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Cruciferous Vegetables
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280 Diseases Researched for Cruciferous Vegetables
Name
AC
CK
Focus
Prostate Cancer: Prevention
7
138
Breast Cancer
48
108
Oxidative Stress
36
80
Prostate Cancer
36
66
Lung Cancer
20
59
Inflammation
19
55
Pancreatic Cancer
20
55
Cancers: All
24
53
Diabetes Mellitus: Type 2: Prevention
2
40
Bladder Cancer
10
39
Ovarian Cancer
8
38
Breast Cancer: Triple Negative
9
34
Cardiovascular Disease: Prevention
3
31
DNA damage
10
31
Colon Cancer
14
29
Colorectal Cancer
6
27
Diabetes Mellitus: Type 2
12
27
Melanoma
11
25
Lung Cancer: Prevention
4
23
Autism Spectrum Disorders
2
20
Breast engorgement
2
20
Cancers: Drug Resistant
8
20
Cognitive Decline/Dysfunction
6
20
Digestive System Neoplasms
1
20
Glaucoma
1
20
Kidney Cancer: Prevention
1
20
Non-Hodgkin Lymphoma
1
20
Liver Cancer
16
19
Cancer Metastasis
11
17
Helicobacter Pylori Infection
5
17
Insulin Resistance
4
16
Breast Cancer: Prevention
4
15
Cardiovascular Diseases
6
15
Alzheimer's Disease
6
13
Aging
2
12
Air Pollution Linked Toxicity
3
12
Atherosclerosis
2
12
Autism
2
12
Diesel Exhaust Particle Toxicity
3
12
Glutathione Deficiency
3
12
Smoking
2
12
Systemic Lupus Erythematosus
2
12
Chemotherapy-Induced Toxicity: Cisplatin
6
11
HDL: Low
2
11
Lipopolysaccharide-Induced Toxicity
8
11
Skin Diseases
2
11
Anemia: Sickle Cell
1
10
Asthma
1
10
Bladder Degeneration
1
10
COPD
1
10
Cholesterol: High
1
10
Cystic Fibrosis
1
10
Diabetes Mellitus: Type 1
5
10
Esophageal Cancer
1
10
Estrogen Dysregulation: 2/4/16 hydroxyestrone ratios
1
10
Fatty Liver
1
10
Fibroids: Uterine
1
10
Gastritis
1
10
High Cholesterol
1
10
Hypercholesterolemia
1
10
Hyperinsulinism
1
10
Kidney Cancer
1
10
Lung Diseases
1
10
Lupus Erythematosus: Systemic
1
10
Magnesium Deficiency
1
10
Nasopharyngeal Cancer
6
10
Prostate: PSA Doubling
1
10
Pulmonary Fibrosis
1
10
Radical Prostatectomy
1
10
Respiratory Diseases
1
10
Schizophrenia
1
10
Stroke: Ischemic
1
10
Chemotherapy-Induced Toxicity: Doxorubicin
6
9
Obesity
5
9
Cervical Cancer
6
8
Chemically-Induced Liver Damage
5
8
Endothelial Dysfunction
3
8
Advanced Glycation End products (AGE)
4
7
Cancer Stem Cells
6
7
Cerebral Ischemia
4
7
Leukemia
6
7
Adenomatous Polyposis Coli
3
6
Breast Cancer: Lung Metastasis
2
6
Neurodegenerative Diseases
5
6
Benzo[a]pyrene-induced Toxicity
4
5
Diabetes: Oxidative Stress
3
5
Endothelial Damage
1
5
Glioblastoma
4
5
Hypoxia
4
5
Immune Disorders: Low Immune Function
3
5
Liver Damage: Aflatoxin-Induced
3
5
Liver Fibrosis
3
5
Rheumatoid Arthritis
3
5
Skin Cancer
4
5
Acetaminophen (Tylenol) Toxicity
2
4
Aflatoxicosis
3
4
Alcohol Toxicity
2
4
Aspirin-Induced Toxicity
2
4
Brain Injury: Traumatic
2
4
Brain: Microglial Activation
2
4
Breast Cancer: Bone Metastasis
1
4
Breast Cancer: Metastatic
3
4
Cadmium Poisoning
3
4
Cancers: Multi-Drug Resistant
2
4
Cervical Dysplasia
2
4
Depression
2
4
Diabetic Complications
2
4
Dioxin Toxicity
1
4
Furan Toxicity
1
4
Gastric Cancer
3
4
Intestinal Polyps
2
4
Ischemia
2
4
NSAID-induced toxicity
2
4
Organ Transplantation: Pancreatic Islet Cells
2
4
Osteosarcoma
3
4
Skin Cancer: Prevention
2
4
Spinal Cord Injuries
2
4
Traumatic Brain Injury
2
4
Acute Myeloid Leukemia
2
3
Aging Skin
2
3
Bacterial Infections and Mycoses
2
3
Blood-Brain-Barrier Disorders
2
3
Brain Cancer
3
3
Brain Damage
2
3
Brain Inflammation
2
3
Carcinoma: Non-Small-Cell Lung
2
3
Chemotherapy-Induced Toxicity
2
3
Diabetes Mellitus: Type 1: Prevention
2
3
Diabetic Nephropathy
2
3
Drug-Induced Toxicity: Indomethacin
2
3
Gastric Ulcer
2
3
Glioma
3
3
Head and Neck Cancer
3
3
Hydrogen Peroxide Induced Toxicity
3
3
Hyperglycemia
2
3
Intestinal Diseases
2
3
Liver Cancer: Prevention
2
3
Liver Damage
2
3
Liver Disease
2
3
Low Disorders: Low TH1
2
3
Melanoma: Metastatic
2
3
Multiple Myeloma
2
3
Myocardial Ischemia
2
3
Oral Cancer
2
3
Parkinson's Disease
3
3
Petroleum Exposure And Toxicity
2
3
Polycyclic aromatic hydrocarbon (PAH) toxicity
2
3
Skin Diseases: Photo-Aging
2
3
Tumors
2
3
Acute lymphoblastic leukemia (ALL)
1
2
Amphetamine Addiction/Withdrawal
1
2
Anxiety Disorders
1
2
Autoimmune Diseases
1
2
Bisphenol Toxicity
1
2
Bladder Dysfunction
1
2
Bladder Outlet Obstruction
1
2
Brain Edema
1
2
Brain Hypoxia
2
2
Breast Cancer: BRCA1
2
2
Carbon Monoxide Poisoning
1
2
Cerebral Stroke
1
2
Chagas Disease
1
2
Chemical Exposure
1
2
Chemical Weapon Agent Injury
1
2
Clostridium Infections
1
2
Depressive Disorder
1
2
Diabetes: Cognitive Dysfunction
1
2
Diabetes: Kidney Function
1
2
Diabetes: Memory Problems
1
2
Drug Toxicity: Methotrexate
1
2
Duchenne's Muscular Dystrophy
1
2
Epstein-Barr Virus Infections
1
2
Estrogen Dominance
2
2
Food Allergies
1
2
Fungal Infection
1
2
Gastrointestinal Cancer
1
2
Gout
1
2
Gram-Positive Bacterial Infections
2
2
Heart Failure
1
2
High Fat Diet
1
2
High-Grade Prostatic Intraepithelial Neoplastic Lesions
1
2
Hypertension
1
2
Hypoglycemia
2
2
Immune Dysregulation: TH1/TH2 imbalance
1
2
Intoxication
1
2
Kidney Diseases
1
2
Laryngeal Cancer
1
2
Lead Poisoning
1
2
Light Sensitivity
1
2
Liver Steatosis
1
2
Low Immune Function: Natural Killer Cells
1
2
Malathion Toxicity
1
2
Mercury Poisoning
1
2
Metabolic Diseases
1
2
Muscle Damage: Exercise-Induced
1
2
Muscle Fatigue
1
2
Muscle Soreness
1
2
Myocardial Infarction
1
2
Nephropathy
1
2
Neurologic Disorders
1
2
Neuropathic Pain
1
2
Nicotine/Tobacco Toxicity
1
2
Nonalcoholic fatty liver disease (NAFLD)
1
2
Organ Transplantation
1
2
Pain
1
2
Pancreatitis
1
2
Papillomavirus Infections
1
2
Polycystic Ovary Syndrome
1
2
Prenatal Chemical Exposures
1
2
Promyelocytic leukemia
2
2
Radiation Induced Illness
1
2
Respiratory Syncytial Virus Infections
1
2
Respiratory Tract Infections
1
2
Salivary Gland Adenoid Cystic Carcinoma.
2
2
Salivary Gland Diseases
2
2
Schwannoma: Vestibular
1
2
Seizures
1
2
Serotonin Disorders
1
2
Staphylococcal Infections
1
2
Stroke
1
2
Stroke: Recovery
1
2
Testicular Injury: Chemical/Metal Induced
1
2
Acne
1
1
Allergies
1
1
Androgen-Induced Diseases
1
1
Aortic Plaques
1
1
Arsenic Poisoning
1
1
Bone Destructive Diseases: Over-Active Osteoclasts
1
1
Brain Cancer Stem Cells
1
1
Brain Injury: Hippocampal Damage
1
1
Breast Cancer Stem Cells
1
1
Breast Cancer: HER-2 Overexpressed
1
1
Burkitt Lymphoma
1
1
Candida Albicans
1
1
Candida Infection
1
1
Candidiasis
1
1
Cardiac Hypertrophy
1
1
Cholesterol: LDL/HDL ratio
1
1
Chronic Lymphocytic Leukemia
1
1
Colon Cancer Stem Cells
1
1
Colon Cancer: Prevention
1
1
Colorectal Tumors
1
1
Dopamine Deficiency
1
1
Drug-Induced Toxicity
1
1
Dystrophic retinal detachment (DRD)
1
1
Encephalomyelitis
1
1
Endometrial Cancer
1
1
Excitotoxicity
1
1
Fibrosis
1
1
Gastrointestinal Diseases
1
1
Gram-Negative Bacterial Infections
1
1
HIV Infections
1
1
Hepatitis C
1
1
Heterocyclic Aromatic Amine Induced Toxicity
1
1
Human Papillomavirus (HPV)
1
1
IgE-Mediated Hypersensitivity
1
1
Keloid
1
1
Kidney Damage
1
1
Leukemia: Acute myelogenous leukemia (AML)
1
1
Leukemia: Acute promyelocytic leukemia
1
1
Liver Cancer Stem Cells
1
1
Macular Degeneration
1
1
Medulloblastoma
1
1
Melanism
1
1
Microcystis aeruginosa
1
1
Mitochondrial Diseases
1
1
Multiple Sclerosis
1
1
Oral Cancer: Prevention
1
1
Osteoporosis
1
1
Osteoporosis: Over-active Osteoclasts
1
1
Pancreatic Cancer Stem Cell
1
1
Pesticide Toxicity
1
1
Prediabetes
1
1
Restenosis
1
1
Retinal Diseases
1
1
Stomach Cancer
1
1
Striatonigral Degeneration: Autosomal Dominant
1
1
Sunburn
1
1
Tin Poisoning
1
1
Ultraviolet Radiation Induced Damage
1
1
103 Pharmacological Actions Researched for Cruciferous Vegetables
Name
AC
CK
Focus
Chemopreventive
83
292
Anticarcinogenic Agents
102
291
Antioxidants
82
208
Apoptotic
123
187
Anti-Inflammatory Agents
56
143
Antiproliferative
81
138
Nrf2 activation
40
80
Neuroprotective Agents
34
66
Cell cycle arrest
40
52
Phase II Detoxification Enzyme Inducer
14
40
Interleukin-6 Downregulation
19
39
Chemotherapeutic
19
34
Tumor Necrosis Factor (TNF) Alpha Inhibitor
20
34
Hepatoprotective
13
30
NF-kappaB Inhibitor
23
28
Anti-metastatic
19
26
Cardioprotective
12
25
Chemosensitizer
19
25
Interleukin-1 beta downregulation
15
25
Cytoprotective
6
23
Cyclooxygenase 2 Inhibitors
16
22
Antineoplastic Agents
17
21
Histone deacetylase inhibitor
12
21
MicroRNA modulator
16
20
Enzyme Inhibitors
8
17
NF-E2-Related Factor-2 (Nrf2) Modulator
8
13
Anti-Allergic Agents
2
12
Anti-Apoptotic
8
12
Glutathione Upregulation
3
12
Chemoprotective Agents
6
11
Genoprotective
2
11
Anti-atherogenic
1
10
Insulin Down-Regulation
1
10
Heme oxygenase-1 up-regulation
7
9
Immunomodulatory
6
9
Matrix metalloproteinase-2 (MMP-2) inhibitor
5
9
Superoxide Dismutase Up-regulation
3
9
Matrix metalloproteinase-9 (MMP-9) inhibitor
6
8
Angiogenesis Inhibitors
4
7
Anti-Angiogenic
5
7
Bcl-2 protein down-regulation
6
7
Tumor Suppressor Protein p53 Upregulation
6
7
Renoprotective
4
6
Anti-Bacterial Agents
4
5
Anti-Fibrotic
4
5
Antiviral Agents
4
5
Telomerase Inhibitor
5
5
Antidepressive Agents
2
4
Antifungal Agents
3
4
Antinoceceptive
2
4
Catalase Up-Regulation
2
4
Hypoglycemic Agents
3
4
Hypolipidemic
2
4
Interleukin-18 down-regulation
2
4
Proteasome Inhibitors
3
4
Anti-Glycation Agents
2
3
Anti-Ulcer Agents
2
3
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
2
3
P21 Activation
2
3
Radioprotective
2
3
Anti-Anxiety Agents
1
2
Anti-Estrogenic
1
2
Anticonvulsants
1
2
Autophagy Inhibitors
1
2
Autophagy Up-regulation
2
2
Detoxifier
2
2
Epidermal growth factor receptor (EGFR) inhibitor
1
2
Estrogen Receptor Modulators
2
2
Gastroprotective
1
2
Heat Shock Protein Inducer
1
2
Hypotensive
1
2
Immunomodulatory: Th17 downregulation
1
2
Interleukin-10 downregulation
1
2
Interleukin-17 downregulation
1
2
Interleukin-2 upregulation
1
2
Leptin Down-Regulation
1
2
Pancreato Protective Agents
1
2
Phase I Detoxification Enzyme Inducer
1
2
Prostaglandin PGE2 downregulation
1
2
Serotonergic
1
2
Vascular Endothelial Growth Factor Inhibitors
1
2
Wnt/β-catenin signaling pathway modulation
2
2
Anti-Proliferative
1
1
Antimitotic Agents
1
1
Beta-Defensin-2 Up-Regulation
1
1
Caspase-3 Activation
1
1
Cell Differentiation Inducer
1
1
Cytotoxic
1
1
DNA Repair Up-regulation
1
1
Interferon Gamma Reducer
1
1
Interleukin-10 upregulation
1
1
Interleukin-4 upregulation
1
1
Interleukin-8 downregulation
1
1
Multidrug Resistance Gene Modulators
1
1
Postaglandin PGE2 downregulation
1
1
Quinone Reductase-Inducer
1
1
Radiopharmaceuticals
1
1
Radiosensitizer
1
1
Survivin Down-Regulation
1
1
Vascular Cell Adhesion Molecule-1 Inhibitor
1
1
Vascular Endothelial Growth Factor Regulator
1
1
Wnt/β-catenin pathway down-regulation
1
1
anti-inflammatory
1
1
Research Articles
521
Cumulative Knowledge Score
842
Overall Research Rating
EXCELLENT
Related Topics
The Following are Sub-Topics of Cruciferous Vegetables
Cabbage
Cauliflower
Kale
Collards
Bok Choy
Mustard Greens
Sulforaphane
Indole-3-Carbinol
DIM (3,3'-diindolylmethane)
Cruciferous Vegetables is a Sub of the following Topic
Sulfur Rich Natural Substances
View the Evidence:
582 Abstracts with Cruciferous Vegetables Research
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[+]
Combined fruit and vegetable consumption was associated with decreased non-Hodgkin lymphoma risk.
Jan 31, 2018
Click here to read the entire abstract
Pubmed Data
: Leuk Lymphoma. 2018 Feb ;59(2):434-447. Epub 2017 Aug 28. PMID:
28847196
Article Published Date
: Jan 31, 2018
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Cruciferous Vegetables
Diseases
:
Non-Hodgkin Lymphoma
Additional Keywords
:
Risk Reduction
[+]
Consumption of cruciferous vegetables may reduce the risk of ovarian cancer.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Asia Pac J Clin Nutr. 2015 ;24(1):101-9. PMID:
25740748
Article Published Date
: Dec 31, 2014
Study Type
: Meta Analysis
Additional Links
Substances
:
Cruciferous Vegetables
Diseases
:
Ovarian Cancer
Additional Keywords
:
Risk Reduction
[+]
Cruciferous vegetable intake might be inversely associated with the incidence of pancreatic cancer.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: World J Surg Oncol. 2015 ;13:44. Epub 2015 Feb 12. PMID:
25889229
Article Published Date
: Dec 31, 2014
Study Type
: Meta Analysis
Additional Links
Substances
:
Cruciferous Vegetables
Diseases
:
Pancreatic Cancer
Additional Keywords
:
Risk Reduction
[+]
Cruciferous vegetables intake is related to the decreased risk of prostate cancer.
Jan 31, 2012
Click here to read the entire abstract
Pubmed Data
: Int J Urol. 2012 Feb ;19(2):134-41. Epub 2011 Nov 28. PMID:
22121852
Article Published Date
: Jan 31, 2012
Study Type
: Meta Analysis
Additional Links
Substances
:
Cruciferous Vegetables
Diseases
:
Prostate Cancer: Prevention
Pharmacological Actions
:
Chemopreventive
[+]
Evidence exists indicating that Brassica vegetables reduce prostate cancer risk.
Jan 01, 2002
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2002;42(1):1-9. PMID:
12235639
Article Published Date
: Jan 01, 2002
Study Type
: Meta Analysis
Additional Links
Substances
:
Bok Choy
,
Broccoli
,
Cabbage
,
Collards
,
Kale
,
Mustard Greens
Diseases
:
Prostate Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
Additional Keywords
:
Risk Reduction
[+]
Higher consumption of cruciferous vegetables is associated with a significantly decreased risk of type 2 diabetes.
Jan 05, 2016
Click here to read the entire abstract
Pubmed Data
: Prim Care Diabetes. 2016 Jan 6. Epub 2016 Jan 6. PMID:
26778708
Article Published Date
: Jan 05, 2016
Study Type
: Meta Analysis
Additional Links
Substances
:
Cruciferous Vegetables
Diseases
:
Diabetes Mellitus: Type 2: Prevention
Additional Keywords
:
Risk Reduction
[+]
Higher intake of fruits, vegetables or their fiber reduces the risk of type 2 diabetes
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Diabetes Investig. 2016 Jan ;7(1):56-69. Epub 2015 Jun 22. PMID:
26816602
Article Published Date
: Dec 31, 2015
Study Type
: Meta Analysis
Additional Links
Substances
:
Berries: All
,
Cruciferous Vegetables
,
Fiber
,
Fruit: All
,
Green Leafy Vegetables
Diseases
:
Diabetes Mellitus: Type 2: Prevention
Additional Keywords
:
Risk Reduction
[+]
Sulforaphane and EGCG restore estrogen receptor expression by modulating epigenetic events in the breast cancer cell line MDA-MB-231.
Oct 17, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Nutrigenet Nutrigenomics. 2017 Oct 18 ;10(3-4):126-135. Epub 2017 Oct 18. PMID:
29040973
Article Published Date
: Oct 17, 2017
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Sulforaphane
Diseases
:
Breast Cancer: Triple Negative
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
Additional Keywords
:
Epigenetic Modification In Cancer
[+]
This meta-analysis study found a high daily intake of green leafy vegetables significantly reduced incidence of several types of CVD.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: JRSM Cardiovasc Dis. 2016 Jan-Dec;5:2048004016661435. Epub 2016 Aug 1. PMID:
27540481
Article Published Date
: Dec 31, 2015
Study Type
: Meta Analysis
Additional Links
Substances
:
Cruciferous Vegetables
,
Green Leafy Vegetables
Diseases
:
Cardiovascular Disease: Prevention
Additional Keywords
:
Risk Reduction
[+]
This meta-analysis suggested that high intake of cruciferous vegetables was inversely associated with renal cell carcinoma risk among Americans.
Dec 31, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2013 ;8(10):e75732. Epub 2013 Oct 28. PMID:
24204579
Article Published Date
: Dec 31, 2012
Study Type
: Meta Analysis
Additional Links
Substances
:
Cruciferous Vegetables
Diseases
:
Kidney Cancer: Prevention
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Risk Reduction
[+]
This study provides support that cruciferous vegetable intake protects against cancer of the colon and the significance of gene diet interactions.
Dec 31, 2013
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2014 ;66(1):128-39. Epub 2013 Dec 16. PMID:
24341734
Article Published Date
: Dec 31, 2013
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Cruciferous Vegetables
Diseases
:
Colorectal Cancer
,
Digestive System Neoplasms
Additional Keywords
:
Risk Reduction
[+]
A diet that includes cruciferous vegetables could be an important modifiable risk factor for ovarian cancer.
Apr 24, 2018
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2018 Apr 25:1-6. Epub 2018 Apr 25. PMID:
29693426
Article Published Date
: Apr 24, 2018
Study Type
: Human Study
Additional Links
Substances
:
Cruciferous Vegetables
Diseases
:
Ovarian Cancer
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Dose Response
[+]
A greater intake of fresh fruits and cruciferous vegetables may be able to reduce the incidence of uterine fibroids.
Oct 11, 2015
Click here to read the entire abstract
Pubmed Data
: J Obstet Gynaecol Res. 2015 Oct 12. Epub 2015 Oct 12. PMID:
26458740
Article Published Date
: Oct 11, 2015
Study Type
: Human Study
Additional Links
Substances
:
Cruciferous Vegetables
,
Fruit: All
Diseases
:
Fibroids: Uterine
Therapeutic Actions
:
Dietary Modification: Vegetarian
Additional Keywords
:
Risk Reduction
[+]
A higher intake of certain fruits and vegetables may be associated with a decreased risk of glaucoma.
Jun 01, 2008
Click here to read the entire abstract
Pubmed Data
: Am J Ophthalmol. 2008 Jun;145(6):1081-9. Epub 2008 Mar 20. PMID:
18355790
Article Published Date
: Jun 01, 2008
Study Type
: Human Study
Additional Links
Substances
:
Collards
,
Fruit: All
,
Kale
,
Vegetables: All
Diseases
:
Glaucoma
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Risk Reduction
[+]
After 4 weeks consuming broccoli sprouts powder it resulted in a significant decrease in serum insulin concentration in patients.
Oct 31, 2012
Click here to read the entire abstract
Pubmed Data
: Int J Food Sci Nutr. 2012 Nov ;63(7):767-71. Epub 2012 Apr 26. PMID:
22537070
Article Published Date
: Oct 31, 2012
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Diabetes Mellitus: Type 2
,
Hyperinsulinism
,
Insulin Resistance
Pharmacological Actions
:
Antioxidants
,
Insulin Down-Regulation
[+]
Broccoli sprout homogenate is safe in stable SCD patients and may induce changes in gene expression levels.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2016 ;11(4):e0152895. Epub 2016 Apr 12. PMID:
27071063
Article Published Date
: Dec 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Anemia: Sickle Cell
Additional Keywords
:
Gene Expression Regulation
[+]
Broccoli sprouts may enhance detoxication of airborne pollutants and attenuate their associated health risks.
Dec 31, 2011
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2012 Jan ;33(1):101-7. Epub 2011 Nov 1. PMID:
22045030
Article Published Date
: Dec 31, 2011
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Air Pollution Linked Toxicity
,
DNA damage
Additional Keywords
:
Isothiocyanates
[+]
Broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans.
Apr 01, 2009
Click here to read the entire abstract
Pubmed Data
: Cancer Prev Res (Phila Pa). 2009 Apr;2(4):353-60. PMID:
19349290
Article Published Date
: Apr 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
Broccoli
,
Broccoli Sprouts
,
Sprouts
,
Sulforaphane
Diseases
:
Gastritis
,
Helicobacter Pylori Infection
[+]
Calcium content in vegetables is correlated with bitterness.
Apr 01, 2009
Click here to read the entire abstract
Pubmed Data
: Appetite. 2009 Apr;52(2):498-504. PMID:
19260165
Article Published Date
: Apr 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
Calcium
,
Collards
Additional Keywords
:
Bitter Principle
[+]
Chilled and room temperature cabbage leaves are equally effective in treating breast engorgement.
Sep 01, 1995
Click here to read the entire abstract
Pubmed Data
: J Hum Lact. 1995 Sep;11(3):191-4. PMID:
7669238
Article Published Date
: Sep 01, 1995
Study Type
: Human Study
Additional Links
Substances
:
Cabbage
Diseases
:
Breast engorgement
[+]
Chilled cabbage leaves and chilled gelpaks are equally effective in reducing breast engorgement.
Mar 01, 1995
Click here to read the entire abstract
Pubmed Data
: J Hum Lact. 1995 Mar;11(1):17-20. PMID:
7718101
Article Published Date
: Mar 01, 1995
Study Type
: Human Study
Additional Links
Substances
:
Cabbage
Diseases
:
Breast engorgement
[+]
Consumption of a diet rich in cruciferous vegetables may reduce the risk of lung cancer among smokers.
Dec 31, 2009
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Cancer. 2010 ;10:162. Epub 2010 Apr 27. PMID:
20423504
Article Published Date
: Dec 31, 2009
Study Type
: Human Study
Additional Links
Substances
:
Cruciferous Vegetables
,
Isothiocyanates
Diseases
:
Lung Cancer
,
Lung Cancer: Prevention
,
Smoking
Pharmacological Actions
:
Anticarcinogenic Agents
Additional Keywords
:
Risk Reduction
[+]
Consumption of broccoli sprouts modulated the excretion of biomarkers linked to inflammation and vascular reactions.
Apr 14, 2015
Click here to read the entire abstract
Pubmed Data
: Food Chem. 2015 Apr 15 ;173:1187-94. Epub 2014 Nov 7. PMID:
25466142
Article Published Date
: Apr 14, 2015
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
Additional Keywords
:
Plant Extracts
[+]
Consumption of cruciferous and apiaceous vegetables reduced circulating IL-6.
Oct 31, 2014
Click here to read the entire abstract
Pubmed Data
: J Nutr. 2014 Nov ;144(11):1850-7. Epub 2014 Aug 27. PMID:
25165394
Article Published Date
: Oct 31, 2014
Study Type
: Human Study
Additional Links
Substances
:
Cruciferous Vegetables
,
Isothiocyanate
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
[+]
Consumption of fruit and vegetables-particularly cruciferous and green leafy vegetables, citrus fruit and juice reduced ischemic stroke risk.
Oct 05, 1999
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: JAMA. 1999 Oct 6 ;282(13):1233-9. PMID:
10517425
Article Published Date
: Oct 05, 1999
Study Type
: Human Study
Additional Links
Substances
:
Cruciferous Vegetables
,
Fruit: All
,
Vegetables: All
Diseases
:
Stroke: Ischemic
Additional Keywords
:
Risk Reduction
[+]
Consumption of fruit or fiber-fruit decreases the risk of cardiovascular disease.
Mar 16, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2017 Mar 17 ;9(3). Epub 2017 Mar 17. PMID:
28304346
Article Published Date
: Mar 16, 2017
Study Type
: Human Study
Additional Links
Substances
:
Cruciferous Vegetables
,
Fiber
,
Fruit: All
Diseases
:
Cardiovascular Disease: Prevention
,
Cardiovascular Diseases
Pharmacological Actions
:
Cardioprotective
[+]
Cruciferous vegetable consumption was strongly associated with reduced risk of prostate cancer progression.
Jun 30, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Cancer. 2012 Jul 1 ;131(1):201-10. Epub 2011 Aug 30. PMID:
21823116
Article Published Date
: Jun 30, 2012
Study Type
: Human Study
Additional Links
Substances
:
Broccoli
,
Cruciferous Vegetables
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Disease Progression
,
Risk Reduction
[+]
Cruciferous vegetable intake could influence breast cancer risk.
Jul 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Curr Dev Nutr. 2017 Aug ;1(8):e000448. Epub 2017 Jul 18. PMID:
29955715
Article Published Date
: Jul 31, 2017
Study Type
: Human Study
Additional Links
Substances
:
Cruciferous Vegetables
Diseases
:
Breast Cancer
Pharmacological Actions
:
Chemopreventive
[+]
Cruciferous vegetable intake may be associated with a reduction in lung cancer risk among men who are currently nonsmokers.
Apr 04, 2017
Click here to read the entire abstract
Pubmed Data
: J Nutr. 2017 Apr 5. Epub 2017 Apr 5. PMID:
28381528
Article Published Date
: Apr 04, 2017
Study Type
: Human Study
Additional Links
Substances
:
Cruciferous Vegetables
,
Isothiocyanates
Diseases
:
Lung Cancer
,
Lung Cancer: Prevention
Pharmacological Actions
:
Chemopreventive
[+]
Daily administration of free sulforaphane shows promise in managing biochemical recurrences in prostate cancer after radical prostatectomy.
May 11, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Prev Res (Phila). 2015 May 12. Epub 2015 May 12. PMID:
25968598
Article Published Date
: May 11, 2015
Study Type
: Human Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Prostate: PSA Doubling
,
Radical Prostatectomy
Additional Keywords
:
Recurrence Risk
,
Significant Treatment Outcome
[+]
Data from a series of case control studies suggested a favourable role of high intakes of fruit and vegetables in the risk of many common cancers, particularly of the digestive tract.
Mar 31, 2015
Click here to read the entire abstract
Pubmed Data
: Br J Nutr. 2015 Apr ;113 Suppl 2:S102-10. PMID:
26148912
Article Published Date
: Mar 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Apples
,
Cruciferous Vegetables
,
Dietary Modification: Mediterranean Diet.
,
Fruit: All
,
Tomato
,
Vegetables: All
Diseases
:
Cancers: All
Additional Keywords
:
Risk Reduction
[+]
DIM improves the estrogen profile in postmenopausal women with a history of early-stage breast cancer.
Jan 01, 2004
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2004;50(2):161-7. PMID:
15623462
Article Published Date
: Jan 01, 2004
Study Type
: Human Study
Additional Links
Substances
:
DIM (3,3'-diindolylmethane)
Diseases
:
Estrogen Dysregulation: 2/4/16 hydroxyestrone ratios
[+]
Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients.
Apr 23, 2018
Click here to read the entire abstract
Pubmed Data
: Cancer Prev Res (Phila). 2018 Apr 24. Epub 2018 Apr 24. PMID:
29691233
Article Published Date
: Apr 23, 2018
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Melanoma
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Chemopreventive
[+]
Fruit, vegetable and particularly banana consumption is strongly inversely associated with kidney cancer risk.
Jan 20, 2005
Click here to read the entire abstract
Pubmed Data
: Int J Cancer. 2005 Jan 20;113(3):451-5. PMID:
15455348
Article Published Date
: Jan 20, 2005
Study Type
: Human Study
Additional Links
Substances
:
Banana
,
Cabbage
,
Fruit: All
,
Vegetables: All
Diseases
:
Kidney Cancer
Pharmacological Actions
:
Chemopreventive
[+]
Glucosinolate and isothiocyanate intakes are inversely associated with breast cancer risk.
Mar 31, 2018
Click here to read the entire abstract
Pubmed Data
: Br J Nutr. 2018 Apr ;119(8):957-964. PMID:
29644960
Article Published Date
: Mar 31, 2018
Study Type
: Human Study
Additional Links
Substances
:
Cruciferous Vegetables
,
Isothiocyanate
Diseases
:
Breast Cancer
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Risk Reduction
[+]
Greater vegetable and fruit intake is associated with a lower risk of breast cancer among Chinese women.
Jul 01, 2009
Click here to read the entire abstract
Pubmed Data
: Int J Cancer. 2009 Jul 1;125(1):181-8. PMID:
19358284
Article Published Date
: Jul 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
Banana
,
Cantaloupe
,
Carrot
,
Cruciferous Vegetables
,
Fruit: All
,
Green Leafy Vegetables
,
Papaya
,
Tomato
,
Vegetables: All
,
Watermelon
Diseases
:
Breast Cancer: Prevention
Pharmacological Actions
:
Chemopreventive
[+]
High cruciferous vegetable consumption may reduce bladder cancer risk.
Apr 07, 1999
Click here to read the entire abstract
Pubmed Data
: J Natl Cancer Inst. 1999 Apr 7;91(7):605-13. PMID:
10203279
Article Published Date
: Apr 07, 1999
Study Type
: Human Study
Additional Links
Substances
:
Cruciferous Vegetables
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Risk Reduction
[+]
High intake of fruit during adolescence could be associated with a lower risk of breast cancer.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMJ. 2016 ;353:i2343. Epub 2016 May 11. PMID:
27170029
Article Published Date
: Dec 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Apples
,
Banana
,
Fruit: All
,
Grape
,
Kale
,
Vegetables: All
Diseases
:
Breast Cancer
Additional Keywords
:
Risk Reduction
[+]
Higher intake of fruits and vegetables may reduce the risk of breast cancer.
Jul 05, 2018
Click here to read the entire abstract
Pubmed Data
: Int J Cancer. 2018 Jul 6. Epub 2018 Jul 6. PMID:
29978479
Article Published Date
: Jul 05, 2018
Study Type
: Human Study
Additional Links
Substances
:
Cruciferous Vegetables
,
Fruit: All
Diseases
:
Breast Cancer
Pharmacological Actions
:
Chemopreventive
[+]
Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Autism. 2018 ;9:35. Epub 2018 May 30. PMID:
29854372
Article Published Date
: Dec 31, 2017
Study Type
: Human Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Autism Spectrum Disorders
Pharmacological Actions
:
Antioxidants
[+]
Increasing vegetables in the diet may have benefits for the prevention of subclinical atherosclerosis in older adult women.
Apr 03, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Am Heart Assoc. 2018 Apr 4 ;7(8). Epub 2018 Apr 4. PMID:
29618474
Article Published Date
: Apr 03, 2018
Study Type
: Human Study
Additional Links
Substances
:
Cruciferous Vegetables
,
Vegetables: All
Diseases
:
Atherosclerosis
Pharmacological Actions
:
Anti-atherogenic
[+]
Indole-3 carbinol may be beneficial in the treatment of systemic lupus erythematosus.
Jan 01, 2001
Click here to read the entire abstract
Pubmed Data
: Lupus. 2001;10(11):779-83. PMID:
11789487
Article Published Date
: Jan 01, 2001
Study Type
: Human Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Lupus Erythematosus: Systemic
,
Systemic Lupus Erythematosus
[+]
Kale juice significantly improves blood lipid profiles in hypercholesterolemic men.
Apr 01, 2008
Click here to read the entire abstract
Pubmed Data
: Biomed Environ Sci. 2008 Apr;21(2):91-7. PMID:
18548846
Article Published Date
: Apr 01, 2008
Study Type
: Human Study
Additional Links
Substances
:
Kale
Diseases
:
Cholesterol: High
,
HDL: Low
,
High Cholesterol
,
Hypercholesterolemia
[+]
Magnesium absorption is high from collards in human subjects.
Apr 01, 1984
Click here to read the entire abstract
Pubmed Data
: Am J Clin Nutr. 1984 Apr;39(4):571-6. PMID:
6711467
Article Published Date
: Apr 01, 1984
Study Type
: Human Study
Additional Links
Substances
:
Collards
,
Green Leafy Vegetables
,
Magnesium
Diseases
:
Magnesium Deficiency
[+]
Oral sulforaphane safely and effectively induces mucosal Phase II enzyme expression in the upper airway of human subjects.
Mar 01, 2009
Click here to read the entire abstract
Pubmed Data
: Clin Immunol. 2009 Mar;130(3):244-51. Epub 2008 Nov 22. PMID:
19028145
Article Published Date
: Mar 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
COPD
,
Cystic Fibrosis
,
Glutathione Deficiency
,
Lung Diseases
,
Pulmonary Fibrosis
,
Respiratory Diseases
Pharmacological Actions
:
Antioxidants
,
Glutathione Upregulation
,
Phase II Detoxification Enzyme Inducer
Additional Keywords
:
Isothiocyanates
[+]
Our data strongly support that high vegetable consumption, especially cruciferous vegetable intake, may protect against bladder cancer.
Jul 01, 2009
Click here to read the entire abstract
Pubmed Data
: Cancer Epidemiol Biomarkers Prev. 2009 Jul;18(7):2090-7. Epub 2009 Jun 23. PMID:
19549811
Article Published Date
: Jul 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
Cruciferous Vegetables
,
Fruit: All
,
Vegetables: All
Diseases
:
Bladder Cancer
Additional Keywords
:
Risk Reduction
[+]
Pre diagnostic cruciferous vegetables intake is associated with better survival of lung cancer in Chinese women.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2015 ;5:10306. Epub 2015 May 19. PMID:
25988580
Article Published Date
: Dec 31, 2014
Study Type
: Human Study
Additional Links
Substances
:
Cruciferous Vegetables
Diseases
:
Lung Cancer
Additional Keywords
:
Significant Treatment Outcome
[+]
Raw broccoli results in faster absorption, higher bioavailability, and higher peak plasma amounts of sulforaphane, compared to cooked broccoli.
Nov 26, 2008
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2008 Nov 26;56(22):10505-9. PMID:
18950181
Article Published Date
: Nov 26, 2008
Study Type
: Human Study
Additional Links
Substances
:
Broccoli
,
Sulforaphane
Pharmacological Actions
:
Anticarcinogenic Agents
Additional Keywords
:
Raw versus Cooked
[+]
Safety Study: Brocolli sprouts (sulforaphane) are safe, tolerable and do not adversely effect thyroid hormone levels.
Jan 01, 2006
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2006;55(1):53-62. PMID:
16965241
Article Published Date
: Jan 01, 2006
Study Type
: Human Study
Additional Links
Substances
:
Broccoli
,
Sprouts
,
Sulforaphane
Pharmacological Actions
:
Anticarcinogenic Agents
Additional Keywords
:
Isothiocyanates
,
Plant Extracts
[+]
Sulforaphane detoxifies benzene, an air pollutant, in a dose-dependent manner and may attentuate attenuate associated long-term health risks of air pollution.
Jul 03, 2019
Click here to read the entire abstract
Pubmed Data
: Am J Clin Nutr. 2019 Jul 3. Epub 2019 Jul 3. PMID:
31268126
Article Published Date
: Jul 03, 2019
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Air Pollution Linked Toxicity
,
Benzene Toxicity
Pharmacological Actions
:
Antioxidant Effects
,
Detoxifier
Additional Keywords
:
Airborne Pollution
,
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Dose Response
,
Environmental Pollutant
,
Environmental Pollution
Problem Substances
:
Airborne Pollution
,
Benzene
[+]
Sulforaphane from broccoli was able to reduce some of the symptoms of autism.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Glob Adv Health Med. 2017 ;6:2164957X17735826. Epub 2017 Oct 26. PMID:
29147630
Article Published Date
: Dec 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Autism
[+]
Sulforaphane has a novel chemopreventive mechanism in human colon cancer cells and prostate epithelial cells, namely the inhibition of histone deacetylase (HDAC). I
Feb 01, 2007
Click here to read the entire abstract
Pubmed Data
: Exp Biol Med (Maywood). 2007 Feb;232(2):227-34. PMID:
17259330
Article Published Date
: Feb 01, 2007
Study Type
: Human Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Colon Cancer
,
Prostate Cancer
,
Prostate Cancer: Prevention
Pharmacological Actions
:
Chemopreventive
,
Enzyme Inhibitors
,
Histone deacetylase inhibitor
[+]
Sulforaphane protects against chemically-induced damage in bladder cells and tissues.
Jan 01, 2003
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2003 Jan;17(1):66-9. PMID:
20810543
Article Published Date
: Jan 01, 2003
Study Type
: Human Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Bladder Cancer
,
Bladder Degeneration
,
DNA damage
Pharmacological Actions
:
Chemopreventive
,
Genoprotective
[+]
Sulforaphane treatment resulted in a significant reduction in specific airway resistance and also increased small airway luminal area.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Respir Res. 2015 ;16:106. Epub 2015 Sep 15. PMID:
26369337
Article Published Date
: Dec 31, 2014
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Asthma
,
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Nrf2 activation
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
[+]
Sulforaphane-containing broccoli sprout extracts induce a cytoprotective phase 2 response in mouse and human skin.
Apr 01, 2007
Click here to read the entire abstract
Pubmed Data
: Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):847-51. PMID:
17416783
Article Published Date
: Apr 01, 2007
Study Type
: Human Study
Additional Links
Substances
:
Broccoli
,
Sulforaphane
Diseases
:
Skin Diseases
Pharmacological Actions
:
Phase II Detoxification Enzyme Inducer
Additional Keywords
:
Plant Extracts
[+]
Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles.
Dec 31, 2013
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2014 Jan ;5(1):35-41. PMID:
24287881
Article Published Date
: Dec 31, 2013
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Diesel Exhaust Particle Toxicity
Pharmacological Actions
:
Anti-Allergic Agents
Additional Keywords
:
Isothiocyanates
,
Plant Extracts
[+]
Sulforaphane’s capacity to activate the Keap1–Nrf2 cytoprotective signaling pathway, and may protect against environmental and endogenous risk factors in autism spectrum disorders.
Oct 27, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Proc Natl Acad Sci U S A. 2014 Oct 28 ;111(43):15550-5. Epub 2014 Oct 13. PMID:
25313065
Article Published Date
: Oct 27, 2014
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
,
Isothiocyanates
,
Sulforaphane
Diseases
:
Autism Spectrum Disorders
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cytoprotective
,
Neuroprotective Agents
,
Nrf2 activation
Additional Keywords
:
Risk Factors
[+]
Supplementation therapy of sulforaphane rich broccoli sprout extract may have the potential to improve cognitive deficits in patients with schizophrenia.
Apr 29, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Clin Psychopharmacol Neurosci. 2015 Apr 30 ;13(1):62-7. PMID:
25912539
Article Published Date
: Apr 29, 2015
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Schizophrenia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
Additional Keywords
:
Plant Extracts
,
Significant Treatment Outcome
[+]
Supplementation with sulforaphane rich broccoli sprout extract could improve liver function through reduction of oxidative stress.
Nov 20, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: World J Gastroenterol. 2015 Nov 21 ;21(43):12457-67. PMID:
26604653
Article Published Date
: Nov 20, 2015
Study Type
: Human Study
Additional Links
Substances
:
Broccoli
,
Sulforaphane
Diseases
:
Fatty Liver
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
Additional Keywords
:
Plant Extracts
[+]
The bioavailability of isothiocyanates from fresh broccoli is approximately three times greater than that from cooked broccoli,
Jan 01, 2000
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2000;38(2):168-78. PMID:
11525594
Article Published Date
: Jan 01, 2000
Study Type
: Human Study
Additional Links
Substances
:
Broccoli
,
Sulforaphane
Pharmacological Actions
:
Anticarcinogenic Agents
Additional Keywords
:
Raw versus Cooked
[+]
The bioavailability of sulforaphane from glucoraphanin supplements was equal to that from broccoli sprouts.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(11):e0140963. Epub 2015 Nov 2. PMID:
26524341
Article Published Date
: Dec 31, 2014
Study Type
: Human Study
Additional Links
Substances
:
Broccoli
,
Sulforaphane
Additional Keywords
:
Food Vs. Supplement
,
Increased Bioavailability
,
Plant Extracts
[+]
The intake of green leafy vegetables and fruits lowered the risk of esophageal cancer in this study.
Feb 28, 2015
Click here to read the entire abstract
Pubmed Data
: Tumour Biol. 2015 Mar ;36(3):1627-42. Epub 2014 Nov 1. PMID:
25361631
Article Published Date
: Feb 28, 2015
Study Type
: Human Study
Additional Links
Substances
:
Cruciferous Vegetables
Diseases
:
Esophageal Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
Additional Keywords
:
Betel Leaf
,
Increased Risk
,
P16 Hypermethylation
,
Tobacco Chewing
[+]
The results of this study found that dosing twice a day may be important for increasing or prolonging certain chemopreventive benefits associated with sulforaphane consumption.
Feb 28, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Nutr Food Res. 2015 Mar ;59(3):424-33. Epub 2015 Jan 22. PMID:
25522265
Article Published Date
: Feb 28, 2015
Study Type
: Human Study
Additional Links
Substances
:
Cruciferous Vegetables
,
Sulforaphane
Diseases
:
Cancers: All
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Absorption
,
Bioavailability
,
Dietary Modification
[+]
Week-long oral administration of sulforaphane increased blood and thalamic glutathione levels in healthy human subjects.
May 01, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Neuropsychiatry. 2018 May ;3(4):214-222. Epub 2018 Apr 17. PMID:
29888232
Article Published Date
: May 01, 2018
Study Type
: Human Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Psychiatric Disorders
Pharmacological Actions
:
Glutathione Upregulation
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
psychiatric disorders
[+]
Women consuming the most green leafy vegetables experienced slower decline than women consuming the least amount
Apr 30, 2005
Click here to read the entire abstract
Pubmed Data
: Ann Neurol. 2005 May ;57(5):713-20. PMID:
15852398
Article Published Date
: Apr 30, 2005
Study Type
: Human Study
Additional Links
Substances
:
Cruciferous Vegetables
,
Green Leafy Vegetables
,
Vegetables: All
Diseases
:
Aging
,
Cognitive Decline/Dysfunction
Additional Keywords
:
Risk Reduction
[+]
A diet rich in sulforaphane and related mustard oils may be considered as a supportive nutritional strategy to enhance therapeutic efficacy in patients suffering from pancreatic cancer.
Mar 29, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2014 Mar 30 ;5(6):1621-34. PMID:
24742583
Article Published Date
: Mar 29, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Cruciferous Vegetables
,
Sulforaphane
Diseases
:
Cancers: Drug Resistant
,
Pancreatic Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Chemotherapeutic
Additional Keywords
:
Cancer Stem Cells
,
Dietary Concentrations
[+]
Cabbage juices and indoles modulate the expression profile of AhR, ERα, and Nrf2 in human breast cell lines.
Sep 22, 2015
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2015 Sep 23:1-13. Epub 2015 Sep 23. PMID:
26399169
Article Published Date
: Sep 22, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Cabbage
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Chemopreventive
,
NF-E2-Related Factor-2 (Nrf2) Modulator
Additional Keywords
:
Vegetable Juice
[+]
Free radicals enhance the activation of Antioxidant Response Element (ARE) by sulforaphane, despite suppression of Nrf2 nuclear accumulation.
Jan 20, 2018
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2018 08 20 ;124:532-540. Epub 2018 Jun 30. PMID:
29969714
Article Published Date
: Jan 20, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Antioxidant Effects
,
Nrf2 activation
Additional Keywords
:
Antioxidants
,
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
[+]
Sulforaphane attentuates cadmium-induced carcinogenesis through Nrf2, antioxidant, and autophagy mechanisms.
Jan 15, 2018
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2018 08 15 ;353:23-30. Epub 2018 Jun 6. PMID:
29885333
Article Published Date
: Jan 15, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cadmium Poisoning
,
Cancers
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antioxidant
,
Antioxidant Effects
,
Apoptotic
,
Autophagy Up-regulation
,
NF-E2-Related Factor-2 (Nrf2) Modulator
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Isothiocyanates
[+]
Sulforaphane combats colon cancer in vitro by inhibiting COX-2 and prostaglandin E1 synthase and exhibiting anti-angiogenic, anti-proliferative, and anti-metastatic properties.
Jan 01, 2018
Click here to read the entire abstract
Pubmed Data
: Cells Tissues Organs. 2018 ;206(1-2):46-53. Epub 2018 Jul 24. PMID:
30041241
Article Published Date
: Jan 01, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Colon Cancer
Pharmacological Actions
:
Anti-Angiogenic
,
Anti-cancer
,
Anti-metastatic
,
Anti-Proliferative
,
Cyclooxygenase 2 Inhibitors
,
Hypoxia-inducible factor-1 (HIF-1) inhibitor
,
Prostaglandin E Synthase-1 (PGES-1) Down-Regulation
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
[+]
Sulforaphane decreases leukemia cell viability in vitro by inhibiting NADPH oxidase enzymes and redox transporter signaling.
Jan 01, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2018 ;2018:4125297. Epub 2018 Nov 18. PMID:
30581529
Article Published Date
: Jan 01, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Cruciferous Vegetables
,
Sulforaphane
Diseases
:
Leukemia
Pharmacological Actions
:
Antioxidant
,
Antioxidant Effects
,
Antiproliferative
,
NADPH Oxidase Inhibitors
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Isothiocyanates
[+]
Sulforaphane delays fibroblast aging in vitro by decreasing glycolysis and reducing oxidative stress.
Jan 01, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2018 ;2018:5642148. Epub 2018 Nov 22. PMID:
30595796
Article Published Date
: Jan 01, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Aging
,
Oxidative Stress
Pharmacological Actions
:
Nrf2 activation
Additional Keywords
:
calorie restriction
,
High Sugar Diet
,
Isothiocyanates
[+]
Sulforaphane inhibits Wnt/β-catenin signaling in colorectal cancer cells, supressing proliferation and inducing cell death.
Sep 21, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2018 Sep 21 ;9(74):33982-33994. Epub 2018 Sep 21. PMID:
30338040
Article Published Date
: Sep 21, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Colorectal Cancer
,
Colorectal Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Wnt/β-catenin pathway down-regulation
Additional Keywords
:
Anti-cancer
[+]
Sulforaphane may prevent or treat breast cancer by reversing estrogen-induced metabolic changes or alterations in methylation.
Dec 01, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: FEBS Open Bio. 2018 Dec ;8(12):2022-2034. Epub 2018 Nov 14. PMID:
30524952
Article Published Date
: Dec 01, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Breast Cancer: Estrogen
Additional Keywords
:
Estrogen Positive Breast Cancer
,
Folate
,
Methylation
[+]
Sulforaphane prevents hepatic insulin resistance through a ceramide-dependent mechanism.
May 27, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2019 May 27 ;11(5). Epub 2019 May 27. PMID:
31137828
Article Published Date
: May 27, 2019
Study Type
: Human In Vitro
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Diabetes Mellitus: Type 2
,
Insulin Disorders
,
Insulin Resistance
Pharmacological Actions
:
Glucose Uptake Optimization
,
Insulin Sensitizers
Additional Keywords
:
Broccoli
,
Cruciferous Vegetables
,
glucose control
,
Glucose Uptake Enhancement
[+]
Sulforaphane protected the injury of vascular endothelial cell by LPC by enhancing anti-oxidative capabilities mediated by Nrf-2 translocation.
May 25, 2015
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2015 May 26. Epub 2015 May 26. PMID:
26008201
Article Published Date
: May 25, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Endothelial Damage
,
Endothelial Dysfunction
Pharmacological Actions
:
Antioxidants
,
Phase II Detoxification Enzyme Inducer
,
Superoxide Dismutase Up-regulation
[+]
Sulforaphane protects against ethanol-induced apoptosis in neural crest cells, a characteristic of Fetal Alcohol Syndrome, through restoration of Snail1 expression and epithelial-mesenchymal transition.
Jul 08, 2019
Click here to read the entire abstract
Pubmed Data
: Biochim Biophys Acta Mol Basis Dis. 2019 Jul 8 ;1865(10):2586-2594. Epub 2019 Jul 8. PMID:
31295528
Article Published Date
: Jul 08, 2019
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Fetal Alcoholism
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
Additional Keywords
:
Alcohol
,
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Mesenchymal Stem Cells
,
Pregnancy And Fetal Growth
[+]
Sulforaphane protects against oxidative stress in culture of adult cardiomyocytes.
Aug 01, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 Aug ;104:165-171. Epub 2018 May 15. PMID:
29772437
Article Published Date
: Aug 01, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Nrf2 activation
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Isothiocyanates
[+]
Sulforaphane regulates xenobiotic metabolism phase II and III enzymes differently in colorectal cancer and untransformed epithelial colon cells.
Oct 31, 2016
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2016 Nov-Dec;68(8):1338-1348. Epub 2016 Aug 16. PMID:
27636860
Article Published Date
: Oct 31, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Colon Cancer
Pharmacological Actions
:
Cytoprotective
,
Nrf2 activation
Additional Keywords
:
Gene Expression Regulation
,
Selective Cytotoxicity
[+]
Sulforaphane rescues amyloid-β peptide-mediated decrease in MerTK expression through its anti-inflammatory effect.
Mar 11, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Neuroinflammation. 2018 Mar 12 ;15(1):75. Epub 2018 Mar 12. PMID:
29530050
Article Published Date
: Mar 11, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Neuroprotective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Sulforaphane suppresses proliferation and enhances apoptosis of gastric cancer stem cells in vitro.
Aug 01, 2019
Click here to read the entire abstract
Pubmed Data
: Int J Food Sci Nutr. 2019 Aug ;70(5):570-578. Epub 2019 Jan 9. PMID:
30624124
Article Published Date
: Aug 01, 2019
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Gastric Cancer
,
Gastric Cancer: Prevention
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
Additional Keywords
:
Anti-cancer
[+]
Sulforaphene inhibits liver cancer cell proliferation by stimulating apoptosis and causing cytotoxicity.
Jun 04, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2018 Jun 4 ;10(6). Epub 2018 Jun 4. PMID:
29866995
Article Published Date
: Jun 04, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Isothiocyanates
[+]
Sulforphane exhibits immunomodulatory properties on human placenta cells in vitro.
Feb 01, 2019
Click here to read the entire abstract
Pubmed Data
: J Reprod Immunol. 2019 Feb ;131:44-49. Epub 2018 Dec 29. PMID:
30641297
Article Published Date
: Feb 01, 2019
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Immune Enhancing Properties
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Pregnancy
[+]
The addition of broccoli and watercress in the diet may reduce risk of breast cancer
Dec 01, 2005
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2005 Dec 1 ;209(2):105-13. Epub 2005 Jun 13. PMID:
15953625
Article Published Date
: Dec 01, 2005
Study Type
: Human In Vitro
Additional Links
Substances
:
Broccoli
,
Sulforaphane
,
Watercress
Diseases
:
Breast Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Isothiocyanates
,
Plant Extracts
[+]
This study demonstrates that sulforaphane targets multiple signaling pathways to suppress ovarian cancer in vitro and in vivo.
Nov 01, 2018
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2018 Nov ;42(5):2447-2458. Epub 2018 Sep 6. PMID:
30226534
Article Published Date
: Nov 01, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
,
Female
,
Ovarian Cancer
Pharmacological Actions
:
Anti-Tumor
,
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
HER-2 oncoprotein down-regulation
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Drug Synergy
,
Isothiocyanates
[+]
"Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin."
Oct 31, 2012
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2012 Nov ;56(11):1675-87. Epub 2012 Oct 5. PMID:
23038615
Article Published Date
: Oct 31, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Erucin
,
Sulforaphane
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Chemopreventive
[+]
"Inhibition of Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells by dietary sulforaphane."
May 28, 2012
Click here to read the entire abstract
Pubmed Data
: Mol Carcinog. 2012 May 29. Epub 2012 May 29. PMID:
22641235
Article Published Date
: May 28, 2012
Study Type
: Insect Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Epstein-Barr Virus Infections
,
Nasopharyngeal Cancer
[+]
"Neuroprotective effects of sulforaphane after contusive spinal cord injury."
Oct 31, 2012
Click here to read the entire abstract
Pubmed Data
: J Neurotrauma. 2012 Nov 1 ;29(16):2576-86. Epub 2012 Sep 20. PMID:
22853439
Article Published Date
: Oct 31, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Spinal Cord Injuries
Pharmacological Actions
:
Neuroprotective Agents
[+]
"Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation."
Dec 31, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2012 ;2012:821936. Epub 2012 Sep 23. PMID:
23050040
Article Published Date
: Dec 31, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Diabetic Nephropathy
[+]
"Protective effects of the antioxidant sulforaphane on behavioral changes and neurotoxicity in mice after the administration of methamphetamine."
Jun 30, 2012
Click here to read the entire abstract
Pubmed Data
: Psychopharmacology (Berl). 2012 Jul ;222(1):37-45. Epub 2011 Dec 27. PMID:
22200890
Article Published Date
: Jun 30, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Amphetamine Addiction/Withdrawal
,
Brain: Microglial Activation
,
Neurodegenerative Diseases
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
"Sulforaphane induces phase II detoxication enzymes in mouse skin and prevents mutagenesis induced by a mustard gas analog."
Nov 29, 2012
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2012 Nov 30. Epub 2012 Nov 30. PMID:
23201461
Article Published Date
: Nov 29, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Chemical Weapon Agent Injury
,
Skin Cancer: Prevention
Pharmacological Actions
:
Phase II Detoxification Enzyme Inducer
[+]
"Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice."
Sep 01, 2011
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2011 Sep ;26(3):603-8. Epub 2011 May 20. PMID:
21617865
Article Published Date
: Sep 01, 2011
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
[+]
"ulforaphane Protects Small Intestinal Mucosa From Aspirin/NSAID-Induced Injury by Enhancing Host Defense Systems Against Oxidative Stress and by Inhibiting Mucosal Invasion of Anaerobic Enterobacteria."
Aug 22, 2012
Click here to read the entire abstract
Pubmed Data
: Curr Pharm Des. 2012 Aug 23. Epub 2012 Aug 23. PMID:
22950492
Article Published Date
: Aug 22, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Aspirin-Induced Toxicity
,
NSAID-induced toxicity
[+]
3,3'-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice.
Apr 01, 2005
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2005 Apr;26(4):771-8. Epub 2005 Jan 20. PMID:
15661811
Article Published Date
: Apr 01, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Cruciferous Vegetables
Diseases
:
Breast Cancer
,
Breast Cancer: Metastatic
Pharmacological Actions
:
Anti-Angiogenic
,
Anticarcinogenic Agents
[+]
A phenolic rich extract of wild cabbage has the potential to form a multi-component drug to target diabetes and its related complications.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Springerplus. 2015 ;4:212. Epub 2015 May 3. PMID:
26020019
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Cabbage
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Antioxidants
,
Catalase Up-Regulation
,
Hypoglycemic Agents
,
Hypolipidemic
,
Superoxide Dismutase Up-regulation
Additional Keywords
:
Plant Extracts
[+]
A variety of vegetables reduce the absorption and enhance excretion of dioxin and furan toxins.
May 01, 1999
Click here to read the entire abstract
Pubmed Data
: Fukuoka Igaku Zasshi. 1999 May;90(5):171-83. PMID:
10396873
Article Published Date
: May 01, 1999
Study Type
: Animal Study
Additional Links
Substances
:
Broccoli
,
Cabbage
,
Chives
,
Kale
,
Onion
,
Perilla
,
Spinach
,
Vegetables: All
Diseases
:
Dioxin Toxicity
,
Furan Toxicity
[+]
Anti-cancer and cardioprotective effects of indol-3-carbinol in doxorubicin-treated mice.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: J Infect Chemother. 2016 Jan ;22(1):36-43. Epub 2015 Nov 19. PMID:
26603425
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Breast Cancer
,
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Cardioprotective
,
Chemoprotective Agents
,
Chemosensitizer
Additional Keywords
:
Chemotherapeutic Synergy: Doxorubicin
[+]
Antiobesity activities of indole-3-carbinol in high-fat-diet-induced obese mice.
Mar 31, 2011
Click here to read the entire abstract
Pubmed Data
: Nutrition. 2011 Apr ;27(4):463-70. PMID:
21392705
Article Published Date
: Mar 31, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
[+]
Attenuation of hyperglycemia-mediated oxidative stress by indole-3-carbinol and its metabolite 3, 3'- diindolylmethane.
May 31, 2014
Click here to read the entire abstract
Pubmed Data
: J Physiol Biochem. 2014 Jun ;70(2):525-34. Epub 2014 Apr 9. PMID:
24715233
Article Published Date
: May 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Diabetes: Oxidative Stress
,
Diabetes Mellitus: Type 2
,
Hyperglycemia
Pharmacological Actions
:
Antioxidants
,
Catalase Up-Regulation
,
Superoxide Dismutase Up-regulation
[+]
Authors conclude that data from this study provides evidence for the use of sulforaphane in preventing stroke in selected high-risk patient cohorts.
Jan 01, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Br J Pharmacol. 2018 08 ;175(16):3333-3346. Epub 2018 Jul 3. PMID:
29797311
Article Published Date
: Jan 01, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Stroke
Pharmacological Actions
:
Platelet aggregation inhibitor: collagen-induced aggregation
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
[+]
Benzyl isothiocyanate (BITC), a constituent of edible cruciferous vegetables, inhibits growth of human breast cancer cells in culture.
Dec 15, 2009
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 2009 Dec 15;69(24):9473-80. PMID:
19934325
Article Published Date
: Dec 15, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Cruciferous Vegetables
Diseases
:
Breast Cancer
,
Breast Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
[+]
Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.
Sep 28, 2006
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2006 Sep 28;241(2):275-80. Epub 2006 Jan 4. PMID:
16386831
Article Published Date
: Sep 28, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Benzyl isothiocyanate
,
Sulforaphane
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Isothiocyanates
,
Stilbenes
[+]
Both indole-3-carbinol and myo-inositol inhibit the development of vinyl carbamate induced pulmonary adenocarcinoma in mice.
Jan 31, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Carcinogenesis. 2010 Feb ;31(2):239-45. Epub 2009 Jul 22. PMID:
19625346
Article Published Date
: Jan 31, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
,
Myo-inositol
Diseases
:
Lung Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
Problem Substances
:
Vinyl Carbamate
[+]
Brassica rapa (Mustard Greens) have a protective effect on cisplatin-induced nephrotoxicity in cells and rats.
Dec 01, 2006
Click here to read the entire abstract
Pubmed Data
: Biol Pharm Bull. 2006 Dec;29(12):2436-41. PMID:
17142978
Article Published Date
: Dec 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Mustard Greens
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Antineoplastic Agents
,
Plant Extracts
[+]
Broccoli and its phytochemical sulforaphane activate detoxification enzymes that may protect against polycyclic aromatic hydrocarbon induced toxicity.
Mar 01, 2009
Click here to read the entire abstract
Pubmed Data
: Chemosphere. 2009 Mar;74(9):1145-51. Epub 2009 Jan 13. PMID:
19144376
Article Published Date
: Mar 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Oxidative Stress
,
Petroleum Exposure And Toxicity
,
Polycyclic aromatic hydrocarbon (PAH) toxicity
Pharmacological Actions
:
Phase II Detoxification Enzyme Inducer
[+]
Broccoli sprout could be prophylactic vegetable to prevent or minimize the relapse by inflammation in the remission state of depressed patients.
Oct 10, 2016
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2016 Oct 11 ;39:134-144. Epub 2016 Aug 11. PMID:
27833054
Article Published Date
: Oct 10, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Depression
,
Depressive Disorder
,
Inflammation
Pharmacological Actions
:
Antidepressive Agents
Additional Keywords
:
Risk Reduction
[+]
Broccoli sprout extract containing sulforaphane attentuated alcohol-induced oxidative stress and endoplasmic reticulum stress through restoration of antioxidant enzyme function in mice.
Jun 06, 2018
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2018 Jun 6 ;66(22):5574-5580. Epub 2018 May 23. PMID:
29730925
Article Published Date
: Jun 06, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Alcohol Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Malondialdehyde Down-regulation
,
Nrf2 activation
,
Phase II Detoxification Enzyme Inducer
,
Superoxide Dismutase Up-regulation
Additional Keywords
:
Plant Extracts
[+]
Broccoli sprouts can serve as a good dietary source of sulforaphane in vivo and that they have significant inhibitory effects on prostate tumorigenesis.
Oct 01, 2009
Click here to read the entire abstract
Pubmed Data
: Pharm Res. 2009 Oct;26(10):2324-31. Epub 2009 Aug 8. PMID:
19669099
Article Published Date
: Oct 01, 2009
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Broccoli
,
Sprouts
,
Sulforaphane
Diseases
:
Prostate Cancer
,
Prostate Cancer: Prevention
Pharmacological Actions
:
Apoptotic
Additional Keywords
:
Plant Extracts
[+]
Broccoli sprouts contain compounds which protect the skin against damage by UV radiation.
Oct 30, 2007
Click here to read the entire abstract
Pubmed Data
: Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17500-5. Epub 2007 Oct 23. PMID:
17956979
Article Published Date
: Oct 30, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Broccoli
,
Sprouts
,
Sulforaphane
Diseases
:
Aging Skin
[+]
Brocolli sprout extract and the active compound known as sulforaphane demonstrates chemopreventive action in mammary tissue.
Jul 01, 2007
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2007 Jul;28(7):1485-90. Epub 2007 Mar 7. PMID:
17347138
Article Published Date
: Jul 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Broccoli
,
Sulforaphane
Diseases
:
Breast Cancer
Pharmacological Actions
:
Chemopreventive
[+]
Brussel sprouts induce detoxifying enzymes.
Aug 01, 2010
Click here to read the entire abstract
Pubmed Data
: J Food Sci. 2010 Aug 1;75(6):H190-9. PMID:
20722931
Article Published Date
: Aug 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Brussel sprouts
,
Sulforaphane
Diseases
:
Chemical Exposure
,
Intoxication
Pharmacological Actions
:
Phase I Detoxification Enzyme Inducer
,
Phase II Detoxification Enzyme Inducer
Additional Keywords
:
Isothiocyanates
,
Plant Extracts
[+]
Cabbage (Brassica oleracea) inhibits Trypanosoma protozoa.
Feb 01, 2002
Click here to read the entire abstract
Pubmed Data
: Fitoterapia. 2002 Feb;73(1):17-21 PMID:
11864758
Article Published Date
: Feb 01, 2002
Study Type
: Animal Study
Additional Links
Substances
:
Cabbage
Diseases
:
Chagas Disease
[+]
Cabbage extracts have a pancreato-protective effect.
Jan 19, 2017
Click here to read the entire abstract
Pubmed Data
: Nat Prod Res. 2017 Jan 20:1-4. Epub 2017 Jan 20. PMID:
28107794
Article Published Date
: Jan 19, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Cabbage
Diseases
:
Alcohol Toxicity
,
Pancreatitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Interleukin-18 down-regulation
,
Interleukin-1 beta downregulation
,
Pancreato Protective Agents
Additional Keywords
:
Alcohol Toxicity
,
Anti-Inflammatory Agents
,
Antioxidants
,
Cabbage
,
Pancreatitis
,
Plant Extracts
[+]
Cabbage reduces mammary tumorigenesis in the rat.
Jul 01, 1990
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 1990 Jul;11(7):1159-63. PMID:
2372873
Article Published Date
: Jul 01, 1990
Study Type
: Animal Study
Additional Links
Substances
:
Cabbage
,
Red Cabbage
Diseases
:
Breast Cancer: Prevention
Pharmacological Actions
:
Chemopreventive
[+]
Characterization of juice fermented with Lactobacillus plantarum EM and its cholesterol-lowering effects on rats fed a high-fat and high-cholesterol diet.
Oct 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Food Sci Nutr. 2019 Nov ;7(11):3622-3634. Epub 2019 Sep 27. PMID:
31763011
Article Published Date
: Oct 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Apple
,
Cabbage
,
Fermented Foods and Beverages
,
Lactobacillus plantarum
Diseases
:
Hypercholesterolemia
Pharmacological Actions
:
Anticholesteremic Agents
[+]
Chinese cabbage powder effectively reduced the incidence of liver tumour induced by aflatoxin B1 from 6.67% to 0% in animals.
Oct 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Food Chem. 2015 Nov 1 ;186:13-9. Epub 2015 Mar 6. PMID:
25976785
Article Published Date
: Oct 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cabbage
Diseases
:
Liver Cancer: Prevention
,
Liver Damage: Aflatoxin-Induced
Pharmacological Actions
:
Anticarcinogenic Agents
Additional Keywords
:
Risk Reduction
[+]
Co-administration of SFN reversed the DOX-associated reduction in nuclear Nrf2 binding activity and restored cardiac expression of Nrf2-regulated genes, at both the RNA and protein levels.
May 25, 2015
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2015 May 26. Epub 2015 May 26. PMID:
26025579
Article Published Date
: May 25, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Cardioprotective
,
Chemoprotective Agents
,
Nrf2 activation
[+]
Co-treatment with vitamin E, sulphoraphane and Ficus religiosa were found to be effective in reversing cadmium induced reproductive toxicity.
Jul 31, 2014
Click here to read the entire abstract
Pubmed Data
: Syst Biol Reprod Med. 2014 Aug ;60(4):199-205. Epub 2014 Apr 23. PMID:
24758558
Article Published Date
: Jul 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Fig
,
Sulforaphane
,
Vitamin E
Diseases
:
Cadmium Poisoning
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Cytoprotective
Additional Keywords
:
Plant Extracts
Problem Substances
:
Cadmium
[+]
Collards and cabbage prevent pulmonary metastasis of mammary cancer in mice.
Jan 01, 1989
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 1989;12(2):121-6. PMID:
2710654
Article Published Date
: Jan 01, 1989
Study Type
: Animal Study
Additional Links
Substances
:
Cabbage
,
Collards
Diseases
:
Breast Cancer
,
Breast Cancer: Lung Metastasis
,
Cancer Metastasis
,
Lung Cancer
Pharmacological Actions
:
Anti-metastatic
,
Chemopreventive
[+]
Combination of two or three components showed striking synergetic effect with gemcitabine in vitro.
Jan 11, 2017
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2017 Jan 12. Epub 2017 Jan 12. PMID:
28089829
Article Published Date
: Jan 11, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Capsaicin
,
Piceatannol
,
Resveratrol
,
Sulforaphane
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Chemosensitizer
,
Chemotherapeutic
Additional Keywords
:
Chemotherapeutic Synergy: Gemcitabine
,
Natural Substance Synergy
[+]
Continuous exposure of pancreatic cancer cells to dietary bioactive agents does not induce drug resistance unlike chemotherapy.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Death Dis. 2016 ;7(6):e2246. Epub 2016 Jun 2. PMID:
27253410
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Quercetin
,
Sulforaphane
Diseases
:
Cancers: Drug Resistant
,
Pancreatic Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
[+]
Cruciferous and leguminous sprouts protect against genotoxicity, in vitro and in vivo.
Jul 01, 2004
Click here to read the entire abstract
Pubmed Data
: Cancer Epidemiol Biomarkers Prev. 2004 Jul;13(7):1199-205. PMID:
15247131
Article Published Date
: Jul 01, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Cruciferous Vegetables
,
Legumes
,
Sprouts
Diseases
:
DNA damage
[+]
Curry leaves (M. koenigii) and Mustard Greens (B. juncea) have multiple blood sugar lowering effects.
Sep 01, 2005
Click here to read the entire abstract
Pubmed Data
: Am J Clin Nutr. 2005 Sep;82(3):668-74. PMID:
7642200
Article Published Date
: Sep 01, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Curry Leaves
,
Mustard Greens
Diseases
:
Diabetes Mellitus: Type 1
,
Diabetes Mellitus: Type 2
[+]
Curry leaves (M. koenigii) and Mustard Greens (B. juncea) improves kidney function in diabetic rats.
Mar 01, 2003
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2003 Mar;85(1):1-5. PMID:
12576195
Article Published Date
: Mar 01, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Curry Leaves
,
Mustard Greens
Diseases
:
Diabetes: Kidney Function
,
Diabetes Mellitus: Type 1
,
Diabetes Mellitus: Type 2
[+]
Curry leaves (M. koenigii) and Mustard Greens (B. juncea) inhibit colon and intestine neoplasms in a rat model.
Jan 01, 1996
Click here to read the entire abstract
Pubmed Data
: Invest New Drugs. 1996;14(4):365-9. PMID:
9157071
Article Published Date
: Jan 01, 1996
Study Type
: Animal Study
Additional Links
Substances
:
Curry Leaves
,
Mustard Greens
Diseases
:
Colon Cancer
[+]
dietary intake of SFN-rich broccoli sprouts during the juvenile and adolescence may prevent the onset of psychosis at adulthood.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(6):e0127244. Epub 2015 Jun 24. PMID:
26107664
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Cognitive Decline/Dysfunction
,
Neurologic Disorders
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
,
Nrf2 activation
Additional Keywords
:
Plant Extracts
[+]
DIM inhibits lung metastasis of mammary cancer cells in mice.
Oct 28, 2009
Click here to read the entire abstract
Pubmed Data
: J Nutr. 2009 Oct 28. PMID:
19864400
Article Published Date
: Oct 28, 2009
Study Type
: Animal Study
Additional Links
Substances
:
DIM (3,3'-diindolylmethane)
Diseases
:
Breast Cancer
,
Breast Cancer: Lung Metastasis
Pharmacological Actions
:
Anti-metastatic
[+]
Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin.
Mar 31, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Carcinogenesis. 2011 Apr ;32(4):561-7. Epub 2011 Jan 27. PMID:
21273642
Article Published Date
: Mar 31, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
,
Silibinin
Diseases
:
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Chemopreventive
Additional Keywords
:
Natural Substance Synergy
[+]
Glucoraphanin supplementation attenuated weight gain, decreased hepatic steatosis, and improved glucose tolerance and insulin sensitivity.
Feb 15, 2017
Click here to read the entire abstract
Pubmed Data
: Diabetes. 2017 Feb 16. Epub 2017 Feb 16. PMID:
28209760
Article Published Date
: Feb 15, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Insulin Resistance
,
Nonalcoholic fatty liver disease (NAFLD)
,
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Hepatoprotective
,
Nrf2 activation
Additional Keywords
:
Anti-Obesity Agents
,
Gene Expression Regulation
[+]
Immunoregulatory effects of indole-3-carbinol on monocyte-derived macrophages in systemic lupus erythematosus.
Jul 31, 2018
Click here to read the entire abstract
Pubmed Data
: Autoimmunity. 2018 Aug ;51(5):199-209. Epub 2018 Oct 5. PMID:
30289282
Article Published Date
: Jul 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Autoimmune Diseases
,
Systemic Lupus Erythematosus
Pharmacological Actions
:
Immunomodulatory
[+]
In vivo pharmacodynamics of indole-3-carbinol in the inhibition of prostate cancer in transgenic adenocarcinoma.
Sep 30, 2012
Click here to read the entire abstract
Pubmed Data
: Mol Carcinog. 2012 Oct ;51(10):761-70. Epub 2011 Aug 11. PMID:
21837756
Article Published Date
: Sep 30, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Oxidative Stress
,
Prostate Cancer
Pharmacological Actions
:
Antioxidants
,
Apoptotic
,
Cell cycle arrest
,
Chemopreventive
,
Nrf2 activation
[+]
Indole-3 carbinol inhibits lung tumorigenesis and DNA methylation.
May 01, 1990
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 1990 May 1;50(9):2613-7. PMID:
2328487
Article Published Date
: May 01, 1990
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Lung Cancer
[+]
Indole-3 carbinol prevents human papilloma virus induced cervical cancer and cervical dysplasia in transgenic mice.
Aug 15, 1999
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 1999 Aug 15;59(16):3991-7. PMID:
10463597
Article Published Date
: Aug 15, 1999
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Cervical Cancer
,
Cervical Dysplasia
,
Papillomavirus Infections
Pharmacological Actions
:
Chemopreventive
[+]
Indole-3 carbinol reverses multidrug resistant melanoma in vivo.
Feb 01, 1996
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 1996 Feb 1;56(3):574-81. PMID:
8564974
Article Published Date
: Feb 01, 1996
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Cancers: Multi-Drug Resistant
,
Melanoma
[+]
Indole-3 carbinol, a compound found in cabbage, may prevent and treat breast cancer bone metastasis.
Nov 01, 2006
Click here to read the entire abstract
Pubmed Data
: Mol Cancer Ther. 2006 Nov;5(11):2747-56. PMID:
17121921
Article Published Date
: Nov 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Cabbage
,
Indole-3-Carbinol
Diseases
:
Breast Cancer: Bone Metastasis
[+]
Indole-3-carbinol affects murine leukemia WEHI-3 cells both in vitro and in vivo.
Aug 07, 2012
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2012 Aug 8 ;60(31):7634-43. Epub 2012 Jul 26. PMID:
22775144
Article Published Date
: Aug 07, 2012
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Leukemia
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Plant Extracts
[+]
Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 rats.
Dec 31, 2013
Click here to read the entire abstract
Pubmed Data
: Reprod Toxicol. 2014 Jan ;43:56-66. Epub 2013 Nov 17. PMID:
24257414
Article Published Date
: Dec 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Bisphenol Toxicity
,
Prenatal Chemical Exposures
Pharmacological Actions
:
Cytoprotective
Problem Substances
:
Bisphenol A
[+]
Indole-3-carbinol diminishes proliferation and increases apoptosis of tumor cells in an experimental model of inflammatory breast cancer.
Jun 03, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Cancer. 2018 Jun 4 ;18(1):626. Epub 2018 Jun 4. PMID:
29866056
Article Published Date
: Jun 03, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Breast Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Chemotherapeutic
[+]
Indole-3-carbinol enhances the sensitivity of murine breast adenocarcinoma cells to doxorubicin.
Jun 24, 2018
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2018 Jun 25 ;290:19-36. Epub 2018 May 15. PMID:
29775573
Article Published Date
: Jun 24, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Breast Cancer
,
Oxidative Stress
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Anti-Inflammatory Agents
,
Antioxidants
,
Apoptotic
,
Chemosensitizer
,
Cyclooxygenase 2 Inhibitors
,
Heme oxygenase-1 up-regulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Nrf2 activation
Additional Keywords
:
Chemotherapeutic Synergy: Doxorubicin
[+]
Indole-3-carbinol has anti-proliferative effects in human breast cancer cells.
Sep 11, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Biol. 2014 Sep 12 ;12:72. Epub 2014 Sep 12. PMID:
25209720
Article Published Date
: Sep 11, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
Anti Therapeutic Actions
:
Assisted Reproductive Technique
[+]
Indole-3-carbinol improves neurobehavioral symptoms in a cerebral ischemic stroke model.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Naunyn Schmiedebergs Arch Pharmacol. 2018 06 ;391(6):613-625. Epub 2018 Mar 30. PMID:
29602953
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Cerebral Stroke
Pharmacological Actions
:
Neuroprotective Agents
[+]
Indole-3-carbinol inhibited the growth of nasopharyngeal carcinoma cells and induced apoptosis effectively in vivo and in vitro.
Aug 04, 2016
Click here to read the entire abstract
Pubmed Data
: Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Aug 5 ;30(15):1215-1218. PMID:
29798332
Article Published Date
: Aug 04, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Nasopharyngeal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Chemopreventive
[+]
Indole-3-carbinol inhibited tobacco smoke carcinogen-induced lung adenocarcinoma.
Nov 30, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Lett. 2011 Dec 1 ;311(1):57-65. Epub 2011 Jul 2. PMID:
21767909
Article Published Date
: Nov 30, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Lung Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
[+]
Indole-3-carbinol inhibits cell proliferation and induces apoptosis in Hep-2 laryngeal cancer cells.
Jun 30, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Rep. 2013 Jul ;30(1):227-33. Epub 2013 Apr 22. PMID:
23604413
Article Published Date
: Jun 30, 2013
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Laryngeal Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
[+]
Indole-3-carbinol inhibits lipid deposition and promotes autophagy in hyperlipidemia.
Jul 31, 2019
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol Pharmacol. 2019 Aug ;70:103205. Epub 2019 Jun 7. PMID:
31195360
Article Published Date
: Jul 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Atherosclerosis
,
Hyperlipidemia
Pharmacological Actions
:
Hypolipidemic
[+]
Indole-3-carbinol inhibits LPS-induced inflammatory response by blocking TRIF-dependent signaling pathway in macrophages.
Jun 30, 2013
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2013 Jul ;57:256-61. Epub 2013 Apr 15. PMID:
23597448
Article Published Date
: Jun 30, 2013
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Indole-3-carbinol inhibits nasopharyngeal carcinoma cell growth.
Jun 30, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2014 Jul ;8(1):207-212. Epub 2014 Apr 25. PMID:
24944623
Article Published Date
: Jun 30, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Nasopharyngeal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
[+]
Indole-3-carbinol inhibits nasopharyngeal carcinoma growth through cell cycle arrest in vivo and in vitro.
Dec 31, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2013 ;8(12):e82288. Epub 2013 Dec 16. PMID:
24358165
Article Published Date
: Dec 31, 2012
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Nasopharyngeal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biochim Biophys Acta. 2015 Jan ;1853(1):244-53. Epub 2014 Oct 25. PMID:
25447674
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Cancers: Drug Resistant
,
Liver Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
MicroRNA modulator
[+]
Indole-3-carbinol is a potent inhibitor of ischemia-reperfusion-induced inflammation.
Jun 30, 2017
Click here to read the entire abstract
Pubmed Data
: J Surg Res. 2017 Jul ;215:34-46. Epub 2017 Mar 31. PMID:
28688659
Article Published Date
: Jun 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Inflammation
,
Ischemia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
NF-kappaB Inhibitor
[+]
Indole-3-carbinol is a powerful treatment to reduce impact of clostridium difficile infection in mice.
Jun 07, 2016
Click here to read the entire abstract
Pubmed Data
: Ann Surg. 2016 Jun 8. Epub 2016 Jun 8. PMID:
27280500
Article Published Date
: Jun 07, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Clostridium Infections
[+]
Indole-3-carbinol prevented ethanol-induced liver injury via attenuating the damaging effect of ethanol on the gut-liver-adipose tissue axis.
Apr 30, 2018
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2018 May ;55:12-25. Epub 2017 Dec 10. PMID:
29331880
Article Published Date
: Apr 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Alcohol Toxicity
,
Chemically-Induced Liver Damage
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Hepatoprotective
[+]
Indole-3-carbinol prevents the loss of the tumor suppressor gene PTEN in cervical cancer in vivo.
Jan 01, 2011
Click here to read the entire abstract
Pubmed Data
: Lipids. 2011 Jan;46(1):37-46. Epub 2010 Nov 2. PMID:
16557333
Article Published Date
: Jan 01, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Cervical Cancer
,
Cervical Dysplasia
[+]
Indole-3-carbinol provides protection against cisplatin-induced nephrotoxicity.
Jul 14, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2016 Jul 15 ;6:29857. Epub 2016 Jul 15. PMID:
27417335
Article Published Date
: Jul 14, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions
:
Chemoprotective Agents
[+]
Indole-3-carbinol supports oral tolerance against OVA and improves peanut allergy symptoms in mice.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2017 ;12(6):e0180321. Epub 2017 Jun 30. PMID:
28666018
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Food Allergies
Pharmacological Actions
:
Anti-Allergic Agents
[+]
Indole-3-carbinol would be effective for enhancing sensitivity of pancreatic cancer cells to gemcitabine.
Mar 31, 2013
Click here to read the entire abstract
Pubmed Data
: Anticancer Res. 2013 Apr ;33(4):1473-81. PMID:
23564788
Article Published Date
: Mar 31, 2013
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Cancers: Drug Resistant
,
Pancreatic Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemosensitizer
Additional Keywords
:
Chemotherapeutic Synergy: Gemcitabine
[+]
Indoles can effectively suppress acute hepatic inflammation caused by Staphylococcal enterotoxin B.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(2):e0118506. Epub 2015 Feb 23. PMID:
25706292
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Liver Damage
,
Staphylococcal Infections
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Apoptotic
,
Hepatoprotective
,
MicroRNA modulator
[+]
Intranasal administration of Indole-3-carbinol liposomes led to a 100-fold higher lung exposure than the oral route of administration.
Dec 29, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Pharm. 2014 Dec 30 ;477(1-2):96-101. Epub 2014 Oct 11. PMID:
25311179
Article Published Date
: Dec 29, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Lung Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
,
Chemotherapeutic
[+]
Involvement of SIRT1-AMPK signaling in the protective action of indole-3-carbinol against hepatic steatosis in mice fed a high-fat diet.
Jun 30, 2013
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2013 Jul ;24(7):1393-400. Epub 2013 Jan 18. PMID:
23337346
Article Published Date
: Jun 30, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
High Fat Diet
,
Liver Steatosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Isothiocyanates exhibit anti-myeloma activity.
Aug 01, 2011
Click here to read the entire abstract
Pubmed Data
: Haematologica. 2011 Aug ;96(8):1170-9. Epub 2011 Jun 28. PMID:
21712538
Article Published Date
: Aug 01, 2011
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Isothiocyanate
,
Sulforaphane
Diseases
:
Multiple Myeloma
Pharmacological Actions
:
Apoptotic
[+]
Linagliptin and indole-3-carbinol combination might represent a beneficial therapeutic modality for amelioration of polycystic ovarian syndrome.
Jul 31, 2017
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2017 Aug 1 ;273:190-199. Epub 2017 Jun 13. PMID:
28619389
Article Published Date
: Jul 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Polycystic Ovary Syndrome
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Heme oxygenase-1 up-regulation
,
Interleukin-10 downregulation
,
Nrf2 activation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Mustard Greens (B. juncea) prevents the development of insulin resistance in rats fed a fructose rich diet.
Mar 01, 2009
Click here to read the entire abstract
Pubmed Data
: Basic Clin Pharmacol Toxicol. 2009 Mar;104(3):262-71. Epub 2009 Jan 20. PMID:
15182915
Article Published Date
: Mar 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Mustard Greens
Diseases
:
Diabetes Mellitus: Type 2
,
Insulin Resistance
Additional Keywords
:
Fructose-Induced Insulin Resistance
[+]
Mustard Greens (B. juncea) protect against oxidative stress in diabetic rats. - Article 1
Apr 01, 2003
Click here to read the entire abstract
Pubmed Data
: J Nutr Sci Vitaminol (Tokyo). 2003 Apr;49(2):87-93. PMID:
12887153
Article Published Date
: Apr 01, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Mustard Greens
Diseases
:
Advanced Glycation End products (AGE)
,
Diabetes: Oxidative Stress
,
Diabetes Mellitus: Type 1
[+]
Mustard leaf has protective effect against gamma-radiation and genotoxic chemicals.
Jun 01, 2008
Click here to read the entire abstract
Pubmed Data
: Environ Mol Mutagen. 2008 Jun;49(5):335-42. PMID:
18418865
Article Published Date
: Jun 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Mustard Greens
Diseases
:
DNA damage
,
Radiation Induced Illness
[+]
Nanocapsules improve indole-3-carbinol photostability and prolong its antinociceptive action in acute pain models.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Eur J Pharm Sci. 2018 Jan 1 ;111:133-141. Epub 2017 Sep 28. PMID:
28966097
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Pain
Pharmacological Actions
:
Antinoceceptive
[+]
Obesity may increase susceptibility to chronic pain often due to poor diet.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Eur J Pain. 2018 08 ;22(7):1203-1213. Epub 2018 Mar 2. PMID:
29436058
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
EGCG (Epigallocatechin gallate)
,
Ginseng
,
Resveratrol
,
Sulforaphane
Diseases
:
Chronic Pain
,
Inflammation
,
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Inflammatory Diet
,
Risk Factors
[+]
Oncogenic c-Myc is a target of sulforaphane to prevent and eliminate the onset of human prostate cancer.
Mar 14, 2016
Click here to read the entire abstract
Pubmed Data
: J Cell Biochem. 2016 Mar 15. Epub 2016 Mar 15. PMID:
26990292
Article Published Date
: Mar 14, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Cancer Stem Cells
[+]
OSU-A9, an indole-3-carbinol derivative, induces cytotoxicity in acute myeloid leukemia.
Nov 14, 2013
Click here to read the entire abstract
Pubmed Data
: Biochem Pharmacol. 2013 Nov 15 ;86(10):1430-40. Epub 2013 Sep 13. PMID:
24041743
Article Published Date
: Nov 14, 2013
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Acute Myeloid Leukemia
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
[+]
Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.
Sep 15, 2005
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 2005 Sep 15;65(18):8548-57. PMID:
16166336
Article Published Date
: Sep 15, 2005
Study Type
: Animal Study
Additional Links
Substances
:
NAC (N-acetyl-L-cysteine)
,
Phenethyl isothiocyanate
,
Sulforaphane
Diseases
:
Lung Cancer
,
Nicotine/Tobacco Toxicity
,
Smoking
Pharmacological Actions
:
Anticarcinogenic Agents
Additional Keywords
:
Isothiocyanates
[+]
Pre-treatment with sulforaphane or thymoquinone can reduce acetylsalicylic acid-induced gastric ulcers.
Jun 14, 2016
Click here to read the entire abstract
Pubmed Data
: J Surg Res. 2016 Jun 15 ;203(2):348-59. Epub 2016 Mar 24. PMID:
27363643
Article Published Date
: Jun 14, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
,
Thymoquinone
Diseases
:
Gastric Ulcer
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Anti-Ulcer Agents
,
Antioxidants
,
Gastroprotective
[+]
Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism.
Apr 12, 2018
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2018 Apr 13. Epub 2018 Apr 13. PMID:
29668854
Article Published Date
: Apr 12, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Chemopreventive
[+]
Protective effects of sulforaphane in experimental vascular cognitive impairment.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: J Cereb Blood Flow Metab. 2018 Jan 1:271678X18764083. Epub 2018 Jan 1. PMID:
29533123
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cognitive Decline/Dysfunction
Pharmacological Actions
:
Neuroprotective Agents
,
Nrf2 activation
[+]
Sufloraphane has a protective effect on preserved pancreas and may have a potential clinical implication to improve hemodynamically unstable pancreas donor condition.
Jan 01, 2004
Click here to read the entire abstract
Pubmed Data
: Ann Transplant. 2004;9(3):68-71. PMID:
15759553
Article Published Date
: Jan 01, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Organ Transplantation: Pancreatic Islet Cells
Pharmacological Actions
:
Antioxidants
[+]
Suforaphane, a compound found within broccoli, inhibits lung metastasis induced by melanoma cells in tumor-bearing animals.
Oct 01, 2006
Click here to read the entire abstract
Pubmed Data
: Breast Cancer Res Treat. 2006 Oct;99(3):333-40. Epub 2006 May 9. PMID:
16600309
Article Published Date
: Oct 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Broccoli
,
Sulforaphane
Diseases
:
Lung Cancer
,
Melanoma
,
Melanoma: Metastatic
Pharmacological Actions
:
Anti-metastatic
[+]
Sulforaphane alone or in combination with other therapies may be potentially useful for glioblastoma therapy.
Jan 05, 2017
Click here to read the entire abstract
Pubmed Data
: J Neurosurg. 2017 Jan 6:1-12. Epub 2017 Jan 6. PMID:
28059653
Article Published Date
: Jan 05, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Glioblastoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
Additional Keywords
:
Antiproliferative
,
Apoptotic
,
Cancer Stem Cells
,
glioblastoma (GBM)
,
Sulforaphane
[+]
Sulforaphane ameliorates autism-like symptoms through suppression of Th17 related signalling and rectification of oxidant-antioxidant imbalance.
Feb 18, 2019
Click here to read the entire abstract
Pubmed Data
: Behav Brain Res. 2019 Feb 19 ;364:213-224. Epub 2019 Feb 19. PMID:
30790585
Article Published Date
: Feb 18, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Autism
Pharmacological Actions
:
Antioxidants
,
Immunomodulatory: Th17 downregulation
,
Nrf2 activation
[+]
Sulforaphane ameliorates okadaic acid induced memory impairment in rats by activating the Nrf2/HO-1 antioxidant pathway.
Oct 02, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Neurobiol. 2015 Oct 3. Epub 2015 Oct 3. PMID:
26433376
Article Published Date
: Oct 02, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Brain Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
,
Nrf2 activation
[+]
Sulforaphane ameliorates some features of clinical diabetic complications particularly the lipid profile and insulin responsiveness.
Apr 19, 2016
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2016 Apr 20 ;7(4):2060-5. PMID:
27025193
Article Published Date
: Apr 19, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Diabetic Complications
,
Insulin Resistance
Pharmacological Actions
:
Hypolipidemic
[+]
Sulforaphane and curcumin protect against malathion toxicity.
Jun 30, 2012
Click here to read the entire abstract
Pubmed Data
: Eur Rev Med Pharmacol Sci. 2012 Jul ;16 Suppl 3:144-8. PMID:
22957429
Article Published Date
: Jun 30, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Sulforaphane
Diseases
:
Malathion Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Sulforaphane and dibenzoylmethane alone as well as their combination are potent natural dietary compounds for chemoprevention of gastrointestinal cancers.
Oct 15, 2007
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 2007 Oct 15;67(20):9937-44. PMID:
17942926
Article Published Date
: Oct 15, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Dibenzoylmethane (DBM)
,
Sulforaphane
Diseases
:
Adenomatous Polyposis Coli
,
Gastrointestinal Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Apoptotic
,
Chemopreventive
[+]
Sulforaphane and NAC (N-acetyl-L-cysteine) upregulate T(H)1 immunity in aging.
May 01, 2008
Click here to read the entire abstract
Pubmed Data
: J Allergy Clin Immunol. 2008 May;121(5):1255-1261.e7. Epub 2008 Mar 5. PMID:
18325578
Article Published Date
: May 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
NAC (N-acetyl-L-cysteine)
,
Sulforaphane
Diseases
:
Aging
,
Immune Disorders: Low Immune Function
,
Immune Dysregulation: TH1/TH2 imbalance
,
Low Disorders: Low TH1
Pharmacological Actions
:
Antioxidants
,
Immunomodulatory
[+]
Sulforaphane and vitamin E could ameliorate cognitive decline and oxidative damage in pups with lead exposure at lactation from maternal milk.
Nov 30, 2017
Click here to read the entire abstract
Pubmed Data
: J Trace Elem Med Biol. 2017 Dec ;44:88-92. Epub 2017 Jun 15. PMID:
28965607
Article Published Date
: Nov 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
,
Vitamin E
Diseases
:
Cognitive Decline/Dysfunction
,
Lead Poisoning
Pharmacological Actions
:
Neuroprotective Agents
Problem Substances
:
Lead
[+]
Sulforaphane attenuates postnatal proteasome inhibition and improves spatial learning in adult mice.
Oct 03, 2017
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2017 Oct 4 ;51:69-79. Epub 2017 Oct 4. PMID:
29096318
Article Published Date
: Oct 03, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Pharmacological Actions
:
Neuroprotective Agents
[+]
Sulforaphane contributes to the protection of gastrointestinal mucosa against oxidative injury induced by H. pylori or NSAIDs.
Feb 05, 2017
Click here to read the entire abstract
Pubmed Data
: Curr Pharm Des. 2017 Feb 6. Epub 2017 Feb 6. PMID:
28176666
Article Published Date
: Feb 05, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Aspirin-Induced Toxicity
,
Drug-Induced Toxicity: Indomethacin
,
Helicobacter Pylori Infection
,
NSAID-induced toxicity
Pharmacological Actions
:
Antioxidants
Problem Substances
:
Aspirin
,
Indomethacin
,
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]
Sulforaphane could inhibit inflammation in human umbilical vein ECs exposed to advanced glycation end products.
Apr 20, 2016
Click here to read the entire abstract
Pubmed Data
: Nutr Metab Cardiovasc Dis. 2016 Apr 21. Epub 2016 Apr 21. PMID:
27212619
Article Published Date
: Apr 20, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Advanced Glycation End products (AGE)
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Sulforaphane could prevent the memory impairment and apoptosis of hippocampal neurons in diabetic rat.
Aug 08, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Physiol Biochem. 2016 Aug 9 ;39(3):901-907. Epub 2016 Aug 9. PMID:
27497670
Article Published Date
: Aug 08, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Diabetes: Memory Problems
,
Diabetic Complications
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Sulforaphane elicits antioxidant, anti-inflammatory, and extracellular matrix remodelling effects in a rat model of diabetic peripheral neuropathy.
Aug 01, 2018
Click here to read the entire abstract
Pubmed Data
: Inflammation. 2018 Aug ;41(4):1460-1476. PMID:
29704151
Article Published Date
: Aug 01, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Interleukin-10 upregulation
,
Malonaldehyde (MDA) Down-Regulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Neuroprotective Agents
,
NF-kappaB Inhibitor
,
Nitric Oxide Inhibitor
,
Superoxide Dismutase Up-regulation
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Isothiocyanates
[+]
Sulforaphane elicits insulin-sensitizing, hepatoprotective, and vasculoprotective effects comparable to that of pioglitazone in insulin-resistant rats.
Feb 01, 2019
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol Pharmacol. 2019 Feb ;66:43-54. Epub 2018 Dec 13. PMID:
30597379
Article Published Date
: Feb 01, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
C-Reactive Protein
,
Diabetes Mellitus: Type 2
,
Dyslipidemias
,
Fatty Liver
,
Insulin Resistance
Pharmacological Actions
:
Hepatoprotective
,
Hypoglycemic Agents
,
Insulin Sensitizers
Additional Keywords
:
Isothiocyanates
Problem Substances
:
Fructose
[+]
Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury.
Nov 15, 2005
Click here to read the entire abstract
Pubmed Data
: J Neurosci Res. 2005 Nov 15;82(4):499-506. PMID:
16211562
Article Published Date
: Nov 15, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Brain Edema
,
Traumatic Brain Injury
[+]
Sulforaphane enhances leptin sensitivity and prevents weigh gain in diet-induced obese mice.
Sep 15, 2018
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2018 Sep 15 ;835:108-114. Epub 2018 Jul 29. PMID:
30063917
Article Published Date
: Sep 15, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Obesity
Additional Keywords
:
Body Mass Index (BMI)
,
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Isothiocyanates
,
leptin
[+]
Sulforaphane enhances lipid metabolism through improved mitochondrial function by Nrf-2 and PGC-1a-dependent mechanisms.
Jan 01, 2019
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2019 02 ;63(4):e1800795. Epub 2019 Jan 11. PMID:
30578708
Article Published Date
: Jan 01, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Mitochondrial Dysfunction
Pharmacological Actions
:
Lipolytic
,
Nrf2 activation
,
Peroxisome Proliferators
Additional Keywords
:
Mitochondria
,
mitochondria dysfunction
,
Mitochondrial Biogenesis
[+]
Sulforaphane enhances the anticancer activity of a chemo-agent against pancreatic cancer.
Aug 29, 2011
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2011 Aug 29. Epub 2011 Aug 29. PMID:
21875325
Article Published Date
: Aug 29, 2011
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Broccoli
,
Sprouts
,
Sulforaphane
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Chemosensitizer
Additional Keywords
:
Drug Synergy
[+]
Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis.
Nov 01, 2008
Click here to read the entire abstract
Pubmed Data
: Clin Cancer Res. 2008 Nov 1;14(21):6855-66. PMID:
18980980
Article Published Date
: Nov 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
Additional Keywords
:
Drug-Plant-Vitamin Synergies
[+]
Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma.
Oct 03, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2017 Oct 4 ;7(1):12651. Epub 2017 Oct 4. PMID:
28978924
Article Published Date
: Oct 03, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Liver Cancer
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Chemopreventive
,
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Sulforaphane exhibits antiproliferative, apoptotic, anti-inflammatory, and anti-angiogenic properties and ameliorates a rat model of endometriosis.
Apr 01, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Dose Response. 2019 Apr-Jun;17(2):1559325819855538. Epub 2019 Jun 11. PMID:
31217757
Article Published Date
: Apr 01, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Endometriosis
Pharmacological Actions
:
Anti-Angiogenic
,
Anti Inflammatory
,
Antiproliferative
,
Apoptotic
,
Interferon Gamma Reducer
,
Interleukin-10 downregulation
,
PI3K-AKT inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
Additional Keywords
:
Cytokines
,
Inflammation
,
Interleukin-6 Downregulation
,
women's health
[+]
Sulforaphane exhibits chemopreventive properties against intestinal polyps in mice.
Dec 01, 2006
Click here to read the entire abstract
Pubmed Data
: Biopharm Drug Dispos. 2006 Dec;27(9):407-20. PMID:
16952200
Article Published Date
: Dec 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Adenomatous Polyposis Coli
,
Intestinal Polyps
Pharmacological Actions
:
Anticarcinogenic Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Sulforaphane has anticonvulsant properties and could improve mitochondrial function.
Sep 13, 2015
Click here to read the entire abstract
Pubmed Data
: J Neurochem. 2015 Sep 14. Epub 2015 Sep 14. PMID:
26365487
Article Published Date
: Sep 13, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Seizures
Pharmacological Actions
:
Anticonvulsants
,
Antioxidants
,
Nrf2 activation
[+]
Sulforaphane has antidepressant and anxiolytic like activities in stressed mice model of depression.
Dec 21, 2015
Click here to read the entire abstract
Pubmed Data
: Behav Brain Res. 2015 Dec 22 ;301:55-62. Epub 2015 Dec 22. PMID:
26721468
Article Published Date
: Dec 21, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Anxiety Disorders
,
Depression
Pharmacological Actions
:
Anti-Anxiety Agents
,
Anti-Inflammatory Agents
,
Antidepressive Agents
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Sulforaphane has both anti-nociceptive and anti-inflammatory actions.
Jan 31, 2017
Click here to read the entire abstract
Pubmed Data
: Inflammopharmacology. 2017 Feb ;25(1):99-106. Epub 2017 Jan 4. PMID:
28054242
Article Published Date
: Jan 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Neuropathic Pain
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antinoceceptive
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Dose Response
[+]
Sulforaphane has immunomodulatory properties.
Aug 01, 2007
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2007 Aug;14(7-8):538-45. Epub 2006 Nov 3. PMID:
17084602
Article Published Date
: Aug 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Immune Disorders: Low Immune Function
Pharmacological Actions
:
Immunomodulatory
[+]
Sulforaphane has potential as a therapeutic agent to protect T2DM patients from cognitive deficiencies.
Apr 19, 2018
Click here to read the entire abstract
Pubmed Data
: Neuroscience. 2018 Apr 20. Epub 2018 Apr 20. PMID:
29684505
Article Published Date
: Apr 19, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Diabetes: Cognitive Dysfunction
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
,
Nrf2 activation
[+]
Sulforaphane has preventive action in oxidative stress-mediated liver injury associated with acetaminophen (APAP)-induced toxicity.
May 31, 2015
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2015 Jun ;80:193-200. Epub 2015 Mar 25. PMID:
25818464
Article Published Date
: May 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Acetaminophen (Tylenol) Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
Problem Substances
:
Acetaminophen
,
Paracetamol
[+]
Sulforaphane has significant protective effects against oxidative stress and could ameliorate bladder dysfunction.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2016 ;2016:7598294. Epub 2016 Jun 28. PMID:
27433291
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Bladder Dysfunction
,
Bladder Outlet Obstruction
Pharmacological Actions
:
Antioxidants
,
Nrf2 activation
[+]
Sulforaphane has the potential to prevent neuronal disorders by enhancing Brain-derived Neurotrophic Factor (BDNF) and its TrkB signaling pathways.
Jan 01, 2017
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2017 02 ;61(2). Epub 2016 Nov 30. PMID:
27735126
Article Published Date
: Jan 01, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Neurodegenerative Diseases
Pharmacological Actions
:
Brain-derived neurotrophic factor modulator
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Epigenetic Modification
,
Isothiocyanates
[+]
Sulforaphane improved cardiac function and remodelling by inhibiting oxidative stress and inflammation.
Mar 11, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Med Sci Monit. 2018 Mar 12 ;24:1473-1483. Epub 2018 Mar 12. PMID:
29527002
Article Published Date
: Mar 11, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Heart Failure
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cardioprotective
[+]
Sulforaphane improved islet function in vivo, indicating that combination of a free radical scavenger and an antioxidant (sulforaphane) may be used to increase the effectiveness of islet transplantation.
Feb 01, 2010
Click here to read the entire abstract
Pubmed Data
: Muscle Nerve. 2010 Feb;41(2):185-90. PMID:
16504726
Article Published Date
: Feb 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Organ Transplantation
,
Organ Transplantation: Pancreatic Islet Cells
Pharmacological Actions
:
Anticarcinogenic Agents
[+]
Sulforaphane improves cognitive function administered following traumatic brain injury.
Aug 28, 2009
Click here to read the entire abstract
Pubmed Data
: Neurosci Lett. 2009 Aug 28;460(2):103-7. Epub 2009 Apr 15. PMID:
19515491
Article Published Date
: Aug 28, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Blood-Brain-Barrier Disorders
,
Brain Damage
,
Brain Injury: Traumatic
,
Cognitive Decline/Dysfunction
Pharmacological Actions
:
Anticarcinogenic Agents
,
Neuroprotective Agents
[+]
Sulforaphane improves LPS-induced spatial learning and memory dysfunction, likely by upregulating neurogenesis through the BDNF-mTOR pathway.
Jan 15, 2018
Click here to read the entire abstract
Pubmed Data
: Neuroscience. 2018 09 15 ;388:357-366. Epub 2018 Aug 4. PMID:
30086367
Article Published Date
: Jan 15, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
,
Memory Disorders
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neurogenesis
Additional Keywords
:
Brain-derived neurotrophic factor modulator
,
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Isothiocyanates
[+]
Sulforaphane improves neuronal mitochondrial function in brain tissue in acute carbon monoxide poisoning.
Dec 15, 2016
Click here to read the entire abstract
Pubmed Data
: Basic Clin Pharmacol Toxicol. 2016 Dec 16. Epub 2016 Dec 16. PMID:
27983767
Article Published Date
: Dec 15, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Carbon Monoxide Poisoning
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
,
Nrf2 activation
[+]
Sulforaphane improves outcomes and slows cerebral ischemic/reperfusion injury
Feb 08, 2017
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2017 Feb 9 ;45:74-78. Epub 2017 Feb 9. PMID:
28189971
Article Published Date
: Feb 08, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cerebral Ischemia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-18 down-regulation
,
Interleukin-1 beta downregulation
[+]
Sulforaphane increases cell-mediated immune response in melanoma-induced metastatic tumor-bearing mice.
Apr 01, 2010
Click here to read the entire abstract
Pubmed Data
: J Clin Invest. 2010 Apr 1;120(4):1043-55. Epub 2010 Mar 24. PMID:
17849266
Article Published Date
: Apr 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cancer Metastasis
,
Melanoma
Pharmacological Actions
:
Anti-metastatic
,
Anticarcinogenic Agents
,
Interleukin-1 beta downregulation
,
Interleukin-2 upregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Sulforaphane increases the effectiveness of various cytotoxic drugs against pancreatic cancer stem cells without inducing additional toxicity in mice.
Jun 01, 2004
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2004 Summer;7(2):157-61. PMID:
20940707
Article Published Date
: Jun 01, 2004
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cancers: Multi-Drug Resistant
,
Pancreatic Cancer
Pharmacological Actions
:
Chemosensitizer
Additional Keywords
:
Drug-Plant-Vitamin Synergies
[+]
Sulforaphane induced Nrf2 can alleviate muscle inflammation in mdx mice by inhibiting NF-κB signaling pathway.
May 25, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Biol Chem. 2015 May 26. Epub 2015 May 26. PMID:
26013831
Article Published Date
: May 25, 2015
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Duchenne's Muscular Dystrophy
,
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Nrf2 activation
[+]
Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo.
Nov 01, 2007
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2007 Nov;18(5):1263-8. PMID:
17914583
Article Published Date
: Nov 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Osteosarcoma
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Sulforaphane induces cell cycle arrest and programmed cell death in human lung cancer cells and retards growth of human lung cancer tumors in a xenograft animal model.
Oct 15, 2008
Click here to read the entire abstract
Pubmed Data
: J Nat Prod. 2008 Oct 15. Epub 2008 Oct 15. PMID:
18855447
Article Published Date
: Oct 15, 2008
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Lung Cancer
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
[+]
Sulforaphane induces cell death in primary human colorectal cancer.
Jan 01, 2012
Click here to read the entire abstract
Pubmed Data
: Evid Based Complement Alternat Med. 2012 ;2012:415231. Epub 2011 Jul 17. PMID:
21804859
Article Published Date
: Jan 01, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Apoptotic
[+]
Sulforaphane induces miR135b-5p and its target gene to inhibit the progression of pancreatic cancer.
Sep 26, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Ther Oncolytics. 2019 Sep 27 ;14:74-81. Epub 2019 Apr 6. PMID:
31044154
Article Published Date
: Sep 26, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Antiproliferative
,
MicroRNA modulator
[+]
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors.
May 28, 2002
Click here to read the entire abstract
Pubmed Data
: Proc Natl Acad Sci U S A. 2002 May 28;99(11):7610-5. PMID:
12032331
Article Published Date
: May 28, 2002
Study Type
: Animal Study
Additional Links
Substances
:
Broccoli
,
Sulforaphane
Diseases
:
Gastric Cancer
,
Helicobacter Pylori Infection
Additional Keywords
:
Multi-Drug Resistant Pathogens
[+]
Sulforaphane inhibits multiple inflammasomes through a novel mechanism and contributes to our understanding of the beneficial effects of sulforaphane.
Aug 11, 2015
Click here to read the entire abstract
Pubmed Data
: J Leukoc Biol. 2015 Aug 12. Epub 2015 Aug 12. PMID:
26269198
Article Published Date
: Aug 11, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Gout
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
[+]
Sulforaphane inhibits oral cancer cell growth in vitro and in an animal model.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: J Clin Biochem Nutr. 2010 Jan;46(1):60-7. Epub 2009 Dec 29. PMID:
20104266
Article Published Date
: Jan 01, 2010
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Oral Cancer
Pharmacological Actions
:
Cell cycle arrest
[+]
Sulforaphane inhibits pancreatic cancer proliferation through AMPK activation and Nrf2 translocation in vitro and in vivo.
Jan 01, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Physiol Biochem. 2018 ;50(3):1201-1215. Epub 2018 Oct 24. PMID:
30355942
Article Published Date
: Jan 01, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Anti-Tumor
,
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Nrf2 activation
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Isothiocyanates
[+]
Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in association with increased cytotoxicity of natural killer cells.
Mar 01, 2009
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 2009 Mar 1;69(5):2117-25. Epub 2009 Feb 17. PMID:
19223537
Article Published Date
: Mar 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cancer Metastasis
,
Low Immune Function: Natural Killer Cells
,
Lung Cancer
,
Prostate Cancer
Pharmacological Actions
:
Anti-Angiogenic
,
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
[+]
Sulforaphane inhibits respiratory syncytial virus replication and virus-induced inflammation in the lungs of mice.
Jan 15, 2009
Click here to read the entire abstract
Pubmed Data
: Am J Respir Crit Care Med. 2009 Jan 15;179(2):138-50. Epub 2008 Oct 17. PMID:
18931336
Article Published Date
: Jan 15, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Oxidative Stress
,
Respiratory Syncytial Virus Infections
,
Respiratory Tract Infections
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Antiviral Agents
[+]
Sulforaphane inhibits the acquisition of tobacco smoke-induced lung cancer stem cell-like properties.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Theranostics. 2019 ;9(16):4827-4840. Epub 2019 Jul 9. PMID:
31367260
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Lung Cancer
,
Nicotine/Tobacco Toxicity
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Cancer Stem Cells
[+]
Sulforaphane inhibits vestibular schwannoma growth in vitro and in vivo.
Nov 01, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2016 Nov 2 ;6:36215. Epub 2016 Aug 2. PMID:
27805058
Article Published Date
: Nov 01, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Schwannoma: Vestibular
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Sulforaphane is a novel inhibitory modulator of EGFR expression and is effective in inhibiting the tumor growth of EGFR-TKI-resistant NSCLC cells.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Biomed Sci. 2015 ;22:38. Epub 2015 Jun 3. PMID:
26036303
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Carcinoma: Non-Small-Cell Lung
Pharmacological Actions
:
Antiproliferative
,
Chemotherapeutic
,
Epidermal growth factor receptor (EGFR) inhibitor
[+]
Sulforaphane is a promising agent to restore glucose tolerance through upregulation of insulin signaling in obese mice.
Sep 19, 2018
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2018 Sep 19 ;9(9):4695-4701. PMID:
30091431
Article Published Date
: Sep 19, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Insulin Resistance
Pharmacological Actions
:
Glucose Uptake Optimization
,
Insulin Sensitizers
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Isothiocyanates
Problem Substances
:
Insulin
[+]
Sulforaphane is a protective agent against acetaminophen-induced liver damage.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Bratisl Lek Listy. 2017 ;118(8):453-459. PMID:
29050482
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Acetaminophen (Tylenol) Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Hepatoprotective
Problem Substances
:
Acetaminophen
,
Paracetamol
[+]
Sulforaphane may attenuate aflatoxin-induced liver carcinogenesis.
May 01, 2011
Click here to read the entire abstract
Pubmed Data
: Toxicol Sci. 2011 May ;121(1):57-62. Epub 2011 Jan 28. PMID:
21278056
Article Published Date
: May 01, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Aflatoxicosis
,
Liver Cancer
,
Liver Damage: Aflatoxin-Induced
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
Problem Substances
:
Aflatoxin
[+]
Sulforaphane may be a potential a candidate for use in the treatment of acute lung injury.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2016 Jan ;37(1):182-8. Epub 2015 Oct 27. PMID:
26531002
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-E2-Related Factor-2 (Nrf2) Modulator
,
Prostaglandin PGE2 downregulation
[+]
Sulforaphane may be a potential compound that can inhibit Aβ oligomer production in Alzheimer's disease.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: J Alzheimers Dis. 2018 ;62(4):1803-1813. PMID:
29614663
Article Published Date
: Dec 31, 2017
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Sulforaphane may have therapeutic value in the treatment of rheumatoid arthritis.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: Arthritis Rheum. 2010 Jan;62(1):159-70. PMID:
20039434
Article Published Date
: Jan 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Apoptotic
,
Interleukin-17 downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Sulforaphane may modulate serotonin levels.
Jul 01, 2008
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 2008 Jul 1;68(13):5487-91. PMID:
18593952
Article Published Date
: Jul 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Colon Cancer
,
Serotonin Disorders
Pharmacological Actions
:
Serotonergic
[+]
Sulforaphane might be a promising therapeutic agent for cognitive enhancement in Alzheimer's disease.
Jun 01, 2016
Click here to read the entire abstract
Pubmed Data
: Neurochem Res. 2016 Jun 2. Epub 2016 Jun 2. PMID:
27255600
Article Published Date
: Jun 01, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Alzheimer's Disease
,
Cognitive Decline/Dysfunction
Pharmacological Actions
:
Neuroprotective Agents
[+]
Sulforaphane might emerge as a novel strategy to protect the bladder against ischemia-induced oxidative damage.
Nov 07, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2016 Nov 8 ;6:36110. Epub 2016 Aug 8. PMID:
27824068
Article Published Date
: Nov 07, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Autophagy Inhibitors
[+]
Sulforaphane normalizes the kidney epigenome and improves blood pressure in hypertensive rats.
Nov 03, 2011
Click here to read the entire abstract
Pubmed Data
: Am J Hypertens. 2011 Nov 3. Epub 2011 Nov 3. PMID:
22052072
Article Published Date
: Nov 03, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Hypertension
,
Kidney Diseases
Pharmacological Actions
:
Hypotensive
Additional Keywords
:
Epigenetic Modification
[+]
Sulforaphane offers protection against angiotensin II induced testicular injury.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2017 ;2017:5374897. Epub 2017 Jan 16. PMID:
28191275
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Testicular Injury: Chemical/Metal Induced
Pharmacological Actions
:
Antioxidants
,
Cytoprotective
,
Nrf2 activation
[+]
Sulforaphane potently induces phase 2 enzymes in bladder tissues and should be investigated as a bladder cancer preventive agent.
Jan 01, 2006
Click here to read the entire abstract
Pubmed Data
: BMC Cancer. 2006;6:62. Epub 2006 Mar 15. PMID:
16539699
Article Published Date
: Jan 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Phase II Detoxification Enzyme Inducer
[+]
Sulforaphane prevents and/or retards adenoma formation in the gastrointestinal tract of mice.
Oct 01, 2006
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2006 Oct;27(10):2038-46. Epub 2006 May 4. PMID:
16675473
Article Published Date
: Oct 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Adenomatous Polyposis Coli
,
Colorectal Cancer
,
Intestinal Polyps
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Chemopreventive
[+]
Sulforaphane prevents cell death and inflammation in nephropathy.
Jun 16, 2011
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2011 Jun 16. Epub 2011 Jun 16. PMID:
21684138
Article Published Date
: Jun 16, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
,
Nephropathy
Pharmacological Actions
:
Renoprotective
Problem Substances
:
Cisplatin
Adverse Pharmacological Actions
:
Nephrotoxic
[+]
Sulforaphane prevents chemically-induced skin cancer in mice.
Aug 15, 2006
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 2006 Aug 15;66(16):8293-6. PMID:
16912211
Article Published Date
: Aug 15, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Skin Cancer
,
Skin Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
[+]
Sulforaphane prevents methylmercury-induced oxidative damage and excitotoxicity.
Jan 06, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Neurobiol. 2016 Jan 7. Epub 2016 Jan 7. PMID:
26742517
Article Published Date
: Jan 06, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Mercury Poisoning
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Cytoprotective
,
Nrf2 activation
[+]
Sulforaphane prevents retinal ganglion cell death and acts as a potent neuroprotective modulator in retinal ischemia/reperfusion injury.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419861777. PMID:
31266422
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Ischemia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
[+]
Sulforaphane protects against benzo(a)pyrene induced toxicity.
Sep 15, 2010
Click here to read the entire abstract
Pubmed Data
: Pulm Pharmacol Ther. 2010 Sep 15. Epub 2010 Sep 15. PMID:
20833254
Article Published Date
: Sep 15, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Benzo[a]pyrene-induced Toxicity
Pharmacological Actions
:
Antioxidants
[+]
Sulforaphane protects against cadmium-induced testicular injury by activation of Nrf2-ARE pathway.
Jul 19, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2018 Jul 19 ;23(7). Epub 2018 Jul 19. PMID:
30029485
Article Published Date
: Jul 19, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Heavy Metal Toxicity
,
Oxidative Stress
,
Testicular Injury: Cadmium-Induced
Pharmacological Actions
:
Antioxidants
,
Apoptotic
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Isothiocyanates
[+]
Sulforaphane protects against cisplatin-induced liver and mitochondrial damage.
Aug 15, 2011
Click here to read the entire abstract
Pubmed Data
: Toxicology. 2011 Aug 15 ;286(1-3):20-7. Epub 2011 May 6. PMID:
21575670
Article Published Date
: Aug 15, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Chemically-Induced Liver Damage
,
Chemotherapy-Induced Toxicity: Cisplatin
,
Oxidative Stress
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antineoplastic Agents
,
Antioxidants
Problem Substances
:
Cisplatin
Adverse Pharmacological Actions
:
Hepatotoxic
[+]
Sulforaphane protects against cisplatin-induced nephrotoxicity.
Aug 01, 2007
Click here to read the entire abstract
Pubmed Data
: Int J Sport Nutr Exerc Metab. 2007 Aug;17(4):352-63. PMID:
19913604
Article Published Date
: Aug 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Chemotherapy-Induced Toxicity
,
Chemotherapy-Induced Toxicity: Cisplatin
,
Oxidative Stress
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antineoplastic Agents
,
Apoptotic
,
Renoprotective
[+]
Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway.
Feb 15, 2009
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2009 Feb 15;235(1):57-67. Epub 2008 Nov 21. PMID:
19071154
Article Published Date
: Feb 15, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Diabetes Mellitus: Type 1
,
Diabetes Mellitus: Type 1: Prevention
Pharmacological Actions
:
Apoptotic
,
NF-kappaB Inhibitor
Additional Keywords
:
Beta Cell Protection
,
Beta Cell Regeneration
[+]
Sulforaphane protects against hypoxic-ischemic injury.
Jul 09, 2010
Click here to read the entire abstract
Pubmed Data
: Brain Res. 2010 Jul 9;1343:178-85. Epub 2010 Apr 24. PMID:
20417626
Article Published Date
: Jul 09, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cerebral Ischemia
,
Hypoxia
,
Stroke
Pharmacological Actions
:
Neuroprotective Agents
[+]
Sulforaphane protects against intermittent hypoxia-induced cardiomyopathy through Nrf2 activation.
Jan 10, 2018
Click here to read the entire abstract
Pubmed Data
: Redox Biol. 2018 10 ;19:11-21. Epub 2018 Jul 21. PMID:
30096613
Article Published Date
: Jan 10, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cardiomyopathy
,
Hypoxia
Pharmacological Actions
:
Antioxidant Effects
,
Metallothionein Up-regulation
,
Nrf2 activation
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Isothiocyanates
[+]
Sulforaphane protects ischemic injury of hearts.
Aug 11, 2008
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2008 Aug 11. PMID:
19948220
Article Published Date
: Aug 11, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Myocardial Infarction
,
Myocardial Ischemia
Pharmacological Actions
:
Antioxidants
[+]
Sulforaphane protects liver injury induced by intestinal ischemia in an animal model.
Jun 28, 2010
Click here to read the entire abstract
Pubmed Data
: World J Gastroenterol. 2010 Jun 28;16(24):3002-10. PMID:
20572303
Article Published Date
: Jun 28, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Intestinal Diseases
,
Liver Disease
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antioxidants
[+]
Sulforaphane protects the male reproductive system of mice from obesity-induced damage.
Oct 06, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Environ Res Public Health. 2019 Oct 7 ;16(19). Epub 2019 Oct 7. PMID:
31591291
Article Published Date
: Oct 06, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Hypogonadism
,
Obesity
Pharmacological Actions
:
Antioxidants
,
Malondialdehyde Down-regulation
,
Nrf2 activation
[+]
Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents.
Jan 30, 2006
Click here to read the entire abstract
Pubmed Data
: Neurosci Lett. 2006 Jan 30;393(2-3):108-12. Epub 2005 Oct 17. PMID:
16233958
Article Published Date
: Jan 30, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Cerebral Ischemia
,
Stroke: Recovery
Pharmacological Actions
:
Neuroprotective Agents
[+]
Sulforaphane reduces inflammation following spinal cord injury in mice.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: Ann Clin Lab Sci. 2010;40(4):354-60. PMID:
20947810
Article Published Date
: Jan 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Spinal Cord Injuries
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Sulforaphane reduces the apoptosis of neurons in brain trauma-induced diffuse axonal injury.
Jun 23, 2019
Click here to read the entire abstract
Pubmed Data
: J Cell Biochem. 2019 Jun 24. Epub 2019 Jun 24. PMID:
31232487
Article Published Date
: Jun 23, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Brain Damage
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
,
Nrf2 activation
[+]
Sulforaphane significantly decreased leptin-induced vascular smooth muscle cell proliferation.
Mar 09, 2016
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2016 Mar 10 ;32:73-84. Epub 2016 Mar 10. PMID:
27142739
Article Published Date
: Mar 09, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Atherosclerosis
,
Obesity
Pharmacological Actions
:
Leptin Down-Regulation
Anti Therapeutic Actions
:
Western Diet
[+]
Sulforaphane supplementation normalize endothelial dysfunction associated with type 2 diabetes.
