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18 Diseases Researched for Proanthocyanidins
NameACCKFocus
Hypertension110Locked
Menopausal Syndrome110Locked
Diabetes Mellitus: Type 223Locked
Blood Sugar Problems12Locked
Circadian Dysregulation12Locked
Hyperglycemia12Locked
Hyperinsulinism12Locked
Kidney Damage12Locked
Liver Damage12Locked
Bladder Cancer11Locked
Escherichia coli Infections11Locked
Head and Neck Cancer11Locked
Infection: Antibiotic Resistant11Locked
Norovirus11Locked
Ovarian Cancer11Locked
Periodontal Diseases11Locked
Retinal Degeneration: Light-Induced11Locked
Urinary Tract Infections11Locked
12 Pharmacological Actions Researched for Proanthocyanidins
NameACCKFocus
Antioxidants211Locked
Antihypertensive Agents110Locked
Antiproliferative 22Locked
Hepatoprotective12Locked
Renoprotective12Locked
Anti-Angiogenic11Locked
Anti-Apoptotic11Locked
Anti-Bacterial Agents11Locked
Antiviral Agents11Locked
Apoptotic11Locked
Epidermal growth factor receptor (EGFR) inhibitor11Locked
NF-kappaB Inhibitor11Locked

View the Evidence:
24 Abstracts with Proanthocyanidins Research

[+]

Grape seed proanthocyanidin extract is effective in improving the physical and psychological symptoms of menopause while increasing muscle mass and reducing blood pressure.Aug 31, 2014

Pubmed Data : Menopause. 2014 Sep ;21(9):990-6. PMID: 24518152
Article Published Date : Aug 31, 2014
Study Type : Human Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Hypertension, Menopausal Syndrome
Pharmacological Actions : Antihypertensive Agents, Antioxidants
Additional Keywords : Significant Treatment Outcome
[+]

Oral grape seed proanthocyanidin extract therapy for 1 year improved hard exudates in patients with non-proliferative diabetic retinopathy.Apr 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicine (Baltimore). 2019 May ;98(21):e15515. PMID: 31124931
Article Published Date : Apr 30, 2019
Study Type : Human Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Diabetic Retinopathy
[+]

Grape seed proanthocyanidin extract treatment maintained nocturnal melatonin levels and altered the oscillations of some metabolites in plasma.Apr 30, 2015

Pubmed Data : Mol Nutr Food Res. 2015 May ;59(5):865-78. Epub 2015 Mar 23. PMID: 25677201
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Melatonin, Proanthocyanidins
Diseases : Circadian Dysregulation
Additional Keywords : Chronobiotic, Circadian Clock Proteins, Plant Extracts
[+]

Grape seed proanthocyanidins is superior to metformin to promote insulin signaling in rats fed high calorie diet.Sep 11, 2013

Pubmed Data : J Cell Commun Signal. 2013 Sep 12. Epub 2013 Sep 12. PMID: 24026800
Article Published Date : Sep 11, 2013
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Blood Sugar Problems, Diabetes Mellitus: Type 2, Hyperglycemia, Hyperinsulinism
Additional Keywords : Superiority of Natural Substances versus Drugs
Problem Substances : Metformin
[+]

Grape seeds proanthocyanidin extract ameliorates Ehrlich solid tumor induced renal tissue and DNA damage in mice.Jun 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Jul ;115:108908. Epub 2019 May 17. PMID: 31108378
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : DNA damage, Ehrlich carcinoma, Kidney Damage
Pharmacological Actions : Renoprotective
[+]

Lipophilic grape seed proanthocyanidin inhibited the growth of PC3-derived mouse xenografts by inhibiting tumor cell proliferation and inducing apoptosis.Jan 08, 2019

Pubmed Data : J Agric Food Chem. 2019 Jan 9 ;67(1):229-235. Epub 2018 Dec 28. PMID: 30562012
Article Published Date : Jan 08, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Lotus seed procyanidins prevent oxidative stress by extremely low frequency electromagnetic fields in mice.Aug 01, 2016

Pubmed Data : Biomed Pharmacother. 2016 Aug ;82:640-8. Epub 2016 Jun 13. PMID: 27470407
Article Published Date : Aug 01, 2016
Study Type : Animal Study
Additional Links
Substances : Lotus , Proanthocyanidins
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Malondialdehyde Down-regulation
Anti Therapeutic Actions : Electromagnetic Fields, Electromagnetic Radiation
Adverse Pharmacological Actions : Oxidant
[+]

Lotus seed skin proanthocyanidin extract exhibits potent antioxidant property via activation of the Nrf2-ARE pathway.Dec 31, 2018

Pubmed Data : Acta Biochim Biophys Sin (Shanghai). 2019 Jan 1 ;51(1):31-40. PMID: 30544155
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lotus , Proanthocyanidins
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Nrf2 activation
Additional Keywords : Plant Extracts, Proanthocyanidins
[+]

Pretreatment of grape seed proanthocyanidin extract exerts neuroprotective effect in murine model of neonatal hypoxic-ischemic brain injury.May 29, 2019

Pubmed Data : Cell Mol Neurobiol. 2019 May 30. Epub 2019 May 30. PMID: 31147852
Article Published Date : May 29, 2019
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Brain Ischemia
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Proanthocyanidin-rich date seed extract protects against chemically induced hepatorenal toxicity.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Food. 2015 Mar ;18(3):280-9. Epub 2015 Jan 8. PMID: 25569813
Article Published Date : Feb 28, 2015
Study Type : Animal Study
Additional Links
Substances : Date Seeds, Proanthocyanidins
Diseases : Kidney Damage, Liver Damage
Pharmacological Actions : Hepatoprotective, Renoprotective
[+]

These findings provide potential mechanisms for grape seed proanthocyanidin intake to improve lipid metabolism.Jun 07, 2019

Pubmed Data : J Nutr. 2019 Jun 8. Epub 2019 Jun 8. PMID: 31175811
Article Published Date : Jun 07, 2019
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Hyperlipidemia
Pharmacological Actions : Gastrointestinal Agents, Hypolipidemic
[+]

Antitumor effect of proanthocyanidin induced apoptosis in human colorectal cancer (HT-29) cells and its molecular docking studies.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Chem. 2019 Dec ;13(1):21. Epub 2019 Feb 4. PMID: 31384770
Article Published Date : Nov 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Proanthocyanidins
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Bilberry and lingonberry containing anthocyanidins, procyanidin, and resveratrol exert protective effects against blue LED light-induced retinal photoreceptor cell damage.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2014 ;14:120. Epub 2014 Apr 2. PMID: 24690313
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Anthocyanins, Bilberry, Lingonberry, Polyphenols, Proanthocyanidins, Resveratrol
Diseases : Retinal Degeneration: Light-Induced
Pharmacological Actions : Anti-Apoptotic, Antioxidants, NF-kappaB Inhibitor
Additional Keywords : Light-Emitting Diodes (LEDs), Phytotherapy, Plant Extracts
Anti Therapeutic Actions : Blue Light (400−495 nm)
[+]

Blueberry proanthocyanidins have potential as preventive and therapeutic options for foodborne viral illnesses.Apr 30, 2017

Pubmed Data : Food Microbiol. 2017 May ;63:263-267. Epub 2016 Nov 30. PMID: 28040178
Article Published Date : Apr 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Blueberry, Proanthocyanidins
Diseases : Norovirus
Pharmacological Actions : Antiviral Agents
[+]

Cranberry proanthocyanidins may have therapeutic value in periodontal disease.Nov 14, 2011

Pubmed Data : J Agric Food Chem. 2011 Nov 14. Epub 2011 Nov 14. PMID: 22082264
Article Published Date : Nov 14, 2011
Study Type : Review
Additional Links
Substances : Cranberry, Proanthocyanidins
Diseases : Periodontal Diseases
[+]

Cranberry proanthrocyanidins have anti-ovarian cell activity. Sep 12, 2011

Pubmed Data : Int J Oncol. 2011 Sep 12. Epub 2011 Sep 12. PMID: 21922132
Article Published Date : Sep 12, 2011
Study Type : In Vitro Study
Additional Links
Substances : Cranberry, Proanthocyanidins
Diseases : Ovarian Cancer
Pharmacological Actions : Anti-Angiogenic
[+]

Grape seed proanthocyanidin (GSP) enhances the anti cancer effect of interferon on T24 human bladder carcinoma cellsJan 01, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer. 2012 ;3:107-12. Epub 2012 Mar 1. PMID: 22393334
Article Published Date : Jan 01, 2012
Study Type : In Vitro Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Bladder Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Plant Extracts, Proanthocyanidins
[+]

Grape seed proanthocyanidins, honokiol and EGCG appear to be promising bioactive phytochemicals for the management of head and neck cancer.Nov 23, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2016 Nov 24 ;21(12). Epub 2016 Nov 24. PMID: 27886147
Article Published Date : Nov 23, 2016
Study Type : Review
Additional Links
Substances : EGCG (Epigallocatechin gallate), Grape Seed Extract, Honokiol, Proanthocyanidins
Diseases : Head and Neck Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Inhibition of viral RNA synthesis in canine distemper virus infection by proanthocyanidin A2.Nov 30, 2011

Pubmed Data : Antiviral Res. 2011 Dec ;92(3):447-52. Epub 2011 Oct 13. PMID: 22020306
Article Published Date : Nov 30, 2011
Study Type : In Vitro Study
Additional Links
Substances : Proanthocyanidins
Diseases : Animal Diseases: Canine Distemper Virus
Pharmacological Actions : Antiviral Agents
Additional Keywords : Proanthocyanidins
[+]

Inhibition of β-amyloid-induced neurotoxicity by planar analogues of procyanidin B3.Jul 22, 2019

Pubmed Data : Bioorg Med Chem Lett. 2019 Jul 23. Epub 2019 Jul 23. PMID: 31371134
Article Published Date : Jul 22, 2019
Study Type : In Vitro Study
Additional Links
Substances : Proanthocyanidins
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Phenolic compounds present in fruit extracts of Malus spp. show antioxidative and pro-apoptotic effects on human gastric cancer cell lines.Aug 31, 2019

Pubmed Data : J Food Biochem. 2019 Sep 1:e13028. Epub 2019 Sep 1. PMID: 31475373
Article Published Date : Aug 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Apple, Proanthocyanidins
Diseases : Gastric Cancer
Pharmacological Actions : Antioxidants, Apoptotic
[+]

PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma.May 16, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Clin Cancer Res. 2019 May 17 ;38(1):204. Epub 2019 May 17. PMID: 31101057
Article Published Date : May 16, 2019
Study Type : In Vitro Study
Additional Links
Substances : Proanthocyanidins
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Proanthocyanidin inhibits the adherence of multi-drug resistant E. coli. Jun 19, 2011

Pubmed Data : Urol Res. 2011 Jun 19. Epub 2011 Jun 19. PMID: 21688109
Article Published Date : Jun 19, 2011
Study Type : In Vitro Study
Additional Links
Substances : Cranberry, Proanthocyanidins
Diseases : Escherichia coli Infections, Infection: Antibiotic Resistant, Urinary Tract Infections
Pharmacological Actions : Anti-Bacterial Agents
[+]

Proanthocyanidins are the major anti-diabetic components of cinnamon water extract.Mar 06, 2013

Pubmed Data : Food Chem Toxicol. 2013 Mar 7 ;56C:398-405. Epub 2013 Mar 7. PMID: 23499750
Article Published Date : Mar 06, 2013
Study Type : In Vitro Study
Additional Links
Substances : Cinnamon, Proanthocyanidins
Diseases : Diabetes Mellitus: Type 2

Copyright: radiantskies / 123RF Stock Photo

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