976

Pubmed Data : Br J Dermatol. 1976 Jul;95(1):19-24. PMID: 952737
Article Published Date : Jul 01, 1976
Study Type : Human Study
Additional Links
Problem Substances : Aspirin , Azo Dyes, Food Colorings, Sodium Benzoate
[+]

Pill-induced esophageal injury is a common occurence.Aug 01, 2005

Pubmed Data : Endoscopy. 2005 Aug;37(8):740-4. PMID: 16032493
Article Published Date : Aug 01, 2005
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity
Problem Substances : Alendronate (trade name Fosamax) , Aspirin , Bisphosphonates, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Potassium Chloride
[+]

Preoperative use of aspirin plus clopidogrel is associated with an increased risk of infection after coronary artery bypass surgery. Apr 27, 2009

Pubmed Data : Arch Intern Med. 2009 Apr 27;169(8):788-96. PMID: 19398691
Article Published Date : Apr 27, 2009
Study Type : Human Study
Additional Links
Diseases : Coronary Artery Disease
Problem Substances : Aspirin , Clopidogrel
[+]

Prior aspirin use predicts worse outcomes in patients with non-ST-elevation acute coronary syndromes. Apr 15, 1999

Pubmed Data : Am J Cardiol. 1999 Apr 15;83(8):1147-51. PMID: 10215274
Article Published Date : Apr 15, 1999
Study Type : Human Study
Additional Links
Diseases : Cardiac Mortality , Coronary Artery Disease
Problem Substances : Aspirin
Adverse Pharmacological Actions : Cardiotoxic
[+]

Regular aspirin-use preceding the onset of primary intracerebral hemorrhage is an independent predictor for death.Jan 01, 2006

Pubmed Data : Stroke. 2006 Jan;37(1):129-33. Epub 2005 Dec 1. PMID: 16322483
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Diseases : Cardiac Mortality
Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Salicylic acid, a non-steroidal anti-inflammatory drug, is present in fruits and vegetables and is found in higher concentrations in vegetarians than non-vegetarians.Jun 30, 2001

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Pathol. 2001 Jul ;54(7):553-5. PMID: 11429429
Article Published Date : Jun 30, 2001
Study Type : Human Study
Additional Links
Substances : Salicylic acid
Diseases : Inflammation, Pain
Therapeutic Actions : Dietary Modification: Vegetarian
Pharmacological Actions : Anti-Inflammatory Agents
Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Short-term administration of low-dose aspirin is associated with small bowel injuries and blood flow.Jan 14, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2011 Jan 14 ;17(2):226-30. PMID: 21245996
Article Published Date : Jan 14, 2011
Study Type : Human Study
Additional Links
Diseases : Aspirin-Induced Toxicity , Gastrointestinal Hemorrhage, NSAID-induced toxicity
Pharmacological Actions : Anti-Ulcer Agents
Problem Substances : Aspirin
[+]

The evidence is not clear that aspirin is effective in the primary prevention of major cardiovascular events in people with diabetes. Jan 01, 2009

Pubmed Data : BMJ. 2009;339:b4531. Epub 2009 Nov 6. PMID: 19897665
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Problem Substances : Aspirin
[+]

The risks of aspirin therapy may outweigh the benefits for primary prevention of cardiovascular disease. Feb 01, 2010

Pubmed Data : Evid Based Med. 2010 Feb;15(1):31-3. PMID: 20176886
Article Published Date : Feb 01, 2010
Study Type : Human Study
Additional Links
Diseases : Cardiovascular Diseases
Problem Substances : Aspirin
[+]

The severity of gastric mucosal injury produced by aspirin was significantly greater in the morning compared to the evening.Dec 31, 1986

Pubmed Data : Chronobiol Int. 1987 ;4(1):111-6. PMID: 3677213
Article Published Date : Dec 31, 1986
Study Type : Human Study
Additional Links
Additional Keywords : Circadian Rhythm
Problem Substances : Aspirin
[+]

The use of a combination of clopidogrel and aspirin after coronary artery bypass surgery is associated with adverse events. Dec 01, 2001

Pubmed Data : Crit Care Med. 2001 Dec;29(12):2271-5. PMID: 11801823
Article Published Date : Dec 01, 2001
Study Type : Human Study
Additional Links
Diseases : Coronary Artery Disease
Problem Substances : Aspirin , Clopidogrel
[+]

There is an association between anticoagulant medication and massive intraocular hemorrhage in age-related macular degeneration.Jun 01, 2000

Pubmed Data : Graefes Arch Clin Exp Ophthalmol. 2000 Jun;238(6):482-5. PMID: 10943671
Article Published Date : Jun 01, 2000
Study Type : Human Study
Additional Links
Diseases : Intraocular Hemorrhage, Macular Degeneration
Problem Substances : Anticoagulants, Aspirin
[+]

There is high mortality rate associated with aspirin or clopidogrel or both in elderly patients who have head trauma resulting in intracranial hemmorhage. Oct 01, 2008

Pubmed Data : J Trauma. 2008 Oct;65(4):785-8. PMID: 18849791
Article Published Date : Oct 01, 2008
Study Type : Human Study
Additional Links
Diseases : Brain Injury: Traumatic, Intracranial Hemmorhage
Problem Substances : Aspirin , Clopidogrel
[+]

Under hypoxic conditions, the presence of aspirin would not help to inhibit further platelet activation.May 01, 1999

Pubmed Data : Eur J Clin Invest. 1999 May;29(5):438-44. PMID: 10354201
Article Published Date : May 01, 1999
Study Type : Human Study
Additional Links
Diseases : Aspirin-Induced Toxicity , Hypoxia
Problem Substances : Aspirin
[+]

Warfarin, aspirin, or clopidogrel prescription is associated with higher mortality among hemodialysis patients.Apr 01, 2009

Pubmed Data : J Am Soc Nephrol. 2009 Apr;20(4):872-81. Epub 2009 Mar 18. PMID: 19297555
Article Published Date : Apr 01, 2009
Study Type : Human Study
Additional Links
Diseases : Hemodialysis
Problem Substances : Anticoagulants, Antiplatelet Drugs, Aspirin , Clopidogrel, Thrombolytics, Warfarin
[+]

Yogurt containing Lactobacillus gasseri mitigates aspirin-induced small bowel injuries.Dec 31, 2016

Pubmed Data : Digestion. 2017 ;95(1):49-54. Epub 2017 Jan 5. PMID: 28052291
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Substances : Lactobacillus gasseri, Yoghurt
Diseases : Aspirin-Induced Toxicity
Pharmacological Actions : Gastrointestinal Agents, Gastroprotective
Problem Substances : Aspirin
[+]

"Esophageal mucosal lesion with low-dose aspirin and prasugrel mimics malignancy: a case report."Sep 21, 2011

Pubmed Data : World J Gastroenterol. 2011 Sep 21 ;17(35):4048-51. PMID: 22046096
Article Published Date : Sep 21, 2011
Study Type : Human: Case Report
Additional Links
Diseases : Esophageal Cancer
Pharmacological Actions : Platelet Aggregation Inhibitors
Additional Keywords : Misdiagnosis Of Malignancy
Problem Substances : Aspirin
[+]

Hearing loss due to aspirin has been reported.Feb 01, 2009

Pubmed Data : Ther Drug Monit. 2009 Feb;31(1):1-2. PMID: 19155962
Article Published Date : Feb 01, 2009
Study Type : Human: Case Report
Additional Links
Diseases : Drug-Induced Toxicity , Hearing Loss
Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Adverse Pharmacological Actions : Neurotoxic
[+]

[Long-term remission induced by measles infection and followed by immunosuppressive therapy in a case of refractory juvenile rheumatoid arthritis].Feb 29, 1988

Pubmed Data : Pediatr Med Chir. 1988 Mar-Apr;10(2):191-3. PMID: 3174483
Article Published Date : Feb 29, 1988
Study Type : Human: Case Report
Additional Links
Diseases : Arthritis: Juvenile Rheumatoid, Rheumatoid Arthritis
Additional Keywords : Health Benefits of Measles Infection
Problem Substances : Aspirin
[+]

"Aspirin's ability to induce intestinal injury in rats is dependent on bile and can be reversed if pre-associated with phosphatidylcholine."Aug 01, 2011

Pubmed Data : J Physiol Pharmacol. 2011 Aug ;62(4):491-6. PMID: 22100851
Article Published Date : Aug 01, 2011
Study Type : Animal Study
Additional Links
Substances : Phosphatidylcholine
Diseases : Aspirin-Induced Toxicity
Pharmacological Actions : Gastroprotective
Problem Substances : Aspirin
[+]

"Female But Not Male Mice Show Delayed Cutaneous Wound Healing By Aspirin Administration."Dec 13, 2012

Pubmed Data : Clin Exp Pharmacol Physiol. 2012 Dec 14. Epub 2012 Dec 14. PMID: 23240590
Article Published Date : Dec 13, 2012
Study Type : Animal Study
Additional Links
Diseases : Wound Healing, Wound Healing: Delayed
Problem Substances : Aspirin
[+]

An ethanolic extract of curcuma longa ointment containing 10% curcumin displayed remarkable healing process against wound retardation by aspirin.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Indian J Pharmacol. 2015 Mar-Apr;47(2):160-6. PMID: 25878374
Article Published Date : Feb 28, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin, Turmeric
Diseases : Wound Healing, Wound Healing: Delayed
Problem Substances : Aspirin
[+]

Antipyretics increase influenza-associated mortality.Oct 01, 2010

Pubmed Data : J R Soc Med. 2010 Oct;103(10):403-11. PMID: 20929891
Article Published Date : Oct 01, 2010
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Aspirin-Induced Toxicity , Influenza, Influenza: Mortality
Problem Substances : Aspirin , Ibuprofen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Artesunate affords protection against aspirin-induced gastric injury.Mar 31, 2018

Pubmed Data : Pharmacol Rep. 2018 Apr ;70(2):390-397. Epub 2017 Jun 15. PMID: 29397336
Article Published Date : Mar 31, 2018
Study Type : Animal Study
Additional Links
Substances : Artesunate
Diseases : Aspirin-Induced Toxicity , Gastric Ulcer, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Ulcer Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
Additional Keywords : Natural Substances Versus Drugs
Problem Substances : Aspirin
[+]

Aspirin (Acetylsalicylic acid) does not prevent arachidonic acid induced cardiac mortality in an animal model.Sep 01, 1980

Pubmed Data : Biull Eksp Biol Med. 1980 Sep;90(9):276-9. PMID: 7426725
Article Published Date : Sep 01, 1980
Study Type : Animal Study
Additional Links
Diseases : Fatty Acid Disorders/Imbalances: Arachidonic Acid
Problem Substances : Aspirin
[+]

Aspirin causes permanent reductions in neural activity in the cochlea and auditory brainstem response.Jun 14, 2010

Pubmed Data : Hear Res. 2010 Jun 14;265(1-2):63-9. Epub 2010 Mar 6. PMID: 20214971
Article Published Date : Jun 14, 2010
Study Type : Animal Study
Additional Links
Diseases : Hearing Loss, Tinnitus
Problem Substances : Aspirin
Adverse Pharmacological Actions : Neurotoxic
[+]

Aspirin chemically modifies human hemoglobin through acetylation.Jul 01, 1975

Pubmed Data : J Clin Invest. 1975 Jul;56(1):201-7. PMID: 237937
Article Published Date : Jul 01, 1975
Study Type : Animal Study
Additional Links
Problem Substances : Aspirin
[+]

Aspirin may be contraindicated in children with febrile illness because it causes gastrointestinal bleeding.Sep 01, 1989

Pubmed Data : Taiwan Yi Xue Hui Za Zhi. 1989 Sep;88(9):869-73. PMID: 2621427
Article Published Date : Sep 01, 1989
Study Type : Animal Study
Additional Links
Diseases : Cold and Flu: Infants & Children , Febrile Seizures, Fever
Problem Substances : Aspirin
[+]

Aspirin may exacerbate the adverse effects of vitamin E deficiency.Oct 01, 1980

Pubmed Data : J Nutr. 1980 Oct;110(10):1958-64. PMID: 7420204
Article Published Date : Oct 01, 1980
Study Type : Animal Study
Additional Links
Diseases : Vitamin E Deficiency
Problem Substances : Aspirin
[+]

Astragaloside IV protects rat gastric mucosa against aspirin-induced damage.Nov 30, 2016

Pubmed Data : Int Immunopharmacol. 2016 Dec ;41:47-55. Epub 2016 Nov 2. PMID: 27816726
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Aspirin-Induced Toxicity , Gastric Ulcer, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Gastroprotective, Superoxide Dismutase Up-regulation
Problem Substances : Aspirin
[+]

Basil may be used as a nutritional supplement or therapeutic drug to protect against aspirin-induced gastric ulcers.Aug 14, 2018

Pubmed Data : Food Funct. 2018 Aug 15 ;9(8):4457-4468. PMID: 30073231
Article Published Date : Aug 14, 2018
Study Type : Animal Study
Additional Links
Substances : Basil
Diseases : Aspirin-Induced Toxicity , Gastric Ulcer
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Gastroprotective, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Aspirin
[+]

Drinking hydrogen-rich water may protect healthy individuals from gastric damage caused by oxidative stress.Mar 02, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2014 Mar 3 ;14:81. Epub 2014 Mar 3. PMID: 24589018
Article Published Date : Mar 02, 2014
Study Type : Animal Study
Additional Links
Substances : Hydrogen Water
Diseases : Aspirin-Induced Toxicity , Oxidative Stress
Pharmacological Actions : Antioxidants, Gastroprotective
Problem Substances : Aspirin
[+]

Dual anti-platelet therapy might pose a hazard when applied to a patient with undiagnosed and untreated malignant cancer prone to undergo vascular mimicry.Apr 02, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2018 Apr 3 ;9(25):17810-17824. Epub 2018 Apr 3. PMID: 29707148
Article Published Date : Apr 02, 2018
Study Type : Animal Study
Additional Links
Diseases : Breast Cancer, Cancer Mortality
Additional Keywords : Increased Risk, Molecular Mimicry
Problem Substances : Aspirin , Clopidogrel
[+]

Fucoidan exhibits a gastro-protective effect against aspirin-induced ulceration in rats.Jan 31, 2011

Pubmed Data : Int Immunopharmacol. 2011 Feb ;11(2):157-63. Epub 2010 Nov 26. PMID: 21084063
Article Published Date : Jan 31, 2011
Study Type : Animal Study
Additional Links
Substances : Fucoidan
Diseases : Aspirin-Induced Toxicity , Gastric Ulcer
Pharmacological Actions : Anti-Ulcer Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor
Problem Substances : Aspirin
Adverse Pharmacological Actions : Ulcerogenic
[+]

Gastric mucosal protection by aegle marmelos against gastric mucosal damage.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Gastroenterol. 2015 Jan-Feb;21(1):35-42. PMID: 25672237
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Bael
Diseases : Aspirin-Induced Toxicity , Gastric Ulcer
Pharmacological Actions : Gastroprotective
Additional Keywords : Plant Extracts
Problem Substances : Aspirin
[+]

High doses of salicylate (aspirin) increase the gain of the central auditory system, presumably by down-regulating GABA-mediated inhibition, leading to an exaggerated acoustic startle response.Mar 03, 2009

Pubmed Data : Neuroscience. 2009 Mar 3;159(1):325-34. Epub 2008 Dec 24. PMID: 19154777
Article Published Date : Mar 03, 2009
Study Type : Animal Study
Additional Links
Diseases : Tinnitus
Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Hydrogen rich water pre-treatment alleviated the aspirin-induced gastric lesions.Feb 13, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2014 Feb 14 ;20(6):1614-22. PMID: 24587639
Article Published Date : Feb 13, 2014
Study Type : Animal Study
Additional Links
Substances : Hydrogen Water
Diseases : Aspirin-Induced Toxicity , Gastrointestinal Inflammation, Oxidative Stress
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Gastroprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Aspirin
[+]

Long-term administration of salicylate (aspirin) may adversely effect presin levels resulting in tinnitus.Jan 01, 2009

Pubmed Data : Int J Audiol. 2009 Jan;48(1):18-23. PMID: 19173110
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Diseases : Hearing Loss, Tinnitus
Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Adverse Pharmacological Actions : Neurotoxic
[+]

Nigella sativa has protective effect on aspirin-induced nephrotoxicity in rats.Sep 30, 2018

Pubmed Data : J Coll Physicians Surg Pak. 2018 Oct ;28(10):735-738. PMID: 30266114
Article Published Date : Sep 30, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Aspirin-Induced Toxicity , Kidney Damage: Drug-Induced
Pharmacological Actions : Renoprotective
Additional Keywords : Phytotherapy, Plant Extracts
Problem Substances : Aspirin
[+]

Olive-derived hydroxytyrosol shows anti-inflammatory effect without gastric damage in rats.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2019 ;42(7):1120-1127. PMID: 31257288
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Hydroxytyrosol
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Gastrointestinal Agents
Problem Substances : Aspirin
[+]

Protective effect of essential oil from Citrus limon against aspirin-induced toxicity.Dec 18, 2018

Pubmed Data : Hum Exp Toxicol. 2018 Dec 19:960327118819044. Epub 2018 Dec 19. PMID: 30565488
Article Published Date : Dec 18, 2018
Study Type : Animal Study
Additional Links
Substances : Lemon
Diseases : Aspirin-Induced Toxicity
Pharmacological Actions : Antioxidants, Cytoprotective, Gastroprotective
Additional Keywords : Essential Oils
Problem Substances : Aspirin
[+]

Royal jelly has potent anti-inflammatory effects compared to aspirin and it could be used in the treatment of inflammation.Jan 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Jundishapur J Nat Pharm Prod. 2015 Feb ;10(1):e22466. Epub 2015 Feb 20. PMID: 25866724
Article Published Date : Jan 31, 2015
Study Type : Animal Study
Additional Links
Substances : Royal Jelly
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Superiority of Natural Substances versus Drugs
Problem Substances : Aspirin
[+]

Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:314-321. Epub 2018 Nov 3. PMID: 30396089
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Spirulina
Diseases : Aspirin-Induced Toxicity , Gastric Ulcer
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Gastroprotective, Malondialdehyde Down-regulation, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Aspirin
[+]

Sulforaphane contributes to the protection of gastrointestinal mucosa against oxidative injury induced by H. pylori or NSAIDs.Feb 05, 2017

Pubmed Data : Curr Pharm Des. 2017 Feb 6. Epub 2017 Feb 6. PMID: 28176666
Article Published Date : Feb 05, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Aspirin-Induced Toxicity , Drug-Induced Toxicity: Indomethacin, Helicobacter Pylori Infection, NSAID-induced toxicity
Pharmacological Actions : Antioxidants
Problem Substances : Aspirin , Indomethacin, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

The administration of aspirin increases the retention of plutonium 238 in the skeleton of rats.Apr 01, 1983

Pubmed Data : Radiat Res. 1983 Apr;94(1):89-96. PMID: 6856771
Article Published Date : Apr 01, 1983
Study Type : Animal Study
Additional Links
Diseases : Aspirin-Induced Toxicity , Radiation-Induced Illness: Plutonium
Additional Keywords : Problem Substance Synergy
Problem Substances : Aspirin , Plutonium 238
[+]

There is evidence that aspirin causing tinnitus in the rat model.Feb 17, 2010

Pubmed Data : Neuroscience. 2010 Feb 17;165(4):1323-32. Epub 2009 Dec 1. PMID: 19958810
Article Published Date : Feb 17, 2010
Study Type : Animal Study
Additional Links
Diseases : Hearing Loss, Tinnitus
Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Adverse Pharmacological Actions : Neurotoxic
[+]

Toxic-induced hypoglycemia in clinical practice.Jan 01, 2004

Pubmed Data : Rom J Intern Med. 2004;42(2):447-55. PMID: 15529635
Article Published Date : Jan 01, 2004
Study Type : Animal Study
Additional Links
Diseases : Hypoglycemia
Problem Substances : Anti-diabetic drugs, Aspirin , Beta Blockers, Ethanol
[+]

Zucchini has a protective effect against aspirin induced gastric and duodenal ulcer in rats. Sep 01, 2008

Pubmed Data : Indian J Exp Biol. 2008 Sep;46(9):639-45. PMID: 18949893
Article Published Date : Sep 01, 2008
Study Type : Animal Study
Additional Links
Substances : Zucchini
Diseases : Aspirin-Induced Toxicity , Duodenal Ulcer, Gastric Ulcer, Gastroduodenal Ulcer
Pharmacological Actions : Anti-Ulcer Agents, Gastroprotective
Additional Keywords : Plant Extracts
Problem Substances : Aspirin
[+]

"Acetylsalicylate and salicylates in foods."Mar 18, 1997

Pubmed Data : Cancer Lett. 1997 Mar 19 ;114(1-2):163-4. PMID: 9103279
Article Published Date : Mar 18, 1997
Study Type : Review
Additional Links
Problem Substances : Aspirin
[+]

Aspirin causes gastric mucosal cell injury in vitro by reducing intracellular pH,Jan 01, 1993

Pubmed Data : J Clin Gastroenterol. 1993;17 Suppl 1:S1-4. PMID: 8283002
Article Published Date : Jan 01, 1993
Study Type : In Vitro Study
Additional Links
Problem Substances : Aspirin
[+]

Aspirin has been associated with a significant increase in mortality and antagonism of clot lysis in clinical and animal studies, respectively. Aug 01, 1997

Pubmed Data : Exp Neurol. 1997 Aug;146(2):513-7. PMID: 9270062
Article Published Date : Aug 01, 1997
Study Type : Commentary
Additional Links
Diseases : Thrombosis
Problem Substances : Aspirin
[+]

Aspirin in combination with hydrogen peroxide causes hemolysis, in vitro. Sep 01, 1978

Pubmed Data : Pediatr Res. 1978 Sep;12(9):927-31. PMID: 714540
Article Published Date : Sep 01, 1978
Study Type : In Vitro Study
Additional Links
Problem Substances : Aspirin
[+]

Aspirin may inhibit lymphocyte function. Aug 01, 2008

Pubmed Data : Bosn J Basic Med Sci. 2008 Aug;8(3):210-3. PMID: 18816250
Article Published Date : Aug 01, 2008
Study Type : Commentary
Additional Links
Diseases : Immune Disorders: Low Immune Function
Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Adverse Pharmacological Actions : Immunotoxic
[+]

HLA-related and other genetic markers involved in severe hypersensitivity reactions to aspirin and other drugsJul 31, 2010

Pubmed Data : Curr Opin Allergy Clin Immunol. 2010 Aug ;10(4):280-90. PMID: 20485159
Article Published Date : Jul 31, 2010
Study Type : Review
Additional Links
Diseases : Aspirin-Induced Toxicity , Drug-Induced Toxicity , Hypersensitivity
Problem Substances : Allopurinol, Antibiotics, Aspirin
[+]

Long-term low-dose aspirin therapy may not be effective in preventing cardiovascular disease and may double the risk of gastrointestinal bleeding.Nov 01, 2009

Pubmed Data : Drug Ther Bull. 2009 Nov;47(11):122-5. PMID: 19887685
Article Published Date : Nov 01, 2009
Study Type : Commentary
Additional Links
Diseases : Cardiovascular Diseases, Gastrointestinal Hemorrhage
Problem Substances : Aspirin
[+]

Non-steroidal anti-inflammatory drugs exhibit direct cytotoxicity against erthyrocytes (red blood cells) in vitro in an acidic media. Dec 01, 2002

Pubmed Data : Pharmazie. 2002 Dec;57(12):848-51. PMID: 12561250
Article Published Date : Dec 01, 2002
Study Type : In Vitro Study
Additional Links
Diseases : Anemia
Problem Substances : Aspirin , Ibuprofen, Indomethacin, Meloxicam, Naproxen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Paracetamol
[+]

Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity.Mar 01, 1987

Pubmed Data : Proc Natl Acad Sci U S A. 1987 Mar ;84(5):1417-20. PMID: 3103135
Article Published Date : Mar 01, 1987
Study Type : In Vitro Study
Additional Links
Substances : Salicylic acid
Diseases : Inflammation
Pharmacological Actions : Cyclooxygenase Inhibitors, Prostaglandin PGE2 downregulation
Additional Keywords : Natural Substances Versus Drugs
Problem Substances : Aspirin
[+]

The active ingredient in aspirin is sodium salicyclate which induces degeneration of cochlea spiral ganglion neurons. This may explain why aspirin use has been associated wtih Reye's syndrome, tinnitus and hearing loss.Jun 16, 2010

Pubmed Data : Neuroscience. 2010 Jun 16;168(1):288-99. Epub 2010 Mar 15. PMID: 20298761
Article Published Date : Jun 16, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Hearing Loss, Reye Syndrome, Tinnitus
Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Adverse Pharmacological Actions : Neurotoxic
[+]

The aqueous extracts of the leaves of Gymnema sylvestre possess anti ulcerogenic, Anti allergic, Anti stress, properties.Feb 21, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2014 Feb 22 ;14:70. Epub 2014 Feb 22. PMID: 24559073
Article Published Date : Feb 21, 2014
Study Type : In Vitro Study
Additional Links
Substances : Gymnema Sylvestre
Diseases : Gastric Ulcer
Pharmacological Actions : Anti-Bacterial Agents, Anti-Ulcer Agents, Antioxidants, Gastroprotective
Additional Keywords : Phytotherapy, Plant Extracts
Problem Substances : Aspirin
[+]

The combination of clopidogrel and aspirin may be harmful, compared with aspirin alone.Nov 01, 2007

Pubmed Data : Curr Treat Options Neurol. 2007 Nov;9(6):442-50. PMID: 18173943
Article Published Date : Nov 01, 2007
Study Type : Commentary
Additional Links
Diseases : Stroke: Prevention
Additional Keywords : Drug Interaction
Problem Substances : Aspirin , Clopidogrel

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For decades, doctors recommended a so-called “baby” or "low-dose" aspirin to prevent heart attacks and stroke. New research shows that his practice is outdated, and may have life-threatening side effects, including deadly brain bleeding.
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