Melatonin

Name	AC	CK
Oxidative Stress	51	107
Breast Cancer	39	83
Sleep Disorders	4	52
Alzheimer's Disease	16	49
Inflammation	15	45
Circadian Dysregulation	7	44
Hormone Imbalances: Low Melatonin	7	38
Parkinson's Disease	6	35
Chemotherapy and Radiation Toxicity	9	31
Delirium	3	31
Neurodegenerative Diseases	9	31
C-Reactive Protein	2	30
Tinnitus	3	30
Brain Injury: Traumatic	5	26
Lipid Peroxidation	9	26
Aging	12	23
Cancers: All	4	23
Chronic Pain	4	23
Jet Lag	4	23
Insomnia	3	22
Metabolic Syndrome X	2	22
Gastroesophageal Reflux	3	21
Headache: Migraine	3	21
Delayed Sleep Phase Disorder	1	20
Depressive Disorder	2	20
Multiple Sclerosis: Relapsing-Remitting	2	20
Overweight	1	20
Purpura: Thrombocytopenic	2	20
Thrombocytopenia	2	20
Diabetes Mellitus: Type 2	5	18
Liver Cancer	9	18
Cognitive Decline/Dysfunction	4	16
Multiple Sclerosis	4	15
Obesity	8	15
Aging: Brain	7	14
Ovarian Cancer	4	14
Prostate Cancer	4	14
Aging Skin	3	13
Bisphenol Toxicity	8	13
Epilepsy	3	13
Headache	4	13
Sepsis	3	13
Autism	2	12
Brain: Oxidative Stress	7	12
Breast Cancer: Metastatic	2	12
Chemically-Induced Liver Damage	2	12
Chemotherapy-Induced Toxicity: Cyclophosphamide	2	12
Lipopolysaccharide-Induced Toxicity	5	12
Nocturia	2	12
Osteoporosis	2	12
Scoliosis	2	12
Anxiety Disorders	2	11
Bipolar Disorder	2	11
Depression	7	11
Fibromyalgia	2	11
Muscle Damage: Exercise-Induced	2	11
Pancreatitis	2	11
Periodontal Diseases	2	11
Abdominal Obesity (Midsection Fat)	1	10
Aneurysmal subarachnoid hemorrhage (SAH)	1	10
Asperger Syndrome	1	10
Athletic Performance	1	10
Benzo[a]pyrene-induced Toxicity	1	10
Bone Fractures	1	10
Chronic Fatigue Syndrome	1	10
Colorectal Cancer	1	10
Coronary Artery Disease	1	10
Coronary Bypass Surgery	1	10
Cortisol: High	1	10
Depression: Breast Cancer Related	1	10
Erythema	1	10
Graves Disease	1	10
Human Growth Hormone: Enhancement	1	10
Osteopenia	1	10
Retinal Diseases	1	10
Retinal Sensitivity	1	10
Sclerosis: Systemic	1	10
Skin Diseases	1	10
Skin Diseases: Photo-Aging	1	10
Weight Gain: Drug-Induced	1	10
Brain Inflammation	5	9
Liver Injury: Ischemia/reperfusion	5	8
Mobile Phone-Induced Oxidative Stress	4	8
Aluminum Toxicity	4	7
Anxiety	5	7
Cancer Metastasis	3	7
Diabetic Nephropathy	4	7
Myocardial Infarction	4	7
Insulin Resistance	3	6
Kidney Damage	3	6
Lung Cancer	2	6
Mitochondrial Dysfunction	4	6
Myocardial Ischemia	3	6
Osteosarcoma	2	6
Periodontitis	3	6
Spinal Cord Injuries	3	6
Stress	3	6
Stroke: Attenuation/Recovery	5	6
Testicular Injury: Chemical/Metal Induced	3	6
DNA damage	4	5
Endometriosis	3	5
Hypertension	3	5
Neuroblastoma	1	5
Osteoporosis: Inflammation Induced	1	5
Pancreatic Cancer	4	5
Radiation Induced Illness	3	5
Ultraviolet Radiation Induced Damage	4	5
Breast Cancer: Triple Negative	3	4
Cardiovascular Diseases	3	4
Cerebral Hypoperfusion	2	4
Chemotherapy-Induced Toxicity	3	4
Encephalitis	2	4
Fluoride Toxicity	3	4
High Fat Diet	2	4
High Fructose Diet	2	4
Hypoxia	2	4
Infertility	2	4
Kidney Diseases	2	4
Liver Fibrosis	2	4
Memory Disorders	2	4
Metabolic Diseases	2	4
Neonatal Stroke	2	4
Pesticide Toxicity	2	4
Pregnancy Complications	2	4
Stroke: Ischemic	2	4
Amyotrophic Lateral Sclerosis	3	3
Arsenic Poisoning	2	3
Brain Damage	2	3
Brain Ischemia	2	3
Breast Cancer: Estrogen	3	3
Breast Cancer: estrogen receptor alpha-positive	2	3
Cadmium Poisoning	2	3
Cervical Cancer	2	3
Colon Cancer	3	3
Gastric Ulcer	2	3
Glioblastoma	3	3
Irritable Bowel Syndrome	3	3
Ischemia	2	3
Leukemia	2	3
Liver Damage	2	3
Liver Disease	2	3
Nicotine/Tobacco Toxicity	2	3
Pituitary Tumours	2	3
Psychiatric Disorders	2	3
Schizophrenia	2	3
Ulcerative Colitis	2	3
Acetaminophen (Tylenol) Toxicity	1	2
Acrylamide-induced toxicity	1	2
Air Pollution Linked Toxicity	1	2
Alcohol Toxicity	1	2
Alcoholic Liver Disease	1	2
Amnesia	1	2
Autism Spectrum Disorders	2	2
Benzene Toxicity	1	2
Bile Duct Injury	1	2
Breast Cancer: Lung Metastasis	1	2
Cataract: Radiation-Induced	1	2
Cell Phone Induced Disease	1	2
Cerebral Ischemia	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Chemotherapy-Induced Toxicity: Oxaliplatin	1	2
Cocaine Addiction	1	2
Cocaine Withdrawal	1	2
Colitis	1	2
Colon Cancer: Prevention	1	2
Cough	1	2
Dementia	1	2
Demyelinating Diseases	1	2
Depression	1	2
Depression: Stress Related	1	2
Diabetes: Oxidative Stress	1	2
Diabetic Retinopathy	1	2
Drug-Induced Toxicity: Bisphosphonates	1	2
Drug-Induced Toxicity: Indomethacin	1	2
Drug-Induced Toxicity: Methotrexate	1	2
Dysbiosis	1	2
Edema	1	2
Electromagnetic Radiation	1	2
Endometrial Cancer	1	2
Endothelial Dysfunction	1	2
Estrogen Deficiency	1	2
Gastric Cancer	2	2
Glaucoma	3	2
Gliomas	1	2
Glutathione Deficiency	1	2
Headache: Cluster	2	2
Heart Disease	1	2
Herbicide Toxicity	1	2
High Homocysteine	1	2
Hydrogen Peroxide Induced Toxicity	2	2
Hyperalgesia	1	2
Hyperbilirubinemia: Hereditary	1	2
Hyperglycemia	1	2
Hyperlipidemia	1	2
Hypertension: Pulmonary	1	2
Hyperthyroidism	1	2
Hypoxia: Brain	1	2
Immune Disorders: Low Immune Function	1	2
Inflammation: Brain	1	2
Intestinal Ischemia	1	2
Kidney Damage: Drug-Induced	1	2
Kidney Failure	1	2
Leiomyosarcoma	1	2
Low Immune Function: Natural Killer Cells	1	2
Macular Degeneration	3	2
Morphine Tolerance/Dependence	1	2
Multi-Organ Failure	1	2
Neural Tube Defects	1	2
Neuralgia: Post Herpetic	1	2
Neuritis: Brachial Plexus	1	2
Obstructive Nephropathy	1	2
Oral Cancer	2	2
Ovariectomy Associated Adverse Changes	1	2
Prediabetes	1	2
Prenatal Nutrition: Prevention of Problems	1	2
Quality of Life: Poor	1	2
Radiation-Induced Illness: Cesium-137 Exposure	1	2
Sleep Apnea: Central	1	2
Snake Bite: Venom Toxicity	1	2
Subarachnoid hemorrhage	2	2
Testicular Injury: Formaldehyde-Induced	1	2
Testicular Injury: Nicotine-Induced	1	2
Traumatic Brain Injury	1	2
Tumors	2	2
Vaginal Cancer	1	2
Acute T cell Leukemias	1	1
Amphetamine Addiction/Withdrawal	1	1
Amyotrophic lateral sclerosis (ALS)	1	1
Brain Edema	1	1
Cancers: Drug Resistant	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Chemotherapy-Induced Toxicity: Arsenic Trioxide	1	1
Chronic Disease	1	1
Chronic Kidney Disease (CKD)	1	1
Crohn's Disease	1	1
Diabetes Mellitus: Type 1	1	1
Ebola Virus Infections	1	1
Endocrine Diseases	1	1
Estrogen Dominance	1	1
Fractures: Bone	1	1
Fragile X Syndrome	1	1
Gallbladder Inflammation	1	1
Gallstones	1	1
Gastritis	1	1
Head and Neck Cancer	1	1
Heavy Metal Toxicity	1	1
Huntington Disease	1	1
Liver Damage: Aflatoxin-Induced	1	1
Mastitis	1	1
Melanoma	1	1
Migraine Disorders	1	1
Migraines	1	1
Mitochondrial Diseases	1	1
Mood Disorders	1	1
Napthalene-Induced Toxicity	1	1
Nasopharyngeal Cancer	1	1
Non-Small-Cell Lung Carcinoma	1	1
Organ Transplantation	1	1
Organ Transplantation: Liver	1	1
Osteoarthritis	1	1
Osteoarthritis: Knee	1	1
Pancreatic Diseases	1	1
Pineal Gland Calcification	1	1
Pineal Gland Diseases	1	1
Post-Traumatic Stress Disorders (PTSD)	1	1
Prostatic Hyperplasia: Benign	1	1
Renal Cancer	1	1
Retinopathy of Prematurity	1	1
Rheumatoid Arthritis	1	1
Sarcoma: Ewing's	1	1
Septic Shock	1	1
Squamous cell carcinoma	1	1
Stroke: Hemorrhagic	1	1
Systemic Lupus Erythematosus	1	1
Wound Healing: Delayed	1	1
Abdominal Adhesions	1	0
Sarcoidosis	1	0

Name	AC	CK
Antioxidants	121	266
Neuroprotective Agents	73	158
Anti-Inflammatory Agents	51	132
Tumor Necrosis Factor (TNF) Alpha Inhibitor	15	57
Apoptotic	34	54
Antiproliferative	31	50
Anti-Apoptotic	24	40
Antidepressive Agents	7	38
Hepatoprotective	20	36
Interleukin-6 Downregulation	6	35
Prophylactic Agents	5	33
Brain-derived neurotrophic factor modulator	4	26
Renoprotective	13	24
NF-kappaB Inhibitor	15	23
Secretagogue	3	22
Anti-metastatic	15	21
Chemosensitizer	16	21
Antinoceceptive	1	20
Cardioprotective	11	20
Cyclooxygenase 2 Inhibitors	10	20
Interleukin-1 beta downregulation	10	19
Malondialdehyde Down-regulation	5	18
Tumor Suppressor Protein p53 Upregulation	15	18
Osteogenic	3	17
Cytoprotective	9	16
Radioprotective	9	15
Angiogenesis Inhibitors	6	12
Insulin Sensitizers	2	12
Proton Pump Inhibitor	2	11
Adiponectin upregulation	1	10
Anxiolytic	1	10
Bcl-2 protein down-regulation	7	10
Chemoprotective Agents	6	10
Insulin-Like Growth Factor Inhibition/Downregulation	1	10
Superoxide Dismutase Up-regulation	6	10
Vasodilator Agents	1	10
Anticarcinogenic Agents	5	9
Chemopreventive	5	9
Immunomodulatory	6	9
Nrf2 activation	7	9
Antihypertensive Agents	5	8
Antineoplastic Agents	6	8
Cell cycle arrest	8	8
Hypolipidemic	4	8
Matrix metalloproteinase-2 (MMP-2) inhibitor	4	8
Vascular Endothelial Growth Factor Inhibitors	4	8
Chemotherapeutic	7	7
Matrix metalloproteinase-9 (MMP-9) inhibitor	6	7
Analgesics	5	6
Gastroprotective	4	6
Regenerative	3	6
Gastrointestinal Agents	3	5
MicroRNA modulator	4	5
Nitric Oxide Inhibitor	1	5
Prostaglandin PGE2 downregulation	1	5
Anti-Anxiety Agents	3	4
Autophagy Inhibitors	2	4
Genoprotective	3	4
Hypoglycemic Agents	2	4
Antiviral Agents	2	3
Aromatase Inhibitors	3	3
Caspase-3 Activation	2	3
Heme oxygenase-1 up-regulation	3	3
Photoprotective	2	3
Radiosensitizer	3	3
Acetylcholinesterase Inhibitor	1	2
Adenosine Monophosphate (AMP)-activated Protein Kinase (AMPK	1	2
Anti-Angiogenic	2	2
Anti-Proliferative	1	2
Anti-Ulcer Agents	1	2
Anticonvulsants	1	2
Antimutagenic Agents	1	2
Autophagy Up-regulation	1	2
BRCA-1 Downregulation	2	2
Detoxifier	1	2
Fertility Agents	1	2
Heat Shock Protein Down-Regulation	1	2
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	2	2
Interleukin-10 downregulation	1	2
Interleukin-4 downregulation	1	2
Neurogenesis	1	2
Neuroplasticity enhancement	1	2
Neurorestorative	1	2
Receptor-Related Orphan Receptor (ROR)-Alpha1 Inhibitor	1	2
SIRT1 Activator	1	2
12-lipoxygenase (12-LOX) Inhibitor	1	1
Apaf-1/caspase-dependent apoptotic pathway activator	1	1
Bax/Bcl2 ratio: Increase	1	1
Caspase-9 Activation	1	1
Catalase Up-Regulation	1	1
Cell Differentiation Inducer	1	1
Chondroprotective	1	1
Cyclooxygenase Inhibitors	1	1
DNA Repair Up-regulation	1	1
Drug synergy	1	1
Enzyme Inhibitors	1	1
Glutathione Upregulation	1	1
Interleukin-8 downregulation	1	1
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	1
P21 Activation	1	1
P38 Mitogen-Activated Protein Kinase Modulator	1	1
PI3K/Akt/signaling suppression	1	1
Selective estrogen enzyme modulator (SEEM)	1	1
Telomerase Inhibitor	1	1
Telomerase Upregulation	1	1
Vascular Endothelial Growth Factor A Inhibitor	1	1
p300/NF-κB down-regulation	1	1

[+]

Melatonin could have an effect on body weight. Nov 28, 2016

Click here to read the entire abstract

Pubmed Data : Curr Pharm Des. 2016 Nov 29. Epub 2016 Nov 29. PMID: 27897121

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2017 Nov 21 ;8(59):100582-100592. Epub 2017 Oct 5. PMID: 29246003

Article Published Date : Nov 20, 2017

Study Type : Meta Analysis, Review

Additional Links

Substances : Melatonin

Diseases : Chronic Pain

Pharmacological Actions : Antinoceceptive , Brain-derived neurotrophic factor modulator

Additional Keywords : Antinoceceptive, Brain-derived neurotrophic factor modulator, Chronic Pain, melatonin

[+]

There is evidence that melatonin treatment after traumatic brain injury significantly improves both behavioural outcomes and pathological outcomes.Jun 13, 2018

Click here to read the entire abstract

Pubmed Data : J Neurotrauma. 2018 Jun 14. Epub 2018 Jun 14. PMID: 29901413

Click here to read the entire abstract

Pubmed Data : J Pineal Res. 2006 Oct;41(3):195-200. PMID: 16948779

Article Published Date : Oct 01, 2006

Study Type : Human Study

Additional Links

Substances : Betaine , Folic Acid , Melatonin, Methionine, Tryptophan, Vitamin B-12, Vitamin B-6

Diseases : Gastroesophageal Reflux

Pharmacological Actions : Proton Pump Inhibitor

Additional Keywords : Superiority of Natural Substances versus Drugs

[+]

Pharmacological Actions : Antidepressive Agents

[+]

Circadian melatonin disruption can be used as an indicator of delirium.Sep 30, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sleep Sci. 2016 Oct-Dec;9(4):285-288. Epub 2016 Aug 10. PMID: 28154742

Article Published Date : Sep 30, 2016

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Circadian Dysregulation, Delirium

[+]

Coadministration of melatonin with olanzapine in adolescents with bipolar disorder could reduce the sharp weight gain side effect.Mar 23, 2017

Click here to read the entire abstract

Pubmed Data : J Child Adolesc Psychopharmacol. 2017 Mar 24. Epub 2017 Mar 24. PMID: 28339282

Article Published Date : Mar 23, 2017

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Weight Gain: Drug-Induced

Additional Keywords : Risk Reduction

Problem Substances : Olanzapine

[+]

Combined treatment including melatonin resulted in the improvement of general conditions in 81.7% of the patientsDec 31, 2012

Click here to read the entire abstract

Pubmed Data : Klin Med (Mosk). 2013 ;91(3):50-3. PMID: 23789453

Meditation results in acute increases in night-time plasma melatonin levels.May 01, 2000

Pubmed Data : BMJ. 1989 Mar 18;298(6675):705-7. PMID: 2496815

Article Published Date : Mar 18, 1989

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Jet Lag

[+]

Melatonin can modulate the inflammatory actions in periodontal patients.Nov 30, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Clin Exp Dent. 2015 Dec ;7(5):e628-e633. Epub 2015 Dec 1. PMID: 26644840

Article Published Date : Nov 30, 2015

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : C-Reactive Protein, Inflammation, Periodontal Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Melatonin could be effective and safe for decreasing daytime seizure frequency in patients with intractable epilepsy.Feb 28, 2012

Click here to read the entire abstract

Pubmed Data : J Child Neurol. 2012 Feb 28. Epub 2012 Feb 28. PMID: 22378657

Article Published Date : Feb 28, 2012

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Epilepsy

[+]

Melatonin could be used in migraine prophylaxis treatments. Dec 31, 2017

Click here to read the entire abstract

Pubmed Data : Iran J Child Neurol. 2018 ;12(1):47-54. PMID: 29379562

Article Published Date : Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Physiol Pharmacol. 2016 Apr ;67(2):235-42. PMID: 27226183

Article Published Date : Mar 31, 2016

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Chronic Fatigue Syndrome, Multiple Sclerosis

Pharmacological Actions : Antioxidants

[+]

Pubmed Data : Breast Cancer Res Treat. 2014 Jun ;145(3):683-95. Epub 2014 Apr 23. PMID: 24756186

Article Published Date : May 31, 2014

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Depression: Breast Cancer Related

Therapeutic Actions : Placebo Effect

Pharmacological Actions : Antidepressive Agents

[+]

Melatonin treatment is associated with significant nocturia response rate.Mar 01, 2004

Click here to read the entire abstract

Pubmed Data : J Urol. 2004 Mar;171(3):1199-202. PMID: 14767300

Article Published Date : Mar 01, 2004

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Nocturia

[+]

Melatonin was superior to amitriptyline in the percentage of patients with a greater than 50% reduction in migraine frequency.May 09, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Neurol Neurosurg Psychiatry. 2016 May 10. Epub 2016 May 10. PMID: 27165014

Article Published Date : May 09, 2016

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Headache: Migraine

Pharmacological Actions : Prophylactic Agents

Additional Keywords : Superiority of Natural Substances versus Drugs

Problem Substances : Antidepressants

[+]

Melatonin, quercetin and NAC are beneficial in reducing oxidative stress in the patients with Grave's Disease. Sep 01, 2005

Click here to read the entire abstract

Pubmed Data : Pharmazie. 2005 Sep;60(9):696-700. PMID: 16222871

Article Published Date : Sep 01, 2005

Study Type : Human Study

Additional Links

Substances : Melatonin, NAC (N-acetyl-L-cysteine), Quercetin

Diseases : Graves Disease

Pharmacological Actions : Antioxidants

[+]

Mobile phone exposure may affect melatonin onset time.Feb 01, 2006

Click here to read the entire abstract

Pubmed Data : Int J Radiat Biol. 2006 Feb ;82(2):69-76. PMID: 16546905

Article Published Date : Feb 01, 2006

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Sleep Disorders

Anti Therapeutic Actions : Electromagnetic Fields, Electromagnetic Radiation, Mobile Phone Radiation

Problem Substances : Cell Phone Exposure

Adverse Pharmacological Actions : Melatonin Interference

[+]

one-year treatment with melatonin increased bone mineral density at femoral neck in a dose-dependent manner, while high dose melatonin increased vBMD in the spine.Jun 02, 2015

Click here to read the entire abstract

Pubmed Data : J Pineal Res. 2015 Jun 3. Epub 2015 Jun 3. PMID: 26036434

Article Published Date : Jun 02, 2015

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Bone Fractures, Osteopenia, Osteoporosis

Pharmacological Actions : Osteogenic

Additional Keywords : Dose Response, Significant Treatment Outcome

[+]

Click here to read the entire abstract

Pubmed Data : J Altern Complement Med. 2004 Apr;10(2):261-8. PMID: 15165407

Article Published Date : Apr 01, 2004

Study Type : Human Study

Additional Links

Substances : Melatonin

Pharmacological Actions : Secretagogue

[+]

50 Hz electromagnetic fields stimulate superoxide radical anion formation in human K562 cells which is attentuated by melatonin.Nov 01, 2010

Click here to read the entire abstract

Pubmed Data : Radiat Environ Biophys. 2010 Nov ;49(4):731-41. Epub 2010 Jun 26. PMID: 20582429

Article Published Date : Nov 01, 2010

Study Type : Human In Vitro

Additional Links

Substances : Melatonin

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants

Anti Therapeutic Actions : Electromagnetic Fields, Electromagnetic Radiation

Adverse Pharmacological Actions : Oxidant

[+]

Dose-dependent DNA damage resulting from mobile phone radiation is attentuated by pretreatment with melatonin in vitro.Nov 01, 2013

Click here to read the entire abstract

Pubmed Data : Int J Radiat Biol. 2013 Nov ;89(11):993-1001. Epub 2013 Sep 3. PMID: 23952262

Article Published Date : Nov 01, 2013

Study Type : Human In Vitro

Click here to read the entire abstract

Pubmed Data : J Pineal Res. 2012 Sep ;53(2):154-65. Epub 2012 Feb 21. PMID: 22348531

Article Published Date : Aug 31, 2012

Study Type : Human In Vitro

Additional Links

Substances : Melatonin

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Dose Response

[+]

These results show that breast cancer stem cells, in both a canine and a human cell lines are responsive to melatonin treatment.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2016 ;11(3):e0150407. Epub 2016 Mar 2. PMID: 26934679

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell J. 2016 ;18(1):46-51. Epub 2016 Apr 4. PMID: 27054118

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Melatonin, Vitamin C

Diseases : Chemotherapy and Radiation Toxicity

Pharmacological Actions : Radioprotective

Additional Keywords : Natural Substance Synergy

Anti Therapeutic Actions : Radiotherapy

[+]

Administration of melatonin, retinoic acid and Nigella sativa reduced the carcinogenic effects of DMBA.Nov 30, 2005

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Exp Pathol. 2005 Dec ;86(6):383-96. PMID: 16309544

Click here to read the entire abstract

Pubmed Data : Mol Neurobiol. 2017 Oct 30. Epub 2017 Oct 30. PMID: 29086246

Article Published Date : Oct 29, 2017

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Obesity

Pharmacological Actions : Neuroprotective Agents

[+]

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Kidney bean sprouts could be a good source of dietary melatonin and other bioactive compounds known to have health benefits.Feb 29, 2016

Click here to read the entire abstract

Pubmed Data : Food Funct. 2016 Mar ;7(3):1438-45. PMID: 26841704

Article Published Date : Feb 29, 2016

Study Type : Animal Study

Additional Links

Substances : Beans: All , Melatonin

Diseases : Hormone Imbalances: Low Melatonin

Pharmacological Actions : Antioxidants

[+]

Lycopene alone and combined with melatonin provided significant improvement against renal damage caused by methotrexate.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(14):6061-6. PMID: 26320496

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Lycopene, Melatonin

Diseases : Drug-Induced Toxicity: Methotrexate

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective

[+]

Magnetic fields induce morphological changes in the rat liver which to which melatonin has a mild protective effect.May 01, 2002

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Okajimas Folia Anat Jpn. 2002 May ;79(1):25-31. PMID: 12199535

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2015;2015:703709. Epub 2015 Jun 21. PMID: 26185593

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2018 May 26 ;105:73-82. Epub 2018 May 26. PMID: 29843047

Article Published Date : May 25, 2018

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Bisphenol Toxicity

Pharmacological Actions : Cytoprotective

Problem Substances : Bisphenol A

[+]

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2000 Nov;48(11):5630-9. PMID: 19159082

Article Published Date : Nov 01, 2000

Study Type : Animal Study

Additional Links

Substances : Glandulars, Melatonin

Diseases : Fluoride Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

Melatonin and caffeic acid phenethyl ester prevent renal tubular injury by reducing oxidative stress and protect the kidney from oxidative damage induced by 900 MHz mobile phone.Aug 01, 2005

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Pubmed Data : Mol Cell Biochem. 2005 Aug ;276(1-2):31-7. PMID: 16132682

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Pubmed Data : Saudi J Gastroenterol. 2015 Sep-Oct;21(5):284-9. PMID: 26458854

Article Published Date : Aug 31, 2015

Study Type : Animal Study

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Substances : Melatonin, Thymoquinone

Diseases : Intestinal Ischemia, Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

Melatonin attentuates the spermatotoxic effects of radiofrequency radiation in mice.May 01, 2018

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Pubmed Data : Toxicol Ind Health. 2018 May ;34(5):315-327. Epub 2018 Mar 21. PMID: 29562845

Article Published Date : May 01, 2018

Study Type : Animal Study

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Substances : Melatonin

Diseases : DNA damage, Infertility: Male, Oxidative Stress, Sperm Quality: Low

Pharmacological Actions : Antioxidants, Genoprotective

Anti Therapeutic Actions : Electromagnetic Fields, Electromagnetic Radiation

Adverse Pharmacological Actions : Oxidant

[+]

Melatonin attenuated the brain damage and cognitive impairment partially through MT2 melatonin receptor in mice with chronic cerebral hypoperfusion.Sep 25, 2017

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Pubmed Data : Oncotarget. 2017 Sep 26 ;8(43):74320-74330. Epub 2017 Aug 22. PMID: 29088788

Article Published Date : Sep 25, 2017

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Brain Damage, Cerebral Hypoperfusion

Pharmacological Actions : Neuroprotective Agents

[+]

Melatonin attenuates 1-Bromopropane-induced CNS toxicity through its ROS scavenging effect. Dec 31, 2015

Article Published Date : Mar 21, 2016

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Epilepsy

Pharmacological Actions : Anticonvulsants

[+]

Melatonin can be useful as a therapeutic adjuvant for patients under long-term opioid treatment for pain relief.Mar 20, 2016

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Pubmed Data : Life Sci. 2016 Mar 21. Epub 2016 Mar 21. PMID: 27012766

Article Published Date : Mar 20, 2016

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Brain Inflammation , Morphine Tolerance/Dependence

Pharmacological Actions : Anti-Inflammatory Agents, Heat Shock Protein Down-Regulation

[+]

Melatonin can exert receptor-mediated signaling effects to attenuate inflammation and oxidative stress of the retina. Dec 31, 2015

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Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:3528274. Epub 2016 Apr 6. PMID: 27143993

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Diabetic Retinopathy

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Melatonin can help protect against Wi-Fi-induced oxidative stress in the lens of rats.Dec 31, 2013

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Pubmed Data : Indian J Ophthalmol. 2014 Jan ;62(1):12-5. PMID: 24492496

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Neural Regen Res. 2019 Feb ;14(2):328-338. PMID: 30531017

Article Published Date : Jan 31, 2019

Study Type : Animal Study

Additional Links

Substances : Chondroitin Sulfate, Melatonin

Diseases : Neuritis: Brachial Plexus

Pharmacological Actions : Regenerative

Additional Keywords : Nerve Regeneration

[+]

Melatonin confers protective effects to rat neurons following 2.45 GHz electromagnetic radiation exposure.Feb 01, 2012

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Pubmed Data : Physiol Behav. 2012 Feb 1 ;105(3):683-92. Epub 2011 Oct 12. PMID: 22019785

Article Published Date : Feb 01, 2012

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Calcium Channel Blockers

Anti Therapeutic Actions : Electromagnetic Fields, Electromagnetic Radiation, Electromagnetic Radiation: 2.4 GHz

[+]

Melatonin confers radioprotective effects against mobil phone-induced oxidative stress in the rat brain.Nov 01, 2008

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Pubmed Data : J Radiat Res. 2008 Nov ;49(6):579-86. Epub 2008 Sep 29. PMID: 18827438

Article Published Date : Nov 01, 2008

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Pubmed Data : Ulus Cerrahi Derg. 2016 ;32(4):233-237. Epub 2016 Oct 27. PMID: 28149117

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Pubmed Data : Syst Biol Reprod Med. 2008 Jul-Aug;54(4-5):169-76. PMID: 18942024

Article Published Date : Jun 30, 2008

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Oxidative Stress, Testicular Injury: Formaldehyde-Induced

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation

[+]

Melatonin has a significant effect on the protection of the heart against isoproterenol induced myocardial infarction through maintaining endogenous antioxidant enzyme activities.Oct 09, 2010

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Pubmed Data : Eur J Pharmacol. 2010 Oct 10 ;644(1-3):160-8. Epub 2010 Jul 13. PMID: 20624385

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Pubmed Data : Eur Spine J. 2004 Dec;13(8):724-32. Epub 2004 Jul 1. PMID: 15232723

[+]

Melatonin is present in walnuts and can increase blood melatonin concentrations.Aug 31, 2005

Article Published Date : Mar 14, 2011

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Aging

Pharmacological Actions : Anti-Apoptotic, Caspase-3 Activation

[+]

Melatonin may have a potential therapeutic effects against irradiation.May 31, 2016

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Pubmed Data : Exp Ther Med. 2016 Jun ;11(6):2385-2390. Epub 2016 Mar 31. PMID: 27313671

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Bratisl Lek Listy. 2015 ;116(2):96-100. PMID: 25665474

Article Published Date : Jan 01, 2015

Study Type : Animal Study

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Pubmed Data : Med Sci Monit. 2017 Dec 16 ;23:5951-5959. Epub 2017 Dec 16. PMID: 29247156

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Pubmed Data : J Radiat Res (Tokyo). 2005 Jun;46(2):277-82. PMID: 15988147

Article Published Date : Jun 01, 2005

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Cataract: Radiation-Induced, Radiation Induced Illness

Pharmacological Actions : Antioxidants, Radioprotective

[+]

Melatonin protects against thioacetamide-induced liver fibrosis in rats.Jul 31, 2015

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Pubmed Data : Nutr Res. 2015 Jul 6. Epub 2015 Jul 6. PMID: 26250620

Article Published Date : Jul 05, 2015

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Inflammation, Obesity

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Risk Reduction

[+]

Melatonin supplementation contributes to the rescue of cognitive decline, and may alleviate mental disorders.Dec 31, 2015

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Pubmed Data : Andrologia. 2014 Feb ;46(1):65-72. Epub 2012 Nov 12. PMID: 23145464

Article Published Date : Feb 01, 2014

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Pubmed Data : Physiol Res. 2018 Jan 5. Epub 2018 Jan 5. PMID: 29303602

Article Published Date : Jan 04, 2018

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Air Pollution Linked Toxicity, Cough

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Pharmacological Actions : Gastroprotective, Malondialdehyde Down-regulation

[+]

Melatonin, curcumin, quercetin, and resveratrol ameliorate chemically-induced kidney damage.Dec 01, 2007

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Pubmed Data : Neuro Endocrinol Lett. 2007 Dec;28(6):739-44. PMID: 18684806

Article Published Date : Dec 01, 2007

Study Type : Animal Study

Additional Links

Substances : Curcumin, Melatonin, Quercetin, Resveratrol

Diseases : Kidney Damage, Oxidative Stress

Pharmacological Actions : Antioxidants, Renoprotective

Additional Keywords : Stilbenes

[+]

Melatonin, minocycline and ascorbic acid have an antiviral effect involving their anti-oxidant properties, and suggesting a potential use of these compounds for human VEE virus infection.Jul 09, 2015

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Pubmed Data : Brain Res. 2015 Jul 10. Epub 2015 Jul 10. PMID: 26168898

Article Published Date : Jul 09, 2015

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Pubmed Data : Acta Medica (Hradec Kralove). 2015 ;58(1):21-4. PMID: 26454803

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants, Detoxifier

Problem Substances : Freund adjuvant

[+]

The possible neuroprotective effects of melatonin in aluminum chloride-induced neurotoxicity.Feb 03, 2019

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Pubmed Data : Environ Sci Pollut Res Int. 2019 Feb 4. Epub 2019 Feb 4. PMID: 30719664

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Pubmed Data : Regul Toxicol Pharmacol. 2017 Oct ;89:1-12. Epub 2017 Jul 8. PMID: 28694170

Article Published Date : Sep 30, 2017

Study Type : Animal Study

Additional Links

Substances : Melatonin, Pumpkin Seeds

Diseases :

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View the Evidence: 492 Abstracts with Melatonin Research

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Melatonin could have an effect on body weight. Nov 28, 2016

Melatonin is effective in advancing sleep-wake rhythm and endogenous melatonin rhythm in delayed sleep phase disorder.Dec 01, 2010

Melatonin reduces the risk of death from cancer. Nov 01, 2005

Melatonin supplementation had a significant preventive effect in decreasing the incidence of delirium in elderly patients.Jul 20, 2015

The current meta-analysis supports the use of melatonin for anti-nociception.Nov 20, 2017

There is evidence that melatonin treatment after traumatic brain injury significantly improves both behavioural outcomes and pathological outcomes.Jun 13, 2018

This meta-analysis clearly supports the use of melatonin as a management for patients with secondary sleep disorders.Jun 13, 2018

This meta-analysis provided some evidence that melatonin improves sleep quality in patients with AD and PD.Aug 08, 2015

This meta-analysis showed the promising effect of melatonin administration on reducing CRP and IL-6 among patients with MetS and related disorders.Jun 14, 2018

A dietary supplement containing melatonin, l-tryptophan, vitamin B6, folic acid, vitamin B12, methionine and betaine, is superior to omeprazole in treating GERD. Oct 01, 2006

A low physiological dose of melatonin (.5 mg) is almost effective as a pharmacological dose of 5.0 mg in alleviating jet lag. Nov 01, 1998

Administration of melatonin as an adjuvant therapy in the treatment of neonatal sepsis is associated with improvement of clinical and laboratory outcomes.Oct 08, 2015

Administration of melatonin, alone or in a combination with fluoxetine was effective in the treatment of patients with fibromyalgia.Mar 31, 2011

Application of melatonin cream 12.5% protects against natural sunlight induced erythema.Aug 08, 2016

Both melatonin and light treatment have positive effects on various sleep outcomes.Oct 09, 2016

Bright light treatment in elderly patients with major depressive disorder improved mood, enhanced sleep efficiency and increased melatonin level.Dec 31, 2010

Circadian melatonin disruption can be used as an indicator of delirium.Sep 30, 2016

Coadministration of melatonin with olanzapine in adolescents with bipolar disorder could reduce the sharp weight gain side effect.Mar 23, 2017

Combined treatment including melatonin resulted in the improvement of general conditions in 81.7% of the patientsDec 31, 2012

Disruption of melatonin circadian rhythm production is frequent among RRMS patients and seemingly related to higher disability and fatigue scores.Jun 14, 2015

Elevated melatonin during mania and elevated cortisol during depression may characterize bipolar disorder. May 01, 1989

Exercise-induced Human Growth Hormone secretion is enhanced by the oral ingestion of melatonin in healthy adult male subjects.Jul 01, 1999

Exogenous melatonin reverses the enhanced oxidative damage to membrane lipids and improves skin biophysical characteristics in former-smokers.Dec 22, 2017

Geomagnetic activity may play a role in the entrainment of human melatonin rhythms.Jun 12, 2008

Higher urinary melatonin levels were associated with reduced breast cancer risk in this cohort of postmenopausal women.Nov 08, 2016

Lower serum levels of melatonin in ovarian cancer patients which may contribute to the pathogenesis of ovarian cancer.Dec 31, 2015

Meditation results in acute increases in night-time plasma melatonin levels.May 01, 2000

Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease.Dec 11, 2017

Melatonin and L-Tryptophan have a protective effect on acute pancreatitisJan 01, 2003

Melatonin and to a lesser degree mothewort decrease retinal sensitivity and improves the emotional state in anxious young subjects.Nov 01, 2006

Melatonin and vitamin E may be safe and effective in patients with systemic sclerosis. Nov 01, 2010

Melatonin appears to be effective in the treatment of sleep disturbances, as well as improving behavioral measures in children with Asperger disorder. Dec 01, 2009

Melatonin can alleviate jet lag and tiredness after long haul flights.Mar 18, 1989

Melatonin can modulate the inflammatory actions in periodontal patients.Nov 30, 2015

Melatonin could be effective and safe for decreasing daytime seizure frequency in patients with intractable epilepsy.Feb 28, 2012

Melatonin could be used in migraine prophylaxis treatments. Dec 31, 2017

Melatonin could decrease fatigue in survivors of aneurysmal subarachnoid hemorrhage.Nov 15, 2016

Melatonin deficiency may play a role in the pathogenesis of adolescent idiopathic scoliosis - Article 2. Apr 01, 2009

Melatonin exerts beneficial effects in MS patients based on its' proved antioxidative properties.Mar 31, 2016

Melatonin has a drug sparing and synergistic effect with chemotherapy in the treatment of metastatic colorectal patients. Mar 01, 2003

Melatonin has a role in the improvement of gastroesophageal reflux disease.Jan 01, 2010

Melatonin has been demonstrated to slow the proliferation of hormone-refractory prostate cancer in animal and human studies. Oct 01, 2003

Melatonin is associated with a statistically significant decrease in tinnitus intensity and improved sleep quality in patients with chronic tinnitus.Jul 01, 2011

Melatonin levels are associated with hypothalamic gray matter volume loss and disease severity in PD patients. Mar 11, 2016

Melatonin may be a safe treatment for patients with idiopathic tinnitus. Article 1Feb 01, 2006

Melatonin may be a safe treatment for patients with idiopathic tinnitus. Article 2Mar 01, 1998

Melatonin may be effective in treating refractory idiopathic thrombocytopenic purpura.Dec 01, 2001

Melatonin may be effective in treating severe bleeding associated with refractory idiopathic thrombocytopenic purpura. Mar 01, 2003

Melatonin significantly improvement impaired sleep maintenance in children with Autism. Jan 01, 2008

Melatonin significantly improves insomnia in patients aged 55 years or older. Jan 01, 2000

Melatonin significantly reduced the risk of depressive symptoms in women with breast cancer during a three-month period after surgery.May 31, 2014

Melatonin treatment is associated with significant nocturia response rate.Mar 01, 2004

Melatonin was superior to amitriptyline in the percentage of patients with a greater than 50% reduction in migraine frequency.May 09, 2016

Melatonin, quercetin and NAC are beneficial in reducing oxidative stress in the patients with Grave's Disease. Sep 01, 2005

Mobile phone exposure may affect melatonin onset time.Feb 01, 2006

one-year treatment with melatonin increased bone mineral density at femoral neck in a dose-dependent manner, while high dose melatonin increased vBMD in the spine.Jun 02, 2015

Overnight melatonin secretion was significantly higher after using a blue-light shield on self-luminous devices. Dec 31, 2015

Patients treated with melatonin-containing emulsion experienced significantly reduced radiation dermatitis.Feb 29, 2016

Patients treated with melatonin-containing emulsion experienced significantly reduced radiation dermatitis.Feb 29, 2016

Radiofrequency and temporally stable 60-Hz exposures were associated with increased estrogen metabolite excretion among postmenopausal women. Women with low nocturnal melatonin may be particularly susceptible. Oct 01, 2007

Recommendations for the prevention of breast cancer in shift workers.Nov 30, 2011

Selected antioxidants have a protective effect against beta-cyfluthrin-induced oxidative stress in human erythrocytes in vitro.Apr 01, 2010

Sleep deprivation may contribute to increased breast cancer risk.Jan 31, 2013

Somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide led to an overall clinical benefit been achieved in 75% of cases.Dec 31, 2012

The data reflects a beneficial effect of melatonin treatment in resistance-training athletes.Feb 12, 2017

The prevalence of cognitive impairment and depressed mood decreased with increases in physiological melatonin levels in this study. Jun 07, 2015

These data support future studies evaluating the safety and effectiveness of melatonin supplementation in relapsing-remitting multiple sclerosis patients.Dec 26, 2018

This pilot study shows promising results, in terms of headache frequency reduction and daily quality of life improvement.Mar 07, 2016

This pilot study suggests that the combination of melatonin, vitamin B6, and medicinal plants may be beneficial in mild-to-moderate insomnia.Jul 31, 2019

This study hypothesized that the greater preservation of neurocognitive functions in the morning patients was associated with elevated melatonin levels.May 24, 2015

This suggests a possibly beneficial effect of melatonin on body composition and lipid metabolism as one year of treatment reduces fat mass and increases lean mass.Sep 08, 2015

Yogic practices can be used as psychophysiologic stimuli to increase endogenous secretion of melatonin, which, in turn, might be responsible for improved sense of well-being.Apr 01, 2004

Melatonin

View the Evidence:
492 Abstracts with Melatonin Research