Aluminum

Name	AC	CK
Aluminum Toxicity	111	284
Vaccine-induced Toxicity	25	79
Macrophagic myofasciitis	14	74
Autism Spectrum Disorders	9	50
Breast Cancer	6	37
Heavy Metal Toxicity	5	36
Oxidative Stress	13	32
Alzheimer's Disease	16	31
Neurodegenerative Diseases	17	26
Autism	3	21
Brain Inflammation	9	21
Autoimmune Diseases	7	17
Cognitive Decline/Dysfunction	4	16
Inflammation	6	16
Gulf War Syndrome	3	13
Infant Chemical Exposures	2	11
Atherosclerosis	1	10
Brain: Oxidative Stress	5	10
C-Reactive Protein	1	10
Clostridium Infections	1	10
Diarrhea	1	10
High Cholesterol	1	10
Hypothyroidism	1	10
Immune Dysregulation: TH1/TH2 imbalance	1	10
Infant Mortality	1	10
Intima Media Thickening	1	10
Low Immune Function: Natural Killer Cells	1	10
Premature Birth	1	10
Memory Disorders	4	8
Multiple Sclerosis	3	7
Acrylamide-induced toxicity	3	6
Dementia	2	6
Prenatal Chemical Exposures	2	6
Aging	3	5
Breast Cancer: Triple Negative	1	5
Cancer Metastasis	1	5
Chemically-Induced Liver Damage	2	4
Chronic Fatigue Syndrome	2	4
Fluoride Toxicity	2	4
Lipid Peroxidation	2	4
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA)	3	3
Central Nervous System Diseases	1	3
Pseudolymphoma	1	3
Amyotrophic lateral sclerosis (ALS)	1	2
Anxiety Disorders	1	2
Chemotherapy-Induced Toxicity: Oxaliplatin	1	2
Colitis	1	2
DNA damage	1	2
Dysbiosis	1	2
High Fat Diet	1	2
Infertility: Male	1	2
Inflammatory Bowel Diseases	1	2
Kidney Damage: Chemically-Induced	1	2
Lipopolysaccharide-Induced Toxicity	1	2
Liver Damage	1	2
Motor Neuron Disease	1	2
Neuropathic Pain	1	2
Osteoporosis	1	2
Peripheral Neuropathies	1	2
Sjogren's Syndrome	1	2
Social Behavior	1	2
Systemic Lupus Erythematosus	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Uremia	1	2
Wound Healing	1	2
Attention Deficit Disorder	1	1
Benzo[a]pyrene-induced Toxicity	1	1
Bipolar Disorder	1	1
Bisphenol Toxicity	1	1
Cancers: Estrogen Responsive	1	1
Crohn's Disease	1	1
Estrogen Dominance	1	1
Febrile Seizures	1	1
Fibromyalgia	1	1
Guillain-Barre Syndrome	1	1
Infant Nutrition: Infant Formula	1	1
Lymphoma	1	1
Myopathies	1	1
Neurodevelopmental Disorders	1	1
New Variant Creutzfeldt-Jakob Disease	1	1
Parkinson's Disease	1	1
Prostate Cancer	1	1

Name	AC	CK
Neurotoxic	27	72
Immunotoxic	4	15
Inflammatory	7	13
Cardiotoxic	2	12
Endocrine Disruptor	2	11
Immunosuppressive	2	11
Genotoxic	2	4
Hematoxic	1	2
Hepatotoxic	1	2
Hypertensive	1	2
Apoptotic	1	1
Carcinogenic	1	1
Cytotoxic	1	1
Estrogenic	1	1
Hemolytic	1	1
Hypermethylation	1	1
Irritant	1	1

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Pubmed Data : Best Pract Res Clin Endocrinol Metab. 2009 Dec;23(6):781-92. PMID: 19942153

Article Published Date : Dec 01, 2009

Study Type : Human Study

Additional Links

Diseases : Hypothyroidism

Problem Substances : Antacids: Aluminium-Containing, Bile Acid Sequestrants, Calcium Carbonate, Ferrous Sulphate, Phosphate Binders, Proton-Pump Inhibitors, Raloxifene, Sucralfate

[+]

Administration of 240 mg of anthocyanins a day for 30 days caused a substantial increase of glutathione peroxidase and catalase activities. While decreasing the lead, aluminum and cooper concentrations.Oct 31, 2005

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Pubmed Data : Pol Merkur Lekarski. 2005 Nov ;19(113):651-3. PMID: 16498804

Article Published Date : Oct 31, 2005

Study Type : Human Study

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Pubmed Data : J Inorg Biochem. 2007 Sep ;101(9):1344-6. Epub 2007 Jun 12. PMID: 17629949

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Pubmed Data : J Inorg Biochem. 2009 Nov;103(11):1555-62. Epub 2009 Aug 20. PMID: 19740540

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Pubmed Data : Sci Rep. 2018 Nov 13 ;8(1):16729. Epub 2018 Nov 13. PMID: 30425257

Article Published Date : Nov 12, 2018

Study Type : Human Study

Additional Links

Diseases : All-Cause Mortality, Aluminum Toxicity , Hemodialysis

Additional Keywords : Increased Risk

Problem Substances : Aluminum

[+]

Breastfed infants in Brazil receiving a full recommended schedule of immunizations showed an exceedingly high exposure of Al (225 to 1750 μg per dose) when compared with estimated levels absorbed from breast milk.Nov 01, 2010

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Pubmed Data : J Expo Sci Environ Epidemiol. 2010 Nov ;20(7):598-601. Epub 2009 Dec 16. PMID: 20010978

Article Published Date : Nov 01, 2010

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Pubmed Data : J Inorg Biochem. 2015 Aug 1. Epub 2015 Aug 1. PMID: 26265215

Problem Substances : Aluminum, Nanoparticles

Adverse Pharmacological Actions : Cytotoxic, Genotoxic

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Thimerosal at low nanomolar concentrations was able to induce significant cellular toxicity in human neuron and fetal cells.May 31, 2009

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Pubmed Data : Toxicol Environ Chem. 2009 Jun ;91(3-4):735-749. Epub 2009 Jun 11. PMID: 24532866

Article Published Date : May 31, 2009

Study Type : Human In Vitro

Additional Links

Problem Substances : Aluminum, Lead, Mercury, Thimerosal

Adverse Pharmacological Actions : Neurotoxic

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The pathogenic role of aluminium hydroxide is now recognized by the presence of chronic fatigue syndrome, macrophagic myofasciitis and subcutaneous pseudolymphoma, linked to intramuscular injection of aluminium hydroxide-containing vaccines.Mar 14, 2012

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Pubmed Data : J Trace Elem Med Biol. 2012 Mar 14. Epub 2012 Mar 14. PMID: 22425036

Article Published Date : Mar 14, 2012

Study Type : Human: Case Report, Review

Additional Links

Diseases : Chronic Fatigue Syndrome, Macrophagic myofasciitis , Pseudolymphoma

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Aluminum Hydroxide, Vaccine Adjuvants

Adverse Pharmacological Actions : Immunotoxic

[+]

A case of multiple sclerosis improvement following removal of heavy metal intoxication has been reported.Mar 22, 2012

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Pubmed Data : Biometals. 2012 Mar 22. Epub 2012 Mar 22. PMID: 22438029

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Pubmed Data : Med J Aust. 2005 Aug 1 ;183(3):145-6. PMID: 16053418

Article Published Date : Jul 31, 2005

Study Type : Human: Case Report

Additional Links

Diseases : Aluminum Toxicity , Macrophagic myofasciitis , Vaccine-induced Toxicity

Problem Substances : Aluminum

[+]

Pediatric Wells syndrome (eosinophilic cellulitis) after vaccination.Aug 31, 2018

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Pubmed Data : Pediatr Dermatol. 2018 Sep ;35(5):e262-e264. Epub 2018 Jul 12. PMID: 29998475

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Pubmed Data : Pathophysiology. 2015 Mar ;22(1):39-48. Epub 2014 Dec 13. PMID: 25577494

Article Published Date : Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Proc Natl Acad Sci U S A. 1990 Nov ;87(22):9024-7. PMID: 2247478

Pubmed Data : Toxicol Lett. 2000 Jan 5;111(3):235-42. PMID: 10643868

Article Published Date : Jan 05, 2000

Study Type : Animal Study

Additional Links

Problem Substances : Aluminum Hydroxide

Adverse Pharmacological Actions : Hematoxic

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Aluminum is predominantly identified in macrophages after administration to normal mice.Mar 01, 1996

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Pubmed Data : Pharmacol Toxicol. 1996 Mar ;78(3):123-8. PMID: 8882343

Article Published Date : Mar 01, 1996

Study Type : Animal Study

Additional Links

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Aluminum, Aluminum Hydroxide, Vaccine Adjuvants

[+]

Aluminum nanoparticles are more neurotoxic than micrometer aluminum.Jun 01, 2018

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Pubmed Data : Biol Trace Elem Res. 2018 Jun ;183(2):261-269. Epub 2017 Aug 30. PMID: 28856594

Article Published Date : Jun 01, 2018

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Pubmed Data : Vet Pathol. 2019 05 ;56(3):418-428. Epub 2018 Oct 31. PMID: 30381018

Article Published Date : Jan 01, 2019

Study Type : Animal Study

Additional Links

Diseases : Granuloma, Vaccine-induced Toxicity

Additional Keywords : Vaccine Research

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Aluminum, Vaccine Adjuvants

[+]

B. monniera whole-plant extracts can be considered as a possible remedy to counteract aluminum-associated neurological disorders.Oct 30, 2014

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Pubmed Data : Chin J Physiol. 2014 Oct 31 ;57(5):279-85. PMID: 25241988

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2015 ;10(6):e0127665. Epub 2015 Jun 4. PMID: 26042788

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Pubmed Data : Pathophysiology. 2015 Jun ;22(2):105-15. Epub 2015 Apr 2. PMID: 25863844

Article Published Date : May 31, 2015

Study Type : Animal Study

Additional Links

Diseases : Neurodegenerative Diseases

Additional Keywords : Increased Risk

Problem Substances : Aluminum, Fluoride, Sodium Fluoride

Adverse Pharmacological Actions : Neurotoxic

[+]

Extra virgin olive oil can decrease the frequency of cardiac complications and genotoxicity induced by co-exposure to aluminum and acrylamide.Sep 01, 2015

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Pubmed Data : Food Funct. 2015 Sep 2 ;6(9):3098-108. PMID: 26215160

Pubmed Data : J Autoimmun. 2014 Nov ;54:21-32. Epub 2014 Jul 16. PMID: 25042822

Article Published Date : Oct 31, 2014

Study Type : Animal Study

Additional Links

Diseases : Anxiety Disorders, Systemic Lupus Erythematosus, Vaccine-induced Toxicity

Anti Therapeutic Actions : Vaccination: Hepatitis B

Problem Substances : Aluminum Hydroxide

[+]

L. plantarum CCFM639 could alleviate aluminum induced hepatic and renal injuries.Sep 13, 2016

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Pubmed Data : Biol Trace Elem Res. 2016 Sep 14. Epub 2016 Sep 14. PMID: 27627960

Article Published Date : Sep 13, 2016

Study Type : Animal Study

Additional Links

Substances : Lactobacillus plantarum

Diseases : Aluminum Toxicity

Pharmacological Actions : Hepatoprotective, Renoprotective

Problem Substances : Aluminum

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L. plantarum CCFM639 has a potential as dietary supplement ingredient that provides protection against aluminum induced injury.Dec 31, 2016

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Pubmed Data : Evid Based Complement Alternat Med. 2017 ;2017:7426538. Epub 2017 Apr 26. PMID: 28529531

Article Published Date : Dec 31, 2016

Study Type : Animal Study

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Pubmed Data : J Mol Neurosci. 2011 Mar ;43(3):284-9. Epub 2010 Aug 20. PMID: 20725867

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Pubmed Data : J Pineal Res. 2005 Sep ;39(2):129-36. PMID: 16098089

Article Published Date : Aug 31, 2005

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Aluminum Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Additional Keywords : Gene Expression Regulation

Problem Substances : Aluminum

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Memory enhancement of acteoside in a senescent mice model.Jul 31, 2015

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Pubmed Data : Phytother Res. 2015 Aug ;29(8):1131-6. Epub 2015 Apr 21. PMID: 25900014

Article Published Date : Jul 31, 2015

Study Type : Animal Study

Additional Links

Substances : Verbascoside

Diseases : Aging, Aluminum Toxicity , Memory Disorders

Pharmacological Actions : Neuroprotective Agents

Problem Substances : Aluminum

[+]

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Pubmed Data : Environ Sci Pollut Res Int. 2016 Apr 8. Epub 2016 Apr 8. PMID: 27055897

Article Published Date : Apr 07, 2016

Study Type : Animal Study

Additional Links

Substances : Omega-3 Fatty Acids

Diseases : Aluminum Toxicity

Pharmacological Actions : Antioxidants, Cytoprotective

Problem Substances : Aluminum

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Prolonged aluminium sulphate intake accelerates features of senescence in the adult mice liver.Mar 31, 2008

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Pubmed Data : Exp Gerontol. 2008 Apr ;43(4):330-8. Epub 2008 Feb 2. PMID: 18337038

Article Published Date : Mar 31, 2008

Study Type : Animal Study

Additional Links

Diseases : Aging, Aluminum Toxicity

Problem Substances : Aluminum

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Protective effects of alpha-ketoglutarate against aluminum toxicity in Drosophila melanogaster.Nov 29, 2018

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Pubmed Data : Comp Biochem Physiol C Toxicol Pharmacol. 2018 Nov 30 ;217:41-53. Epub 2018 Nov 30. PMID: 30508642

Article Published Date : Nov 29, 2018

Study Type : Insect Study

Additional Links

Substances : Alpha Ketoglutarate

Diseases : Aluminum Toxicity

Pharmacological Actions : Antioxidants

Problem Substances : Aluminum

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Rats fed aluminum retain 0.01% to 0.05% of the aluminum in tissue compared to rats injected with aluminum.Nov 01, 1991

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Pubmed Data : J Nutr. 1991 Nov ;121(11):1755-62. PMID: 1941183

Article Published Date : Nov 01, 1991

Study Type : Animal Study

Additional Links

Diseases : Vaccine-induced Toxicity

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Aluminum

[+]

Rats fed with canned soft drinks had higher concentrations of Aluminum in blood, liver and bone than rats fed with glass bottled soft drinks. Jan 01, 1994

Article Published Date : Apr 01, 2011

Study Type : Environmental

Additional Links

Diseases : Aluminum Toxicity

Problem Substances : Aluminum

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The effects of low dose aluminum on hemorheological and hematological parameters in rats.Dec 31, 2006

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Pubmed Data : Arch Toxicol. 2007 Jan ;81(1):11-7. Epub 2006 May 24. PMID: 16721596

Article Published Date : Dec 31, 2006

Study Type : Animal Study

Additional Links

Diseases : Aluminum Toxicity

Problem Substances : Aluminum

[+]

Problem Substances : Aluminum, Vaccine Adjuvants

Adverse Pharmacological Actions : Bioaccumulator, Neurotoxic

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Treatment with quercetin may represent a therapeutic strategy to attenuate the neuronal death against aluminum-induced neurodegeneration.Mar 01, 2016

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Pubmed Data : Neuroscience. 2016 Mar 2. Epub 2016 Mar 2. PMID: 26944603

Article Published Date : Mar 01, 2016

Study Type : Animal Study

Additional Links

Substances : Quercetin

Diseases : Aluminum Toxicity , Neurodegenerative Diseases

Pharmacological Actions : Neuroprotective Agents

Problem Substances : Aluminum

Adverse Pharmacological Actions : Neurotoxic

[+]

Yerba mate has potential antioxidant effects on aluminium toxicity.Nov 06, 2017

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Pubmed Data : J Inorg Biochem. 2017 Nov 7. Epub 2017 Nov 7. PMID: 29150325

Article Published Date : Nov 06, 2017

Study Type : Animal Study

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Pubmed Data : Pharmacol Toxicol. 2001 Apr ;88(4):159-67. PMID: 11322172

Article Published Date : Apr 01, 2001

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Pubmed Data : Biol Trace Elem Res. 2018 May 7. Epub 2018 May 7. PMID: 29732485

Article Published Date : May 06, 2018

Study Type : Review

Additional Links

Substances : Melatonin

Diseases : Aluminum Toxicity , Neurodegenerative Diseases

Pharmacological Actions : Neuroprotective Agents

Problem Substances : Aluminum

[+]

A significant correlation exists between the number of pediatric aluminum-adjuvanted vaccines administered and the rate of autism spectrum disorders.Jun 30, 2013

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Pubmed Data : Immunol Res. 2013 Jul ;56(2-3):304-16. PMID: 23609067

Article Published Date : Jun 30, 2013

Study Type : Review

Additional Links

Diseases : Aluminum Toxicity , Autism Spectrum Disorders

Problem Substances : Aluminum, Vaccine Adjuvants

[+]

A wide range of metals have been identified to have estrogenic properties.May 01, 2006

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Pubmed Data : J Appl Toxicol. 2006 May-Jun;26(3):191-7. PMID: 16489580

Article Published Date : May 01, 2006

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Pubmed Data : Vaccine. 1995 Oct ;13(14):1263-76. PMID: 8585280

Article Published Date : Sep 30, 1995

Study Type : Review

Additional Links

Diseases : Aluminum Toxicity

Problem Substances : Aluminum, Vaccine Adjuvants

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Adverse reactions after injection of adsorbed DTP vaccine are not due only to pertussis organisms or pertussis components in the vaccine.Sep 30, 1991

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Pubmed Data : Vaccine. 1991 Oct ;9(10):699-702. PMID: 1759487

Article Published Date : Sep 30, 1991

Pubmed Data : Morphologie. 2016 Jun ;100(329):85-94. Epub 2016 Apr 6. PMID: 26948677

Article Published Date : Jun 01, 2016

Study Type : Review

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Pubmed Data : Z Lebensm Unters Forsch. 1994 Apr;198(4):313-6. PMID: 8197828

Article Published Date : Apr 01, 1994

Study Type : In Vitro Study

Additional Links

Problem Substances : Aluminium Cans, Sugary soda

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Aluminium has been demonstrated to impact the CNS at every level, including by changing gene expression.Dec 31, 2013

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Pubmed Data : Immunotherapy. 2014 ;6(10):1055-71. PMID: 25428645

Article Published Date : Dec 31, 2013

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Pubmed Data : Food Addit Contam Part B Surveill. 2018 Jun ;11(2):153-159. Epub 2018 Mar 16. PMID: 29486656

Article Published Date : May 31, 2018

Study Type : In Vitro Study

Additional Links

Diseases : Aluminum Toxicity

Problem Substances : Aluminum

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Aluminium may play an active role in the pathogenesis of critical neuropathologic lesion in Alzheimer's disease and other related disorders.Jan 01, 2006

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Pubmed Data : J Alzheimers Dis. 2006 ;9(3 Suppl):291-300. PMID: 17004365

Article Published Date : Jan 01, 2006

Study Type : Review

Additional Links

Diseases : Neurodegenerative Diseases

Problem Substances : Aluminum

Adverse Pharmacological Actions : Neurotoxic

[+]

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Pubmed Data : Adv Neurobiol. 2017 ;18:183-197. PMID: 28889268

Article Published Date : Jan 01, 2017

Pubmed Data : Clin Lab Med. 1990 Jun ;10(2):403-22. PMID: 2197055

Article Published Date : Jun 01, 1990

Study Type : Review

Additional Links

Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Kidney Failure: Chronic, Parkinson's Disease

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Aluminum

Adverse Pharmacological Actions : Bioaccumulator, Nephrotoxic, Neurotoxic

[+]

aluminum may induce apoptosis in astrocytes via ER stress by impairing the protein-folding machinery.Dec 31, 2010

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Pubmed Data : Environ Health Prev Med. 2011 Jan ;16(1):16-24. Epub 2010 Jun 22. PMID: 21432213

Article Published Date : Dec 31, 2010

Study Type : In Vitro Study

Additional Links

Diseases : Aluminum Toxicity

Additional Keywords : Gene Expression

Problem Substances : Aluminum

Adverse Pharmacological Actions : Neurotoxic

[+]

Aluminum potentially enhanced apoptotic proteins and inflammatory markers in neuronal cells.Nov 06, 2015

Brain translocation of aluminum particles is linked to a trojan horse mechanism previously described for infectious particles.Dec 31, 2014

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Pubmed Data : Front Neurol. 2015 ;6:4. Epub 2015 Feb 5. PMID: 25699008

Article Published Date : Dec 31, 2014

Study Type : Review

Additional Links

Diseases : Aluminum Toxicity , Autoimmune Diseases, Macrophagic myofasciitis

Additional Keywords : Biopersistence, Genomic Variation, Gulf War Syndrome, Risk Factors

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Aluminum Hydroxide

Adverse Pharmacological Actions : Neurotoxic

[+]

Chlorogenic acid has neuroprotective effects against aluminium-induced cytotoxicity by chelation and antioxidant activation.Jul 25, 2017

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Pubmed Data : Food Funct. 2017 Jul 26. Epub 2017 Jul 26. PMID: 28745369

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Pubmed Data : Neurochem Res. 2012 Mar ;37(3):639-46. Epub 2011 Dec 1. PMID: 22130689

Article Published Date : Feb 29, 2012

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Aluminum Toxicity , Brain Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Aluminum

[+]

Deficits in the proline-rich synapse-associated shank3 protein in multiple neuropsychiatric disorders.Dec 31, 2016

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Pubmed Data : Neurochem Res. 2016 Apr 25. Epub 2016 Apr 25. PMID: 27113042

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Pubmed Data : BMC Pediatr. 2010;10:63. Epub 2010 Aug 31. PMID: 20807425

Article Published Date : Jan 01, 2010

Study Type : Review

Additional Links

Diseases : Aluminum Toxicity , Infant Chemical Exposures, Infant Nutrition: Infant Formula

Problem Substances : Aluminum, Infant Formula

[+]

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Pubmed Data : Neurotoxicology. 2015 Dec 11. Epub 2015 Dec 11. PMID: 26687397

Pubmed Data : Neurotoxicol Teratol. 1995 Jul-Aug;17(4):515-21. PMID: 7565498

Article Published Date : Jul 01, 1995

Study Type : Review

Additional Links

Additional Keywords : Pregnancy

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Aluminum

Adverse Pharmacological Actions : Neurotoxic

[+]

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Pubmed Data : J Trace Elem Med Biol. 2015 Apr ;30:90-5. Epub 2014 Nov 20. PMID: 25498314

Article Published Date : Apr 01, 2015

Study Type : Review

Additional Links

Additional Keywords : Vaccine Research

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Aluminum, Vaccine Adjuvants

[+]

This review focuses on the roles and mechanisms of action of different adjuvants which lead to the autoimmune/inflammatory response that leads to the autoimmune syndrome induced by adjuvants (ASIA).Dec 01, 2013

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Pubmed Data : J Autoimmun. 2013 Dec ;47:1-16. Epub 2013 Nov 13. PMID: 24238833

Article Published Date : Dec 01, 2013

Study Type : Review

Additional Links

Diseases : Autoimmune Diseases, Autoimmune Syndrome Induced by Adjuvants (ASIA), Inflammation

Additional Keywords : Blood Brain Barrier, Iatrogenic Disease

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Aluminum, Vaccine Adjuvants

Adverse Pharmacological Actions : Inflammatory

[+]

This review outlines the toxicity of chronic aluminum exposure.Jun 01, 2016

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Pubmed Data : Morphologie. 2016 Jun ;100(329):51-5. Epub 2016 Feb 28. PMID: 26922890

Article Published Date : Jun 01, 2016

Study Type : Review

Additional Links

Diseases : Aluminum Toxicity , Breast Cancer

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Aluminum

[+]

This review provides an overview of heavy metals as neurotoxins and their relevance to neurological diseases. The author also indicates that neurotoxin-free vaccine adjuvants are prudent.Jan 05, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Environ Res Public Health. 2017 12 5 ;14(12). Epub 2017 Dec 5. PMID: 29206191

Article Published Date : Jan 05, 2017

Study Type : Review

Additional Links

Diseases : Female, Neurodegenerative Diseases

Additional Keywords : Vaccine Research

Problem Substances : Aluminum, Heavy Metals, Lead, Mercury, Vaccine Adjuvants

Adverse Pharmacological Actions : Neurotoxic

[+]

This review provides evidence for the effects of aluminum on the immune system.Jan 01, 2013

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Pubmed Data : Environ Toxicol Pharmacol. 2013 Jan ;35(1):82-7. Epub 2012 Nov 26. PMID: 23274174

Article Published Date : Jan 01, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Psychiatry. 2004 Apr ;9(4):358-70. PMID: 14745455

Article Published Date : Mar 31, 2004

Study Type : In Vitro Study

Additional Links

Diseases : Attention Deficit Disorder, Autism Spectrum Disorders, Neurodevelopmental Disorders

Problem Substances : Aluminum, Ethanol, Lead, Thimerosal

Adverse Pharmacological Actions : Hypermethylation

[+]

This study suggests that excitotoxicity may be the central mechanism of autism spectrum disorders and that excitotoxins like aluminum, fluoride, and mercury may exacerbate excitotoxicity.Jan 01, 2009

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Pubmed Data : Curr Med Chem. 2009 ;16(2):157-70. PMID: 19149568

Article Published Date : Jan 01, 2009

Study Type : Review

Additional Links

Diseases : Autism, Autism Spectrum Disorders, Brain: Microglial Activation, Heavy Metal Toxicity

Additional Keywords : Heavy Metals and Autism, Vaccine Research

Problem Substances : Aluminum, Fluoride, Mercury

Adverse Pharmacological Actions : Excitotoxic, Neurotoxic

[+]

Vaccination with adjuvants may be responsible for a number of disorders. Feb 01, 2003

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Pubmed Data : Rev Neurol (Paris). 2003 Feb;159(2):162-4. PMID: 12660567

Article Published Date : Feb 01, 2003

Study Type : Commentary

Additional Links

Diseases : Chronic Fatigue Syndrome, Fibromyalgia, Gulf War Syndrome, Macrophagic myofasciitis , Vaccine-induced Toxicity

Problem Substances : Aluminum Hydroxide

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Chronic exposure to aluminum is associated with increased risk of Alzheimer's disease.Jan 01, 2016

This meta-analysis shows that the data available on the safety of aluminum adjuvants is severely lacking. There is also only data available for aluminum hydroxide and does not consider the toxicity of amorphous aluminum hydroxyphosphate.Feb 01, 2004

"Circulating levels of metals are related to carotid atherosclerosis in elderly."Dec 15, 2011

A number of commonly used drugs interfere with the absorption of levothyroxine. Dec 01, 2009

Administration of 240 mg of anthocyanins a day for 30 days caused a substantial increase of glutathione peroxidase and catalase activities. While decreasing the lead, aluminum and cooper concentrations.Oct 31, 2005

Aluminium content is higher in nipple aspirate fluid of breast cancer-affected women versus healthy controls. Apr 01, 2011

Aluminium in brain tissue in familial Alzheimer's disease.Feb 28, 2017

Aluminium is found in human breast tissue and may be connected to breast cancer incidence. Sep 01, 2007

Aluminium, carbonyls and cytokines in human nipple aspirate fluids: Possible relationship between inflammation, oxidative stress and breast cancer microenvironment.Jul 11, 2013

Aluminum can be distributed to the brain both in patients with renal insufficiency and healthy controls. Dec 01, 1987

Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration.Nov 01, 2009

Aluminum hydroxide-induced macrophagic myofasciitis (MMF) associated with vaccination has been reported. Nov 01, 2011

Aluminum vaccine adjuvants appear to contribute to the rising prevalence of autism.Nov 01, 2011

Association of serum aluminum levels with mortality in patients on chronic hemodialysis.Nov 12, 2018

Breastfed infants in Brazil receiving a full recommended schedule of immunizations showed an exceedingly high exposure of Al (225 to 1750 μg per dose) when compared with estimated levels absorbed from breast milk.Nov 01, 2010

Hair mercury levels in ASD patients were more than 3-fold and 2-fold higher as compared to the controls and children with catatonia in ASD.Dec 31, 2018

In infancy, exposures to aluminum and thimerosal binary mixtures is associated with increased risk of tics and other developmental disorders.Dec 01, 2019

In the present study, intracytoplasmic inclusions were constantly detected in macrophages of the MMF lesions and were shown to contain aluminium by three different methods.Aug 31, 2001

Increased aluminum content in certain brain structures is correlated with higher silicon concentration in alcoholic use disorder.May 02, 2019

Intramuscular injection of alum-containing vaccine was associated with the appearance of aluminum deposits in distant organs.Apr 03, 2013

Lead and mercury negatively affect infant milestones like walking and talking.Apr 01, 2014

Levels of mercury, lead, and aluminum in the hair of autistic children are higher than controls.Dec 31, 2014

Long-term persistence of vaccine-derived aluminum hydroxide within the body assessed by MMF is associated with cognitive dysfunction.Oct 31, 2009

Macrophagic myofasciitis in children is a localized reaction to vaccination.May 31, 2008

Parenteral nutrition formulas for neonates have potentially toxic levels of aluminum.Feb 01, 2010

Selective accumulation of aluminum in cerebral arteries in Alzheimer's disease.Aug 31, 2013

The association with DTwP vaccines and increased infant mortality in females may be due to vaccine adjuvants and Th2 polarizing effects.Jan 01, 2011

The brain aluminium content is extraordinarily high in people with autism. Feb 28, 2018

The CDC's safety data for aluminum adjuvant safety in infants is based on the pharmacokinetics of a non-adjuvant aluminum compound in one adult male.Nov 28, 2011

The results suggest that aluminum-induced CRP may in part contribute to a pathophysiological state associated with a chronic systemic inflammation of the human vasculature.Jul 31, 2015

The use of acid-suppressive therapy, particularly proton pump inhibitors, and NSAIDs are associated with an increased risk of community-acquired C difficile.Dec 21, 2005

The use of aluminum utensils for cooking meals is associated with chronic aluminum toxicity.Mar 31, 2019

The vaccines containing the adjuvant aluminium hydroxide may trigger macrophagic myofasciitis in some patients.Dec 31, 2014

These results provide a neurobiological substrate for brain dysfunction in aluminum hydroxide adjuvant-induced macrophagic myofasciitis patients.Dec 31, 2014

This data supports the historic evidence that heavy metals play a role in the development of ASD.Dec 31, 2011

This study demonstrates a significant positive association between the severity of autism and the relative body burden of toxic metals.Jan 01, 2009

This study is the only study examining changes in serum and urinary levels of aluminum in 15 infants after a routine 2-month vaccination. The data for the post-vacc measurements are missing.Sep 01, 2013

Up-to-date children were exposed to 11-26% more aluminum from vaccines than undervaccinated children between 2004 and 2011.Nov 26, 2015

Using morin stain, this study demonstrates that macrophagic myofasciitis (mostly pediatric) patient's macrophages test positive for aluminum.Jan 01, 2017

Aluminum could increase the migration of human breast cancer cells irrespective of their oestrogen responsiveness.Sep 07, 2015

Aluminum hydroxide-stimulated macrophages contain large and persistent intracellular crystalline inclusions.Aug 13, 2004

Aluminum in neurological and neurodegenerative disease.Jan 30, 2019

Aluminum induces inflammatory and proteolytic alterations in human monocytic cell line.Sep 20, 2015

Aluminum nanoparticles are genotoxic in vitro.Feb 01, 2016

Iron influences the binding of aluminum to transferrin.May 01, 1997

Most human placental samples contain aluminum. Aug 31, 2010

NP concentrations over 200 μg/mL are large enough to induce cytotoxic and genotoxic effects to cells.May 01, 2015

Thimerosal at low nanomolar concentrations was able to induce significant cellular toxicity in human neuron and fetal cells.May 31, 2009

The pathogenic role of aluminium hydroxide is now recognized by the presence of chronic fatigue syndrome, macrophagic myofasciitis and subcutaneous pseudolymphoma, linked to intramuscular injection of aluminium hydroxide-containing vaccines.Mar 14, 2012

A case of multiple sclerosis improvement following removal of heavy metal intoxication has been reported.Mar 22, 2012

Central nervous system disease in patients with macrophagic myofasciitis.Apr 30, 2001

Elevated urinary excretion of aluminium and iron in multiple sclerosis has been observed. Oct 01, 2006

Macrophagic myofasciitis associated with vaccine-derived aluminium.Jul 31, 2005

Pediatric Wells syndrome (eosinophilic cellulitis) after vaccination.Aug 31, 2018

This case report described a man whose occupational exposure to aluminum suggests a role for aluminum in disease aetiology.Feb 10, 2014

"Aluminium content of drinking waters, fruit juices and soft drinks: contribution to dietary intake."Jun 26, 2002

A histological study of toxic effects of aluminium sulfate on rat hippocampus.Jan 31, 2015

A white button mushroom extract acted as a potent dietary antioxidant and protects against Al-mediated neurotoxicity, by abrogating neuronal oxidative stress.Aug 31, 2014

Administration of resveratrol along with aluminum + fluoride showed significant reversal of oxidative stress and neuronal damage.May 31, 2016

Alhydrogel injected at low dose in mouse muscle may selectively induce long-term Al cerebral accumulation and neurotoxic effects.Nov 27, 2016

Alum induces a Sjögren’s syndrome-like disorder in mice.Feb 28, 2014

Aluminium accelerates the reduction of neural stem cells, cell proliferation, and neuroblast differentiation.Dec 31, 2013

Aluminium chelation by glutathione can provide an alleviatory remedy of neuropathic pain for cancer patients with oxaliplatin-induced neuropathic pain.Dec 31, 2016

Aluminium could induce imbalance of the normal intestinal flora in mice.Nov 30, 1998

Aluminium may cause severe motor neuron damage in rat spinal cord resembling amyotrophic lateral sclerosis.Mar 31, 1999

Aluminium, fluoride and a combination of aluminium-fluoride treatments caused an increase in brain lipid peroxidation products and reactive oxygen species formation.Feb 28, 2015

Aluminium-adjuvanted vaccines transiently increase aluminium levels in murine brain tissue.Mar 31, 1992

Aluminum adjuvants can impair social behaviour if applied in the early period of postnatal development.Nov 20, 2017

Aluminum adjuvants in vaccines are transported by the iron transporter, transferrin. This animal study demonstrates that cells in the brain have a high affinity for transferrin, independent of the metal being transported. Nov 01, 1990

Aluminum adjuvants linked to Gulf War illness induces motor neuron death in mice. Jan 01, 2007

Aluminum and copper in drinking water enhance inflammatory or oxidative events specifically in the brain.Jun 30, 2006

Aluminum

View the Evidence:
271 Abstracts with Aluminum Research