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Melatonin
Views 13091
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Abstracts
Focused Research Topics
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Click any topic below to filter + focus research
279 Diseases Researched for Melatonin
Name
AC
CK
Focus
Oxidative Stress
51
107
Breast Cancer
39
83
Sleep Disorders
4
52
Alzheimer's Disease
16
49
Inflammation
15
45
Circadian Dysregulation
7
44
Hormone Imbalances: Low Melatonin
7
38
Parkinson's Disease
6
35
Chemotherapy and Radiation Toxicity
9
31
Delirium
3
31
Neurodegenerative Diseases
9
31
C-Reactive Protein
2
30
Tinnitus
3
30
Brain Injury: Traumatic
5
26
Lipid Peroxidation
9
26
Aging
12
23
Cancers: All
4
23
Chronic Pain
4
23
Jet Lag
4
23
Insomnia
3
22
Metabolic Syndrome X
2
22
Gastroesophageal Reflux
3
21
Headache: Migraine
3
21
Delayed Sleep Phase Disorder
1
20
Depressive Disorder
2
20
Multiple Sclerosis: Relapsing-Remitting
2
20
Overweight
1
20
Purpura: Thrombocytopenic
2
20
Thrombocytopenia
2
20
Diabetes Mellitus: Type 2
5
18
Liver Cancer
9
18
Cognitive Decline/Dysfunction
4
16
Multiple Sclerosis
4
15
Obesity
8
15
Aging: Brain
7
14
Ovarian Cancer
4
14
Prostate Cancer
4
14
Aging Skin
3
13
Bisphenol Toxicity
8
13
Epilepsy
3
13
Headache
4
13
Sepsis
3
13
Autism
2
12
Brain: Oxidative Stress
7
12
Breast Cancer: Metastatic
2
12
Chemically-Induced Liver Damage
2
12
Chemotherapy-Induced Toxicity: Cyclophosphamide
2
12
Lipopolysaccharide-Induced Toxicity
5
12
Nocturia
2
12
Osteoporosis
2
12
Scoliosis
2
12
Anxiety Disorders
2
11
Bipolar Disorder
2
11
Depression
7
11
Fibromyalgia
2
11
Muscle Damage: Exercise-Induced
2
11
Pancreatitis
2
11
Periodontal Diseases
2
11
Abdominal Obesity (Midsection Fat)
1
10
Aneurysmal subarachnoid hemorrhage (SAH)
1
10
Asperger Syndrome
1
10
Athletic Performance
1
10
Benzo[a]pyrene-induced Toxicity
1
10
Bone Fractures
1
10
Chronic Fatigue Syndrome
1
10
Colorectal Cancer
1
10
Coronary Artery Disease
1
10
Coronary Bypass Surgery
1
10
Cortisol: High
1
10
Depression: Breast Cancer Related
1
10
Erythema
1
10
Graves Disease
1
10
Human Growth Hormone: Enhancement
1
10
Osteopenia
1
10
Retinal Diseases
1
10
Retinal Sensitivity
1
10
Sclerosis: Systemic
1
10
Skin Diseases
1
10
Skin Diseases: Photo-Aging
1
10
Weight Gain: Drug-Induced
1
10
Brain Inflammation
5
9
Liver Injury: Ischemia/reperfusion
5
8
Mobile Phone-Induced Oxidative Stress
4
8
Aluminum Toxicity
4
7
Anxiety
5
7
Cancer Metastasis
3
7
Diabetic Nephropathy
4
7
Myocardial Infarction
4
7
Insulin Resistance
3
6
Kidney Damage
3
6
Lung Cancer
2
6
Mitochondrial Dysfunction
4
6
Myocardial Ischemia
3
6
Osteosarcoma
2
6
Periodontitis
3
6
Spinal Cord Injuries
3
6
Stress
3
6
Stroke: Attenuation/Recovery
5
6
Testicular Injury: Chemical/Metal Induced
3
6
DNA damage
4
5
Endometriosis
3
5
Hypertension
3
5
Neuroblastoma
1
5
Osteoporosis: Inflammation Induced
1
5
Pancreatic Cancer
4
5
Radiation Induced Illness
3
5
Ultraviolet Radiation Induced Damage
4
5
Breast Cancer: Triple Negative
3
4
Cardiovascular Diseases
3
4
Cerebral Hypoperfusion
2
4
Chemotherapy-Induced Toxicity
3
4
Encephalitis
2
4
Fluoride Toxicity
3
4
High Fat Diet
2
4
High Fructose Diet
2
4
Hypoxia
2
4
Infertility
2
4
Kidney Diseases
2
4
Liver Fibrosis
2
4
Memory Disorders
2
4
Metabolic Diseases
2
4
Neonatal Stroke
2
4
Pesticide Toxicity
2
4
Pregnancy Complications
2
4
Stroke: Ischemic
2
4
Amyotrophic Lateral Sclerosis
3
3
Arsenic Poisoning
2
3
Brain Damage
2
3
Brain Ischemia
2
3
Breast Cancer: Estrogen
3
3
Breast Cancer: estrogen receptor alpha-positive
2
3
Cadmium Poisoning
2
3
Cervical Cancer
2
3
Colon Cancer
3
3
Gastric Ulcer
2
3
Glioblastoma
3
3
Irritable Bowel Syndrome
3
3
Ischemia
2
3
Leukemia
2
3
Liver Damage
2
3
Liver Disease
2
3
Nicotine/Tobacco Toxicity
2
3
Pituitary Tumours
2
3
Psychiatric Disorders
2
3
Schizophrenia
2
3
Ulcerative Colitis
2
3
Acetaminophen (Tylenol) Toxicity
1
2
Acrylamide-induced toxicity
1
2
Air Pollution Linked Toxicity
1
2
Alcohol Toxicity
1
2
Alcoholic Liver Disease
1
2
Amnesia
1
2
Autism Spectrum Disorders
2
2
Benzene Toxicity
1
2
Bile Duct Injury
1
2
Breast Cancer: Lung Metastasis
1
2
Cataract: Radiation-Induced
1
2
Cell Phone Induced Disease
1
2
Cerebral Ischemia
1
2
Chemotherapy-Induced Toxicity: Cisplatin
1
2
Chemotherapy-Induced Toxicity: Doxorubicin
1
2
Chemotherapy-Induced Toxicity: Gentamicin
1
2
Chemotherapy-Induced Toxicity: Oxaliplatin
1
2
Cocaine Addiction
1
2
Cocaine Withdrawal
1
2
Colitis
1
2
Colon Cancer: Prevention
1
2
Cough
1
2
Dementia
1
2
Demyelinating Diseases
1
2
Depression
1
2
Depression: Stress Related
1
2
Diabetes: Oxidative Stress
1
2
Diabetic Retinopathy
1
2
Drug-Induced Toxicity: Bisphosphonates
1
2
Drug-Induced Toxicity: Indomethacin
1
2
Drug-Induced Toxicity: Methotrexate
1
2
Dysbiosis
1
2
Edema
1
2
Electromagnetic Radiation
1
2
Endometrial Cancer
1
2
Endothelial Dysfunction
1
2
Estrogen Deficiency
1
2
Gastric Cancer
2
2
Glaucoma
3
2
Gliomas
1
2
Glutathione Deficiency
1
2
Headache: Cluster
2
2
Heart Disease
1
2
Herbicide Toxicity
1
2
High Homocysteine
1
2
Hydrogen Peroxide Induced Toxicity
2
2
Hyperalgesia
1
2
Hyperbilirubinemia: Hereditary
1
2
Hyperglycemia
1
2
Hyperlipidemia
1
2
Hypertension: Pulmonary
1
2
Hyperthyroidism
1
2
Hypoxia: Brain
1
2
Immune Disorders: Low Immune Function
1
2
Inflammation: Brain
1
2
Intestinal Ischemia
1
2
Kidney Damage: Drug-Induced
1
2
Kidney Failure
1
2
Leiomyosarcoma
1
2
Low Immune Function: Natural Killer Cells
1
2
Macular Degeneration
3
2
Morphine Tolerance/Dependence
1
2
Multi-Organ Failure
1
2
Neural Tube Defects
1
2
Neuralgia: Post Herpetic
1
2
Neuritis: Brachial Plexus
1
2
Obstructive Nephropathy
1
2
Oral Cancer
2
2
Ovariectomy Associated Adverse Changes
1
2
Prediabetes
1
2
Prenatal Nutrition: Prevention of Problems
1
2
Quality of Life: Poor
1
2
Radiation-Induced Illness: Cesium-137 Exposure
1
2
Sleep Apnea: Central
1
2
Snake Bite: Venom Toxicity
1
2
Subarachnoid hemorrhage
2
2
Testicular Injury: Formaldehyde-Induced
1
2
Testicular Injury: Nicotine-Induced
1
2
Traumatic Brain Injury
1
2
Tumors
2
2
Vaginal Cancer
1
2
Acute T cell Leukemias
1
1
Amphetamine Addiction/Withdrawal
1
1
Amyotrophic lateral sclerosis (ALS)
1
1
Brain Edema
1
1
Cancers: Drug Resistant
1
1
Carcinoma: Non-Small-Cell Lung
1
1
Chemotherapy-Induced Toxicity: Arsenic Trioxide
1
1
Chronic Disease
1
1
Chronic Kidney Disease (CKD)
1
1
Crohn's Disease
1
1
Diabetes Mellitus: Type 1
1
1
Ebola Virus Infections
1
1
Endocrine Diseases
1
1
Estrogen Dominance
1
1
Fractures: Bone
1
1
Fragile X Syndrome
1
1
Gallbladder Inflammation
1
1
Gallstones
1
1
Gastritis
1
1
Head and Neck Cancer
1
1
Heavy Metal Toxicity
1
1
Huntington Disease
1
1
Liver Damage: Aflatoxin-Induced
1
1
Mastitis
1
1
Melanoma
1
1
Migraine Disorders
1
1
Migraines
1
1
Mitochondrial Diseases
1
1
Mood Disorders
1
1
Napthalene-Induced Toxicity
1
1
Nasopharyngeal Cancer
1
1
Non-Small-Cell Lung Carcinoma
1
1
Organ Transplantation
1
1
Organ Transplantation: Liver
1
1
Osteoarthritis
1
1
Osteoarthritis: Knee
1
1
Pancreatic Diseases
1
1
Pineal Gland Calcification
1
1
Pineal Gland Diseases
1
1
Post-Traumatic Stress Disorders (PTSD)
1
1
Prostatic Hyperplasia: Benign
1
1
Renal Cancer
1
1
Retinopathy of Prematurity
1
1
Rheumatoid Arthritis
1
1
Sarcoma: Ewing's
1
1
Septic Shock
1
1
Squamous cell carcinoma
1
1
Stroke: Hemorrhagic
1
1
Systemic Lupus Erythematosus
1
1
Wound Healing: Delayed
1
1
Abdominal Adhesions
1
0
Sarcoidosis
1
0
107 Pharmacological Actions Researched for Melatonin
Name
AC
CK
Focus
Antioxidants
121
266
Neuroprotective Agents
73
158
Anti-Inflammatory Agents
51
132
Tumor Necrosis Factor (TNF) Alpha Inhibitor
15
57
Apoptotic
34
54
Antiproliferative
31
50
Anti-Apoptotic
24
40
Antidepressive Agents
7
38
Hepatoprotective
20
36
Interleukin-6 Downregulation
6
35
Prophylactic Agents
5
33
Brain-derived neurotrophic factor modulator
4
26
Renoprotective
13
24
NF-kappaB Inhibitor
15
23
Secretagogue
3
22
Anti-metastatic
15
21
Chemosensitizer
16
21
Antinoceceptive
1
20
Cardioprotective
11
20
Cyclooxygenase 2 Inhibitors
10
20
Interleukin-1 beta downregulation
10
19
Malondialdehyde Down-regulation
5
18
Tumor Suppressor Protein p53 Upregulation
15
18
Osteogenic
3
17
Cytoprotective
9
16
Radioprotective
9
15
Angiogenesis Inhibitors
6
12
Insulin Sensitizers
2
12
Proton Pump Inhibitor
2
11
Adiponectin upregulation
1
10
Anxiolytic
1
10
Bcl-2 protein down-regulation
7
10
Chemoprotective Agents
6
10
Insulin-Like Growth Factor Inhibition/Downregulation
1
10
Superoxide Dismutase Up-regulation
6
10
Vasodilator Agents
1
10
Anticarcinogenic Agents
5
9
Chemopreventive
5
9
Immunomodulatory
6
9
Nrf2 activation
7
9
Antihypertensive Agents
5
8
Antineoplastic Agents
6
8
Cell cycle arrest
8
8
Hypolipidemic
4
8
Matrix metalloproteinase-2 (MMP-2) inhibitor
4
8
Vascular Endothelial Growth Factor Inhibitors
4
8
Chemotherapeutic
7
7
Matrix metalloproteinase-9 (MMP-9) inhibitor
6
7
Analgesics
5
6
Gastroprotective
4
6
Regenerative
3
6
Gastrointestinal Agents
3
5
MicroRNA modulator
4
5
Nitric Oxide Inhibitor
1
5
Prostaglandin PGE2 downregulation
1
5
Anti-Anxiety Agents
3
4
Autophagy Inhibitors
2
4
Genoprotective
3
4
Hypoglycemic Agents
2
4
Antiviral Agents
2
3
Aromatase Inhibitors
3
3
Caspase-3 Activation
2
3
Heme oxygenase-1 up-regulation
3
3
Photoprotective
2
3
Radiosensitizer
3
3
Acetylcholinesterase Inhibitor
1
2
Adenosine Monophosphate (AMP)-activated Protein Kinase (AMPK
1
2
Anti-Angiogenic
2
2
Anti-Proliferative
1
2
Anti-Ulcer Agents
1
2
Anticonvulsants
1
2
Antimutagenic Agents
1
2
Autophagy Up-regulation
1
2
BRCA-1 Downregulation
2
2
Detoxifier
1
2
Fertility Agents
1
2
Heat Shock Protein Down-Regulation
1
2
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
2
2
Interleukin-10 downregulation
1
2
Interleukin-4 downregulation
1
2
Neurogenesis
1
2
Neuroplasticity enhancement
1
2
Neurorestorative
1
2
Receptor-Related Orphan Receptor (ROR)-Alpha1 Inhibitor
1
2
SIRT1 Activator
1
2
12-lipoxygenase (12-LOX) Inhibitor
1
1
Apaf-1/caspase-dependent apoptotic pathway activator
1
1
Bax/Bcl2 ratio: Increase
1
1
Caspase-9 Activation
1
1
Catalase Up-Regulation
1
1
Cell Differentiation Inducer
1
1
Chondroprotective
1
1
Cyclooxygenase Inhibitors
1
1
DNA Repair Up-regulation
1
1
Drug synergy
1
1
Enzyme Inhibitors
1
1
Glutathione Upregulation
1
1
Interleukin-8 downregulation
1
1
Matrix metalloproteinase-1 (MMP-1) inhibitor
1
1
P21 Activation
1
1
P38 Mitogen-Activated Protein Kinase Modulator
1
1
PI3K/Akt/signaling suppression
1
1
Selective estrogen enzyme modulator (SEEM)
1
1
Telomerase Inhibitor
1
1
Telomerase Upregulation
1
1
Vascular Endothelial Growth Factor A Inhibitor
1
1
p300/NF-κB down-regulation
1
1
Research Articles
461
Cumulative Knowledge Score
745
Overall Research Rating
EXCELLENT
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View the Evidence:
492 Abstracts with Melatonin Research
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[+]
Melatonin could have an effect on body weight.
Nov 28, 2016
Click here to read the entire abstract
Pubmed Data
: Curr Pharm Des. 2016 Nov 29. Epub 2016 Nov 29. PMID:
27897121
Article Published Date
: Nov 28, 2016
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Melatonin
Diseases
:
Overweight
Additional Keywords
:
insomnia
,
melatonin
,
overweight
,
sleep
,
weight-gain
,
Weight Loss
[+]
Melatonin is effective in advancing sleep-wake rhythm and endogenous melatonin rhythm in delayed sleep phase disorder.
Dec 01, 2010
Click here to read the entire abstract
Pubmed Data
: Sleep. 2010 Dec;33(12):1605-14. PMID:
21120122
Article Published Date
: Dec 01, 2010
Study Type
: Meta Analysis
Additional Links
Substances
:
Melatonin
Diseases
:
Delayed Sleep Phase Disorder
,
Sleep Disorders
[+]
Melatonin reduces the risk of death from cancer.
Nov 01, 2005
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2005 Nov;39(4):360-6. PMID:
16207291
Article Published Date
: Nov 01, 2005
Study Type
: Meta Analysis
Additional Links
Substances
:
Melatonin
Diseases
:
Cancers: All
[+]
Melatonin supplementation had a significant preventive effect in decreasing the incidence of delirium in elderly patients.
Jul 20, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Neurobiol. 2015 Jul 21. Epub 2015 Jul 21. PMID:
26189834
Article Published Date
: Jul 20, 2015
Study Type
: Meta Analysis
Additional Links
Substances
:
Melatonin
Diseases
:
Delirium
Additional Keywords
:
Risk Reduction
,
Significant Treatment Outcome
[+]
The current meta-analysis supports the use of melatonin for anti-nociception.
Nov 20, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2017 Nov 21 ;8(59):100582-100592. Epub 2017 Oct 5. PMID:
29246003
Article Published Date
: Nov 20, 2017
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Melatonin
Diseases
:
Chronic Pain
Pharmacological Actions
:
Antinoceceptive
,
Brain-derived neurotrophic factor modulator
Additional Keywords
:
Antinoceceptive
,
Brain-derived neurotrophic factor modulator
,
Chronic Pain
,
melatonin
[+]
There is evidence that melatonin treatment after traumatic brain injury significantly improves both behavioural outcomes and pathological outcomes.
Jun 13, 2018
Click here to read the entire abstract
Pubmed Data
: J Neurotrauma. 2018 Jun 14. Epub 2018 Jun 14. PMID:
29901413
Article Published Date
: Jun 13, 2018
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Melatonin
Diseases
:
Brain Injury: Traumatic
Pharmacological Actions
:
Neuroprotective Agents
[+]
This meta-analysis clearly supports the use of melatonin as a management for patients with secondary sleep disorders.
Jun 13, 2018
Click here to read the entire abstract
Pubmed Data
: Front Neuroendocrinol. 2018 Jun 14. Epub 2018 Jun 14. PMID:
29908879
Article Published Date
: Jun 13, 2018
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Melatonin
Diseases
:
Sleep Disorders
[+]
This meta-analysis provided some evidence that melatonin improves sleep quality in patients with AD and PD.
Aug 08, 2015
Click here to read the entire abstract
Pubmed Data
: Neurol Sci. 2015 Aug 9. Epub 2015 Aug 9. PMID:
26255301
Article Published Date
: Aug 08, 2015
Study Type
: Meta Analysis
Additional Links
Substances
:
Melatonin
Diseases
:
Alzheimer's Disease
,
Neurodegenerative Diseases
,
Parkinson's Disease
[+]
This meta-analysis showed the promising effect of melatonin administration on reducing CRP and IL-6 among patients with MetS and related disorders.
Jun 14, 2018
Click here to read the entire abstract
Pubmed Data
: Inflammopharmacology. 2018 Jun 15. Epub 2018 Jun 15. PMID:
29907916
Article Published Date
: Jun 14, 2018
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Melatonin
Diseases
:
C-Reactive Protein
,
Metabolic Syndrome X
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
[+]
A dietary supplement containing melatonin, l-tryptophan, vitamin B6, folic acid, vitamin B12, methionine and betaine, is superior to omeprazole in treating GERD.
Oct 01, 2006
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2006 Oct;41(3):195-200. PMID:
16948779
Article Published Date
: Oct 01, 2006
Study Type
: Human Study
Additional Links
Substances
:
Betaine
,
Folic Acid
,
Melatonin
,
Methionine
,
Tryptophan
,
Vitamin B-12
,
Vitamin B-6
Diseases
:
Gastroesophageal Reflux
Pharmacological Actions
:
Proton Pump Inhibitor
Additional Keywords
:
Superiority of Natural Substances versus Drugs
[+]
A low physiological dose of melatonin (.5 mg) is almost effective as a pharmacological dose of 5.0 mg in alleviating jet lag.
Nov 01, 1998
Click here to read the entire abstract
Pubmed Data
: Chronobiol Int. 1998 Nov;15(6):655-66. PMID:
9844753
Article Published Date
: Nov 01, 1998
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Jet Lag
Additional Keywords
:
Less is More
[+]
Administration of melatonin as an adjuvant therapy in the treatment of neonatal sepsis is associated with improvement of clinical and laboratory outcomes.
Oct 08, 2015
Click here to read the entire abstract
Pubmed Data
: J Neonatal Perinatal Med. 2015 Oct 9. Epub 2015 Oct 9. PMID:
26485549
Article Published Date
: Oct 08, 2015
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Sepsis
[+]
Administration of melatonin, alone or in a combination with fluoxetine was effective in the treatment of patients with fibromyalgia.
Mar 31, 2011
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2011 Apr ;50(3):267-71. Epub 2010 Dec 16. PMID:
21158908
Article Published Date
: Mar 31, 2011
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Fibromyalgia
Additional Keywords
:
Significant Treatment Outcome
Problem Substances
:
Fluoxetine (trade name Prozac)
[+]
Application of melatonin cream 12.5% protects against natural sunlight induced erythema.
Aug 08, 2016
Click here to read the entire abstract
Pubmed Data
: J Dermatol Sci. 2016 Aug 9. Epub 2016 Aug 9. PMID:
27543364
Article Published Date
: Aug 08, 2016
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Erythema
,
Skin Diseases
,
Skin Diseases: Photo-Aging
Additional Keywords
:
Dose Response
[+]
Both melatonin and light treatment have positive effects on various sleep outcomes.
Oct 09, 2016
Click here to read the entire abstract
Pubmed Data
: Sleep. 2016 Oct 10. Epub 2016 Aug 10. PMID:
27748241
Article Published Date
: Oct 09, 2016
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Insomnia
,
Sleep Disorders
Therapeutic Actions
:
Light Therapy
[+]
Bright light treatment in elderly patients with major depressive disorder improved mood, enhanced sleep efficiency and increased melatonin level.
Dec 31, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Arch Gen Psychiatry. 2011 Jan ;68(1):61-70. PMID:
21199966
Article Published Date
: Dec 31, 2010
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Depressive Disorder
Therapeutic Actions
:
Light Therapy
Pharmacological Actions
:
Antidepressive Agents
[+]
Circadian melatonin disruption can be used as an indicator of delirium.
Sep 30, 2016
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Article Publish Status
: This is a free article.
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Pubmed Data
: Sleep Sci. 2016 Oct-Dec;9(4):285-288. Epub 2016 Aug 10. PMID:
28154742
Article Published Date
: Sep 30, 2016
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Circadian Dysregulation
,
Delirium
[+]
Coadministration of melatonin with olanzapine in adolescents with bipolar disorder could reduce the sharp weight gain side effect.
Mar 23, 2017
Click here to read the entire abstract
Pubmed Data
: J Child Adolesc Psychopharmacol. 2017 Mar 24. Epub 2017 Mar 24. PMID:
28339282
Article Published Date
: Mar 23, 2017
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Weight Gain: Drug-Induced
Additional Keywords
:
Risk Reduction
Problem Substances
:
Olanzapine
[+]
Combined treatment including melatonin resulted in the improvement of general conditions in 81.7% of the patients
Dec 31, 2012
Click here to read the entire abstract
Pubmed Data
: Klin Med (Mosk). 2013 ;91(3):50-3. PMID:
23789453
Article Published Date
: Dec 31, 2012
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Chemically-Induced Liver Damage
Additional Keywords
:
Plant Extracts
[+]
Disruption of melatonin circadian rhythm production is frequent among RRMS patients and seemingly related to higher disability and fatigue scores.
Jun 14, 2015
Click here to read the entire abstract
Pubmed Data
: J Neurol Sci. 2015 Jun 15 ;353(1-2):166-8. Epub 2015 Apr 7. PMID:
25930714
Article Published Date
: Jun 14, 2015
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Circadian Dysregulation
,
Hormone Imbalances: Low Melatonin
,
Inflammation
,
Multiple Sclerosis: Relapsing-Remitting
[+]
Elevated melatonin during mania and elevated cortisol during depression may characterize bipolar disorder.
May 01, 1989
Click here to read the entire abstract
Pubmed Data
: J Nerv Ment Dis. 1989 May;177(5):300-3. PMID:
2708973
Article Published Date
: May 01, 1989
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Bipolar Disorder
,
Cortisol: High
[+]
Exercise-induced Human Growth Hormone secretion is enhanced by the oral ingestion of melatonin in healthy adult male subjects.
Jul 01, 1999
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Pubmed Data
: Eur J Endocrinol. 1999 Jul;141(1):22-6. PMID:
10407218
Article Published Date
: Jul 01, 1999
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Athletic Performance
,
Human Growth Hormone: Enhancement
Pharmacological Actions
:
Insulin-Like Growth Factor Inhibition/Downregulation
[+]
Exogenous melatonin reverses the enhanced oxidative damage to membrane lipids and improves skin biophysical characteristics in former-smokers.
Dec 22, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Ann Agric Environ Med. 2017 Dec 23 ;24(4):659-666. Epub 2017 May 11. PMID:
29284244
Article Published Date
: Dec 22, 2017
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging Skin
,
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Malondialdehyde Down-regulation
[+]
Geomagnetic activity may play a role in the entrainment of human melatonin rhythms.
Jun 12, 2008
Click here to read the entire abstract
Pubmed Data
: Neurosci Lett. 2008 Jun 13 ;438(1):76-9. Epub 2008 Apr 16. PMID:
18472329
Article Published Date
: Jun 12, 2008
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Additional Keywords
:
Geomagnetic Activity
[+]
Higher urinary melatonin levels were associated with reduced breast cancer risk in this cohort of postmenopausal women.
Nov 08, 2016
Click here to read the entire abstract
Pubmed Data
: Cancer Epidemiol Biomarkers Prev. 2016 Nov 9. Epub 2016 Nov 9. PMID:
28151704
Article Published Date
: Nov 08, 2016
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Breast Cancer
Additional Keywords
:
Risk Factors
,
Risk Reduction
[+]
Lower serum levels of melatonin in ovarian cancer patients which may contribute to the pathogenesis of ovarian cancer.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Cancer. 2016 ;7(7):831-6. Epub 2016 Apr 27. PMID:
27162542
Article Published Date
: Dec 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Ovarian Cancer
Additional Keywords
:
Risk Reduction
[+]
Meditation results in acute increases in night-time plasma melatonin levels.
May 01, 2000
Click here to read the entire abstract
Pubmed Data
: Biol Psychol. 2000 May;53(1):69-78. PMID:
10876066
Article Published Date
: May 01, 2000
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Hormone Imbalances: Low Melatonin
Pharmacological Actions
:
Secretagogue
[+]
Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease.
Dec 11, 2017
Click here to read the entire abstract
Pubmed Data
: Clin Nutr. 2017 Dec 12. Epub 2017 Dec 12. PMID:
29275919
Article Published Date
: Dec 11, 2017
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Coronary Artery Disease
,
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Insulin Sensitizers
[+]
Melatonin and L-Tryptophan have a protective effect on acute pancreatitis
Jan 01, 2003
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2003 Jan;34(1):40-52. PMID:
12485371
Article Published Date
: Jan 01, 2003
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
,
Tryptophan
Diseases
:
Pancreatitis
Pharmacological Actions
:
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Melatonin and to a lesser degree mothewort decrease retinal sensitivity and improves the emotional state in anxious young subjects.
Nov 01, 2006
Click here to read the entire abstract
Pubmed Data
: Eksp Klin Farmakol. 2006 Nov-Dec;69(6):17-9. PMID:
17209457
Article Published Date
: Nov 01, 2006
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Anxiety Disorders
,
Retinal Diseases
,
Retinal Sensitivity
Pharmacological Actions
:
Anxiolytic
Additional Keywords
:
Plant Extracts
[+]
Melatonin and vitamin E may be safe and effective in patients with systemic sclerosis.
Nov 01, 2010
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2010 Nov;26(5):673-8. PMID:
16428927
Article Published Date
: Nov 01, 2010
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
,
Vitamin E
Diseases
:
Sclerosis: Systemic
[+]
Melatonin appears to be effective in the treatment of sleep disturbances, as well as improving behavioral measures in children with Asperger disorder.
Dec 01, 2009
Click here to read the entire abstract
Pubmed Data
: Pharmacoepidemiol Drug Saf. 2009 Dec;18(12):1143-9. PMID:
12804129
Article Published Date
: Dec 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Asperger Syndrome
[+]
Melatonin can alleviate jet lag and tiredness after long haul flights.
Mar 18, 1989
Click here to read the entire abstract
Pubmed Data
: BMJ. 1989 Mar 18;298(6675):705-7. PMID:
2496815
Article Published Date
: Mar 18, 1989
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Jet Lag
[+]
Melatonin can modulate the inflammatory actions in periodontal patients.
Nov 30, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: J Clin Exp Dent. 2015 Dec ;7(5):e628-e633. Epub 2015 Dec 1. PMID:
26644840
Article Published Date
: Nov 30, 2015
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
C-Reactive Protein
,
Inflammation
,
Periodontal Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Melatonin could be effective and safe for decreasing daytime seizure frequency in patients with intractable epilepsy.
Feb 28, 2012
Click here to read the entire abstract
Pubmed Data
: J Child Neurol. 2012 Feb 28. Epub 2012 Feb 28. PMID:
22378657
Article Published Date
: Feb 28, 2012
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Epilepsy
[+]
Melatonin could be used in migraine prophylaxis treatments.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Iran J Child Neurol. 2018 ;12(1):47-54. PMID:
29379562
Article Published Date
: Dec 31, 2017
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Headache: Migraine
Pharmacological Actions
:
Prophylactic Agents
Additional Keywords
:
Natural Substances Versus Drugs
[+]
Melatonin could decrease fatigue in survivors of aneurysmal subarachnoid hemorrhage.
Nov 15, 2016
Click here to read the entire abstract
Pubmed Data
: Neurochirurgie. 2016 Nov 16. Epub 2016 Aug 16. PMID:
27865517
Article Published Date
: Nov 15, 2016
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aneurysmal subarachnoid hemorrhage (SAH)
[+]
Melatonin deficiency may play a role in the pathogenesis of adolescent idiopathic scoliosis - Article 2.
Apr 01, 2009
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2009 Apr;46(3):344-8. PMID:
19317797
Article Published Date
: Apr 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Scoliosis
[+]
Melatonin exerts beneficial effects in MS patients based on its' proved antioxidative properties.
Mar 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Physiol Pharmacol. 2016 Apr ;67(2):235-42. PMID:
27226183
Article Published Date
: Mar 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Chronic Fatigue Syndrome
,
Multiple Sclerosis
Pharmacological Actions
:
Antioxidants
[+]
Melatonin has a drug sparing and synergistic effect with chemotherapy in the treatment of metastatic colorectal patients.
Mar 01, 2003
Click here to read the entire abstract
Pubmed Data
: Anticancer Res. 2003 Mar-Apr;23(2C):1951-4. PMID:
12820485
Article Published Date
: Mar 01, 2003
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Colorectal Cancer
Additional Keywords
:
Drug-Plant-Vitamin Synergies
,
Drug Sparing
[+]
Melatonin has a role in the improvement of gastroesophageal reflux disease.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: BMC Gastroenterol. 2010;10:7. Epub 2010 Jan 18. PMID:
20082715
Article Published Date
: Jan 01, 2010
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Gastroesophageal Reflux
Additional Keywords
:
Drug: Omeprazole
[+]
Melatonin has been demonstrated to slow the proliferation of hormone-refractory prostate cancer in animal and human studies.
Oct 01, 2003
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2003 Oct;35(3):177-82. PMID:
12932201
Article Published Date
: Oct 01, 2003
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Prostate Cancer
Additional Keywords
:
Hormone Refractory Prostate Cancer
[+]
Melatonin is associated with a statistically significant decrease in tinnitus intensity and improved sleep quality in patients with chronic tinnitus.
Jul 01, 2011
Click here to read the entire abstract
Pubmed Data
: Ann Otol Rhinol Laryngol. 2011 Jul ;120(7):433-40. PMID:
21859051
Article Published Date
: Jul 01, 2011
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Tinnitus
[+]
Melatonin levels are associated with hypothalamic gray matter volume loss and disease severity in PD patients.
Mar 11, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Mov Disord. 2016 Mar 12. Epub 2016 Mar 12. PMID:
26971528
Article Published Date
: Mar 11, 2016
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Circadian Dysregulation
,
Parkinson's Disease
Additional Keywords
:
Risk Factors
[+]
Melatonin may be a safe treatment for patients with idiopathic tinnitus. Article 1
Feb 01, 2006
Click here to read the entire abstract
Pubmed Data
: Otolaryngol Head Neck Surg. 2006 Feb;134(2):210-3. PMID:
16455366
Article Published Date
: Feb 01, 2006
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Tinnitus
[+]
Melatonin may be a safe treatment for patients with idiopathic tinnitus. Article 2
Mar 01, 1998
Click here to read the entire abstract
Pubmed Data
: Laryngoscope. 1998 Mar;108(3):305-10. PMID:
9504599
Article Published Date
: Mar 01, 1998
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Tinnitus
[+]
Melatonin may be effective in treating refractory idiopathic thrombocytopenic purpura.
Dec 01, 2001
Click here to read the entire abstract
Pubmed Data
: Jpn J Pharmacol. 2001 Dec;87(4):327-32. PMID:
12424512
Article Published Date
: Dec 01, 2001
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Purpura: Thrombocytopenic
,
Thrombocytopenia
[+]
Melatonin may be effective in treating severe bleeding associated with refractory idiopathic thrombocytopenic purpura.
Mar 01, 2003
Click here to read the entire abstract
Pubmed Data
: Am J Ther. 2003 Mar-Apr;10(2):135-6. PMID:
12629593
Article Published Date
: Mar 01, 2003
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Purpura: Thrombocytopenic
,
Thrombocytopenia
[+]
Melatonin significantly improvement impaired sleep maintenance in children with Autism.
Jan 01, 2008
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2008 Jan;44(1):57-64. PMID:
18078449
Article Published Date
: Jan 01, 2008
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Autism
[+]
Melatonin significantly improves insomnia in patients aged 55 years or older.
Jan 01, 2000
Click here to read the entire abstract
Pubmed Data
: J Bone Miner Metab. 2000;18(4):216-22. PMID:
17875243
Article Published Date
: Jan 01, 2000
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Insomnia
[+]
Melatonin significantly reduced the risk of depressive symptoms in women with breast cancer during a three-month period after surgery.
May 31, 2014
Click here to read the entire abstract
Pubmed Data
: Breast Cancer Res Treat. 2014 Jun ;145(3):683-95. Epub 2014 Apr 23. PMID:
24756186
Article Published Date
: May 31, 2014
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Depression: Breast Cancer Related
Therapeutic Actions
:
Placebo Effect
Pharmacological Actions
:
Antidepressive Agents
[+]
Melatonin treatment is associated with significant nocturia response rate.
Mar 01, 2004
Click here to read the entire abstract
Pubmed Data
: J Urol. 2004 Mar;171(3):1199-202. PMID:
14767300
Article Published Date
: Mar 01, 2004
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Nocturia
[+]
Melatonin was superior to amitriptyline in the percentage of patients with a greater than 50% reduction in migraine frequency.
May 09, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: J Neurol Neurosurg Psychiatry. 2016 May 10. Epub 2016 May 10. PMID:
27165014
Article Published Date
: May 09, 2016
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Headache: Migraine
Pharmacological Actions
:
Prophylactic Agents
Additional Keywords
:
Superiority of Natural Substances versus Drugs
Problem Substances
:
Antidepressants
[+]
Melatonin, quercetin and NAC are beneficial in reducing oxidative stress in the patients with Grave's Disease.
Sep 01, 2005
Click here to read the entire abstract
Pubmed Data
: Pharmazie. 2005 Sep;60(9):696-700. PMID:
16222871
Article Published Date
: Sep 01, 2005
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
,
NAC (N-acetyl-L-cysteine)
,
Quercetin
Diseases
:
Graves Disease
Pharmacological Actions
:
Antioxidants
[+]
Mobile phone exposure may affect melatonin onset time.
Feb 01, 2006
Click here to read the entire abstract
Pubmed Data
: Int J Radiat Biol. 2006 Feb ;82(2):69-76. PMID:
16546905
Article Published Date
: Feb 01, 2006
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Sleep Disorders
Anti Therapeutic Actions
:
Electromagnetic Fields
,
Electromagnetic Radiation
,
Mobile Phone Radiation
Problem Substances
:
Cell Phone Exposure
Adverse Pharmacological Actions
:
Melatonin Interference
[+]
one-year treatment with melatonin increased bone mineral density at femoral neck in a dose-dependent manner, while high dose melatonin increased vBMD in the spine.
Jun 02, 2015
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2015 Jun 3. Epub 2015 Jun 3. PMID:
26036434
Article Published Date
: Jun 02, 2015
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Bone Fractures
,
Osteopenia
,
Osteoporosis
Pharmacological Actions
:
Osteogenic
Additional Keywords
:
Dose Response
,
Significant Treatment Outcome
[+]
Overnight melatonin secretion was significantly higher after using a blue-light shield on self-luminous devices.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Chronobiol Int. 2016 ;33(1):134-9. Epub 2016 Jan 5. PMID:
26730983
Article Published Date
: Dec 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Circadian Dysregulation
,
Hormone Imbalances: Low Melatonin
Additional Keywords
:
Light Pollution
[+]
Patients treated with melatonin-containing emulsion experienced significantly reduced radiation dermatitis.
Feb 29, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Isr Med Assoc J. 2016 Mar-Apr;18(3-4):188-92. PMID:
27228641
Article Published Date
: Feb 29, 2016
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Chemotherapy and Radiation Toxicity
Additional Keywords
:
Risk Reduction
[+]
Patients treated with melatonin-containing emulsion experienced significantly reduced radiation dermatitis.
Feb 29, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Isr Med Assoc J. 2016 Mar-Apr;18(3-4):188-92. PMID:
27228641
Article Published Date
: Feb 29, 2016
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Chemotherapy and Radiation Toxicity
Additional Keywords
:
Risk Reduction
[+]
Radiofrequency and temporally stable 60-Hz exposures were associated with increased estrogen metabolite excretion among postmenopausal women. Women with low nocturnal melatonin may be particularly susceptible.
Oct 01, 2007
Click here to read the entire abstract
Pubmed Data
: J Occup Environ Med. 2007 Oct ;49(10):1149-56. PMID:
18000420
Article Published Date
: Oct 01, 2007
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Female
Additional Keywords
:
EMF
,
Estrogen Metabolism
,
Melatonin Production
Anti Therapeutic Actions
:
Electromagnetic Fields
,
Electromagnetic Radiation
[+]
Recommendations for the prevention of breast cancer in shift workers.
Nov 30, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: EPMA J. 2011 Dec ;2(4):351-6. Epub 2011 Dec 23. PMID:
23199173
Article Published Date
: Nov 30, 2011
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Breast Cancer
Anti Therapeutic Actions
:
Shift Work
[+]
Selected antioxidants have a protective effect against beta-cyfluthrin-induced oxidative stress in human erythrocytes in vitro.
Apr 01, 2010
Click here to read the entire abstract
Pubmed Data
: Toxicol In Vitro. 2010 Apr;24(3):879-84. Epub 2009 Dec 2. PMID:
19961921
Article Published Date
: Apr 01, 2010
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
,
Quercetin
,
Rutin
Diseases
:
Benzo[a]pyrene-induced Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Sleep deprivation may contribute to increased breast cancer risk.
Jan 31, 2013
Click here to read the entire abstract
Pubmed Data
: Gynecol Obstet Fertil. 2013 Feb ;41(2):105-9. Epub 2013 Feb 6. PMID:
23395427
Article Published Date
: Jan 31, 2013
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Breast Cancer
Anti Therapeutic Actions
:
Sleep Deprivation
[+]
Somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide led to an overall clinical benefit been achieved in 75% of cases.
Dec 31, 2012
Click here to read the entire abstract
Pubmed Data
: Neuro Endocrinol Lett. 2013 ;34(7):660-8. PMID:
24464005
Article Published Date
: Dec 31, 2012
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
,
Vitamin D
Diseases
:
Breast Cancer
,
Breast Cancer: Metastatic
,
Chemotherapy-Induced Toxicity: Cyclophosphamide
Additional Keywords
:
Natural Substance/Drug Synergy
,
Significant Treatment Outcome
[+]
The data reflects a beneficial effect of melatonin treatment in resistance-training athletes.
Feb 12, 2017
Click here to read the entire abstract
Pubmed Data
: Appl Physiol Nutr Metab. 2017 Feb 13. Epub 2017 Feb 13. PMID:
28192673
Article Published Date
: Feb 12, 2017
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Muscle Damage: Exercise-Induced
Therapeutic Actions
:
Exercise: Resistance Training
Pharmacological Actions
:
Antioxidants
[+]
The prevalence of cognitive impairment and depressed mood decreased with increases in physiological melatonin levels in this study.
Jun 07, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Clin Endocrinol Metab. 2015 Jun 8:jc20151859. Epub 2015 Jun 8. PMID:
26052727
Article Published Date
: Jun 07, 2015
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Alzheimer's Disease
,
Cognitive Decline/Dysfunction
,
Depressive Disorder
Pharmacological Actions
:
Antidepressive Agents
,
Neuroprotective Agents
[+]
These data support future studies evaluating the safety and effectiveness of melatonin supplementation in relapsing-remitting multiple sclerosis patients.
Dec 26, 2018
Click here to read the entire abstract
Pubmed Data
: Arch Med Res. 2018 Dec 27. Epub 2018 Dec 27. PMID:
30595364
Article Published Date
: Dec 26, 2018
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Multiple Sclerosis: Relapsing-Remitting
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
This pilot study shows promising results, in terms of headache frequency reduction and daily quality of life improvement.
Mar 07, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Funct Neurol. 2016 Mar 8:1-5. Epub 2016 Mar 8. PMID:
26954506
Article Published Date
: Mar 07, 2016
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Headache
Pharmacological Actions
:
Prophylactic Agents
Additional Keywords
:
Risk Reduction
[+]
This pilot study suggests that the combination of melatonin, vitamin B6, and medicinal plants may be beneficial in mild-to-moderate insomnia.
Jul 31, 2019
Click here to read the entire abstract
Pubmed Data
: Complement Ther Med. 2019 Aug ;45:104-108. Epub 2019 May 25. PMID:
31331545
Article Published Date
: Jul 31, 2019
Study Type
: Human Study
Additional Links
Substances
:
Lemon Balm
,
Melatonin
,
Passion Flower
,
Poppy
,
Vitamin B-6
Diseases
:
Insomnia
Additional Keywords
:
Plant Extracts
[+]
This study hypothesized that the greater preservation of neurocognitive functions in the morning patients was associated with elevated melatonin levels.
May 24, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Ann Thorac Cardiovasc Surg. 2015 May 25. Epub 2015 May 25. PMID:
26004111
Article Published Date
: May 24, 2015
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Coronary Bypass Surgery
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
,
Vasodilator Agents
Additional Keywords
:
Significant Treatment Outcome
[+]
This suggests a possibly beneficial effect of melatonin on body composition and lipid metabolism as one year of treatment reduces fat mass and increases lean mass.
Sep 08, 2015
Click here to read the entire abstract
Pubmed Data
: Clin Endocrinol (Oxf). 2015 Sep 9. Epub 2015 Sep 9. PMID:
26352863
Article Published Date
: Sep 08, 2015
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Abdominal Obesity (Midsection Fat)
Pharmacological Actions
:
Adiponectin upregulation
[+]
Yogic practices can be used as psychophysiologic stimuli to increase endogenous secretion of melatonin, which, in turn, might be responsible for improved sense of well-being.
Apr 01, 2004
Click here to read the entire abstract
Pubmed Data
: J Altern Complement Med. 2004 Apr;10(2):261-8. PMID:
15165407
Article Published Date
: Apr 01, 2004
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Pharmacological Actions
:
Secretagogue
[+]
50 Hz electromagnetic fields stimulate superoxide radical anion formation in human K562 cells which is attentuated by melatonin.
Nov 01, 2010
Click here to read the entire abstract
Pubmed Data
: Radiat Environ Biophys. 2010 Nov ;49(4):731-41. Epub 2010 Jun 26. PMID:
20582429
Article Published Date
: Nov 01, 2010
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Antioxidants
Anti Therapeutic Actions
:
Electromagnetic Fields
,
Electromagnetic Radiation
Adverse Pharmacological Actions
:
Oxidant
[+]
Dose-dependent DNA damage resulting from mobile phone radiation is attentuated by pretreatment with melatonin in vitro.
Nov 01, 2013
Click here to read the entire abstract
Pubmed Data
: Int J Radiat Biol. 2013 Nov ;89(11):993-1001. Epub 2013 Sep 3. PMID:
23952262
Article Published Date
: Nov 01, 2013
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
DNA damage
,
Infertility
,
Infertility: Male
,
Sperm Quality: Low
Pharmacological Actions
:
Genoprotective
,
Radioprotective
Additional Keywords
:
Cell Phones
,
electromagnetic fields
,
electromagnetic frequencies
,
electromagnetic radiation
,
EMF
,
male infertility
,
Male Infertility and Cellular Phones
Anti Therapeutic Actions
:
Electromagnetic Fields
,
Electromagnetic Radiation
,
Microwave Radiation
,
Mobile Phone Radiation
Problem Substances
:
Cell Phone Exposure
Adverse Pharmacological Actions
:
Genotoxic
[+]
Inhibition of ERK1/2 signalling pathway is involved in melatonin's antiproliferative effect on human MG-63 osteosarcoma cells.
Nov 06, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Physiol Biochem. 2016 Nov 7 ;39(6):2297-2307. Epub 2016 Aug 7. PMID:
27832629
Article Published Date
: Nov 06, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
Osteosarcoma
Pharmacological Actions
:
Antiproliferative
[+]
Melatonin as a novel selective ATF-6 inhibitor can sensitize human hepatoma cells to ER stress inducing apoptosis.
Feb 13, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: World J Gastroenterol. 2017 Feb 14 ;23(6):986-998. PMID:
28246472
Article Published Date
: Feb 13, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Apoptotic
,
Cyclooxygenase 2 Inhibitors
[+]
Melatonin has anti-angiogenic effects at different steps of the angiogenic process in SH-SY5Y neuroblastoma cells.
Feb 13, 2017
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2017 Feb 14. Epub 2017 Feb 14. PMID:
28259965
Article Published Date
: Feb 13, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
Neuroblastoma
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Melatonin has prospects for treating osteoporosis caused by inflammatory factors.
Jun 05, 2016
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2016 Jun 6. Epub 2016 Jun 6. PMID:
27265199
Article Published Date
: Jun 05, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
Inflammation
,
Osteoporosis: Inflammation Induced
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Osteogenic
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Melatonin in combination with HDAC inhibitors may be a novel therapeutic intervention for human lung adenocarcinoma.
Jul 15, 2015
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2015 Jul 16. Epub 2015 Jul 16. PMID:
26184924
Article Published Date
: Jul 15, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
[+]
Melatonin in combination with sorafenib synergistically inhibits proliferation and induces apoptosis in human liver cancer cells.
Feb 07, 2017
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2017 Feb 8. Epub 2017 Feb 8. PMID:
28178378
Article Published Date
: Feb 07, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Chemosensitizer
Additional Keywords
:
Chemothapeutic Synergy: Sorafenib
,
Dose Response
[+]
Melatonin is a potential candidate compound for the treatment of proinflammatory disorders.
Aug 31, 2012
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2012 Sep ;53(2):154-65. Epub 2012 Feb 21. PMID:
22348531
Article Published Date
: Aug 31, 2012
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
NF-kappaB Inhibitor
,
Nitric Oxide Inhibitor
,
Prostaglandin PGE2 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Dose Response
[+]
These results show that breast cancer stem cells, in both a canine and a human cell lines are responsive to melatonin treatment.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2016 ;11(3):e0150407. Epub 2016 Mar 2. PMID:
26934679
Article Published Date
: Dec 31, 2015
Study Type
: Human In Vitro, In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Breast Cancer
,
Cancer Metastasis
Pharmacological Actions
:
Anti-metastatic
Additional Keywords
:
Cancer Stem Cells
[+]
1800-MHz radiofrequency fields disturb plasma melatonin levels in rats.
Jan 01, 2012
Click here to read the entire abstract
Pubmed Data
: J Toxicol Environ Health A. 2012 ;75(18):1120-8. PMID:
22891885
Article Published Date
: Jan 01, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Testosterone
Anti Therapeutic Actions
:
Electromagnetic Fields
,
Electromagnetic Radiation
Adverse Pharmacological Actions
:
Endocrine Disruptor
,
Melatonin Interference
[+]
900 MHz EMF induced mild skin changes that were attentuated by melatonin.
Sep 01, 2004
Click here to read the entire abstract
Pubmed Data
: Toxicol Ind Health. 2004 Sep ;20(6-10):133-9. PMID:
15941010
Article Published Date
: Sep 01, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Radiation Induced Illness
Pharmacological Actions
:
Antioxidants
Anti Therapeutic Actions
:
Electromagnetic Fields
,
Electromagnetic Radiation
[+]
Administration of melatonin and vitamin C as radioprotectors before irradiation may reduce genotoxicity caused by x-ray irradiation.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell J. 2016 ;18(1):46-51. Epub 2016 Apr 4. PMID:
27054118
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Vitamin C
Diseases
:
Chemotherapy and Radiation Toxicity
Pharmacological Actions
:
Radioprotective
Additional Keywords
:
Natural Substance Synergy
Anti Therapeutic Actions
:
Radiotherapy
[+]
Administration of melatonin, retinoic acid and Nigella sativa reduced the carcinogenic effects of DMBA.
Nov 30, 2005
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Exp Pathol. 2005 Dec ;86(6):383-96. PMID:
16309544
Article Published Date
: Nov 30, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Nigella sativa (aka Black Seed)
,
Vitamin A
Diseases
:
Breast Cancer
,
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Anticarcinogenic Agents
Additional Keywords
:
Metabolites
,
Phytotherapy
,
Plant Extracts
[+]
Administration of N-acetylserotonin and melatonin alleviate chronic ketamine-induced behavioural phenotype .
Oct 12, 2015
Click here to read the entire abstract
Pubmed Data
: Behav Brain Res. 2015 Oct 13. Epub 2015 Oct 13. PMID:
26475510
Article Published Date
: Oct 12, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Psychiatric Disorders
Pharmacological Actions
:
Cytoprotective
,
Neuroprotective Agents
[+]
Antivenom administered along with melatonin not only offered 100% survival of experimental mice, but significantly reduced methemoglobin levels, and oxidative stress markers.
Jun 22, 2015
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2015 Jun 23. Epub 2015 Jun 23. PMID:
26103459
Article Published Date
: Jun 22, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Oxidative Stress
,
Snake Bite: Venom Toxicity
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Risk Reduction
,
Significant Treatment Outcome
[+]
Cardioprotection induced by melatonin is mediated by TLR4 to activate the SAFE pathway.
Oct 13, 2015
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2015 Oct 14. Epub 2015 Oct 14. PMID:
26465095
Article Published Date
: Oct 13, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Cardioprotective
[+]
Co-administration of melatonin and resveratrol can be beneficial in BCCAO-induced vascular dementia.
Apr 18, 2017
Click here to read the entire abstract
Pubmed Data
: Neuroimmunomodulation. 2017 Apr 19. Epub 2017 Apr 19. PMID:
28419991
Article Published Date
: Apr 18, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Resveratrol
Diseases
:
Dementia
Pharmacological Actions
:
Neuroprotective Agents
[+]
Co-administration of melatonin mitigated chemotherapy induced testicular dysfunction.
Jun 14, 2015
Click here to read the entire abstract
Pubmed Data
: Drug Chem Toxicol. 2015 Jun 15:1-10. Epub 2015 Jun 15. PMID:
26072956
Article Published Date
: Jun 14, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Chemotherapy-Induced Toxicity
Pharmacological Actions
:
Antioxidants
,
Chemoprotective Agents
,
Superoxide Dismutase Up-regulation
[+]
Curcumin, resveratrol and melatonin protect against cadmium-induced oxidative damage.
Aug 15, 2006
Click here to read the entire abstract
Pubmed Data
: Toxicology. 2006 Aug 15;225(2-3):150-6. Epub 2006 May 26. PMID:
16806632
Article Published Date
: Aug 15, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Melatonin
,
Resveratrol
Diseases
:
Cadmium Poisoning
,
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Stilbenes
[+]
Data support the use of melatonin in therapeutic interventions to reduce brain damage induced by leptin deficiency-dependent obesity.
Oct 29, 2017
Click here to read the entire abstract
Pubmed Data
: Mol Neurobiol. 2017 Oct 30. Epub 2017 Oct 30. PMID:
29086246
Article Published Date
: Oct 29, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Obesity
Pharmacological Actions
:
Neuroprotective Agents
[+]
Daytime blue light enhances the nighttime circadian melatonin inhibition of human prostate cancer growth.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Comp Med. 2015 ;65(6):473-85. PMID:
26678364
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Prostate Cancer
Therapeutic Actions
:
Light Therapy
Pharmacological Actions
:
Antiproliferative
[+]
Dietary melatonin supplementation might limit obesogenic changes in the heart and preserve mitochondrial size and membranes.
Dec 04, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2017 Dec 5 ;9(12). Epub 2017 Dec 5. PMID:
29206172
Article Published Date
: Dec 04, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Obesity
,
Prediabetes
Pharmacological Actions
:
Cardioprotective
[+]
Echinacea purpurea and melatonin augment natural-killer cells in leukemic mice and prolong life span.
Jun 01, 2001
Click here to read the entire abstract
Pubmed Data
: J Altern Complement Med. 2001 Jun;7(3):241-51. PMID:
11439845
Article Published Date
: Jun 01, 2001
Study Type
: Animal Study
Additional Links
Substances
:
Echinacea
,
Melatonin
Diseases
:
Immune Disorders: Low Immune Function
,
Leukemia
,
Low Immune Function: Natural Killer Cells
Pharmacological Actions
:
Immunomodulatory
[+]
Electromagnetic fields may interfere with melatonin synthesis in a season-dependent manner.
Sep 18, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2015 Sep 18 ;5:14206. Epub 2015 Sep 18. PMID:
26381579
Article Published Date
: Sep 18, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Additional Keywords
:
Radio Frequency Electromagnetic Radiation Exposure
Anti Therapeutic Actions
:
Electromagnetic Fields
Adverse Pharmacological Actions
:
Melatonin Interference
[+]
Emerging evidence further suggests the protective benefits of melatonin against BPA nephrotoxicity.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2018 ;2018:3082438. Epub 2018 Feb 18. PMID:
29670679
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Bisphenol Toxicity
Pharmacological Actions
:
Antioxidants
,
Renoprotective
Problem Substances
:
Bisphenol A
[+]
Fertility outcomes can be improved by melatonin it enhances progesterone receptor expression.
Mar 31, 2018
Click here to read the entire abstract
Pubmed Data
: Cell J. 2018 Apr ;20(1):108-112. Epub 2017 Dec 1. PMID:
29308626
Article Published Date
: Mar 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Infertility
Pharmacological Actions
:
Fertility Agents
[+]
Grape seed proanthocyanidin extract treatment maintained nocturnal melatonin levels and altered the oscillations of some metabolites in plasma.
Apr 30, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2015 May ;59(5):865-78. Epub 2015 Mar 23. PMID:
25677201
Article Published Date
: Apr 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Grape Seed Extract
,
Melatonin
,
Proanthocyanidins
Diseases
:
Circadian Dysregulation
Additional Keywords
:
Chronobiotic
,
Circadian Clock Proteins
,
Plant Extracts
[+]
Inhibition of Interleukin-33 with Melatonin provides therapeutic potential in diabetic kidney disease with contrast-induced nephropathy.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mediators Inflamm. 2016 ;2016:9050828. Epub 2016 Feb 18. PMID:
26989334
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Diabetic Nephropathy
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
[+]
Kidney bean sprouts could be a good source of dietary melatonin and other bioactive compounds known to have health benefits.
Feb 29, 2016
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2016 Mar ;7(3):1438-45. PMID:
26841704
Article Published Date
: Feb 29, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Beans: All
,
Melatonin
Diseases
:
Hormone Imbalances: Low Melatonin
Pharmacological Actions
:
Antioxidants
[+]
Lycopene alone and combined with melatonin provided significant improvement against renal damage caused by methotrexate.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Asian Pac J Cancer Prev. 2015 ;16(14):6061-6. PMID:
26320496
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Lycopene
,
Melatonin
Diseases
:
Drug-Induced Toxicity: Methotrexate
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Renoprotective
[+]
Magnetic fields induce morphological changes in the rat liver which to which melatonin has a mild protective effect.
May 01, 2002
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Okajimas Folia Anat Jpn. 2002 May ;79(1):25-31. PMID:
12199535
Article Published Date
: May 01, 2002
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Pharmacological Actions
:
Radioprotective
Anti Therapeutic Actions
:
Electromagnetic Fields
,
Electromagnetic Radiation
Adverse Pharmacological Actions
:
Cytotoxic
,
Hepatotoxic
[+]
Melatonin administration could alleviate the burden of Alzheimer's disease and may be considered a promising pharmaceutical treatment of the disease.
Jul 08, 2015
Click here to read the entire abstract
Pubmed Data
: J Alzheimers Dis. 2015 Jul 9 ;47(1):103-16. PMID:
26402759
Article Published Date
: Jul 08, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Melatonin administration may lower the risk of relapse triggered by cues in cocaine-experienced animals.
Feb 27, 2017
Click here to read the entire abstract
Pubmed Data
: Psychopharmacology (Berl). 2017 Feb 28. Epub 2017 Feb 28. PMID:
28246896
Article Published Date
: Feb 27, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Cocaine Addiction
,
Cocaine Withdrawal
Additional Keywords
:
Cocaine Addiction
,
Cocaine Withdrawal
,
melatonin
[+]
Melatonin administration significantly reduces the apoptotic index occurring after acute unilateral ureteral obstruction.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Cent European J Urol. 2016 ;69(2):225-30. Epub 2016 Jun 20. PMID:
27551563
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Obstructive Nephropathy
Pharmacological Actions
:
Anti-Apoptotic
,
Renoprotective
[+]
Melatonin alleviated acrylamide induced lipid peroxidation and depressed antioxidant capacity.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2015;2015:703709. Epub 2015 Jun 21. PMID:
26185593
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Acrylamide-induced toxicity
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Chemopreventive
Additional Keywords
:
Risk Reduction
Problem Substances
:
Acrylamide
[+]
Melatonin alleviated the distortion of normal hepatic architecture, lowering the incidence of preneoplastic and neoplastic lesions.
Sep 30, 2016
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2016 Oct 1. Epub 2016 Aug 1. PMID:
27696512
Article Published Date
: Sep 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
Additional Keywords
:
Risk Reduction
[+]
Melatonin alleviates aluminium chloride-induced immunotoxicity.
May 29, 2019
Click here to read the entire abstract
Pubmed Data
: Ecotoxicol Environ Saf. 2019 May 30 ;173:131-141. Epub 2019 Feb 13. PMID:
30771656
Article Published Date
: May 29, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aluminum Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Nrf2 activation
Problem Substances
:
Aluminum Chloride
[+]
Melatonin alleviates lipopolysaccharide induced blood-brain barrier disruption.
Feb 02, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Aging Cell. 2017 Feb 3. Epub 2017 Feb 3. PMID:
28156052
Article Published Date
: Feb 02, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Blood Brain Barrier
[+]
Melatonin ameliorates bisphenol A-induced perturbations of the prostate gland of adult Wistar rats.
May 25, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 May 26 ;105:73-82. Epub 2018 May 26. PMID:
29843047
Article Published Date
: May 25, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Bisphenol Toxicity
Pharmacological Actions
:
Cytoprotective
Problem Substances
:
Bisphenol A
[+]
Melatonin ameliorates low-grade inflammation and oxidative stress in young diabetic fatty rats.
Aug 22, 2012
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2012 Aug 23. Epub 2012 Aug 23. PMID:
23020082
Article Published Date
: Aug 22, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Diabetes Mellitus: Type 2
,
Inflammation
,
Insulin Resistance
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Melatonin ameliorates neural function by promoting endogenous neurogenesis in ischemic stroke mice.
Feb 10, 2012
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2012 Feb 10. Epub 2012 Feb 10. PMID:
22330064
Article Published Date
: Feb 10, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Stroke: Ischemic
Pharmacological Actions
:
Neuroprotective Agents
[+]
Melatonin ameliorates symptoms of kidney damage in rats.
Nov 01, 2005
Click here to read the entire abstract
Pubmed Data
: Zhonghua Zhong Liu Za Zhi. 2005 Nov;27(11):667-71. PMID:
18077597
Article Published Date
: Nov 01, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Kidney Diseases
,
Kidney Failure
[+]
Melatonin ameliorates testicular damages induced by nicotine in mice.
May 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Iran J Basic Med Sci. 2018 Jun ;21(6):639-644. PMID:
29942456
Article Published Date
: May 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Testicular Injury: Nicotine-Induced
Pharmacological Actions
:
Anti-Apoptotic
[+]
Melatonin and a compound found within bee propolis have a protective effect against electromagnetic radiation-induced retinal oxidative stress associated with long-term mobile phone exposure.
Jan 01, 2006
Click here to read the entire abstract
Pubmed Data
: : Mol Cell Biochem. 2006 Jan;282(1-2):83-8. PMID:
16317515
Article Published Date
: Jan 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Bee Propolis
,
Melatonin
Diseases
:
Electromagnetic Radiation
,
Mobile Phone-Induced Oxidative Stress
[+]
Melatonin and buffalo pineal proteins attenuate flouride-induced oxidative stress in the rat brain.
Nov 01, 2000
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2000 Nov;48(11):5630-9. PMID:
19159082
Article Published Date
: Nov 01, 2000
Study Type
: Animal Study
Additional Links
Substances
:
Glandulars
,
Melatonin
Diseases
:
Fluoride Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
Melatonin and caffeic acid phenethyl ester prevent renal tubular injury by reducing oxidative stress and protect the kidney from oxidative damage induced by 900 MHz mobile phone.
Aug 01, 2005
Click here to read the entire abstract
Pubmed Data
: Mol Cell Biochem. 2005 Aug ;276(1-2):31-7. PMID:
16132682
Article Published Date
: Aug 01, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Caffeic acid phenethyl ester
,
Melatonin
Diseases
:
Radiation Induced Illness
Pharmacological Actions
:
Antioxidants
,
Malondialdehyde Down-regulation
,
Superoxide Dismutase Up-regulation
Anti Therapeutic Actions
:
Electromagnetic Fields
,
Electromagnetic Radiation
Adverse Pharmacological Actions
:
Nephrotoxic
[+]
Melatonin and coenzyme Q ameliorated most of the impaired fatty acid profile in rodent model with persistent autistic features.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Food Nutr Res. 2016 ;60:28127. Epub 2016 Mar 3. PMID:
26945230
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Coenzyme Q10
,
Melatonin
Diseases
:
Autism
Additional Keywords
:
Gut-brain Axis
[+]
Melatonin and curcumin protect against ndomethacin-induced acute gastric ulceration.
Sep 15, 2006
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2006 Sep 15;41(6):911-25. Epub 2006 Apr 30. PMID:
16934674
Article Published Date
: Sep 15, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Melatonin
Diseases
:
Drug-Induced Toxicity: Indomethacin
,
Gastric Ulcer
Pharmacological Actions
:
Antioxidants
,
Gastroprotective
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Drug: Indomethacin
[+]
Melatonin and omega-3 can protect cells against neuronal damage in the hippocampus induced by 900 MHz EMF.
Jul 20, 2016
Click here to read the entire abstract
Pubmed Data
: Int J Radiat Biol. 2016 Jul 21:1-6. Epub 2016 Jul 21. PMID:
27442260
Article Published Date
: Jul 20, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Omega-3 Fatty Acids
Pharmacological Actions
:
Neuroprotective Agents
Anti Therapeutic Actions
:
Electromagnetic Fields
[+]
Melatonin and pycnogenol have a therapeutic role in the treatment fo endothelial dysfunction.
Aug 01, 2003
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2003 Aug;12(2):269-73. PMID:
20421515
Article Published Date
: Aug 01, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Flavonoids
,
Melatonin
Diseases
:
Endothelial Dysfunction
,
Hypertension
Pharmacological Actions
:
Antihypertensive Agents
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Melatonin and resveratrol, as found in red wine, protect the heart in an experimental model of myocardial infarction.
Feb 23, 2011
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2011 Feb 23. Epub 2011 Feb 23. PMID:
21342247
Article Published Date
: Feb 23, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Resveratrol
,
Wine
Diseases
:
Myocardial Infarction
,
Myocardial Ischemia
Pharmacological Actions
:
Cardioprotective
[+]
Melatonin and selenium induced protective effects against diabetes-induced brain and erythrocyte oxidative injuries.
Aug 04, 2015
Click here to read the entire abstract
Pubmed Data
: Brain Inj. 2015 Aug 5:1-7. Epub 2015 Aug 5. PMID:
26244700
Article Published Date
: Aug 04, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Selenium
Diseases
:
Brain: Oxidative Stress
,
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Neuroprotective Agents
Additional Keywords
:
Cytokines
[+]
Melatonin and selenium induced protective effects against diabetes-induced brain and erythrocyte oxidative injuries.
Aug 11, 2015
Click here to read the entire abstract
Pubmed Data
: Brain Inj. 2015 Aug 12:1-7. Epub 2015 Aug 12. PMID:
26287758
Article Published Date
: Aug 11, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Selenium
Diseases
:
Brain: Oxidative Stress
,
Diabetes: Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Interleukin-1 beta downregulation
,
Interleukin-4 downregulation
[+]
Melatonin and thymoquinone protect against IR-induced injury to intestinal tissues.
Aug 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Saudi J Gastroenterol. 2015 Sep-Oct;21(5):284-9. PMID:
26458854
Article Published Date
: Aug 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Thymoquinone
Diseases
:
Intestinal Ischemia
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Melatonin attentuates the spermatotoxic effects of radiofrequency radiation in mice.
May 01, 2018
Click here to read the entire abstract
Pubmed Data
: Toxicol Ind Health. 2018 May ;34(5):315-327. Epub 2018 Mar 21. PMID:
29562845
Article Published Date
: May 01, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
DNA damage
,
Infertility: Male
,
Oxidative Stress
,
Sperm Quality: Low
Pharmacological Actions
:
Antioxidants
,
Genoprotective
Anti Therapeutic Actions
:
Electromagnetic Fields
,
Electromagnetic Radiation
Adverse Pharmacological Actions
:
Oxidant
[+]
Melatonin attenuated the brain damage and cognitive impairment partially through MT2 melatonin receptor in mice with chronic cerebral hypoperfusion.
Sep 25, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2017 Sep 26 ;8(43):74320-74330. Epub 2017 Aug 22. PMID:
29088788
Article Published Date
: Sep 25, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Brain Damage
,
Cerebral Hypoperfusion
Pharmacological Actions
:
Neuroprotective Agents
[+]
Melatonin attenuates 1-Bromopropane-induced CNS toxicity through its ROS scavenging effect.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Medicine (Baltimore). 2016 Jan ;95(3):e2203. PMID:
26817862
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
Melatonin attenuates bisphenol A-induced toxicity of the adrenal gland of Wistar rats.
Jan 05, 2019
Click here to read the entire abstract
Pubmed Data
: Environ Sci Pollut Res Int. 2019 Jan 6. Epub 2019 Jan 6. PMID:
30613877
Article Published Date
: Jan 05, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Bisphenol Toxicity
Pharmacological Actions
:
Antioxidants
Problem Substances
:
Bisphenol A
[+]
Melatonin attenuates oxidative stress and the associated memory impairment induced by klotho deficiency.
Mar 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Neuropsychopharmacol. 2015 Apr ;18(6). Epub 2014 Dec 30. PMID:
25550330
Article Published Date
: Mar 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Cognitive Decline/Dysfunction
,
Memory Disorders
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
Melatonin attenuates sepsis induced brain injury via activation SIRT1 signaling activation.
Jun 09, 2015
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2015 Jun 10. Epub 2015 Jun 10. PMID:
26094939
Article Published Date
: Jun 09, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Brain: Oxidative Stress
,
Brain Inflammation
,
Sepsis
,
Traumatic Brain Injury
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
SIRT1 Activator
,
Superoxide Dismutase Up-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Significant Treatment Outcome
[+]
Melatonin augments the effects of fluoxetine on depression.
Oct 30, 2017
Click here to read the entire abstract
Pubmed Data
: Neurosci Bull. 2017 Oct 31. Epub 2017 Oct 31. PMID:
29086908
Article Published Date
: Oct 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
,
Brain-derived neurotrophic factor modulator
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
Melatonin can be used in the treatment of seizures.
Mar 21, 2016
Click here to read the entire abstract
Pubmed Data
: Behav Brain Res. 2016 Mar 22. Epub 2016 Mar 22. PMID:
27016427
Article Published Date
: Mar 21, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Epilepsy
Pharmacological Actions
:
Anticonvulsants
[+]
Melatonin can be useful as a therapeutic adjuvant for patients under long-term opioid treatment for pain relief.
Mar 20, 2016
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2016 Mar 21. Epub 2016 Mar 21. PMID:
27012766
Article Published Date
: Mar 20, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Brain Inflammation
,
Morphine Tolerance/Dependence
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Heat Shock Protein Down-Regulation
[+]
Melatonin can exert receptor-mediated signaling effects to attenuate inflammation and oxidative stress of the retina.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2016 ;2016:3528274. Epub 2016 Apr 6. PMID:
27143993
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Diabetic Retinopathy
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
[+]
Melatonin can help protect against Wi-Fi-induced oxidative stress in the lens of rats.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Indian J Ophthalmol. 2014 Jan ;62(1):12-5. PMID:
24492496
Article Published Date
: Dec 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Antioxidants
Anti Therapeutic Actions
:
Electromagnetic Fields
,
Wi-Fi Radiation
[+]
Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence-accelerated prone male mice.
Mar 12, 2012
Click here to read the entire abstract
Pubmed Data
: Age (Dordr). 2012 Mar 13. Epub 2012 Mar 13. PMID:
22411259
Article Published Date
: Mar 12, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging
,
Insulin Resistance
Pharmacological Actions
:
Insulin Sensitizers
[+]
Melatonin can inhibit glioma cell growth both in culture and in vivo.
Feb 01, 2018
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2018 Feb 2. Epub 2018 Feb 2. PMID:
29408377
Article Published Date
: Feb 01, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Gliomas
Pharmacological Actions
:
Antiproliferative
[+]
Melatonin causes regression and atrophy of the endometriotic lesions in rats.
Apr 01, 2008
Click here to read the entire abstract
Pubmed Data
: Fertil Steril. 2008 Apr;89(4):934-42. Epub 2007 Jun 19. PMID:
17582405
Article Published Date
: Apr 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Endometriosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
[+]
Melatonin combined with chondroitin sulfate ABC can promote nerve regeneration after nerve-root avulsion injury of the brachial plexus.
Jan 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Neural Regen Res. 2019 Feb ;14(2):328-338. PMID:
30531017
Article Published Date
: Jan 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Chondroitin Sulfate
,
Melatonin
Diseases
:
Neuritis: Brachial Plexus
Pharmacological Actions
:
Regenerative
Additional Keywords
:
Nerve Regeneration
[+]
Melatonin confers protective effects to rat neurons following 2.45 GHz electromagnetic radiation exposure.
Feb 01, 2012
Click here to read the entire abstract
Pubmed Data
: Physiol Behav. 2012 Feb 1 ;105(3):683-92. Epub 2011 Oct 12. PMID:
22019785
Article Published Date
: Feb 01, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Calcium Channel Blockers
Anti Therapeutic Actions
:
Electromagnetic Fields
,
Electromagnetic Radiation
,
Electromagnetic Radiation: 2.4 GHz
[+]
Melatonin confers radioprotective effects against mobil phone-induced oxidative stress in the rat brain.
Nov 01, 2008
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Radiat Res. 2008 Nov ;49(6):579-86. Epub 2008 Sep 29. PMID:
18827438
Article Published Date
: Nov 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Brain: Oxidative Stress
,
Oxidative Stress
Pharmacological Actions
:
Antioxidant
,
Radioprotective
Anti Therapeutic Actions
:
Electromagnetic Fields
,
Electromagnetic Radiation
Adverse Pharmacological Actions
:
Oxidant
[+]
Melatonin could ameliorate exercise induced damage to liver and kidneys in rats.
Aug 25, 2015
Click here to read the entire abstract
Pubmed Data
: Endocr Metab Immune Disord Drug Targets. 2015 Aug 26. Epub 2015 Aug 26. PMID:
26310355
Article Published Date
: Aug 25, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Therapeutic Actions
:
Exercise
Pharmacological Actions
:
Hepatoprotective
,
Renoprotective
[+]
Melatonin could be beneficial reducing apoptosis and oxidative stress.
Aug 07, 2016
Click here to read the entire abstract
Pubmed Data
: Antivir Chem Chemother. 2016 Aug 8. Epub 2016 Aug 8. PMID:
27503577
Article Published Date
: Aug 07, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Encephalitis
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Malondialdehyde Down-regulation
[+]
Melatonin could be used in the reversal of schizophrenia-like symptoms and immune alterations in mice.
Sep 20, 2016
Click here to read the entire abstract
Pubmed Data
: J Psychiatr Res. 2016 Sep 21 ;84:49-58. Epub 2016 Aug 21. PMID:
27697587
Article Published Date
: Sep 20, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Schizophrenia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
Problem Substances
:
Risperidone
[+]
Melatonin could enhance the sensitivity of breast tumors to adriamycin in vivo.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Eur J Gynaecol Oncol. 2015 ;36(2):197-202. PMID:
26050360
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Breast Cancer: estrogen receptor alpha-positive
,
Quality of Life: Poor
Pharmacological Actions
:
Chemosensitizer
Additional Keywords
:
Drug: Adriamycin
,
Significant Treatment Outcome
[+]
Melatonin could protect against aluminum-induced toxicity in rats.
Jul 15, 2015
Click here to read the entire abstract
Pubmed Data
: Gen Physiol Biophys. 2015 Jul 16. Epub 2015 Jul 16. PMID:
26374992
Article Published Date
: Jul 15, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aluminum Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Hypolipidemic
Problem Substances
:
Aluminum
[+]
Melatonin could protect against liver injury caused by alcohol gastric perfusion.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Alcohol Alcohol. 2016 Jan ;51(1):11-9. Epub 2015 Nov 11. PMID:
26564773
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Alcohol Toxicity
,
Alcoholic Liver Disease
Pharmacological Actions
:
Adenosine Monophosphate (AMP)-activated Protein Kinase (AMPK
,
Hepatoprotective
[+]
Melatonin could significantly reduce endoplasmic reticulum stress in leptin-deficient obese animals.
Apr 18, 2016
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2016 Apr 19. Epub 2016 Apr 19. PMID:
27090356
Article Published Date
: Apr 18, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Obesity
[+]
Melatonin deficiency could be a key mechanism explaining the co-morbidity effect in the association between obesity and periodontitis.
Jun 13, 2018
Click here to read the entire abstract
Pubmed Data
: J Periodontal Res. 2018 Jun 14. Epub 2018 Jun 14. PMID:
29900537
Article Published Date
: Jun 13, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Hormone Imbalances: Low Melatonin
,
Obesity
,
Periodontitis
[+]
Melatonin exerts neuroprotective properties to counteract the negative effects of electromagnetic fields.
Jun 01, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Cell Mol Med. 2014 Jun ;18(6):1060-70. Epub 2014 Feb 18. PMID:
24548607
Article Published Date
: Jun 01, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Pharmacological Actions
:
Antioxidants
,
Calcium Channel Blockers
Anti Therapeutic Actions
:
Electromagnetic Fields
,
Electromagnetic Radiation
[+]
Melatonin exerts potent antioxidant effects in the testes of rats exposed to microwaves by decreasing the intensity of oxidative stress; it also reduces DNA fragmentation.
Apr 30, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Adv Clin Exp Med. 2015 May-Jun;24(3):429-36. PMID:
26467130
Article Published Date
: Apr 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
DNA damage
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Genoprotective
Anti Therapeutic Actions
:
Microwave Radiation
[+]
Melatonin exhibits potent antioxidant properties that may create favourable conditions for the recovery of liver function following IRI.
Apr 30, 2016
Click here to read the entire abstract
Pubmed Data
: Exp Ther Med. 2016 May ;11(5):1955-1960. Epub 2016 Mar 15. PMID:
27168834
Article Published Date
: Apr 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Lipid Peroxidation
,
Liver Injury: Ischemia/reperfusion
Pharmacological Actions
:
Antioxidants
[+]
Melatonin exposure improves liver tissue damage caused by arsenic exposure.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Ulus Cerrahi Derg. 2016 ;32(4):233-237. Epub 2016 Oct 27. PMID:
28149117
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Arsenic Poisoning
Pharmacological Actions
:
Hepatoprotective
Additional Keywords
:
Arsenic Poisoning
,
Hepatoprotective
,
melatonin
Problem Substances
:
Arsenic
[+]
Melatonin had protective roles in hypertension induced renal injury.
Nov 01, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2015 Nov 2. Epub 2015 Nov 2. PMID:
26531807
Article Published Date
: Nov 01, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Hypertension
,
Kidney Damage
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Renoprotective
[+]
Melatonin had significant analgesic effects in the treatment of post herpetic neuralgia.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Clin Exp Med. 2015 ;8(4):5004-9. Epub 2015 Apr 15. PMID:
26131073
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Neuralgia: Post Herpetic
Pharmacological Actions
:
Analgesics
[+]
Melatonin has a favorable effect on the level of oxidative damage and neurodegeneration in age-accelerated mice.
Oct 01, 2008
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2008 Oct;45(3):302-11. Epub 2008 Apr 13. PMID:
18410310
Article Published Date
: Oct 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging
,
Aging: Brain
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
,
Receptor-Related Orphan Receptor (ROR)-Alpha1 Inhibitor
[+]
Melatonin has a protective action against BPA-induced deterioration of oocyte quality in mice.
Feb 07, 2017
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2017 Feb 8. Epub 2017 Feb 8. PMID:
28178360
Article Published Date
: Feb 07, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Bisphenol Toxicity
,
Infertility
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
Problem Substances
:
Bisphenol A
[+]
Melatonin has a protective effect against formaldehyde-induced oxidative damage and apoptosis in rat testes.
Jun 30, 2008
Click here to read the entire abstract
Pubmed Data
: Syst Biol Reprod Med. 2008 Jul-Aug;54(4-5):169-76. PMID:
18942024
Article Published Date
: Jun 30, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Oxidative Stress
,
Testicular Injury: Formaldehyde-Induced
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Malondialdehyde Down-regulation
,
Superoxide Dismutase Up-regulation
[+]
Melatonin has a significant effect on the protection of the heart against isoproterenol induced myocardial infarction through maintaining endogenous antioxidant enzyme activities.
Oct 09, 2010
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2010 Oct 10 ;644(1-3):160-8. Epub 2010 Jul 13. PMID:
20624385
Article Published Date
: Oct 09, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Myocardial Infarction
Pharmacological Actions
:
Antioxidants
,
Cardioprotective
Additional Keywords
:
Drug: Isoproterenol
[+]
Melatonin has ameliorative properties in an animal mode of experimental colitis.
Nov 01, 2006
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2006 Nov;41(4):363-73. PMID:
17014694
Article Published Date
: Nov 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Colitis
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Melatonin has an ameliorative effect against gamma-irradiation-induced oxidative stress and tissue injury.
Feb 01, 2007
Click here to read the entire abstract
Pubmed Data
: Ecotoxicol Environ Saf. 2007 Feb;66(2):278-86. Epub 2006 Jun 21. PMID:
16793135
Article Published Date
: Feb 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Radiation Induced Illness
,
Radiation-Induced Illness: Cesium-137 Exposure
Pharmacological Actions
:
Antioxidants
,
Radioprotective
[+]
Melatonin has an inhibitory effect on DMBA-induced cervical and vaginal cancer in mice.
Aug 11, 2000
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2000 Aug 11;156(2):199-205. PMID:
10880770
Article Published Date
: Aug 11, 2000
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Cervical Cancer
,
Vaginal Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antimutagenic Agents
[+]
Melatonin has an inhibitory effect on the growth of pituitary prolactin-secreting tumor in rats.
Apr 01, 2006
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2006 Apr;40(3):230-5. PMID:
16499559
Article Published Date
: Apr 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Pituitary Tumours
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
[+]
Melatonin has antioxidant, anti-inflammatory and hepatoprotective effects in case of IR.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Ann Ital Chir. 2016 ;87:271-9. PMID:
27346180
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Liver Injury: Ischemia/reperfusion
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Hepatoprotective
[+]
Melatonin has been demonstrated to be a highly efficient anti-aging factor which may reduce age-related skin changes.
Oct 01, 2005
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2005 Oct;39(3):231-7. PMID:
16150102
Article Published Date
: Oct 01, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging
,
Aging Skin
[+]
Melatonin has beneficial effects on cardiological alterations in a mouse model of accelerated aging.
Oct 01, 2010
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2010 Oct;49(3):312-20. Epub 2010 Aug 3. PMID:
20738757
Article Published Date
: Oct 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging
,
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cardioprotective
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Melatonin has beneficial effects on impaired intestinal epithelial permeability in type 2 diabetes.
Mar 28, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Cell Biochem. 2016 Mar 29. Epub 2016 Mar 29. PMID:
27023908
Article Published Date
: Mar 28, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Hypoglycemic Agents
,
Hypolipidemic
[+]
Melatonin has cardioprotective effects in a rat model of cardiorenal syndrome.
Jul 27, 2016
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2016 Jul 28. Epub 2016 Jul 28. PMID:
27465663
Article Published Date
: Jul 27, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Heart Disease
,
Kidney Diseases
,
Multi-Organ Failure
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cardioprotective
,
Interleukin-1 beta downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Melatonin has neuroprotective properties in an animal model of accelerated aging.
May 16, 2011
Click here to read the entire abstract
Pubmed Data
: Rev Neurol. 2011 May 16;52(10):618-622. PMID:
21488009
Article Published Date
: May 16, 2011
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging
,
Aging: Brain
Pharmacological Actions
:
Neuroprotective Agents
[+]
Melatonin has neuroprotective properties superior to methyprednisone in experimental spinal cord injury.
Oct 01, 2005
Click here to read the entire abstract
Pubmed Data
: Surg Neurol. 2005 Oct;64(4):355-61. PMID:
16231427
Article Published Date
: Oct 01, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Lipid Peroxidation
,
Spinal Cord Injuries
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
Additional Keywords
:
Cortisone Alternatives
,
Superiority of Natural Substances versus Drugs
[+]
Melatonin has shown to be effective in controlling metastatic breast cancer in vitro and in vivo.
Aug 20, 2015
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2015 Aug 21. Epub 2015 Aug 21. PMID:
26292662
Article Published Date
: Aug 20, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Breast Cancer
,
Breast Cancer: Lung Metastasis
,
Breast Cancer: Metastatic
Pharmacological Actions
:
Anti-metastatic
[+]
Melatonin improved the depressive behaviour of stressed mice.
Jul 10, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Neurosignals. 2016 Jul 11 ;24(1):48-58. Epub 2016 Jul 11. PMID:
27398923
Article Published Date
: Jul 10, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
,
Neurogenesis
[+]
Melatonin improves functional recovery as effectively as methylpredisolone in experimental spinal cord injury.
Dec 01, 2004
Click here to read the entire abstract
Pubmed Data
: Eur Spine J. 2004 Dec;13(8):724-32. Epub 2004 Jul 1. PMID:
15232723
Article Published Date
: Dec 01, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Spinal Cord Injuries
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
Additional Keywords
:
Cortisone Alternatives
,
Natural Substances Versus Drugs
[+]
Melatonin improves inflammation processes in the liver of age-accelerated prone male mice.
Dec 01, 2010
Click here to read the entire abstract
Pubmed Data
: Exp Gerontol. 2010 Dec;45(12):950-6. Epub 2010 Sep 9. PMID:
20817086
Article Published Date
: Dec 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging
,
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
,
Interleukin-10 downregulation
,
Interleukin-1 beta downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Melatonin improves metabolic syndrome induced by high fructose intake in rats.
Apr 30, 2012
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2012 May ;52(4):403-13. Epub 2012 Jan 6. PMID:
22220562
Article Published Date
: Apr 30, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
High Fructose Diet
,
Insulin Resistance
,
Metabolic Syndrome X
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Melatonin improves pro-survival signals and reduces pro-death signals in age-related impairments of neural processes.
Nov 01, 2008
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2008 Nov;45(4):497-505. Epub 2008 Aug 13. PMID:
18705649
Article Published Date
: Nov 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging
,
Aging: Brain
,
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Melatonin increases brown adipose tissue mass and function.
Feb 05, 2018
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2018 Feb 6. Epub 2018 Feb 6. PMID:
29405372
Article Published Date
: Feb 05, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
[+]
Melatonin induces cognitive enhancement and brain resilience against neurodegenerative processes.
Jun 14, 2018
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2018 Jun 15:e12515. Epub 2018 Jun 15. PMID:
29907977
Article Published Date
: Jun 14, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Neurodegenerative Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
[+]
Melatonin inhibits benzene-induced lipid peroxidation in rat liver.
Mar 01, 2010
Click here to read the entire abstract
Pubmed Data
: Arh Hig Rada Toksikol. 2010 Mar;61(1):11-8. PMID:
20338863
Article Published Date
: Mar 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Benzene Toxicity
,
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
[+]
Melatonin inhibits oxidative stress and programmed cell death in fetal brains of hyperhomocysteinemic rat dams.
Oct 01, 2007
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2007 Oct;43(3):225-31. PMID:
17803518
Article Published Date
: Oct 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
High Homocysteine
,
Lipid Peroxidation
,
Oxidative Stress
,
Prenatal Nutrition: Prevention of Problems
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Neuroprotective Agents
,
Tumor Suppressor Protein p53 Upregulation
[+]
Melatonin intervention reduced autophagy by ameliorating inflammation and oxidative stress in a mouse model of colitis-associated colon carcinogenesis.
Jan 15, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Carcinog. 2015 Jan 16. Epub 2015 Jan 16. PMID:
25598500
Article Published Date
: Jan 15, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Colon Cancer: Prevention
,
Oxidative Stress
,
Ulcerative Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Antioxidants
,
Chemopreventive
,
Nrf2 activation
[+]
Melatonin is a potential means for countering hyperalgesia induced by neonatal morphine exposure in young and adult rats.
Aug 17, 2016
Click here to read the entire abstract
Pubmed Data
: Neurosci Lett. 2016 Aug 18. Epub 2016 Aug 18. PMID:
27546822
Article Published Date
: Aug 17, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Hyperalgesia
Pharmacological Actions
:
Anti-Inflammatory Agents
Problem Substances
:
Morphine
[+]
Melatonin is a promising candidate for effective future therapeutic strategies for Parkinson's disease.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: J Environ Pathol Toxicol Oncol. 2018 ;37(2):139-150. PMID:
30055549
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Parkinson's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Melatonin is an ergogenic aid for exhaustive aerobic exercise only during the wakefulness period.
Oct 27, 2015
Click here to read the entire abstract
Pubmed Data
: Int J Sports Med. 2015 Oct 28. Epub 2015 Oct 28. PMID:
26509365
Article Published Date
: Oct 27, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Therapeutic Actions
:
Exercise
,
Exercise: Aerobic
Pharmacological Actions
:
Antioxidants
[+]
Melatonin is effective in reducing maternal LPS-induced neonatal inflammation and related brain injury.
Jul 20, 2016
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2016 Jul 21. Epub 2016 Jul 21. PMID:
27441728
Article Published Date
: Jul 20, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Brain Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
MicroRNA modulator
,
Neuroprotective Agents
[+]
Melatonin is likely to protect against alterations of the male reproductive system caused by BPA.
Aug 05, 2019
Click here to read the entire abstract
Pubmed Data
: Environ Sci Pollut Res Int. 2019 Aug 6. Epub 2019 Aug 6. PMID:
31388950
Article Published Date
: Aug 05, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Bisphenol Toxicity
,
Infertility: Male
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Risk Factors
,
Risk Reduction
Problem Substances
:
Bisphenol A
[+]
Melatonin is present in walnuts and can increase blood melatonin concentrations.
Aug 31, 2005
Click here to read the entire abstract
Pubmed Data
: Nutrition. 2005 Sep ;21(9):920-4. PMID:
15979282
Article Published Date
: Aug 31, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Walnut
Pharmacological Actions
:
Antioxidants
[+]
Melatonin is superior to methylprednisolone in experimental spinal cord injury.
Jul 01, 2000
Click here to read the entire abstract
Pubmed Data
: J Neurosurg. 2000 Jul;93(1 Suppl):77-84. PMID:
10879762
Article Published Date
: Jul 01, 2000
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Spinal Cord Injuries
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
Additional Keywords
:
Cortisone Alternatives
,
Drug: Methylprednisolone
,
Superiority of Natural Substances versus Drugs
[+]
Melatonin loss in aging could be recompensed through dietary supplementation as a beneficial therapeutic strategy for AD prevention and progression.
Apr 07, 2016
Click here to read the entire abstract
Pubmed Data
: Neurosci Lett. 2016 Apr 8. Epub 2016 Apr 8. PMID:
27068758
Article Published Date
: Apr 07, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Supplementation
[+]
Melatonin may alleviate the side effects of busulfan for male patients during clinical treatment.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Physiol Biochem. 2017 ;44(6):2407-2421. Epub 2017 Dec 18. PMID:
29268276
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Testicular Injury: Chemical/Metal Induced
Pharmacological Actions
:
Cytoprotective
[+]
Melatonin may attenuate chronic cerebral hypoperfusion-induced cognitive impairment and hippocampal neuronal cell damage.
May 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2016 Jun ;11(6):2240-2246. Epub 2016 Apr 1. PMID:
27284307
Article Published Date
: May 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Cerebral Hypoperfusion
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Neuroprotective Agents
[+]
Melatonin may be a promising pharmacological agent against testicular toxicity induced by high-fructose corn syrup.
Jun 04, 2019
Click here to read the entire abstract
Pubmed Data
: Andrologia. 2019 Jun 5:e13327. Epub 2019 Jun 5. PMID:
31168831
Article Published Date
: Jun 04, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
High Fructose Diet
,
Testicular Injury: Chemical/Metal Induced
Pharmacological Actions
:
Cytoprotective
Problem Substances
:
High Fructose Corn Syrup
[+]
Melatonin may delay aging in gastric mucosa tissue by decreasing caspase-3 activity.
Mar 14, 2011
Click here to read the entire abstract
Pubmed Data
: Aging Clin Exp Res. 2011 Mar 14. Epub 2011 Mar 14. PMID:
21406955
Article Published Date
: Mar 14, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging
Pharmacological Actions
:
Anti-Apoptotic
,
Caspase-3 Activation
[+]
Melatonin may have a potential therapeutic effects against irradiation.
May 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2016 Jun ;11(6):2385-2390. Epub 2016 Mar 31. PMID:
27313671
Article Published Date
: May 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Chemotherapy and Radiation Toxicity
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
,
Radioprotective
[+]
Melatonin may have therapeutic value in reducing symptoms of nocturia.
Jul 01, 2010
Click here to read the entire abstract
Pubmed Data
: J Urol. 2010 Jul;184(1):386-91. Epub 2010 May 20. PMID:
20488476
Article Published Date
: Jul 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Nocturia
[+]
Melatonin may increase cell survival in the hippocampus via decreasing oxidative stress and SIRT2 expression and increasing Bcl-2 expression.
Jan 07, 2018
Click here to read the entire abstract
Pubmed Data
: Brain Res Bull. 2018 Jan 8 ;137:306-310. Epub 2018 Jan 8. PMID:
29325994
Article Published Date
: Jan 07, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Melatonin
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Neuroprotective Agents
[+]
Melatonin may offer an adjunct therapy in the treatment of pancreatic cancer.
Oct 01, 2007
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2007 Oct;43(3):270-5. PMID:
17803524
Article Published Date
: Oct 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Pancreatic Cancer
[+]
Melatonin may play a therapeutic role in the treatment of oxidative stress related neurodegenerative disorders.
Aug 19, 2016
Click here to read the entire abstract
Pubmed Data
: Behav Brain Res. 2016 Aug 20. Epub 2016 Aug 20. PMID:
27555536
Article Published Date
: Aug 19, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Brain: Oxidative Stress
,
Neurodegenerative Diseases
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
Melatonin may protect against neurological injury associated with intermittent hypoxia (low oxygen) in patients with obstructive sleep apnea.
Mar 01, 2008
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2008 Mar;44(2):214-21. PMID:
18289174
Article Published Date
: Mar 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Sleep Apnea: Central
[+]
Melatonin may represent an effective treatment option for multiple sclerosis.
Jun 26, 2015
Click here to read the entire abstract
Pubmed Data
: Brain Behav Immun. 2015 Jun 27. Epub 2015 Jun 27. PMID:
26130320
Article Published Date
: Jun 26, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Multiple Sclerosis
Pharmacological Actions
:
Immunomodulatory
[+]
Melatonin may serve as an advanced strategy to strengthen oral health to counteract periodontitis induced destructive damage.
Dec 22, 2017
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2017 Dec 23. Epub 2017 Dec 23. PMID:
29274168
Article Published Date
: Dec 22, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Periodontitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Prophylactic Agents
[+]
Melatonin may stimulate dopaminergic synthesis in the hippocampus in order to suppress stress-induced behaviour.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Folia Biol (Praha). 2016 ;62(6):250-257. PMID:
28189148
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Anxiety
,
Depression: Stress Related
,
Stress
Pharmacological Actions
:
Anti-Anxiety Agents
[+]
Melatonin mediated an antidepressant-like effect in rats with chronic stress-induced depression.
Aug 03, 2016
Click here to read the entire abstract
Pubmed Data
: Eur Neuropsychopharmacol. 2016 Aug 4. Epub 2016 Aug 4. PMID:
27499503
Article Published Date
: Aug 03, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
[+]
Melatonin might act as a prooxidant and reduce the changes produced by fructose consumption.
Apr 30, 2015
Click here to read the entire abstract
Pubmed Data
: Eur Rev Med Pharmacol Sci. 2015 May ;19(10):1915-21. PMID:
26044240
Article Published Date
: Apr 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Metabolic Diseases
,
Oxidative Stress
Pharmacological Actions
:
Antihypertensive Agents
,
Antioxidants
[+]
Melatonin or knockdown of CDK5 reduced MPTP-induced SNCA/α-synuclein aggregation in mice, which is widely thought to trigger the pathogenesis of PD.
Aug 19, 2015
Click here to read the entire abstract
Pubmed Data
: Autophagy. 2015 Aug 20:0. Epub 2015 Aug 20. PMID:
26292069
Article Published Date
: Aug 19, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Parkinson's Disease
Pharmacological Actions
:
Autophagy Inhibitors
,
Neuroprotective Agents
[+]
Melatonin pre-treatment enhances the therapeutic effects of exogenous mitochondria against hepatic ischemia-reperfusion injury in rats.
Mar 17, 2016
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2016 Mar 18. Epub 2016 Mar 18. PMID:
26993080
Article Published Date
: Mar 17, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Liver Injury: Ischemia/reperfusion
Pharmacological Actions
:
Hepatoprotective
[+]
Melatonin pre-treatment replenished the mitochondrial lipid peroxidation levels and protein carbonyl content induced by oxaliplatin.
Aug 02, 2016
Click here to read the entire abstract
Pubmed Data
: Mitochondrion. 2016 Aug 3. Epub 2016 Aug 3. PMID:
27497633
Article Published Date
: Aug 02, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Chemotherapy-Induced Toxicity: Oxaliplatin
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Chemoprotective Agents
,
Neuroprotective Agents
[+]
Melatonin pre-treatment was able to prevent hematopoietic, immunological, and gastrointestinal radiation-induced injury in mice.
Mar 06, 2016
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol. 2016 Mar 7. Epub 2016 Mar 7. PMID:
26948951
Article Published Date
: Mar 06, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Chemotherapy and Radiation Toxicity
Pharmacological Actions
:
Radioprotective
[+]
Melatonin prevented memory impairment that was induced by Sleep deprivation.
Jun 17, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Neurobiol. 2015 Jun 18. Epub 2015 Jun 18. PMID:
26084441
Article Published Date
: Jun 17, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Insomnia
,
Memory Disorders
,
Sleep Disorders
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
Additional Keywords
:
Chronobiotic
[+]
Melatonin prevents acetaminophen-induced kidney injury in rats.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: Int Urol Nephrol. 2009;41(3):695-702. Epub 2009 Jan 1. PMID:
19117117
Article Published Date
: Jan 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Acetaminophen (Tylenol) Toxicity
[+]
Melatonin prevents kidney injury in a high salt diet induced hypertension model by decreasing oxidative stress.
Oct 13, 2015
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2015 Oct 14. Epub 2015 Oct 14. PMID:
26465239
Article Published Date
: Oct 13, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Renoprotective
[+]
Melatonin prevents liver injury by microwave radiation in rats.
Jan 01, 2015
Click here to read the entire abstract
Pubmed Data
: Bratisl Lek Listy. 2015 ;116(2):96-100. PMID:
25665474
Article Published Date
: Jan 01, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Lipid Peroxidation
,
Oxidative Stress
,
Radiation Induced Illness
Pharmacological Actions
:
Antioxidants
,
Malondialdehyde Down-regulation
Additional Keywords
:
Radio Frequency Electromagnetic Radiation Exposure
Anti Therapeutic Actions
:
Electromagnetic Fields
,
Electromagnetic Radiation
Adverse Pharmacological Actions
:
Malondialdehyde (MDA) Up-Regulation
,
Oxidant
[+]
Melatonin prevents obesity through modulation of gut microbiota in mice.
Feb 14, 2017
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2017 Feb 15. Epub 2017 Feb 15. PMID:
28199741
Article Published Date
: Feb 14, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Dysbiosis
,
High Fat Diet
,
Obesity
Pharmacological Actions
:
Gastrointestinal Agents
Additional Keywords
:
Anti-Obesity Agents
,
Microbiota
[+]
Melatonin prevents or restores the inhibition of the intestinal Ca2+ absorption caused by different GSH depleting drugs.
Mar 08, 2016
Click here to read the entire abstract
Pubmed Data
: Comp Biochem Physiol A Mol Integr Physiol. 2016 Mar 9 ;197:16-22. Epub 2016 Mar 9. PMID:
26970583
Article Published Date
: Mar 08, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Glutathione Deficiency
[+]
Melatonin prevents sodium fluoride induced oxidative damage to mouse preimplantation embryos.
Jun 28, 2017
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol Pharmacol. 2017 Jun 29 ;54:133-141. Epub 2017 Jun 29. PMID:
28728132
Article Published Date
: Jun 28, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Oxidative Stress
,
Pregnancy Complications
Pharmacological Actions
:
Antioxidants
,
Cytoprotective
[+]
Melatonin produces a rapid onset and prolonged efficacy in reducing depression-like behaviors in adult rats.
Mar 05, 2017
Click here to read the entire abstract
Pubmed Data
: Neurosci Lett. 2017 Mar 6 ;642:129-135. Epub 2017 Jan 9. PMID:
28082153
Article Published Date
: Mar 05, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
Additional Keywords
:
Antidepressive Agents
,
depression
,
melatonin
[+]
Melatonin promotes brain-derived neurotrophic factor expression and anti-apoptotic effects in neonatal hemolytic hyperbilirubinemia.
Dec 15, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Med Sci Monit. 2017 Dec 16 ;23:5951-5959. Epub 2017 Dec 16. PMID:
29247156
Article Published Date
: Dec 15, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Hyperbilirubinemia: Hereditary
Pharmacological Actions
:
Anti-Apoptotic
,
Brain-derived neurotrophic factor modulator
Additional Keywords
:
Anti-Apoptotic
,
Brain-derived neurotrophic factor modulator
,
Hyperbilirubinemia: Hereditary
,
melatonin
[+]
Melatonin promotes myelination by decreasing white matter inflammation after neonatal stroke.
Jan 01, 2011
Click here to read the entire abstract
Pubmed Data
: Pediatr Res. 2011 Jan;69(1):51-5. PMID:
20856166
Article Published Date
: Jan 01, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Brain Inflammation
,
Demyelinating Diseases
,
Neonatal Stroke
,
Stroke: Attenuation/Recovery
Pharmacological Actions
:
Neuroprotective Agents
,
Neurorestorative
Additional Keywords
:
Remyelination
[+]
Melatonin prorduction dysfunctions is associated with the progression of idiopathic scoliosis.
May 15, 1996
Click here to read the entire abstract
Pubmed Data
: Spine (Phila Pa 1976). 1996 May 15;21(10):1147-52. PMID:
8727188
Article Published Date
: May 15, 1996
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Hormone Imbalances: Low Melatonin
,
Scoliosis
[+]
Melatonin protects against bisphosphanate drug-induced gastric damage.
Aug 01, 2005
Click here to read the entire abstract
Pubmed Data
: Dig Dis Sci. 2005 Aug;50(8):1506-12. PMID:
16110843
Article Published Date
: Aug 01, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Drug-Induced Toxicity: Bisphosphonates
Therapeutic Actions
:
Fasting/Caloric Restriction
Pharmacological Actions
:
Anti-Ulcer Agents
,
Antioxidants
[+]
Melatonin protects against endometriosis via regulation of matrix metalloproteinase-3 and an apoptotic pathway.
May 01, 2006
Click here to read the entire abstract
Pubmed Data
: Ai Zheng. 2006 May;25(5):582-6. PMID:
20609072
Article Published Date
: May 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Endometriosis
Pharmacological Actions
:
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Melatonin protects against lipid-induced mitochondrial dysfunction in hepatocytes and inhibits stellate cell activation during hepatic fibrosis.
Feb 28, 2017
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2017 Mar 1. Epub 2017 Mar 1. PMID:
28247434
Article Published Date
: Feb 28, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Hyperlipidemia
,
Liver Fibrosis
,
Mitochondrial Dysfunction
Pharmacological Actions
:
Hepatoprotective
[+]
Melatonin protects against myocardial ischemia-reperfusion injury.
Jul 31, 2018
Click here to read the entire abstract
Pubmed Data
: Free Radic Res. 2018 Aug ;52(8):840-849. PMID:
30208798
Article Published Date
: Jul 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Antioxidants
,
Cardioprotective
[+]
Melatonin protects against nicotine-induced myocardial injry in newborn rats whose mothers received nicotine.
Aug 01, 2008
Click here to read the entire abstract
Pubmed Data
: Anadolu Kardiyol Derg. 2008 Aug;8(4):243-8. PMID:
18676298
Article Published Date
: Aug 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Nicotine/Tobacco Toxicity
[+]
Melatonin protects against oxidative damage in the kidney induced by 900-MHz emitted mobile phone.
Jul 01, 2005
Click here to read the entire abstract
Pubmed Data
: Arch Med Res. 2005 Jul-Aug;36(4):350-5. PMID:
15950073
Article Published Date
: Jul 01, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Cell Phone Induced Disease
,
Mobile Phone-Induced Oxidative Stress
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Melatonin protects against radiation-induced cataract formation in rats.
Jun 01, 2005
Click here to read the entire abstract
Pubmed Data
: J Radiat Res (Tokyo). 2005 Jun;46(2):277-82. PMID:
15988147
Article Published Date
: Jun 01, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Cataract: Radiation-Induced
,
Radiation Induced Illness
Pharmacological Actions
:
Antioxidants
,
Radioprotective
[+]
Melatonin protects against thioacetamide-induced liver fibrosis in rats.
Jul 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Physiol Pharmacol. 2015 Aug ;66(4):567-79. PMID:
26348081
Article Published Date
: Jul 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Chemically-Induced Liver Damage
,
Liver Fibrosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
[+]
Melatonin protects hepatic cells against hepatic I/R damage through the activation of the Raf-MEK-ERK cascade and phosphorylation of its downstream targets.
May 28, 2015
Click here to read the entire abstract
Pubmed Data
: J Surg Res. 2015 May 29. Epub 2015 May 29. PMID:
26101163
Article Published Date
: May 28, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Liver Damage
Pharmacological Actions
:
Hepatoprotective
[+]
Melatonin protects liver mitochondrial respiratory chain activity in aging-accelerated mice.
Apr 01, 2002
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2002 Apr;32(3):143-8. PMID:
12074097
Article Published Date
: Apr 01, 2002
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging
,
Aging: Brain
,
Lipid Peroxidation
,
Mitochondrial Dysfunction
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
[+]
Melatonin protects mouse spermatogonial stem cells against hexavalent chromium-induced apoptosis and epigenetic histone modification.
Dec 27, 2017
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2017 Dec 28 ;340:30-38. Epub 2017 Dec 28. PMID:
29289671
Article Published Date
: Dec 27, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Testicular Injury: Chemical/Metal Induced
Pharmacological Actions
:
Anti-Apoptotic
,
Cytoprotective
[+]
Melatonin protects prepuberal testis from deleterious effects of bisphenol A or diethylhexyl phthalate.
Apr 13, 2018
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2018 Apr 14:e12497. Epub 2018 Apr 14. PMID:
29655234
Article Published Date
: Apr 13, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Bisphenol Toxicity
,
Testicular Injury: Chemical/Metal Induced
Problem Substances
:
Bisphenol A
,
Phthalates
[+]
Melatonin protects the heart and endothelium against high fructose corn syrup consumption-induced cardiovascular toxicity.
Jun 29, 2019
Click here to read the entire abstract
Pubmed Data
: Hum Exp Toxicol. 2019 Jun 30:960327119860188. Epub 2019 Jun 30. PMID:
31256681
Article Published Date
: Jun 29, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Fructose-Induced Toxicity
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Cardioprotective
Problem Substances
:
High Fructose Corn Syrup
[+]
Melatonin reduced the hyperthyroidism-induced oxidative stress and neuronal cell death in the hippocampus region of brain.
Jun 29, 2016
Click here to read the entire abstract
Pubmed Data
: Exp Gerontol. 2016 Jun 30. Epub 2016 Jun 30. PMID:
27374868
Article Published Date
: Jun 29, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Hyperthyroidism
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Neuroprotective Agents
[+]
Melatonin reduces age-related oxidaitve stress in the brain of age-accelerated mice.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2009 Jan;46(1):106-14. PMID:
19090913
Article Published Date
: Jan 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging: Brain
,
Oxidative Stress
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Neuroprotective Agents
,
Superoxide Dismutase Up-regulation
[+]
Melatonin reduces excitotoxic blood-brain barrier breakdown in neonatal rats.
Nov 01, 2015
Click here to read the entire abstract
Pubmed Data
: Neuroscience. 2015 Nov 2. Epub 2015 Nov 2. PMID:
26542996
Article Published Date
: Nov 01, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Blood Brain Barrier
[+]
Melatonin reduces hypoxic-ischaemic induced autophagy and apoptosis.
Mar 20, 2017
Click here to read the entire abstract
Pubmed Data
: Neurosci Lett. 2017 Mar 21. Epub 2017 Mar 21. PMID:
28341477
Article Published Date
: Mar 20, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Brain Ischemia
,
Neonatal Stroke
Pharmacological Actions
:
Anti-Apoptotic
,
Autophagy Inhibitors
,
Neuroprotective Agents
[+]
Melatonin reduces oxidative damage of neural lipids and proteins in the age-accelerated mouse.
Jul 01, 2002
Click here to read the entire abstract
Pubmed Data
: Neurobiol Aging. 2002 Jul-Aug;23(4):639-44. PMID:
12009513
Article Published Date
: Jul 01, 2002
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging
,
Aging: Brain
,
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Neuroprotective Agents
[+]
Melatonin reduces oxidative stress and increases gene expression in the cerebral cortex and cerebellum of aluminum-exposed rats.
Aug 31, 2005
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2005 Sep ;39(2):129-36. PMID:
16098089
Article Published Date
: Aug 31, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aluminum Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
Additional Keywords
:
Gene Expression Regulation
Problem Substances
:
Aluminum
[+]
Melatonin rescued the apoptotic changes via the intrinsic pathway.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Int J Mol Sci. 2016;17(8). Epub 2016 Aug 20. PMID:
27556445
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Bile Duct Injury
Pharmacological Actions
:
Anti-Apoptotic
,
Hepatoprotective
[+]
Melatonin rescues cardiovascular dysfunction during hypoxic development in the chick embryo.
Oct 06, 2015
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2015 Oct 7. Epub 2015 Oct 7. PMID:
26444711
Article Published Date
: Oct 06, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Hypoxia
,
Pregnancy Complications
Pharmacological Actions
:
Cardioprotective
[+]
Melatonin restores hippocampal neural precursor proliferation and prevents cognitive deficits induced by jet lag.
Feb 07, 2017
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2017 Feb 8. Epub 2017 Feb 8. PMID:
28178375
Article Published Date
: Feb 07, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Cognitive Decline/Dysfunction
,
Jet Lag
Pharmacological Actions
:
Neuroprotective Agents
Anti Therapeutic Actions
:
Shift Work
[+]
Melatonin restores KCC2 expression, inhibits neuronal apoptosis and attenuates secondary brain injury after traumatic brain injury.
May 08, 2016
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2016 May 9. Epub 2016 May 9. PMID:
27159133
Article Published Date
: May 08, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Brain Injury: Traumatic
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Melatonin restores liver mitochondrial physiology in old mice.
Mar 01, 2003
Click here to read the entire abstract
Pubmed Data
: Int J Biochem Cell Biol. 2003 Mar;35(3):367-75. PMID:
12531250
Article Published Date
: Mar 01, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging
,
Liver Disease
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
,
Regenerative
[+]
Melatonin showed the most potent effect on protecting rats from deleterious action of diabetic nephropathy.
Oct 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Biomed Res. 2017 Nov 1. Epub 2017 Nov 1. PMID:
29089475
Article Published Date
: Oct 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Diabetic Nephropathy
[+]
Melatonin significantly amplified prodifferentiating, antiproliferative and immunomodulatory activities Lactobacillus plantarum and inulin.
May 31, 2016
Click here to read the entire abstract
Pubmed Data
: Anticancer Res. 2016 Jun ;36(6):2719-28. PMID:
27272781
Article Published Date
: May 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Inulin
,
Lactobacillus plantarum
,
Melatonin
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
,
Immunomodulatory
[+]
Melatonin significantly increased hippocampal synaptic density and the number of excitatory synapses, decreased the number of inhibitory synapses, and upregulated pre- and postsynaptic proteins.
May 18, 2015
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2015 May 19. Epub 2015 May 19. PMID:
25988948
Article Published Date
: May 18, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Alzheimer's Disease
,
Inflammation: Brain
,
Neurodegenerative Diseases
Pharmacological Actions
:
Antioxidants
,
Neuroplasticity enhancement
,
Neuroprotective Agents
[+]
Melatonin significantly inhibited hyperglycemia-induced oxidative stress and alveolar bone loss.
Jan 31, 2016
Click here to read the entire abstract
Pubmed Data
: J Periodontol. 2016 Feb 1:1-15. Epub 2016 Feb 1. PMID:
26832833
Article Published Date
: Jan 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Hyperglycemia
,
Oxidative Stress
,
Periodontitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Hypoglycemic Agents
[+]
Melatonin significantly reduces AD neuropathology and associated cognitive deficits in a manner that is independent of antioxidant pathways.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Neurodegener. 2015 ;10(1):27. Epub 2015 Jul 11. PMID:
26159703
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
Melatonin supplementation by regulating inflammatory infiltration ameliorates obesity-induced adipokine alteration.
Jul 05, 2015
Click here to read the entire abstract
Pubmed Data
: Nutr Res. 2015 Jul 6. Epub 2015 Jul 6. PMID:
26250620
Article Published Date
: Jul 05, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Inflammation
,
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Risk Reduction
[+]
Melatonin supplementation contributes to the rescue of cognitive decline, and may alleviate mental disorders.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Environ Res Public Health. 2016 ;13(3). Epub 2016 Feb 29. PMID:
26938543
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Cognitive Decline/Dysfunction
Pharmacological Actions
:
Neuroprotective Agents
Problem Substances
:
Formaldehyde
[+]
Melatonin supplementation could prevent the adverse effects of diclofenac sodium.
Sep 11, 2015
Click here to read the entire abstract
Pubmed Data
: Ren Fail. 2015 Sep 12:1-5. Epub 2015 Sep 12. PMID:
26365794
Article Published Date
: Sep 11, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Kidney Damage
Pharmacological Actions
:
Hepatoprotective
Problem Substances
:
Diclofenac
[+]
Melatonin supplementation has protective effect on oxidative stress and antioxidant redox system in the cerebral cortex and blood.
May 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Neural Regen Res. 2014 Jun 1 ;9(11):1112-6. PMID:
25206769
Article Published Date
: May 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Brain: Oxidative Stress
,
Brain Injury: Traumatic
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
Melatonin supplementation may play an important role in the prevention of endometrial cancer in menopause.
Aug 01, 2011
Click here to read the entire abstract
Pubmed Data
: Anticancer Res. 2011 Aug ;31(8):2637-43. PMID:
21778316
Article Published Date
: Aug 01, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Endometrial Cancer
Pharmacological Actions
:
Anti-Proliferative
,
Chemopreventive
[+]
Melatonin supplementation may play an important role in the prevention of neural malformations in diabetic pregnancy.
Oct 06, 2015
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2015 Oct 7. Epub 2015 Oct 7. PMID:
26475080
Article Published Date
: Oct 06, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Neural Tube Defects
Additional Keywords
:
Risk Reduction
[+]
Melatonin supplementation prevented oxidative damage induced by electromagnetic radiation in rat testis.
Feb 01, 2014
Click here to read the entire abstract
Pubmed Data
: Andrologia. 2014 Feb ;46(1):65-72. Epub 2012 Nov 12. PMID:
23145464
Article Published Date
: Feb 01, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Antioxidant
,
Radioprotective
Additional Keywords
:
Male Infertility and Cellular Phones
Anti Therapeutic Actions
:
Electromagnetic Fields
,
Electromagnetic Radiation
[+]
Melatonin supplementation significantly decreased the harmful effects of fructose.
Mar 31, 2016
Click here to read the entire abstract
Pubmed Data
: J Clin Diagn Res. 2016 Apr ;10(4):CF06-11. Epub 2016 Apr 1. PMID:
27190797
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
High Fructose Diet
,
Metabolic Diseases
Pharmacological Actions
:
Antioxidants
,
Hypolipidemic
[+]
Melatonin supplementation therapy is more potent and effective in comparison to estrogen replacement therapy due to its single-handed ability to revert all the ovariectomy-induced changes.
Jul 31, 2012
Click here to read the entire abstract
Pubmed Data
: Climacteric. 2012 Aug ;15(4):382-92. Epub 2011 Dec 20. PMID:
22185471
Article Published Date
: Jul 31, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Estrogen Deficiency
,
Ovariectomy Associated Adverse Changes
Additional Keywords
:
Ovariectomy-Induced Changes
,
Superiority of Natural Substances versus Drugs
[+]
Melatonin treatment alleviates spinal cord injury-induced gut dysbiosis in mice.
Mar 27, 2019
Click here to read the entire abstract
Pubmed Data
: J Neurotrauma. 2019 Mar 28. Epub 2019 Mar 28. PMID:
30693824
Article Published Date
: Mar 27, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Dysbiosis
,
Spinal Cord Injuries
Pharmacological Actions
:
Gastrointestinal Agents
Additional Keywords
:
Risk Reduction
[+]
Melatonin treatment decreased PM2.5-induced oxidative stress level in the brains and lungs and relieved airway inflammation and chronic cough.
Jan 04, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Physiol Res. 2018 Jan 5. Epub 2018 Jan 5. PMID:
29303602
Article Published Date
: Jan 04, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Air Pollution Linked Toxicity
,
Cough
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
[+]
Melatonin treatment has protective effects on the brain and peripheral organs after hypoxic-ischemic brain damage.
Mar 27, 2017
Click here to read the entire abstract
Pubmed Data
: BMC Pediatr. 2017 Mar 28 ;17(1):90. Epub 2017 Mar 28. PMID:
28351378
Article Published Date
: Mar 27, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Cerebral Ischemia
,
Edema
,
Hypoxia: Brain
Pharmacological Actions
:
Neuroprotective Agents
[+]
Melatonin treatment in old mice enables a more youthful response to an inflammation challenge in the brain.
Jan 01, 2007
Click here to read the entire abstract
Pubmed Data
: J Neuroimmunol. 2007 Jan;182(1-2):22-31. Epub 2006 Oct 30. PMID:
17070935
Article Published Date
: Jan 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging: Brain
[+]
Melatonin treatment is an efficient and practical strategy to improve in vitro expansion of BMMSCs for tissue engineering and cytotherapy.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Theranostics. 2016 ;6(11):1899-917. Epub 2016 Aug 8. PMID:
27570559
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Osteoporosis
Pharmacological Actions
:
Osteogenic
,
Regenerative
Additional Keywords
:
Mesenchymal Stem Cells
[+]
Melatonin triggered apoptosis in an in vivo model of ovarian cancer.
Nov 09, 2015
Click here to read the entire abstract
Pubmed Data
: Endocr Relat Cancer. 2015 Nov 10. Epub 2015 Nov 10. PMID:
26555801
Article Published Date
: Nov 09, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Ovarian Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Melatonin, a pineal secretory product with antioxidant properties, protects against cisplatin-induced nephrotoxicity in rats.
Apr 01, 2001
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2001 Apr;30(3):129-38. PMID:
11316323
Article Published Date
: Apr 01, 2001
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
,
Kidney Damage: Drug-Induced
,
Oxidative Stress
Pharmacological Actions
:
Antineoplastic Agents
,
Antioxidants
,
Renoprotective
[+]
Melatonin, ascorbic acid and β-carotene could protect against gastric damage induced by intensive stress.
Oct 11, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Arch Med Sci. 2015 Oct 12 ;11(5):1129-36. PMID:
26528359
Article Published Date
: Oct 11, 2015
Study Type
: Animal Study
Additional Links
Substances
:
beta-Carotene
,
Melatonin
,
Vitamin C
Diseases
:
Stress
Pharmacological Actions
:
Gastroprotective
,
Malondialdehyde Down-regulation
[+]
Melatonin, curcumin, quercetin, and resveratrol ameliorate chemically-induced kidney damage.
Dec 01, 2007
Click here to read the entire abstract
Pubmed Data
: Neuro Endocrinol Lett. 2007 Dec;28(6):739-44. PMID:
18684806
Article Published Date
: Dec 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Melatonin
,
Quercetin
,
Resveratrol
Diseases
:
Kidney Damage
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Renoprotective
Additional Keywords
:
Stilbenes
[+]
Melatonin, minocycline and ascorbic acid have an antiviral effect involving their anti-oxidant properties, and suggesting a potential use of these compounds for human VEE virus infection.
Jul 09, 2015
Click here to read the entire abstract
Pubmed Data
: Brain Res. 2015 Jul 10. Epub 2015 Jul 10. PMID:
26168898
Article Published Date
: Jul 09, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Vitamin C
Diseases
:
Encephalitis
,
Oxidative Stress
Pharmacological Actions
:
Antiviral Agents
Additional Keywords
:
Significant Treatment Outcome
Problem Substances
:
Antibiotics
[+]
Melatonin, quercetin and resveratrol administrations markedly reduced hepatocellular injury in STZ-induced experimental diabetes.
Aug 31, 2015
Click here to read the entire abstract
Pubmed Data
: Hum Exp Toxicol. 2015 Sep ;34(9):859-68. PMID:
26286521
Article Published Date
: Aug 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Quercetin
,
Resveratrol
Diseases
:
Diabetes Mellitus: Type 2
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
[+]
Microwave exposure could adversely affect male fertility through melatonin downregulation in the testis.
Sep 01, 2012
Click here to read the entire abstract
Pubmed Data
: Electromagn Biol Med. 2012 Sep ;31(3):223-32. PMID:
22897403
Article Published Date
: Sep 01, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Infertility: Male
,
Oxidative Stress
Anti Therapeutic Actions
:
5G Millimeter Wave Radiation
,
Electromagnetic Fields
,
Electromagnetic Radiation
,
Electromagnetic Radiation: 6-24 GHz (5G)
Adverse Pharmacological Actions
:
Melatonin Interference
[+]
Microwave radiation causes body mass decrease and anxiety related behaviour in rats, however melatonin causes a reverse of those effects on both body weight and behaviour of irradiated animals.
Dec 31, 2011
Click here to read the entire abstract
Pubmed Data
: Bratisl Lek Listy. 2012 ;113(5):265-9. PMID:
22616582
Article Published Date
: Dec 31, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Mobile Phone-Induced Oxidative Stress
Pharmacological Actions
:
Antioxidants
Anti Therapeutic Actions
:
Microwave Radiation
Problem Substances
:
Cell Phone Exposure
[+]
Microwaves are cytotoxic and genotoxic to the rat thymus and its effects are attentuated by melatonin.
Mar 01, 2013
Click here to read the entire abstract
Pubmed Data
: Gen Physiol Biophys. 2013 Mar ;32(1):79-90. PMID:
23531837
Article Published Date
: Mar 01, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
DNA damage
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
DNA Repair Up-regulation
Anti Therapeutic Actions
:
Electromagnetic Fields
,
Electromagnetic Radiation
Adverse Pharmacological Actions
:
Oxidant
[+]
Neuroprotective effects of melatonin administration against chronic immobilization stress in rats.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Physiol Pathophysiol Pharmacol. 2017 ;9(2):16-27. Epub 2017 Apr 15. PMID:
28533888
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Anxiety
,
Stress
Pharmacological Actions
:
Neuroprotective Agents
[+]
Nocturnal melatonin directly inhibited tumour growth and invasion of human Leiomyosarcoma via suppression of the Warburg effect.
Feb 29, 2016
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2016 Mar ;60(2):167-77. Epub 2015 Dec 23. PMID:
26607298
Article Published Date
: Feb 29, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Leiomyosarcoma
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
Additional Keywords
:
Cancer Glycolysis
[+]
Nocturnal RFID exposure can cause reductions in the levels of both urinary melatonin and 6-OHMS in the rat pineal gland.
Jul 19, 2015
Click here to read the entire abstract
Pubmed Data
: Int J Radiat Biol. 2015 Jul 20:1-40. Epub 2015 Jul 20. PMID:
26189731
Article Published Date
: Jul 19, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Anti Therapeutic Actions
:
Radio-Frequency Identification (RFID) Technology
[+]
Patients should be receiving doxorubicin treatment when their physiological level of melatonin is at its highest.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Med Sci Monit. 2016 ;22:438-46. Epub 2016 Feb 10. PMID:
26861593
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Chemoprotective Agents
Additional Keywords
:
Chronotherapy
[+]
Pre-ischemia melatonin administration significantly protects against cerebral ischemia/reperfusion injury.
Feb 07, 2017
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2017 Feb 8. Epub 2017 Feb 8. PMID:
28178380
Article Published Date
: Feb 07, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Stroke: Ischemic
Pharmacological Actions
:
Neuroprotective Agents
[+]
Pro-inflammatory cytokine IL-1β suppresses melatonin secretion and its action seems to be targeted on the reduction of pineal AA-NAT protein expression.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Res Int. 2015 ;2015:526464. Epub 2015 Aug 3. PMID:
26339621
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Additional Keywords
:
Gene Expression
[+]
Silymarin and melatonin can attenuate renal injury in rats treated with gentamicin.
Dec 22, 2015
Click here to read the entire abstract
Pubmed Data
: J Evid Based Complementary Altern Med. 2015 Dec 23. Epub 2015 Dec 23. PMID:
26703224
Article Published Date
: Dec 22, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Silymarin
Diseases
:
Chemotherapy-Induced Toxicity: Gentamicin
Pharmacological Actions
:
Malondialdehyde Down-regulation
,
Renoprotective
[+]
Supplementation of diet with lycopene and melatonin provided antioxidant defense with strong protective activity against cyclophosphamide induced cytotoxicity.
Jun 30, 2014
Click here to read the entire abstract
Pubmed Data
: Toxicol Ind Health. 2014 Jul ;30(6):570-5. Epub 2012 Sep 28. PMID:
23024110
Article Published Date
: Jun 30, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Lycopene
,
Melatonin
Diseases
:
Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions
:
Antioxidants
,
Chemoprotective Agents
Additional Keywords
:
Natural Substance Synergy
[+]
The antioxidant effect of melatonin revealed in this experiment is based on detoxification rather than common involvement in antioxidant barriers.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Acta Medica (Hradec Kralove). 2015 ;58(1):21-4. PMID:
26454803
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Detoxifier
Problem Substances
:
Freund adjuvant
[+]
The possible neuroprotective effects of melatonin in aluminum chloride-induced neurotoxicity.
Feb 03, 2019
Click here to read the entire abstract
Pubmed Data
: Environ Sci Pollut Res Int. 2019 Feb 4. Epub 2019 Feb 4. PMID:
30719664
Article Published Date
: Feb 03, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aluminum Toxicity
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
,
Nrf2 activation
Problem Substances
:
Aluminum Chloride
[+]
The present study suggests that melatonin treatment exerted neuroprotective effects against LPS-induced depressive-like behaviour.
Feb 15, 2018
Click here to read the entire abstract
Pubmed Data
: Physiol Behav. 2018 Feb 16. Epub 2018 Feb 16. PMID:
29458118
Article Published Date
: Feb 15, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Depression
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Antioxidants
,
Brain-derived neurotrophic factor modulator
,
Neuroprotective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
The protective effect of melatonin was similar to that of amifostine in ameliorating radiation induced oxidative stress and inflammation.
Apr 05, 2016
Click here to read the entire abstract
Pubmed Data
: Inflammation. 2016 Apr 6. Epub 2016 Apr 6. PMID:
27052631
Article Published Date
: Apr 05, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Chemotherapy and Radiation Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Cytoprotective
,
Radioprotective
Additional Keywords
:
Natural Substances Versus Drugs
[+]
The results obtained from this preclinical study indicated that the sunscreen formulation is non toxic and safe in animal models.
Sep 30, 2017
Click here to read the entire abstract
Pubmed Data
: Regul Toxicol Pharmacol. 2017 Oct ;89:1-12. Epub 2017 Jul 8. PMID:
28694170
Article Published Date
: Sep 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Pumpkin Seeds
Diseases
:
Ultraviolet Radiation Induced Damage
Pharmacological Actions
:
Photoprotective