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Cannabinoids
Views 6346
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Abstracts
Focused Research Topics
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Click any topic below to filter + focus research
267 Diseases Researched for Cannabinoids
Name
AC
CK
Focus
Multiple Sclerosis
40
197
Epilepsy
34
158
Inflammation
40
75
Neuropathic Pain
12
75
Cancers: All
36
55
Epilepsy: Childhood
6
53
Inflammatory Bowel Diseases
13
46
Anxiety
12
43
Seizures
8
42
Stroke
2
40
Stroke: Attenuation/Recovery
6
39
Pain
6
35
Dravet syndrome
5
33
Anxiety Disorders
8
29
Chronic Pain
8
27
Huntington Disease
10
27
Glioma
16
26
Morphine Tolerance/Dependence
4
26
Neurodegenerative Diseases
19
26
Tourette Syndrome
4
26
Breast Cancer
16
25
Diabetes Mellitus: Type 2
4
25
Parkinson's Disease
11
25
Amyotrophic lateral sclerosis (ALS)
4
24
Brain Inflammation
16
23
Schizophrenia
10
23
Alzheimer's Disease
17
22
Depression
11
22
Muscle Spasticity
3
22
Autism Spectrum Disorders
3
21
Marijuana Addiction/Withdrawal
3
21
Acne
2
20
Hypoglycemia
1
20
Opioid Tolerance/Dependence
1
20
Post-Traumatic Stress Disorders (PTSD)
8
20
Glioblastoma Multiforme
7
19
Stroke: Ischemic
4
19
Memory Disorders
5
18
Oxidative Stress
11
18
Sleep Disorders
4
17
Hyperalgesia
6
16
Lung Cancer
11
16
Nonalcoholic fatty liver disease (NAFLD)
3
16
Brain Ischemia
7
15
Colitis
7
15
Dry Skin
1
15
Ulcerative Colitis
2
15
Brain Cancer
3
14
HIV Infections
4
14
Lipopolysaccharide-Induced Toxicity
9
14
Spinal Cord Injuries
3
14
Brain Damage: Hypoxic Ischemic Insult
6
13
Brain: Microglial Activation
6
13
Glioblastoma
7
13
Insomnia
2
13
Obsessive-Compulsive Disorder
3
13
Psychoses
4
13
Bladder Dysfunction
2
12
Cancer Metastasis
9
12
Epileptic Seizures
2
12
Hypertension
2
12
Amyotrophic Lateral Sclerosis
7
11
Colon Cancer
7
11
Endocannabinoid Disorders
2
11
Lennox-Gastaut Syndrome
2
11
Astrocytoma
4
10
Attention Deficit Hyperactivity Disorder
1
10
Brachial Plexus Neuropathies
1
10
Delirium: Drug-Induced
1
10
Impairment: Driving Related
1
10
Organ Transplantation: Kidney
1
10
Overactive Bladder
1
10
Pancreatitis: Chronic
1
10
Peripheral Nerve Diseases
1
10
Prostate Cancer
8
10
Quality of Life: Poor
1
10
Social Anxiety Disorder (SAD)
1
10
Sturge-Weber Syndrome
1
10
Tuberous Sclerosis
1
10
Vaccine-induced Toxicity
1
10
Cerebral Ischemia
4
9
Chemotherapy-Induced Toxicity: Cisplatin
4
9
Allodynia
4
8
Breast Cancer: Triple Negative
6
8
Cardiovascular Diseases
3
8
Obesity
4
8
Skin Cancer
5
8
Traumatic Memory Formation
4
8
Dementia
4
7
Endocannabinoid System
7
7
Glaucoma
4
7
Lymphoma
3
7
Melanoma
4
7
Middle Cerebral Artery Occlusion (MCAO)
4
7
Colorectal Cancer
4
6
Myocardial Infarction
3
6
Alcoholic Liver Disease
1
5
Asthma
3
5
Diabetes Mellitus: Type 1: Prevention
3
5
Diabetic Complications
3
5
Drug Abuse
3
5
Gastrointestinal Inflammation
2
5
Psychiatric Disorder: Conditioned Fear
3
5
Psychiatric Disorders
4
5
Acute Myeloid Leukemia
2
4
Bladder Cancer
3
4
Brain Damage
3
4
Brain: Oxidative Stress
2
4
Cachexia
3
4
Cancer: Pain
3
4
Chemotherapy-Induced Toxicity: Doxorubicin
2
4
Colon Cancer: Prevention
2
4
Diabetes Mellitus: Type 1
2
4
Diabetes: Cataract
2
4
Diabetic Neuropathies
1
4
Emesis
1
4
Endotoxemia
2
4
Eye Damage
1
4
Iron Overload
2
4
Liver Cancer
3
4
Metabolic Syndrome X
1
4
Myocardial Ischemia
2
4
Osteoarthritis
3
4
Pancreatic Cancer
4
4
Vomiting
1
4
Aging
2
3
Alcohol Toxicity
2
3
Arthritis
2
3
Astrocytoma: Grade IV
1
3
Autism
2
3
Autoimmune Diseases
2
3
Chemotherapy and Radiation Toxicity
2
3
Chemotherapy-Induced Nausea
3
3
Drug Addiction
2
3
Encephalomyelitis
2
3
Epidermolysis Bullosa
1
3
Epilepsy: Infant
1
3
Epilepsy: Malignant Migrating Partial Seizures
1
3
Febrile Seizures
1
3
Fibrosis
2
3
Gliomas
2
3
Neuroblastoma
2
3
Psychotic Disorders
2
3
Thyroid Cancer
2
3
Aging: Brain
1
2
Alcohol Withdrawal
1
2
Amphetamine Addiction/Withdrawal
1
2
Appetite Disorders: Loss/Lack of
1
2
Arteriosclerosis
1
2
Bipolar Disorder
1
2
Bone Fractures
1
2
Brain Edema
1
2
Brain Injury: Traumatic
1
2
Breast Cancer: Lung Metastasis
1
2
Breast Cancer: Metastatic
1
2
Breast Cancer: Prevention
1
2
Cachexia: Cancer
2
2
Cachexia: Chemotherapy Induced
1
2
Cardiac Arrhythmias
1
2
Cardiomyopathy
1
2
Cerebral Hypoperfusion
1
2
Chemotherapy-Induced Toxicity: Oxaliplatin
1
2
Chemotherapy-Induced Toxicity: Paclitaxel
1
2
Chemotherapy-Induced Toxicity: Vincristine
1
2
Cocaine Toxicity
1
2
Cognitive Decline/Dysfunction
1
2
Degenerative Disk Disease
1
2
Depression
1
2
Depressive Disorder
1
2
Dermatitis
1
2
Dermatitis: Contact
1
2
Diabetes: Cardiovascular Illness
1
2
Diabetes: Memory Problems
1
2
Diabetic Neuropathy
1
2
Diabetic Retinopathy
1
2
Endometrial Cancer
1
2
Endothelial Dysfunction
1
2
Epilepsy: Drug-Induced
1
2
Fatty Liver
1
2
Friedreich Ataxia
1
2
Fulminant Hepatic Failure
1
2
Gastrointestinal Diseases
1
2
Gastroschisis
1
2
Headache
2
2
Heart Attack
1
2
Hepatic Encephalopathy
1
2
Hepatitis C
2
2
High Fat Diet
1
2
Hypersensitivity
1
2
Hypersensitivity: Type IV
1
2
Infant Neurological Development
1
2
Inflammation: Neutrophil-Mediated
1
2
Insulin Resistance
1
2
Interstitial Lung Diseases
1
2
Ischemia
1
2
Leukemia
2
2
Liver Damage
1
2
Liver Failure: Acute
1
2
Liver Injury: Ischemia/reperfusion
1
2
Malaria
1
2
Memory Disorders: Drug-Induced
1
2
Metabolic Diseases
1
2
Mitochondrial Dysfunction
1
2
Multiple Myeloma
2
2
Muscle Soreness
1
2
Myocarditis: Autoimmune
1
2
Neonatal Stroke
1
2
Neuralgia
1
2
Periodontitis
1
2
Prion Diseases
1
2
Psoriasis
2
2
Rhabdomyosarcoma
1
2
Sciatic Nerve Crush Injury
1
2
Sepsis
1
2
Spinal Cord Inflammation
1
2
Staphylococcus aureus: Methicillin-resistant (MRSA)
2
2
Tardive Dyskinesia
1
2
Traumatic Brain Injury
1
2
Tremor
1
2
Urinary Bladder Diseases
1
2
Uveitis
1
2
AIDS
1
1
Acquired Immunodeficiency Syndrome
1
1
Acute T cell Leukemias
1
1
Alcohol Addiction
1
1
Allergic Airway Diseases
1
1
Anorexia
1
1
Appetite Disorders
1
1
Atherosclerosis
1
1
Bone Diseases
1
1
Cancers: Drug Resistant
1
1
Cancers: Multi-Drug Resistant
1
1
Candida Infection
1
1
Carcinoma: Non-Small-Cell Lung
1
1
Central Nervous System Diseases
1
1
Cervical Cancer
1
1
Cirrhosis
1
1
Clostridium Infections
1
1
Cough
1
1
Diabetes: Cognitive Dysfunction
1
1
Ebola Virus Infections
1
1
Gastric Cancer
1
1
Herpes Simplex Virus Type 2
1
1
Herpes: Kaposi-Associated
1
1
Hydrogen Peroxide Induced Toxicity
1
1
Immune Disorders
1
1
Immune Dysregulation: TH1/TH2 imbalance
1
1
Influenza
1
1
Irritable Bowel Syndrome
1
1
Kaposi Disease
1
1
Kidney Cancer
1
1
Kidney Damage
1
1
Leishmaniasis
1
1
Leukemia: T-cell acute Lymphoblastic
1
1
Liver Fibrosis
1
1
Mood Disorders
1
1
Nausea: Chemotherapy-Induced
1
1
Oral Cancer
1
1
Oral Mucositis
1
1
Peripheral Neuropathies
1
1
Prostate: PSA Doubling
1
1
Pseudomonas aeruginosa
1
1
Rheumatoid Arthritis
1
1
Skin Diseases
1
1
Testicular Cancer
1
1
Tobacco Addiction/Withdrawal
1
1
Ultraviolet Radiation Induced Damage
1
1
115 Pharmacological Actions Researched for Cannabinoids
Name
AC
CK
Focus
Anti-Inflammatory Agents
101
250
Neuroprotective Agents
106
236
Anticonvulsants
39
214
Analgesics
36
146
Apoptotic
65
99
Antiproliferative
57
92
Anti-Anxiety Agents
17
62
Tumor Necrosis Factor (TNF) Alpha Inhibitor
22
43
Antioxidants
24
37
Immunomodulatory
17
36
Antineoplastic Agents
22
31
Vasodilator Agents
5
31
Angiogenesis Inhibitors
14
29
Anti-metastatic
20
29
Antidepressive Agents
11
24
Antinoceceptive
6
22
Hypoglycemic Agents
2
22
Cyclooxygenase 2 Inhibitors
6
19
Chemotherapeutic
11
17
Immunosuppressive Agents
6
17
Anti-Apoptotic
10
16
Hepatoprotective
7
15
NF-kappaB Inhibitor
9
15
Antihypertensive Agents
3
13
Cardioprotective
7
13
Interleukin-6 Downregulation
7
13
Antispasmodic
2
12
Matrix metalloproteinase-9 (MMP-9) inhibitor
2
12
Vascular Endothelial Growth Factor Inhibitors
3
12
Antipsychotic Agents
7
11
Anxiolytic
2
11
Cell cycle arrest
8
11
Chemoprotective Agents
5
11
Anti-Tumor
5
10
Anticarcinogenic Agents
7
10
Autophagy Up-regulation
8
10
Chemopreventive
6
10
GABA Modulators
1
10
Interleukin-1 beta downregulation
6
10
Interferon Gamma Reducer
5
9
Chemosensitizer
5
7
Neurogenesis
5
7
Brain-derived neurotrophic factor modulator
3
6
Nitric Oxide Inhibitor
3
6
P38 Mitogen-Activated Protein Kinase Modulator
2
6
Superoxide Dismutase Up-regulation
2
6
Vascular Cell Adhesion Molecule-1 Inhibitor
2
6
Anti-Angiogenic
5
5
Appetite Stimulants
3
5
Cannabinoid Receptor Antagonist/Inverse Agonist
3
5
Hypolipidemic
1
5
Caspase-3 Activation
3
4
Enzyme Inhibitors
2
4
Interleukin-10 downregulation
2
4
Interleukin-17 downregulation
3
4
Interleukin-4 downregulation
2
4
Matrix metalloproteinase-2 (MMP-2) inhibitor
2
4
Osteoprotective
3
4
Prostaglandin PGE2 downregulation
2
4
Vascular Endothelial Growth Factor A Inhibitor
2
4
Vascular Endothelial Growth Factor Regulator
2
4
Gastrointestinal Agents
3
3
Immunomodulatory: Th17 downregulation
2
3
Interleukin-8 downregulation
2
3
Neuritogenic
2
3
Radiosensitizer
2
3
Renoprotective
2
3
Aldose reductase inhibitor
1
2
Anti-Androgen
1
2
Anti-Bacterial Agents
2
2
Anti-Fibrotic
2
2
Anti-atherogenic
1
2
Calcium Channel Blockers
1
2
Cyclooxygenase Inhibitors
1
2
Enzyme Activators
1
2
Epidermal growth factor receptor (EGFR) inhibitor
1
2
Gastroprotective
2
2
Glycine Agents
1
2
Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor
1
2
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
2
2
Immunomodulatory: T-Cell down-regulation
1
2
Interleukin-10 upregulation
1
2
Interleukin-12 downregulation
1
2
Interleukin-2 Downregulation
1
2
Interleukin-5 downregulation
1
2
Intracellular adhesion molecule-1 (ICAM-1)
1
2
Malondialdehyde Down-regulation
1
2
Matrix metalloproteinase-1 (MMP-1) inhibitor
2
2
MicroRNA modulator
2
2
Neuroplasticity enhancement
1
2
Pancreato Protective Agents
1
2
Prophylactic Agents
1
2
Redox Modulator
1
2
Sedative effects
1
2
Topoisomerase II Inhibitor
2
2
Vanilloid Receptor-1 Modulator
1
2
interleukin-13 down-regulation
1
2
Anti-Cachexic Agents
1
1
Anti-Proliferative
1
1
Anti-Psychotic
1
1
Antifungal Agents
1
1
Antiviral Agents
1
1
Caspase-8 activation
1
1
Caspase-9 Activation
1
1
Cyclooxygenase 1 Inhibitor
1
1
Cytotoxic
1
1
Interleukin-2 upregulation
1
1
NADPH Oxidase Inhibitors
1
1
Neuroimmunomodulation
1
1
Nrf2 activation
1
1
Paraptosis
1
1
Photoprotective
1
1
Transient receptor potential vanilloid type-2 activation
1
1
Wnt/β-catenin signaling pathway modulation
1
1
apoptosis
1
1
Research Articles
562
Cumulative Knowledge Score
909
Overall Research Rating
EXCELLENT
Related Topics
Cannabinoids is a Sub of the following Topics
Marijuana
Cannabis
View the Evidence:
589 Abstracts with Cannabinoids Research
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[+]
A review and meta-analysis of the efficacy and safety of cannabidiol in epilepsy.
Nov 02, 2018
Click here to read the entire abstract
Pubmed Data
: Drugs. 2018 Nov 3. Epub 2018 Nov 3. PMID:
30390221
Article Published Date
: Nov 02, 2018
Study Type
: Meta Analysis
Additional Links
Substances
:
Cannabidiol
Diseases
:
Epilepsy
Pharmacological Actions
:
Anticonvulsants
[+]
A systematic review and meta-analysis off the effects of cannabinoids in Amyotrophic lateral sclerosis murine models.
Dec 05, 2018
Click here to read the entire abstract
Pubmed Data
: J Neurochem. 2018 Dec 6. Epub 2018 Dec 6. PMID:
30520038
Article Published Date
: Dec 05, 2018
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Cannabinoids
Diseases
:
Amyotrophic lateral sclerosis (ALS)
[+]
Cannabinoids may have possible therapeutic properties for the management of the multiple sclerosis.
Nov 19, 2010
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2010 Nov 19. Epub 2010 Nov 19. PMID:
21094240
Article Published Date
: Nov 19, 2010
Study Type
: Meta Analysis
Additional Links
Substances
:
Cannabinoids
Diseases
:
Multiple Sclerosis
[+]
Cannabinoids significantly reduced infarct volume and improve functional outcome in experimental stroke models.
Feb 28, 2015
Click here to read the entire abstract
Pubmed Data
: J Cereb Blood Flow Metab. 2015 Mar ;35(3):348-58. Epub 2014 Dec 10. PMID:
25492113
Article Published Date
: Feb 28, 2015
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Cannabinoids
Diseases
:
Stroke
,
Stroke: Attenuation/Recovery
Pharmacological Actions
:
Neuroprotective Agents
[+]
Selective cannabinoids provide a small analgesic benefit in patients with chronic neuropathic pain.
May 18, 2017
Click here to read the entire abstract
Pubmed Data
: Anesth Analg. 2017 May 19. Epub 2017 May 19. PMID:
28537982
Article Published Date
: May 18, 2017
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Cannabinoids
Diseases
:
Neuropathic Pain
Pharmacological Actions
:
Analgesics
[+]
The median effective dose of morphine administered in combination with THC is 3.6 times lower than of morphine alone.
Mar 21, 2017
Click here to read the entire abstract
Pubmed Data
: Neuropsychopharmacology. 2017 Mar 22. Epub 2017 Mar 22. PMID:
28327548
Article Published Date
: Mar 21, 2017
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Cannabinoids
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Morphine Tolerance/Dependence
,
Opioid Tolerance/Dependence
Additional Keywords
:
Medication Reduction
[+]
This meta-analysis and systematic review has highlighted the haemodynamic effects of CBD.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2017 ;8:81. Epub 2017 Feb 24. PMID:
28286481
Article Published Date
: Dec 31, 2016
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Cannabidiol
Diseases
:
Stroke
Pharmacological Actions
:
Vasodilator Agents
[+]
A case report of a female patient who demonstrated disease response after declining standard therapy and taking a combination of Laetrile and CBD oil.
Jul 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Gynecol Oncol Rep. 2019 Aug ;29:10-12. Epub 2019 May 17. PMID:
31193514
Article Published Date
: Jul 31, 2019
Study Type
: Human Study
Additional Links
Substances
:
Amygdalin (laetrile)
,
Cannabidiol
Diseases
:
Ovarian Cancer
Pharmacological Actions
:
Antiproliferative
,
Chemopreventive
[+]
A single dose of cannabidiol reduces blood pressure in healthy volunteers.
Jun 14, 2017
Click here to read the entire abstract
Pubmed Data
: JCI Insight. 2017 Jun 15 ;2(12). Epub 2017 Jun 15. PMID:
28614793
Article Published Date
: Jun 14, 2017
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Hypertension
Pharmacological Actions
:
Antihypertensive Agents
[+]
A tetrahydrocannabinol:cannabidiol (THC:CBD) extract is efficacious for relief of pain in patients with advanced cancer pain not fully relieved by strong opioids.
Jul 01, 2009
Click here to read the entire abstract
Pubmed Data
: Hum Reprod. 2009 Jul;24(7):1717-25. Epub 2009 Mar 11. PMID:
19896326
Article Published Date
: Jul 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Cancers: All
,
Pain
Pharmacological Actions
:
Analgesics
[+]
Add-on cannabidiol may be an efficacious long-term treatment option for treatment-resistant epilepsies.
Jul 11, 2018
Click here to read the entire abstract
Pubmed Data
: Epilepsia. 2018 Jul 12. Epub 2018 Jul 12. PMID:
29998598
Article Published Date
: Jul 11, 2018
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Epilepsy
Pharmacological Actions
:
Anticonvulsants
[+]
Cannabidiol attenuates insular dysfunction during motivational salience processing in subjects at clinical high risk for psychosis.
Aug 21, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Transl Psychiatry. 2019 Aug 22 ;9(1):203. Epub 2019 Aug 22. PMID:
31439831
Article Published Date
: Aug 21, 2019
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Psychoses
Additional Keywords
:
Risk Reduction
[+]
Cannabidiol could be useful in Dravet syndrome treatments.
Mar 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pharmacol Res Perspect. 2016 Apr ;4(2):e00220. Epub 2016 Mar 5. PMID:
27069631
Article Published Date
: Mar 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Dravet syndrome
,
Endocannabinoid Disorders
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Endocannabinoid System
[+]
Cannabidiol for treating drug-resistant epilepsy in children.
Aug 12, 2018
Click here to read the entire abstract
Pubmed Data
: Med J Aust. 2018 Aug 13. Epub 2018 Aug 13. PMID:
30092753
Article Published Date
: Aug 12, 2018
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Epilepsy
[+]
Cannabidiol has antipsychotic properties which balance out the psychotomimetic effects of THC in cannabis.
Apr 01, 2008
Click here to read the entire abstract
Pubmed Data
: Br J Psychiatry. 2008 Apr;192(4):306-7. PMID:
18378995
Article Published Date
: Apr 01, 2008
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Delirium: Drug-Induced
,
Marijuana Addiction/Withdrawal
Additional Keywords
:
The Whole is Superior to the Monochemical Part
,
Whole Food Balance
[+]
Cannabidiol improves frequency and severity of seizures and reduces adverse events.
Aug 08, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Epilepsy Behav. 2018 Aug 9. Epub 2018 Aug 9. PMID:
30100226
Article Published Date
: Aug 08, 2018
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Seizures
Pharmacological Actions
:
Anticonvulsants
[+]
Cannabidiol in the treatment of post-traumatic stress disorder.
Dec 12, 2018
Click here to read the entire abstract
Pubmed Data
: J Altern Complement Med. 2018 Dec 13. Epub 2018 Dec 13. PMID:
30543451
Article Published Date
: Dec 12, 2018
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Post-Traumatic Stress Disorders (PTSD)
Additional Keywords
:
Significant Treatment Outcome
[+]
Cannabidiol levels in different strains of cannabis may determine the degree to which THC interferes with memory in users.
Oct 01, 2010
Click here to read the entire abstract
Pubmed Data
: Br J Psychiatry. 2010 Oct;197(4):285-90. PMID:
20884951
Article Published Date
: Oct 01, 2010
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
Diseases
:
Marijuana Addiction/Withdrawal
,
Memory Disorders
[+]
Cannabidiol may be an effective and well-tolerated treatment option for patients with refractory seizures in Tuberous sclerosis complex.
Sep 30, 2016
Click here to read the entire abstract
Pubmed Data
: Epilepsia. 2016 Oct ;57(10):1617-1624. Epub 2016 Aug 3. PMID:
27696387
Article Published Date
: Sep 30, 2016
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Tuberous Sclerosis
Pharmacological Actions
:
Anticonvulsants
[+]
Cannabidiol may hold benefit for anxiety-related disorders.
Dec 31, 2018
Click here to read the entire abstract
Pubmed Data
: Perm J. 2019 ;23. PMID:
30624194
Article Published Date
: Dec 31, 2018
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Anxiety
Pharmacological Actions
:
Anti-Anxiety Agents
[+]
Cannabidiol might reduce seizure frequency and might have an adequate safety profile in children and young adults with treatment-resistant epilepsy.
Dec 22, 2015
Click here to read the entire abstract
Pubmed Data
: Lancet Neurol. 2015 Dec 23. Epub 2015 Dec 23. PMID:
26724101
Article Published Date
: Dec 22, 2015
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Epilepsy
,
Epilepsy: Childhood
Pharmacological Actions
:
Anticonvulsants
[+]
Cannabidiol reduces anxiety in social anxiety disorder through modulating the limbic and paralimbic brain areas.
Sep 09, 2010
Click here to read the entire abstract
Pubmed Data
: J Psychopharmacol. 2010 Sep 9. Epub 2010 Sep 9. PMID:
20829306
Article Published Date
: Sep 09, 2010
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
Diseases
:
Anxiety Disorders
,
Social Anxiety Disorder (SAD)
Pharmacological Actions
:
Anxiolytic
[+]
Cannabidiol resulted in a greater reduction in convulsive-seizure frequency among patients with Dravet syndrome.
Jan 24, 2017
Click here to read the entire abstract
Pubmed Data
: N Engl J Med. 2017 05 25 ;376(21):2011-2020. PMID:
28538134
Article Published Date
: Jan 24, 2017
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Dravet syndrome
Pharmacological Actions
:
Anticonvulsants
Additional Keywords
:
Significant Treatment Outcome
[+]
Cannabidiol treatment in children with treatment resistant epilepsies led to 42% of children reporting a greater than 80% reduction in seizure frequency and 32% reporting a 25-60% seizure reduction.
Nov 30, 2013
Click here to read the entire abstract
Pubmed Data
: Epilepsy Behav. 2013 Dec ;29(3):574-7. PMID:
24237632
Article Published Date
: Nov 30, 2013
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Epilepsy
,
Epilepsy: Childhood
,
Epileptic Seizures
Pharmacological Actions
:
Anticonvulsants
Additional Keywords
:
Treatment Resistant
[+]
Cannabidiol treatment yielded a significant positive effect on seizure load in patients with intractable epilepsy.
Jan 05, 2016
Click here to read the entire abstract
Pubmed Data
: Seizure. 2016 Jan 6 ;35:41-44. Epub 2016 Jan 6. PMID:
26800377
Article Published Date
: Jan 05, 2016
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
Diseases
:
Epilepsy
,
Epilepsy: Childhood
Pharmacological Actions
:
Anticonvulsants
Additional Keywords
:
Plant Extracts
,
Significant Treatment Outcome
[+]
Cannabinoids may have therapeutic value in the treatment of tics in Tourette syndrome.
Oct 01, 2003
Click here to read the entire abstract
Pubmed Data
: Expert Opin Pharmacother. 2003 Oct;4(10):1717-25. PMID:
14521482
Article Published Date
: Oct 01, 2003
Study Type
: Human Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Tourette Syndrome
[+]
Cannabis could be potentially beneficial reduction in systemic inflammation and immune activation in the context of antiretroviral-treated HIV infection.
Feb 16, 2018
Click here to read the entire abstract
Pubmed Data
: Clin Infect Dis. 2018 Feb 17. Epub 2018 Feb 17. PMID:
29471387
Article Published Date
: Feb 16, 2018
Study Type
: Human Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
Diseases
:
HIV Infections
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Immunomodulatory
[+]
Cannabis extracts can be a useful and safe option for patients with MS with moderate to severe spasticity resistant to common antispastic drugs.
May 08, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Neurol Neurosurg Psychiatry. 2016 May 9. Epub 2016 May 9. PMID:
27160523
Article Published Date
: May 08, 2016
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Multiple Sclerosis
Additional Keywords
:
Plant Extracts
[+]
Cannabis extracts can be considered an alternative in patients with spasticity associated with chronic spinal cord injury.
Sep 30, 2017
Click here to read the entire abstract
Pubmed Data
: Rev Neurol. 2017 Oct 1 ;65(7):295-302. PMID:
28929471
Article Published Date
: Sep 30, 2017
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Spinal Cord Injuries
Additional Keywords
:
Plant Extracts
[+]
Cannabis in ASD patients appears to be well tolerated, safe and effective option to relieve symptoms associated with ASD.
Jan 16, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2019 Jan 17 ;9(1):200. Epub 2019 Jan 17. PMID:
30655581
Article Published Date
: Jan 16, 2019
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
Diseases
:
Autism Spectrum Disorders
[+]
Cannabis is well-tolerated and efficacious in the treatment of neuropathic pain from brachial plexus avulsion.
Dec 01, 2004
Click here to read the entire abstract
Pubmed Data
: Pain. 2004 Dec;112(3):299-306. PMID:
15561385
Article Published Date
: Dec 01, 2004
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Brachial Plexus Neuropathies
,
Neuropathic Pain
Additional Keywords
:
Plant Extracts
[+]
Cannabis may have therapeutic value in the treatment of Tourette syndrome.
Dec 01, 1998
Click here to read the entire abstract
Pubmed Data
: Acta Psychiatr Scand. 1998 Dec;98(6):502-6. PMID:
9879795
Article Published Date
: Dec 01, 1998
Study Type
: Human Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
Diseases
:
Obsessive-Compulsive Disorder
,
Tourette Syndrome
[+]
Cannabis-based medicine is effective in reducing pain and sleep disturbance in patients with multiple sclerosis related central neuropathic pain and is mostly well tolerated.
Sep 27, 2005
Click here to read the entire abstract
Pubmed Data
: Neurology. 2005 Sep 27;65(6):812-9. PMID:
16186518
Article Published Date
: Sep 27, 2005
Study Type
: Human Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
Diseases
:
Insomnia
,
Multiple Sclerosis
,
Pain
,
Sleep Disorders
Pharmacological Actions
:
Analgesics
[+]
Cannabis-based medicine may represent a useful new agent for treatment of the symptomatic relief of spasticity in MS.
Feb 28, 2007
Click here to read the entire abstract
Pubmed Data
: Eur J Neurol. 2007 Mar ;14(3):290-6. PMID:
17355549
Article Published Date
: Feb 28, 2007
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
,
Cannabinoids
,
Cannabis
Diseases
:
Multiple Sclerosis
Additional Keywords
:
Plant Extracts
[+]
CBD could be beneficial for the treatment of brain tumor-related epilepsy.
Oct 23, 2017
Click here to read the entire abstract
Pubmed Data
: Neurocase. 2017 Oct 24:1-5. Epub 2017 Oct 24. PMID:
29063814
Article Published Date
: Oct 23, 2017
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Brain Cancer
,
Epilepsy
Pharmacological Actions
:
Anticonvulsants
[+]
CBD enriched hemp oil could be beneficial in girls with adverse drug effects following human papillomavirus (HPV) vaccine.
Jan 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Isr Med Assoc J. 2017 Feb ;19(2):79-84. PMID:
28457055
Article Published Date
: Jan 31, 2017
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
,
Hemp Seed
Diseases
:
Vaccine-induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antinoceceptive
,
Neuroprotective Agents
Additional Keywords
:
Plant Extracts
Anti Therapeutic Actions
:
Vaccination: HPV (Gardasil)
[+]
CBD has anxiolytic properties in human volunteers submitted to a stressful situation.
Dec 31, 1992
Click here to read the entire abstract
Pubmed Data
: J Psychopharmacol. 1993 Jan ;7(1 Suppl):82-8. PMID:
22290374
Article Published Date
: Dec 31, 1992
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Anxiety
Pharmacological Actions
:
Anti-Anxiety Agents
[+]
CBD may be effective, safe and well tolerated for the treatment of the psychosis in Parkinson's disease.
Oct 31, 2009
Click here to read the entire abstract
Pubmed Data
: J Psychopharmacol. 2009 Nov ;23(8):979-83. Epub 2008 Sep 18. PMID:
18801821
Article Published Date
: Oct 31, 2009
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Parkinson's Disease
,
Psychoses
[+]
CBD restores excitability and morphological impairment in epileptic models to pre-epilepsy control levels.
Mar 24, 2018
Click here to read the entire abstract
Pubmed Data
: Br J Pharmacol. 2018 Mar 25. Epub 2018 Mar 25. PMID:
29574880
Article Published Date
: Mar 24, 2018
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Epilepsy
Pharmacological Actions
:
Neuroprotective Agents
[+]
CBD was found to have potential benefits as add-on therapy for refractory childhood epilepsies.
Mar 07, 2018
Click here to read the entire abstract
Pubmed Data
: Epilepsy Behav. 2018 Mar 8. Epub 2018 Mar 8. PMID:
29526578
Article Published Date
: Mar 07, 2018
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Epilepsy
Pharmacological Actions
:
Anticonvulsants
[+]
CBD-rich botanical extract may be beneficial for symptomatic treatment of ulcerative colitis.
Mar 09, 2018
Click here to read the entire abstract
Pubmed Data
: Inflamm Bowel Dis. 2018 Mar 10. Epub 2018 Mar 10. PMID:
29538683
Article Published Date
: Mar 09, 2018
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Chronic pain treatment with cannabidiol in kidney transplant patients in Uruguay.
Feb 28, 2018
Click here to read the entire abstract
Pubmed Data
: Transplant Proc. 2018 Mar ;50(2):461-464. PMID:
29579828
Article Published Date
: Feb 28, 2018
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Chronic Pain
,
Organ Transplantation: Kidney
Pharmacological Actions
:
Analgesics
[+]
Delta-tetrahydrocannabinol (THC) and cannabidiol have therapeutic value in the management of spasticity associated wtih multiple sclerosis.
Aug 01, 1996
Click here to read the entire abstract
Pubmed Data
: J Nutr Sci Vitaminol (Tokyo). 1996 Aug;42(4):325-37. PMID:
21456949
Article Published Date
: Aug 01, 1996
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Multiple Sclerosis
,
Muscle Spasticity
Pharmacological Actions
:
Antispasmodic
[+]
Delta9-tetrahydrocannabinol administration led to the inhibition of the VEGF Pathway in Two Patients with Glioblastoma Multiforme.
Aug 14, 2004
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Res. 2004 Aug 15 ;64(16):5617-23. PMID:
15313899
Article Published Date
: Aug 14, 2004
Study Type
: Animal Study, Human Study
Additional Links
Substances
:
Cannabinoids
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Glioblastoma Multiforme
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Vascular Endothelial Growth Factor Inhibitors
Additional Keywords
:
Gene Expression Regulation
[+]
Drivers under the influence of synthetic cannabinoids were more frequently impaired with confusion, disorientation, and incoherent, slurred speech than drivers under the influence of marijuana in this population evaluated by drug recognition experts.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Clin Toxicol (Phila). 2016 ;54(1):14-9. PMID:
26653952
Article Published Date
: Dec 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
Diseases
:
Impairment: Driving Related
Additional Keywords
:
Natural Versus Synthetics
,
Plant Extracts
Problem Substances
:
Synthetic Cannabinoids
[+]
Dronabinol is a safe long-term treatment option for neuropathic pain patients.
Oct 25, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Eur Neurol. 2017 Oct 26 ;78(5-6):320-329. Epub 2017 Oct 26. PMID:
29073592
Article Published Date
: Oct 25, 2017
Study Type
: Human Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
Diseases
:
Multiple Sclerosis
,
Neuropathic Pain
Pharmacological Actions
:
Analgesics
[+]
Effects of cannabidiol on brain excitation and inhibition systems.
Feb 05, 2019
Click here to read the entire abstract
Pubmed Data
: Neuropsychopharmacology. 2019 Feb 6. Epub 2019 Feb 6. PMID:
30758329
Article Published Date
: Feb 05, 2019
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Autism Spectrum Disorders
Pharmacological Actions
:
GABA Modulators
[+]
Eighty five percent of all parents reported a reduction in seizure frequency and 14% reported complete seizure freedom.
Apr 28, 2015
Click here to read the entire abstract
Pubmed Data
: Epilepsy Behav. 2015 Apr 29. Epub 2015 Apr 29. PMID:
25935511
Article Published Date
: Apr 28, 2015
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
Diseases
:
Epilepsy
,
Epilepsy: Childhood
Pharmacological Actions
:
Anticonvulsants
Additional Keywords
:
Plant Extracts
[+]
In this trial cannabis induced a clinical remission in 50% of patients with long standing Crohn's disease with 80% nonresponse or intolerance to anti–TNF-α treatment.
Sep 30, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Clin Gastroenterol Hepatol. 2013 Oct ;11(10):1276-1280.e1. Epub 2013 May 4. PMID:
23648372
Article Published Date
: Sep 30, 2013
Study Type
: Human Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Inflammatory Bowel Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Natural Substances Versus Drugs
,
Significant Treatment Outcome
[+]
Long-term add-on CBD treatment had an acceptable safety profile in patients with Lennox-Gastaut syndrome and led to sustained reductions in seizures.
Feb 10, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Epilepsia. 2019 Feb 11. Epub 2019 Feb 11. PMID:
30740695
Article Published Date
: Feb 10, 2019
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Lennox-Gastaut Syndrome
Pharmacological Actions
:
Anticonvulsants
[+]
Long-term cannabidiol treatment in patients with Dravet syndrome.
Dec 22, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Epilepsia. 2018 Dec 23. Epub 2018 Dec 23. PMID:
30582156
Article Published Date
: Dec 22, 2018
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Dravet syndrome
[+]
Observations from this study suggest that cannabis use is associated with lower prevalence of NAFLD.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2017 ;12(4):e0176416. Epub 2017 Apr 25. PMID:
28441459
Article Published Date
: Dec 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Additional Keywords
:
Risk Reduction
,
Significant Treatment Outcome
[+]
Orally administered cannabis extract may provide a therapeutic option to other drugs in the treatment of spasticity in patients with multiple sclerosis
Aug 01, 2004
Click here to read the entire abstract
Pubmed Data
: Mult Scler. 2004 Aug;10(4):417-24. PMID:
15327040
Article Published Date
: Aug 01, 2004
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Multiple Sclerosis
,
Muscle Spasticity
[+]
Parents' reports suggest that cannabidiol may improve autism spectrum disorder comorbidity symptoms.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2018 ;9:1521. Epub 2019 Jan 9. PMID:
30687090
Article Published Date
: Dec 31, 2017
Study Type
: Human Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Autism Spectrum Disorders
[+]
Prolonged CBD treatment appears to have promising therapeutic effects for improving psychological symptoms and cognition in regular cannabis users.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cannabis Cannabinoid Res. 2018 ;3(1):21-34. Epub 2018 Mar 1. PMID:
29607408
Article Published Date
: Dec 31, 2017
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
Pharmacological Actions
:
Neuroprotective Agents
[+]
Sativex is safe and well tolerated in patients with HD, with no severe adverse events or clinical worsening.
May 08, 2016
Click here to read the entire abstract
Pubmed Data
: J Neurol. 2016 May 9. Epub 2016 May 9. PMID:
27159993
Article Published Date
: May 08, 2016
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Huntington Disease
Additional Keywords
:
Plant Extracts
,
Safety of Natural Substances
[+]
Tetrahydrocannabivarin could represent a new therapeutic agent in glycemic control in subjects with type 2 diabetes.
Aug 28, 2016
Click here to read the entire abstract
Pubmed Data
: Diabetes Care. 2016 Aug 29. Epub 2016 Aug 29. PMID:
27573936
Article Published Date
: Aug 28, 2016
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
,
Cannabinoids
Diseases
:
Diabetes Mellitus: Type 2
,
Hypoglycemia
Pharmacological Actions
:
Hypoglycemic Agents
[+]
THC and CBD was effective in select patients with central neuropathic pain and multiple sclerosis.
Aug 31, 2007
Click here to read the entire abstract
Pubmed Data
: Clin Ther. 2007 Sep ;29(9):2068-79. PMID:
18035205
Article Published Date
: Aug 31, 2007
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Multiple Sclerosis
,
Neuropathic Pain
Pharmacological Actions
:
Analgesics
Additional Keywords
:
Plant Extracts
[+]
THC/CBD oromucosal spray has shown to be effective in improving overactive bladder symptoms in multiple sclerosis patients.
Oct 18, 2017
Click here to read the entire abstract
Pubmed Data
: Neurol Sci. 2017 Oct 19. Epub 2017 Oct 19. PMID:
29052091
Article Published Date
: Oct 18, 2017
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Multiple Sclerosis
,
Overactive Bladder
[+]
THC/CBD spray was beneficial for the majority of patients with PNP associated with diabetes or allodynia.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: J Neurol. 2015 Jan ;262(1):27-40. Epub 2014 Sep 30. PMID:
25270679
Article Published Date
: Dec 31, 2014
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Neuropathic Pain
,
Peripheral Nerve Diseases
Pharmacological Actions
:
Analgesics
[+]
THC:CBD oromucosal spray provided symptomatic relief of MS spasticity with good tolerability in a relevant number of previously resistant patients.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Eur Neurol. 2015 ;74(3-4):178-85. Epub 2015 Nov 17. PMID:
26571097
Article Published Date
: Dec 31, 2014
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Multiple Sclerosis
Additional Keywords
:
Plant Extracts
[+]
THC:CBD oromucosal spray provided symptomatic relief of MSS and related troublesome symptoms.
Oct 12, 2016
Click here to read the entire abstract
Pubmed Data
: Eur Neurol. 2016 Oct 13 ;76(5-6):216-226. Epub 2016 Aug 13. PMID:
27732980
Article Published Date
: Oct 12, 2016
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Multiple Sclerosis
[+]
The anti-inflammatory activity of Cannabis extracts on colon epithelial cells derives from a fraction of the extract that contains THCA.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cannabis Cannabinoid Res. 2017 ;2(1):167-182. Epub 2017 Jul 1. PMID:
29082314
Article Published Date
: Dec 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
Diseases
:
Inflammatory Bowel Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
The anxiolytic effect of Cannabidiol has a U shaped dose response curve.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Front Pharmacol. 2017 ;8:259. Epub 2017 May 11. PMID:
28553229
Article Published Date
: Dec 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Anxiety
Pharmacological Actions
:
Anti-Anxiety Agents
[+]
The present study confirms the efficacy of cannabinoids in reducing spasticity in patients with multiple sclerosis.
Mar 20, 2016
Click here to read the entire abstract
Pubmed Data
: Int Clin Psychopharmacol. 2016 Mar 21. Epub 2016 Mar 21. PMID:
27003093
Article Published Date
: Mar 20, 2016
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Multiple Sclerosis
[+]
The results indicate that CBD could be a useful option to treat social anxiety.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Psychol. 2019 ;10:2466. Epub 2019 Nov 8. PMID:
31787910
Article Published Date
: Dec 31, 2018
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Anxiety
Pharmacological Actions
:
Anti-Anxiety Agents
[+]
The results indicate that CBD could be a useful option to treat social anxiety.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Psychol. 2019 ;10:2466. Epub 2019 Nov 8. PMID:
31787910
Article Published Date
: Dec 31, 2018
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Anxiety
Pharmacological Actions
:
Anti-Anxiety Agents
[+]
The results suggest that CBD may have beneficial effects on patient quality of life, distinct from its seizure-reducing effects.
Jun 14, 2017
Click here to read the entire abstract
Pubmed Data
: Epilepsia. 2017 Jun 15. Epub 2017 Jun 15. PMID:
28617940
Article Published Date
: Jun 14, 2017
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Epilepsy: Childhood
,
Quality of Life: Poor
Pharmacological Actions
:
Anticonvulsants
[+]
These findings suggest that CBD has beneficial effects in patients with schizophrenia.
Dec 14, 2017
Click here to read the entire abstract
Pubmed Data
: Am J Psychiatry. 2017 Dec 15:appiajp201717030325. Epub 2017 Dec 15. PMID:
29241357
Article Published Date
: Dec 14, 2017
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Schizophrenia
[+]
These findings support efficacy of artisanal CBD preparations in seizure reduction with few significant side effects.
Feb 07, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Epilepsy Behav. 2018 Feb 8. Epub 2018 Feb 8. PMID:
29429908
Article Published Date
: Feb 07, 2018
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Epilepsy
Pharmacological Actions
:
Anticonvulsants
[+]
These results confirm the clinical benefit of cannabis extracts on spastic hypertonia.
Nov 14, 2016
Click here to read the entire abstract
Pubmed Data
: J Neurol Sci. 2016 Nov 15 ;370:263-268. Epub 2016 Aug 28. PMID:
27772772
Article Published Date
: Nov 14, 2016
Study Type
: Human Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
Diseases
:
Multiple Sclerosis
Additional Keywords
:
Plant Extracts
,
Significant Treatment Outcome
[+]
These results indicate that in cannabis smokers, men exhibit greater cannabis-induced analgesia relative to women.
Aug 04, 2016
Click here to read the entire abstract
Pubmed Data
: Drug Alcohol Depend. 2016 Aug 5. Epub 2016 Aug 5. PMID:
27522535
Article Published Date
: Aug 04, 2016
Study Type
: Human Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
Diseases
:
Pain
Pharmacological Actions
:
Analgesics
[+]
These results reveal an immunosuppressive effect of cannabinoid preparations.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Mol Neurosci. 2017 ;10:14. Epub 2017 Jan 24. PMID:
28174520
Article Published Date
: Dec 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Inflammation
,
Pancreatitis: Chronic
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Immunosuppressive Agents
Additional Keywords
:
Anti-Inflammatory Agents
,
Cannabinoids
,
Immunosuppressive Agents
,
Inflammation
,
Pancreatitis: Chronic
[+]
These results suggest that CBD has anxiolytic properties.
Jan 31, 2004
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Neuropsychopharmacology. 2004 Feb ;29(2):417-26. PMID:
14583744
Article Published Date
: Jan 31, 2004
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Anxiety Disorders
Pharmacological Actions
:
Anti-Anxiety Agents
Additional Keywords
:
Anti-Anxiety Agents
,
Anxiety Disorders
,
Cannabidiol
[+]
This presents the first analysis of Italian clinical practice of the use of cannabinoids for a large variety of chronic pain syndromes.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Pain Res. 2017 ;10:1217-1224. Epub 2017 May 22. PMID:
28579820
Article Published Date
: Dec 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
Diseases
:
Chronic Pain
Pharmacological Actions
:
Analgesics
[+]
This study found that cannabinoid positive patients had milder intracerebral haemorrhage presentation and less disability at discharge.
Jan 28, 2016
Click here to read the entire abstract
Pubmed Data
: Cerebrovasc Dis. 2016 Jan 29 ;41(5-6):248-255. Epub 2016 Jan 29. PMID:
26820826
Article Published Date
: Jan 28, 2016
Study Type
: Human Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
Diseases
:
Stroke: Attenuation/Recovery
,
Stroke: Ischemic
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Risk Reduction
[+]
This study provides preliminary evidence supporting the self-medication theory of cannabis use in ADHD.
May 29, 2017
Click here to read the entire abstract
Pubmed Data
: Eur Neuropsychopharmacol. 2017 May 30. Epub 2017 May 30. PMID:
28576350
Article Published Date
: May 29, 2017
Study Type
: Human Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
Diseases
:
Attention Deficit Hyperactivity Disorder
Additional Keywords
:
Endocannabinoid System
,
Plant Extracts
[+]
This study suggests that cannabidiol may be well tolerated as adjunctive medication for seizure management.
Feb 21, 2017
Click here to read the entire abstract
Pubmed Data
: Pediatr Neurol. 2017 Feb 22. Epub 2017 Feb 22. PMID:
28454984
Article Published Date
: Feb 21, 2017
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Seizures
,
Sturge-Weber Syndrome
Pharmacological Actions
:
Anticonvulsants
[+]
This work further confirms the anticonvulsant efficacy of CBD and supports its application in the treatment of human seizure disorders.
Jun 14, 2017
Click here to read the entire abstract
Pubmed Data
: Epilepsy Behav. 2017 Jun 15 ;73:111-118. Epub 2017 Jun 15. PMID:
28624721
Article Published Date
: Jun 14, 2017
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Seizures
Pharmacological Actions
:
Anticonvulsants
[+]
Treatment with THC/CBD spray appears to be a valid answer to some of the unmet needs in patients with multiple sclerosis.
Nov 25, 2015
Click here to read the entire abstract
Pubmed Data
: J Clin Pharmacol. 2015 Nov 26. Epub 2015 Nov 26. PMID:
26608223
Article Published Date
: Nov 25, 2015
Study Type
: Human Study
Additional Links
Substances
:
Cannabidiol
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Bladder Dysfunction
,
Multiple Sclerosis
Additional Keywords
:
Plant Extracts
[+]
Anandamide is a potent and selective inhibitor of the proliferation of breast cancer cells.
Jul 06, 1998
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Proc Natl Acad Sci U S A. 1998 Jul 7 ;95(14):8375-80. PMID:
9653194
Article Published Date
: Jul 06, 1998
Study Type
: Human In Vitro
Additional Links
Substances
:
Anandamide
,
Cannabinoids
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
Additional Keywords
:
Cannabinoid Receptors
,
Dose Response
[+]
Cannabidiol causes vasorelaxation of the human mesenteric artery.
Aug 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cardiovasc Res. 2015 Sep 1 ;107(4):568-78. Epub 2015 Jun 19. PMID:
26092099
Article Published Date
: Aug 31, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Cannabidiol
Diseases
:
Cardiovascular Diseases
Pharmacological Actions
:
Vasodilator Agents
Additional Keywords
:
Cannabinoid Receptors
[+]
Cannabidiol has anti-inflammatory effects in the acutely inflamed human colon.
Sep 26, 2017
Click here to read the entire abstract
Pubmed Data
: Clin Sci (Lond). 2017 Sep 27. Epub 2017 Sep 27. PMID:
28954820
Article Published Date
: Sep 26, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Cannabidiol
Diseases
:
Inflammatory Bowel Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Cannabidiol has potential as a promising therapeutic agent for the treatment of acne vulgaris.
Aug 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Clin Invest. 2014 Sep ;124(9):3713-24. Epub 2014 Jul 25. PMID:
25061872
Article Published Date
: Aug 31, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Cannabidiol
Diseases
:
Acne
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis.
Dec 31, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2011 ;6(12):e28159. Epub 2011 Dec 6. PMID:
22163000
Article Published Date
: Dec 31, 2010
Study Type
: Animal Study, Human In Vitro
Additional Links
Substances
:
Cannabidiol
Diseases
:
Inflammation
,
Inflammatory Bowel Diseases
,
Ulcerative Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
CBD improved alcohol-induced hepatic metabolic dysregulation and steatosis.
Sep 20, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2017 Sep 21 ;7(1):12064. Epub 2017 Sep 21. PMID:
28935932
Article Published Date
: Sep 20, 2017
Study Type
: Animal Study, Human In Vitro
Additional Links
Substances
:
Cannabidiol
Diseases
:
Alcoholic Liver Disease
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hypolipidemic
[+]
Data suggest that activity at the BBB could represent an as yet unrecognised mechanism of CBD-induced neuroprotection in ischaemic stroke
Oct 23, 2015
Click here to read the entire abstract
Pubmed Data
: Br J Pharmacol. 2015 Oct 24. Epub 2015 Oct 24. PMID:
26497782
Article Published Date
: Oct 23, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Cannabidiol
Diseases
:
Stroke: Attenuation/Recovery
,
Stroke: Ischemic
Pharmacological Actions
:
Neuroprotective Agents
,
Vascular Cell Adhesion Molecule-1 Inhibitor
Additional Keywords
:
Blood Brain Barrier
[+]
Human skin permeation of Delta8-tetrahydrocannabinol, cannabidiol and cannabinol.
Feb 29, 2004
Click here to read the entire abstract
Pubmed Data
: J Pharm Pharmacol. 2004 Mar ;56(3):291-7. PMID:
15025853
Article Published Date
: Feb 29, 2004
Study Type
: Human In Vitro
Additional Links
Substances
:
Cannabidiol
,
Cannabinoids
[+]
Phytocannabinoids could be efficient and safe novel treatments in the management of cutaneous inflammations.
Apr 19, 2016
Click here to read the entire abstract
Pubmed Data
: Exp Dermatol. 2016 Apr 20. Epub 2016 Apr 20. PMID:
27094344
Article Published Date
: Apr 19, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
Cannabidiol
,
Cannabidivarin
,
Cannabigerol
,
Cannabigerovarin
,
Cannabinoids
Diseases
:
Acne
,
Dry Skin
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
The present data suggest that targeting CB(1)/CB(2) may have therapeutic potential for the treatment of mantle cell lymphoma.
Oct 31, 2006
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Pharmacol. 2006 Nov ;70(5):1612-20. Epub 2006 Aug 25. PMID:
16936228
Article Published Date
: Oct 31, 2006
Study Type
: Human In Vitro
Additional Links
Substances
:
Cannabinoids
,
Cannabinoids: Synthetic
Diseases
:
Lymphoma
Pharmacological Actions
:
Apoptotic
,
P38 Mitogen-Activated Protein Kinase Modulator
Additional Keywords
:
Selective Cytotoxicity
[+]
The proapoptotic effect of cannabinoids on tumor cells is mediated by a ceramide dependent upregulation of the stress protein p8.
Mar 31, 2006
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Cell. 2006 Apr ;9(4):301-12. PMID:
16616335
Article Published Date
: Mar 31, 2006
Study Type
: Animal Study, Human In Vitro
Additional Links
Substances
:
Cannabinoids
Diseases
:
Astrocytoma
,
Cancers: All
,
Glioblastoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
Additional Keywords
:
Altered Protein Expression
,
Gene Expression Regulation
[+]
All three patients reported improved pain scores, reduced pruritus and reduction in overall analgesic drug intake.
Oct 21, 2018
Click here to read the entire abstract
Pubmed Data
: Br J Dermatol. 2018 Oct 22. Epub 2018 Oct 22. PMID:
30347109
Article Published Date
: Oct 21, 2018
Study Type
: Human: Case Report
Additional Links
Substances
:
Cannabidiol
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Epidermolysis Bullosa
Pharmacological Actions
:
Analgesics
Additional Keywords
:
Medication Reduction
[+]
A 10-month-old boy with malignant migrating partial seizures in infancy made developmental gains and sustained seizure reduction with the addition of cannabidiol to his antiepileptic regimen.
Apr 30, 2015
Click here to read the entire abstract
Pubmed Data
: Pediatr Neurol. 2015 May ;52(5):544-7. Epub 2015 Feb 19. PMID:
25882081
Article Published Date
: Apr 30, 2015
Study Type
: Human: Case Report
Additional Links
Substances
:
Cannabidiol
Diseases
:
Epilepsy: Infant
,
Epilepsy: Malignant Migrating Partial Seizures
Pharmacological Actions
:
Anticonvulsants
[+]
A case report of the clinical outcome and image response of two patients with secondary high-grade glioma.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Oncol. 2018 ;8:643. Epub 2019 Jan 18. PMID:
30713832
Article Published Date
: Dec 31, 2017
Study Type
: Human: Case Report
Additional Links
Substances
:
Cannabidiol
Diseases
:
Glioma
Pharmacological Actions
:
Chemotherapeutic
[+]
Cannabidiol Has Potential As A Treatment for Febrile Infection-Related Epilepsy Syndrome (FIRES) in the Acute and Chronic Phases.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: J Child Neurol. 2017 Jan ;32(1):35-40. Epub 2016 Sep 29. PMID:
27655472
Article Published Date
: Dec 31, 2016
Study Type
: Human: Case Report
Additional Links
Substances
:
Cannabidiol
Diseases
:
Febrile Seizures
[+]
Cannabidiol oil could be used as a safe treatment for reducing anxiety and improving sleep in posttraumatic stress disorders.
Oct 11, 2016
Click here to read the entire abstract
Pubmed Data
: Perm J. 2016 Oct 12 ;20(4). Epub 2016 Aug 12. PMID:
27768570
Article Published Date
: Oct 11, 2016
Study Type
: Human: Case Report
Additional Links
Substances
:
Cannabidiol
Diseases
:
Anxiety Disorders
,
Insomnia
,
Post-Traumatic Stress Disorders (PTSD)
Pharmacological Actions
:
Anti-Anxiety Agents
[+]
Cannabinoids are a safe and effective treatment for Tourette syndrome and should be considered in treatment-resistant cases.
Aug 23, 2016
Click here to read the entire abstract
Pubmed Data
: Australas Psychiatry. 2016 Aug 24. Epub 2016 Aug 24. PMID:
27558217
Article Published Date
: Aug 23, 2016
Study Type
: Human: Case Report
Additional Links
Substances
:
Cannabidiol
,
Cannabis
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Tourette Syndrome
Additional Keywords
:
Plant Extracts
[+]
Cannabinoids inhibit glioma (brain cancer) through the down-regulation of Tissue Inhibitors of Metalloproteinases (TIMPs).
Jan 01, 2008
Click here to read the entire abstract
Pubmed Data
: Neuropharmacology. 2008 Jan;54(1):235-43. Epub 2007 Jul 1. PMID:
17675107
Article Published Date
: Jan 01, 2008
Study Type
: Human: Case Report, In Vitro Study
Additional Links
Substances
:
Cannabinoids
,
Marijuana
Diseases
:
Astrocytoma
,
Astrocytoma: Grade IV
,
Brain Cancer
,
Glioma
Additional Keywords
:
Tissue Inhibitors of Metalloproteinases (TIMPs)
[+]
Four patients treated with CBD had prompt and substantial reduction in the frequency of REM sleep behaviour disorder related events without side effects.
Sep 30, 2014
Click here to read the entire abstract
Pubmed Data
: J Clin Pharm Ther. 2014 Oct ;39(5):564-6. Epub 2014 May 21. PMID:
24845114
Article Published Date
: Sep 30, 2014
Study Type
: Human: Case Report
Additional Links
Substances
:
Cannabidiol
,
Cannabis
Diseases
:
Sleep Disorders
Additional Keywords
:
Phytotherapy
,
Significant Treatment Outcome
[+]
Further research may be appropriate to elucidate the increasingly recognized effect of cannabis/cannabinoids on gliomas.
Mar 31, 2011
Click here to read the entire abstract
Pubmed Data
: Childs Nerv Syst. 2011 Apr ;27(4):671-9. Epub 2011 Feb 20. PMID:
21336992
Article Published Date
: Mar 31, 2011
Study Type
: Human: Case Report
Additional Links
Substances
:
Cannabinoids
,
Cannabis
Diseases
:
Glioma
Additional Keywords
:
Cannabinoids
,
Cannabis
,
Glioma
,
Spontaneous Tumor Regression
[+]
Successful use of pure cannabidiol for the treatment of super-refractory status epilepticus.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Epilepsy Behav Case Rep. 2018 ;10:141-144. Epub 2018 Jul 17. PMID:
30596011
Article Published Date
: Dec 31, 2017
Study Type
: Human: Case Report
Additional Links
Substances
:
Cannabidiol
Diseases
:
Epilepsy
Pharmacological Actions
:
Anticonvulsants
[+]
THC combined with CBD led to a rapid and highly significant improvement in a patient with Tourette syndrome.
Jul 29, 2018
Click here to read the entire abstract
Pubmed Data
: Int J Psychiatry Med. 2018 Jul 30:91217418791455. Epub 2018 Jul 30. PMID:
30058466
Article Published Date
: Jul 29, 2018
Study Type
: Human: Case Report
Additional Links
Substances
:
Cannabidiol
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Tourette Syndrome
[+]
The data presented here may indicate that CBD led to a partial tumour response in a patient with histologically proven adenocarcinoma of the lung.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: SAGE Open Med Case Rep. 2019 ;7:2050313X19832160. Epub 2019 Feb 21. PMID:
30815264
Article Published Date
: Dec 31, 2018
Study Type
: Human: Case Report, Review
Additional Links
Substances
:
Cannabidiol
Diseases
:
Lung Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Immunomodulatory
[+]
These cases support pre-clinical and preliminary clinical evidence suggesting that CBD may be effective for some patients with epilepsy.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2016 ;7:359. Epub 2016 Aug 30. PMID:
27746737
Article Published Date
: Dec 31, 2015
Study Type
: Human: Case Report
Additional Links
Substances
:
Cannabidiol
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Epilepsy: Childhood
Pharmacological Actions
:
Anticonvulsants
[+]
CBD exhibits anti-seizure properties in acute seizure models.
May 05, 2017
Click here to read the entire abstract
Pubmed Data
: Neurochem Res. 2017 May 6. Epub 2017 May 6. PMID:
28478594
Article Published Date
: May 05, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Epilepsy
Pharmacological Actions
:
Anticonvulsants
[+]
A cannabigerol enriched cannabis extract could be used as an appetite stimulant.
Jan 24, 2017
Click here to read the entire abstract
Pubmed Data
: Behav Pharmacol. 2017 Jan 25. Epub 2017 Jan 25. PMID:
28125508
Article Published Date
: Jan 24, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
Diseases
:
Appetite Disorders: Loss/Lack of
Pharmacological Actions
:
Appetite Stimulants
Additional Keywords
:
Plant Extracts
[+]
A cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis.
Aug 07, 2006
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2006 Aug 7;542(1-3):100-5. Epub 2006 May 20. PMID:
16781706
Article Published Date
: Aug 07, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Amyotrophic Lateral Sclerosis
Pharmacological Actions
:
Neuroprotective Agents
[+]
A cannabis extract with high content in cannabidiol attenuated chemically-induced intestinal inflammation.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2016 ;7:341. Epub 2016 Aug 4. PMID:
27757083
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabinoids
,
Cannabis
Diseases
:
Colitis
,
Gastrointestinal Inflammation
,
Inflammatory Bowel Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Plant Extracts
[+]
A combination of Cannabichromene and Delta-tetrahydrocannabinol leads to enhanced tetrad and anti-inflammatory actions.
Oct 31, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Drug Alcohol Depend. 2010 Nov 1 ;112(1-2):126-33. PMID:
20619971
Article Published Date
: Oct 31, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
A single ultra-low dose of THC before ischemia is a safe and effective treatment that reduces myocardial ischemic damage.
May 31, 2013
Click here to read the entire abstract
Pubmed Data
: Biochem Pharmacol. 2013 Jun 1 ;85(11):1626-33. Epub 2013 Mar 26. PMID:
23537701
Article Published Date
: May 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Myocardial Infarction
,
Myocardial Ischemia
Pharmacological Actions
:
Cardioprotective
,
Neuroprotective Agents
[+]
A synthetic cannabinoid inhibited CXCL12-induced migration and invasive properties of breast cancer cells.
Dec 31, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2011 ;6(9):e23901. Epub 2011 Sep 7. PMID:
21915267
Article Published Date
: Dec 31, 2010
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Breast Cancer
,
Breast Cancer: Metastatic
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
Additional Keywords
:
Cannabinoid Receptors
,
Synthetic Cannabinoids
[+]
Activation of cannabinoid receptors could be a new therapeutic approach for the treatment of skin tumors.
Dec 31, 2002
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Clin Invest. 2003 Jan ;111(1):43-50. PMID:
12511587
Article Published Date
: Dec 31, 2002
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Skin Cancer
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Antineoplastic Agents
,
Apoptotic
,
Vascular Endothelial Growth Factor A Inhibitor
,
Vascular Endothelial Growth Factor Regulator
Additional Keywords
:
Cannabinoid Receptors
[+]
Activation of cannabinoid system may have protective actions on both liver and brain induced by cocaine, minimizing inflammatory injury promoted by cocaine.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mediators Inflamm. 2015 ;2015:523418. Epub 2015 Apr 27. PMID:
25999668
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Cocaine Toxicity
,
Drug Abuse
Pharmacological Actions
:
Hepatoprotective
,
Neuroprotective Agents
[+]
Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion.
Jul 01, 2010
Click here to read the entire abstract
Pubmed Data
: Br J Pharmacol. 2010 Jul;160(5):1234-42. PMID:
20590615
Article Published Date
: Jul 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
Diseases
:
Cardiac Arrhythmias
,
Myocardial Infarction
,
Myocardial Ischemia
Pharmacological Actions
:
Cardioprotective
[+]
Administration of synthetic 2-AG to mice after CHI led to significant reduction of brain oedema, better clinical recovery, reduced infarct volume and reduced hippocampal cell death compared with controls.
Oct 03, 2001
Click here to read the entire abstract
Pubmed Data
: Nature. 2001 Oct 4 ;413(6855):527-31. PMID:
11586361
Article Published Date
: Oct 03, 2001
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
,
Endocannabinoids
Diseases
:
Brain Edema
,
Brain Inflammation
,
Traumatic Brain Injury
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
Additional Keywords
:
Significant Treatment Outcome
[+]
Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload.
Sep 02, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Transl Psychiatry. 2018 Sep 3 ;8(1):176. Epub 2018 Sep 3. PMID:
30177808
Article Published Date
: Sep 02, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Cognitive Decline/Dysfunction
,
Iron Overload
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Anticonvulsant and neuroprotective effects of cannabidiol during the juvenile period.
Aug 27, 2018
Click here to read the entire abstract
Pubmed Data
: J Neuropathol Exp Neurol. 2018 Aug 28. Epub 2018 Aug 28. PMID:
30169677
Article Published Date
: Aug 27, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Epilepsy
Pharmacological Actions
:
Anticonvulsants
[+]
Antidepressant-like effect induced by cannabidiol is dependent on brain serotonin levels.
Jun 05, 2018
Click here to read the entire abstract
Pubmed Data
: Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jun 6. Epub 2018 Jun 6. PMID:
29885468
Article Published Date
: Jun 05, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
[+]
Avidekel cannabis extracts and cannabidiol are as efficient as copaxone in suppressing experimental autoimmune encephalomyelitis in mice.
Oct 04, 2018
Click here to read the entire abstract
Pubmed Data
: Inflammopharmacology. 2018 Oct 5. Epub 2018 Oct 5. PMID:
30291491
Article Published Date
: Oct 04, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
Diseases
:
Multiple Sclerosis
Pharmacological Actions
:
Immunomodulatory
Additional Keywords
:
Natural Substances Versus Drugs
[+]
Cannabichromene could be considered for clinical experimentation in inflammatory bowel disease patients.
Apr 30, 2013
Click here to read the entire abstract
Pubmed Data
: Biochem Pharmacol. 2013 May 1 ;85(9):1306-16. Epub 2013 Feb 12. PMID:
23415610
Article Published Date
: Apr 30, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Cannabigerol
,
Cannabinoids
Diseases
:
Colitis
,
Inflammatory Bowel Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-10 downregulation
,
Interleukin-1 beta downregulation
,
Nitric Oxide Inhibitor
,
Superoxide Dismutase Up-regulation
[+]
Cannabichromene raises the viability of NSPCs while inhibiting their differentiation into astroglia.
Oct 31, 2013
Click here to read the entire abstract
Pubmed Data
: Neurochem Int. 2013 Nov ;63(5):432-7. Epub 2013 Aug 11. PMID:
23941747
Article Published Date
: Oct 31, 2013
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabinoids
Additional Keywords
:
Neural Stem Cells
[+]
Cannabichromene selectively reduces inflammation-induced hypermotility in vivo.
May 31, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Br J Pharmacol. 2012 Jun ;166(4):1444-60. PMID:
22300105
Article Published Date
: May 31, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Cannabidiol acts in the dorsal striatum to improve haloperidol-induced catalepsy.
Apr 26, 2016
Click here to read the entire abstract
Pubmed Data
: Behav Brain Res. 2016 Apr 27 ;309:22-28. Epub 2016 Apr 27. PMID:
27131780
Article Published Date
: Apr 26, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Pharmacological Actions
:
Neuroprotective Agents
Problem Substances
:
Antipsychotic Drugs
[+]
Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function.
Sep 30, 2012
Click here to read the entire abstract
Pubmed Data
: Neuropharmacology. 2012 Oct ;63(5):776-83. Epub 2012 May 30. PMID:
22659086
Article Published Date
: Sep 30, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Brain Damage: Hypoxic Ischemic Insult
,
Brain Ischemia
Pharmacological Actions
:
Neuroprotective Agents
[+]
Cannabidiol and abnormal cannabidiol reduced the infarct volume.
Apr 30, 2005
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Stroke. 2005 May ;36(5):1077-82. Epub 2005 Apr 21. PMID:
15845890
Article Published Date
: Apr 30, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Middle Cerebral Artery Occlusion (MCAO)
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Cannabidiol
,
Middle Cerebral Artery Occlusion (MCAO)
,
Neuroprotective Agents
[+]
Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy.
Dec 14, 2010
Click here to read the entire abstract
Pubmed Data
: J Am Coll Cardiol. 2010 Dec 14;56(25):2115-25. PMID:
21144973
Article Published Date
: Dec 14, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Cardiomyopathy
,
Cardiovascular Diseases
,
Diabetes: Cardiovascular Illness
[+]
Cannabidiol attenuates delayed-type hypersensitivity reactions.
Dec 01, 2010
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2010 Dec;31(12):1611-7. Epub 2010 Nov 1. PMID:
21042286
Article Published Date
: Dec 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Hypersensitivity
,
Hypersensitivity: Type IV
[+]
Cannabidiol attenuates mechanical allodynia in streptozotocin-induced diabeties.
Mar 17, 2019
Click here to read the entire abstract
Pubmed Data
: Brain Res. 2019 Mar 18. Epub 2019 Mar 18. PMID:
30898678
Article Published Date
: Mar 17, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Allodynia
,
Diabetic Neuropathy
Pharmacological Actions
:
Analgesics
[+]
Cannabidiol attenuates seizures and EEG abnormalities in Angelman syndrome model mice.
Sep 09, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Clin Invest. 2019 Sep 10. Epub 2019 Sep 10. PMID:
31503547
Article Published Date
: Sep 09, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Angelman Syndrome
,
Epilepsy
Pharmacological Actions
:
Anticonvulsants
[+]
Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome.
Oct 01, 2017
Click here to read the entire abstract
Pubmed Data
: Proc Natl Acad Sci U S A. 2017 Oct 2. Epub 2017 Oct 2. PMID:
28973916
Article Published Date
: Oct 01, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Autism
,
Dravet syndrome
,
Seizures
Pharmacological Actions
:
Anticonvulsants
[+]
Cannabidiol blocks opioid reward suggests that this compound may be useful in addiction treatment settings.
Aug 08, 2017
Click here to read the entire abstract
Pubmed Data
: Planta Med. 2017 Aug 9. Epub 2017 Aug 9. PMID:
28793355
Article Published Date
: Aug 08, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Morphine Tolerance/Dependence
[+]
Cannabidiol can possibly be used as a therapeutic agent for treatment of type 1 diabetes.
Dec 31, 2007
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Neuropharmacology. 2008 Jan ;54(1):244-9. Epub 2007 Jul 17. PMID:
17714746
Article Published Date
: Dec 31, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Diabetes Mellitus: Type 1: Prevention
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-10 upregulation
,
Interleukin-12 downregulation
[+]
cannabidiol confers cardioprotection in diabetic rats independent of glycemic control.
Dec 19, 2017
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2017 Dec 20 ;820:256-264. Epub 2017 Dec 20. PMID:
29274332
Article Published Date
: Dec 19, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Diabetic Complications
Pharmacological Actions
:
Cardioprotective
[+]
Cannabidiol controls the exaggerated inflammatory response observed in an animal model of asthma.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mediators Inflamm. 2015 ;2015:538670. Epub 2015 May 25. PMID:
26101464
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Asthma
Pharmacological Actions
:
Anti-Inflammatory Agents
,
interleukin-13 down-regulation
,
Interleukin-4 downregulation
,
Interleukin-5 downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Cannabidiol could be used to prevent experimental colitis in mice.
Oct 31, 2009
Click here to read the entire abstract
Pubmed Data
: J Mol Med (Berl). 2009 Nov ;87(11):1111-21. Epub 2009 Aug 20. PMID:
19690824
Article Published Date
: Oct 31, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
Diseases
:
Colitis
Pharmacological Actions
:
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-10 downregulation
,
Interleukin-1 beta downregulation
[+]
Cannabidiol could represent a novel fast antidepressant drug, via enhancing both serotonergic and glutamate cortical signalling.
Dec 18, 2015
Click here to read the entire abstract
Pubmed Data
: Neuropharmacology. 2015 Dec 19. Epub 2015 Dec 19. PMID:
26711860
Article Published Date
: Dec 18, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
[+]
Cannabidiol disrupts the consolidation of specific and generalized fear memories.
Jul 24, 2017
Click here to read the entire abstract
Pubmed Data
: Neuropharmacology. 2017 Jul 25. Epub 2017 Jul 25. PMID:
28754373
Article Published Date
: Jul 24, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Traumatic Memory Formation
[+]
Cannabidiol does not display drug abuse potential in mice behavior.
Jul 17, 2018
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2018 Jul 18. Epub 2018 Jul 18. PMID:
30022153
Article Published Date
: Jul 17, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Psychiatric Disorders
Additional Keywords
:
Safety of Natural Substances
[+]
Cannabidiol enhanced the ability of THC to inhibit cell proliferation, induce cell cycle arrest and apoptosis.
Dec 31, 2009
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Cancer Ther. 2010 Jan ;9(1):180-9. Epub 2010 Jan 6. PMID:
20053780
Article Published Date
: Dec 31, 2009
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabidiol
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Cancer Metastasis
,
Glioblastoma
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Cannabinoid Receptors
,
Natural Substance Synergy
[+]
Cannabidiol exhibits an anticonvulsive effect in the rats with chronic epilepsy.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Clin Exp Med. 2015 ;8(6):8820-7. Epub 2015 Jun 15. PMID:
26309534
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Epilepsy
,
Epilepsy: Drug-Induced
Pharmacological Actions
:
Anticonvulsants
,
Neuroprotective Agents
[+]
Cannabidiol exhibits an antipsychotic-like profile without inducing extrapyramidal-like effects.
Apr 10, 2005
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2005 Apr 11 ;512(2-3):199-205. PMID:
15840405
Article Published Date
: Apr 10, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Pharmacological Actions
:
Antipsychotic Agents
Additional Keywords
:
Antipsychotic Agents
,
Cannabidiol
,
Natural Substances Versus Drugs
[+]
Cannabidiol exhibits therapeutic activity in a mouse model of obsessive-compulsive disorder.
Feb 01, 2006
Click here to read the entire abstract
Pubmed Data
: Platelets. 2006 Feb;17(1):37-41. PMID:
20695034
Article Published Date
: Feb 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
Diseases
:
Obsessive-Compulsive Disorder
[+]
Cannabidiol exhibits therapeutic potential against ischemia/reperfusion liver injury in rats.
Nov 16, 2011
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2011 Nov 16 ;670(1):216-23. Epub 2011 Sep 14. PMID:
21930120
Article Published Date
: Nov 16, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Liver Damage
,
Liver Injury: Ischemia/reperfusion
Pharmacological Actions
:
Hepatoprotective
[+]
Cannabidiol has a neuroprotective and blood-retinal-preserving effect in experimental diabetes.
Jan 01, 2004
Click here to read the entire abstract
Pubmed Data
: Int Urol Nephrol. 2004;36(4):591-8. PMID:
16400026
Article Published Date
: Jan 01, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Diabetes: Cataract
,
Diabetes Mellitus: Type 1
,
Diabetes Mellitus: Type 2
,
Oxidative Stress
Pharmacological Actions
:
Neuroprotective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
,
Vascular Endothelial Growth Factor A Inhibitor
[+]
Cannabidiol has a neuroprotective effect in endotoxin-induced uveitis.
Jan 01, 2008
Click here to read the entire abstract
Pubmed Data
: Mol Vis. 2008;14:2190-203. Epub 2008 Dec 3. PMID:
19052649
Article Published Date
: Jan 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
Diseases
:
Brain: Microglial Activation
,
Endotoxemia
,
Lipopolysaccharide-Induced Toxicity
,
Oxidative Stress
,
Uveitis
Pharmacological Actions
:
Enzyme Inhibitors
,
Neuroprotective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Cannabidiol has a neuroprotective property in newborn rodent hypoxic ischemic insult.
Sep 26, 2016
Click here to read the entire abstract
Pubmed Data
: CNS Neurol Disord Drug Targets. 2016 Sep 27. Epub 2016 Sep 27. PMID:
27686886
Article Published Date
: Sep 26, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Brain Ischemia
,
Infant Neurological Development
Pharmacological Actions
:
Neuroprotective Agents
[+]
Cannabidiol has a pharmacological profile which is compatible with that of an atypical antipsychotic agent.
Dec 31, 1990
Click here to read the entire abstract
Pubmed Data
: Psychopharmacology (Berl). 1991 ;104(2):260-4. PMID:
1678894
Article Published Date
: Dec 31, 1990
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Psychotic Disorders
Pharmacological Actions
:
Antipsychotic Agents
[+]
Cannabidiol has suppressive effects on antigen-specific antibody production.
May 31, 2007
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2007 Jun ;7(6):773-80. Epub 2007 Feb 15. PMID:
17466911
Article Published Date
: May 31, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Pharmacological Actions
:
Interferon Gamma Reducer
,
Interleukin-2 Downregulation
,
Interleukin-4 downregulation
[+]
Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice.
Dec 23, 2010
Click here to read the entire abstract
Pubmed Data
: Br J Pharmacol. 2010 Dec 23. Epub 2010 Dec 23. PMID:
21182490
Article Published Date
: Dec 23, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
Diseases
:
Fulminant Hepatic Failure
,
Hepatic Encephalopathy
,
Liver Failure: Acute
Pharmacological Actions
:
Hepatoprotective
,
Neuroprotective Agents
[+]
Cannabidiol improves metabolic dysfunction in middle-aged diabetic rats submitted to a chronic cerebral hypoperfusion.
Sep 05, 2019
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2019 Sep 6:108819. Epub 2019 Sep 6. PMID:
31499052
Article Published Date
: Sep 05, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Cerebral Ischemia
,
Diabetic Complications
Pharmacological Actions
:
Anticholesteremic Agents
,
Hypolipidemic
,
Neuroprotective Agents
[+]
Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1.
Sep 04, 2019
Click here to read the entire abstract
Pubmed Data
: Redox Biol. 2019 Sep 5 ;28:101321. Epub 2019 Sep 5. PMID:
31518892
Article Published Date
: Sep 04, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Atopic Dermatitis
,
Skin Diseases: Inflammatory
Pharmacological Actions
:
Antioxidants
[+]
Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1.
Apr 01, 2012
Click here to read the entire abstract
Pubmed Data
: FASEB J. 2012 Apr ;26(4):1535-48. Epub 2011 Dec 23. PMID:
22198381
Article Published Date
: Apr 01, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Cancer Metastasis
,
Lung Cancer
Pharmacological Actions
:
Anti-metastatic
,
Intracellular adhesion molecule-1 (ICAM-1)
[+]
Cannabidiol inhibits symptoms of multiple sclerosis-like disease in mice.
Mar 30, 2011
Click here to read the entire abstract
Pubmed Data
: Br J Pharmacol. 2011 Mar 30. Epub 2011 Mar 30. PMID:
21449980
Article Published Date
: Mar 30, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Brain: Microglial Activation
,
Multiple Sclerosis
Pharmacological Actions
:
Immunomodulatory
,
Immunomodulatory: T-Cell down-regulation
[+]
Cannabidiol is a potential therapeutic for the affective-motivational dimension of incision pain in rats.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2017 ;8:391. Epub 2017 Jun 21. PMID:
28680401
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Allodynia
Pharmacological Actions
:
Analgesics
Additional Keywords
:
Dose Response
[+]
Cannabidiol is able to attenuate motor and cognitive impairments induced by reserpine.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2016 ;7:343. Epub 2016 Aug 28. PMID:
27733830
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Memory Disorders: Drug-Induced
,
Parkinson's Disease
,
Tardive Dyskinesia
Pharmacological Actions
:
Neuroprotective Agents
[+]
Cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.
Aug 14, 2000
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Proc Natl Acad Sci U S A. 2000 Aug 15 ;97(17):9561-6. PMID:
10920191
Article Published Date
: Aug 14, 2000
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
Diseases
:
Arthritis
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Immunosuppressive Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Cannabidiol may be a safe and useful therapeutic agent for treating Osteoarthritis joint neuropathic pain.
Aug 31, 2017
Click here to read the entire abstract
Pubmed Data
: Pain. 2017 Sep 1. Epub 2017 Sep 1. PMID:
28885454
Article Published Date
: Aug 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Osteoarthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
,
Prophylactic Agents
Additional Keywords
:
Risk Reduction
[+]
Cannabidiol may be clinically useful in attenuating the rewarding effects of opioids.
Feb 28, 2013
Click here to read the entire abstract
Pubmed Data
: Addict Biol. 2013 Mar ;18(2):286-96. Epub 2012 Aug 2. PMID:
22862835
Article Published Date
: Feb 28, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Morphine Tolerance/Dependence
Problem Substances
:
Analgesic: Non-opioid
[+]
Cannabidiol may have potential as a preventative treatment for Alzheimer's disease.
Dec 31, 2013
Click here to read the entire abstract
Pubmed Data
: J Alzheimers Dis. 2014 ;42(4):1383-96. PMID:
25024347
Article Published Date
: Dec 31, 2013
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Brain: Oxidative Stress
,
Brain Inflammation
,
Memory Disorders
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Neuroprotective Agents
[+]
Cannabidiol may represent a good candidate to normalize motility in patients with inflammatory bowel disease.
Jun 30, 2008
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Br J Pharmacol. 2008 Jul ;154(5):1001-8. Epub 2008 May 12. PMID:
18469842
Article Published Date
: Jun 30, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
Diseases
:
Inflammatory Bowel Diseases
Pharmacological Actions
:
Enzyme Inhibitors
Problem Substances
:
Croton oil
[+]
Cannabidiol may represent a promising new protective strategy against cisplatin-induced nephrotoxicity.
Feb 28, 2009
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Pharmacol Exp Ther. 2009 Mar ;328(3):708-14. Epub 2008 Dec 12. PMID:
19074681
Article Published Date
: Feb 28, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
,
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Chemoprotective Agents
[+]
Cannabidiol might be of therapeutic value in sleep disorders such as excessive somnolence.
Aug 06, 2006
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: FEBS Lett. 2006 Aug 7 ;580(18):4337-45. Epub 2006 Jul 10. PMID:
16844117
Article Published Date
: Aug 06, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Sleep Disorders
[+]
Cannabidiol might become a useful therapeutic tool for the attenuation and treatment of inflammatory lung diseases.
Jan 31, 2015
Click here to read the entire abstract
Pubmed Data
: Immunopharmacol Immunotoxicol. 2015 Feb ;37(1):35-41. Epub 2014 Oct 30. PMID:
25356537
Article Published Date
: Jan 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Interstitial Lung Diseases
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Cannabidiol modulates fear memory formation through Interactions with serotonergic transmission.
Jun 13, 2016
Click here to read the entire abstract
Pubmed Data
: Neuropsychopharmacology. 2016 Jun 14. Epub 2016 Jun 14. PMID:
27296152
Article Published Date
: Jun 13, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Psychiatric Disorder: Conditioned Fear
,
Traumatic Memory Formation
[+]
Cannabidiol modulates serotonergic transmission and prevents allodynia and anxiety-like behavior in a model of neuropathic pain.
Aug 26, 2018
Click here to read the entire abstract
Pubmed Data
: Pain. 2018 Aug 27. Epub 2018 Aug 27. PMID:
30157131
Article Published Date
: Aug 26, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Allodynia
,
Neuropathic Pain
Pharmacological Actions
:
Analgesics
,
Anti-Anxiety Agents
[+]
Cannabidiol normalizes caspase 3, synaptophysin, and mitochondrial fission protein DNM1L expression levels in rats with brain iron overload.
Jan 31, 2014
Click here to read the entire abstract
Pubmed Data
: Mol Neurobiol. 2014 Feb ;49(1):222-33. Epub 2013 Jul 28. PMID:
23893294
Article Published Date
: Jan 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Iron Overload
,
Neurodegenerative Diseases
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Cannabidiol possesses an anti-apoptotic power against the neurodegenerative processes underlying MS development.
Nov 30, 2015
Click here to read the entire abstract
Pubmed Data
: Eur Rev Med Pharmacol Sci. 2015 Dec ;19(24):4906-19. PMID:
26744883
Article Published Date
: Nov 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Multiple Sclerosis
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Cannabidiol possesses neuroprotective characteristics that may, in turn, be promising for future clinical use.
Oct 31, 2013
Click here to read the entire abstract
Pubmed Data
: Eur J Neurosci. 2013 Nov ;38(10):3424-34. Epub 2013 Aug 25. PMID:
23981015
Article Published Date
: Oct 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Sciatic Nerve Crush Injury
Pharmacological Actions
:
Neuroprotective Agents
[+]
Cannabidiol potentiates pharmacological effects of THC.
Jan 09, 2008
Click here to read the entire abstract
Pubmed Data
: Brain Res. 2008 Jan 10 ;1188:157-64. Epub 2007 Oct 12. PMID:
18021759
Article Published Date
: Jan 09, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Memory Disorders
Additional Keywords
:
Natural Substance Synergy
[+]
Cannabidiol protected DNA from oxidative damage, increased endocannabinoid levels and reduced cell proliferation.
Jul 31, 2012
Click here to read the entire abstract
Pubmed Data
: J Mol Med (Berl). 2012 Aug ;90(8):925-34. Epub 2012 Jan 10. PMID:
22231745
Article Published Date
: Jul 31, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Colon Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antineoplastic Agents
,
Antiproliferative
,
Chemopreventive
Additional Keywords
:
Endocannabinoid System
[+]
Cannabidiol protects livers against nonalcoholic steatohepatitis induced by high-fat high cholesterol diet.
Apr 28, 2019
Click here to read the entire abstract
Pubmed Data
: J Cell Physiol. 2019 Apr 29. Epub 2019 Apr 29. PMID:
31032942
Article Published Date
: Apr 28, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
High Fat Diet
,
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Anti-Inflammatory Agents
,
NF-kappaB Inhibitor
[+]
Cannabidiol protects mouse liver from acute alcohol-induced steatosis through multiple mechanisms.
Feb 28, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Free Radic Biol Med. 2014 Mar ;68:260-7. Epub 2014 Jan 4. PMID:
24398069
Article Published Date
: Feb 28, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Alcohol Toxicity
,
Fatty Liver
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Autophagy Up-regulation
,
Hepatoprotective
[+]
Cannabidiol protects retinal neurons by preserving glutamine synthetase activity in diabetes.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: Mol Vis. 2010;16:1487-95. Epub 2010 Aug 4. PMID:
20806080
Article Published Date
: Jan 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
Diseases
:
Diabetes: Cataract
[+]
Cannabidiol provides potent and long-lasting neuroprotection through an anti-inflammatory CB1 receptor-independent mechanism.
Aug 31, 2007
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Neurochem. 2007 Sep ;102(5):1488-96. Epub 2007 Apr 16. PMID:
17437545
Article Published Date
: Aug 31, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Middle Cerebral Artery Occlusion (MCAO)
Pharmacological Actions
:
Neuroprotective Agents
[+]
Cannabidiol reduced cerebral infarction possibly through diminishing TNFR1/NF-κB-induced neurotoxicity in transient focal cerebral ischemia.
Feb 28, 2017
Click here to read the entire abstract
Pubmed Data
: Basic Clin Neurosci. 2017 Mar-Apr;8(2):139-146. PMID:
28539998
Article Published Date
: Feb 28, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Stroke: Ischemic
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
,
NF-kappaB Inhibitor
[+]
Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma.
Nov 23, 2018
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2018 Nov 24. Epub 2018 Nov 24. PMID:
30481497
Article Published Date
: Nov 23, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Asthma
,
Fibrosis
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Cannabidiol reduces anxiety-related behavior in mice.
May 03, 2019
Click here to read the entire abstract
Pubmed Data
: Pharmacol Biochem Behav. 2019 May 4. Epub 2019 May 4. PMID:
31063743
Article Published Date
: May 03, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Anxiety
Pharmacological Actions
:
Anti-Anxiety Agents
[+]
Cannabidiol reduces brain damage and improves functional recovery in a neonatal rat model of arterial ischemic stroke.
Dec 20, 2016
Click here to read the entire abstract
Pubmed Data
: Neuropharmacology. 2016 Dec 21. Epub 2016 Dec 21. PMID:
28012949
Article Published Date
: Dec 20, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Stroke: Ischemic
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Neuroprotective Agents
[+]
Cannabidiol reduces ethanol consumption, motivation and relapse in mice.
Feb 12, 2017
Click here to read the entire abstract
Pubmed Data
: Addict Biol. 2017 Feb 13. Epub 2017 Feb 13. PMID:
28194850
Article Published Date
: Feb 12, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Alcohol Withdrawal
[+]
Cannabidiol reduces lung injury induced by hypoxic-ischemic brain damage.
Apr 06, 2017
Click here to read the entire abstract
Pubmed Data
: Pediatr Res. 2017 Apr 7. Epub 2017 Apr 7. PMID:
28388598
Article Published Date
: Apr 06, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Brain Damage: Hypoxic Ischemic Insult
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
Additional Keywords
:
Anti-Inflammatory Agents
,
Brain Damage: Hypoxic Ischemic Insult
,
Cannabidiol
,
Neuroprotective Agents
[+]
Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models
Dec 25, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Epilepsia. 2018 Dec 26. Epub 2018 Dec 26. PMID:
30588604
Article Published Date
: Dec 25, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Epilepsy
Pharmacological Actions
:
Anticonvulsants
[+]
Cannabidiol regulates the expression of hypothalamus-pituitary-adrenal axis-related genes in response to acute restraint stress.
Oct 15, 2018
Click here to read the entire abstract
Pubmed Data
: J Psychopharmacol. 2018 Oct 16:269881118805495. Epub 2018 Oct 16. PMID:
30324842
Article Published Date
: Oct 15, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Anxiety
,
Depression
Pharmacological Actions
:
Anti-Anxiety Agents
,
Antidepressive Agents
[+]
Cannabidiol represents a potential protective agent against doxorubicin cardiac injury.
Aug 31, 2013
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol Pharmacol. 2013 Sep ;36(2):347-57. Epub 2013 May 10. PMID:
23721741
Article Published Date
: Aug 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cardioprotective
,
Malondialdehyde Down-regulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Cannabidiol reverses deficits in hippocampal long-term potentiation in a model of Alzheimer's disease.
Mar 23, 2018
Click here to read the entire abstract
Pubmed Data
: Neurochem Res. 2018 Mar 24. Epub 2018 Mar 24. PMID:
29574668
Article Published Date
: Mar 23, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Cannabidiol significantly attenuated the effects of disc injury induced by the needle puncture and could be useful in the treatment of intervertebral disc degeneration.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2014 ;9(12):e113161. Epub 2014 Dec 17. PMID:
25517414
Article Published Date
: Dec 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Degenerative Disk Disease
[+]
Cannabidiol therapy reduced acute myocardial infarction size and facilitated restoration of left ventricular function.
Sep 30, 2015
Click here to read the entire abstract
Pubmed Data
: J Cardiovasc Pharmacol. 2015 Oct ;66(4):354-63. PMID:
26065843
Article Published Date
: Sep 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Heart Attack
,
Myocardial Infarction
Pharmacological Actions
:
Cardioprotective
[+]
Cannabidiol treatment had a protective effect against inflammation and oxidative damage in the kidney ischemia/reperfusion model.
Nov 30, 2015
Click here to read the entire abstract
Pubmed Data
: Rev Bras Ter Intensiva. 2015 Dec ;27(4):383-389. PMID:
26761477
Article Published Date
: Nov 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Ischemia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Renoprotective
[+]
Cannabidiol treatment improves endothelium-dependent vasorelaxation in mesenteric arteries of zucker diabetic fatty rats.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2017 ;8:248. Epub 2017 May 18. PMID:
28572770
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Vasodilator Agents
[+]
Cannabidiol treatment significantly reduces the incidence of diabetes in NOD mice.
Feb 28, 2006
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Autoimmunity. 2006 Mar ;39(2):143-51. PMID:
16698671
Article Published Date
: Feb 28, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Diabetes Mellitus: Type 1: Prevention
Pharmacological Actions
:
Immunomodulatory
,
Interferon Gamma Reducer
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Risk Reduction
,
Significant Treatment Outcome
[+]
cannabidiol was able to produce a significant antitumor activity both in vitro and in vivo.
Feb 29, 2004
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Pharmacol Exp Ther. 2004 Mar ;308(3):838-45. Epub 2003 Nov 14. PMID:
14617682
Article Published Date
: Feb 29, 2004
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabidiol
,
Cannabinoids
Diseases
:
Glioma
Pharmacological Actions
:
Anti-Tumor
,
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
[+]
Cannabidiol was found to promote neuronal survival by inhibiting JNK and p38 MAP kinases.
Nov 24, 2016
Click here to read the entire abstract
Pubmed Data
: Fitoterapia. 2016 Nov 25 ;116:77-84. Epub 2016 Nov 25. PMID:
27890794
Article Published Date
: Nov 24, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Multiple Sclerosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interferon Gamma Reducer
,
Interleukin-17 downregulation
,
Neuroprotective Agents
[+]
Cannabidiol will have a palliative action and open new therapeutic possibilities for treating cerebrovascular disorders.
Feb 28, 2007
Click here to read the entire abstract
Pubmed Data
: Neuropharmacology. 2007 Mar ;52(4):1079-87. Epub 2007 Feb 21. PMID:
17320118
Article Published Date
: Feb 28, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Cerebral Ischemia
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Risk Reduction
[+]
Cannabidiol will open new therapeutic possibilities for post-ischemic injury via HMGB1-inhibiting mechanism.
Nov 30, 2008
Click here to read the entire abstract
Pubmed Data
: Neuropharmacology. 2008 Dec ;55(8):1280-6. Epub 2008 Jun 27. PMID:
18634812
Article Published Date
: Nov 30, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Hypertension
,
Middle Cerebral Artery Occlusion (MCAO)
Pharmacological Actions
:
Neuroprotective Agents
[+]
Cannabidiol-induced apoptosis is mediated by activation of Noxa in human colorectal cancer cells.
Jan 17, 2019
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2019 Jan 18 ;447:12-23. Epub 2019 Jan 18. PMID:
30660647
Article Published Date
: Jan 17, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Apoptotic
[+]
Cannabidiol-transdermal delivery has an anti-inflammatory effect in a murine model.
Dec 11, 2003
Click here to read the entire abstract
Pubmed Data
: J Control Release. 2003 Dec 12 ;93(3):377-87. PMID:
14644587
Article Published Date
: Dec 11, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Anti-Inflammatory Agents
,
Cannabidiol
,
Inflammation
[+]
Cannabidivarin-rich cannabis extracts exerted significant anticonvulsant effects in three rat models of seizure.
Sep 30, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Br J Pharmacol. 2013 Oct ;170(3):679-92. PMID:
23902406
Article Published Date
: Sep 30, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabinoids
,
Cannabis
Diseases
:
Epilepsy
,
Seizures
Pharmacological Actions
:
Anticonvulsants
Additional Keywords
:
Plant Extracts
[+]
Cannabigerol could be used for the treatment of neurodegenerative diseases such as Huntington's disease.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Neurotherapeutics. 2015 Jan ;12(1):185-99. PMID:
25252936
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Huntington Disease
,
Neurodegenerative Diseases
Pharmacological Actions
:
Neuroprotective Agents
[+]
Cannabigerol hampers colon cancer progression in vivo and selectively inhibits the growth of colorectal cancer cells.
Nov 30, 2014
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2014 Dec ;35(12):2787-97. Epub 2014 Sep 30. PMID:
25269802
Article Published Date
: Nov 30, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Cannabigerol
,
Cannabinoids
,
Cannabis
Diseases
:
Colon Cancer
,
Colon Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
Additional Keywords
:
Selective Antiproliferation
[+]
Cannabigerol is able to stimulate appetite in pre-satiated rats.
Aug 08, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Psychopharmacology (Berl). 2016 Aug 9. Epub 2016 Aug 9. PMID:
27503475
Article Published Date
: Aug 08, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Cannabigerol
,
Cannabinoids
Diseases
:
Cachexia
,
Cachexia: Chemotherapy Induced
Pharmacological Actions
:
Appetite Stimulants
[+]
Cannabigerol may be useful in the treatment of bladder dysfunctions.
May 31, 2015
Click here to read the entire abstract
Pubmed Data
: Nat Prod Commun. 2015 Jun ;10(6):1009-12. PMID:
26197538
Article Published Date
: May 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
Diseases
:
Bladder Dysfunction
Additional Keywords
:
Plant Extracts
[+]
Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia.
May 01, 2011
Click here to read the entire abstract
Pubmed Data
: Nat Chem Biol. 2011 May;7(5):296-303. Epub 2011 Apr 3. PMID:
21460829
Article Published Date
: May 01, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Pain
Pharmacological Actions
:
Analgesics
,
Glycine Agents
[+]
Cannabinoid receptor agonists HU210 and Delta(9)-tetrahydrocannabinol lowers the viability of translocation-positive rhabdomyosarcoma cells through the induction of apoptosis.
Jun 30, 2009
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Cancer Ther. 2009 Jul ;8(7):1838-45. Epub 2009 Jun 9. PMID:
19509271
Article Published Date
: Jun 30, 2009
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabinoids
,
Cannabinoids: Synthetic
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Rhabdomyosarcoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cannabinoid Receptor Antagonist/Inverse Agonist
,
Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor
Additional Keywords
:
Chemotherapeutic Synergy: Cisplatin
,
Chemotherapeutic Synergy: Doxorubicin
[+]
Cannabinoids ameliorate disease progression in a model of multiple sclerosis in mice.
May 31, 2012
Click here to read the entire abstract
Pubmed Data
: Neuropharmacology. 2012 Jun ;62(7):2299-308. Epub 2012 Feb 8. PMID:
22342378
Article Published Date
: May 31, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
,
Cannabinoids: Synthetic
Diseases
:
Multiple Sclerosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Cannabinoids are effective in reducing memory impairment in AβPP/PS1 mice.
Aug 09, 2016
Click here to read the entire abstract
Pubmed Data
: J Alzheimers Dis. 2016 Aug 10. Epub 2016 Aug 10. PMID:
27567873
Article Published Date
: Aug 09, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Dementia
Pharmacological Actions
:
Neuroprotective Agents
[+]
Cannabinoids as a potential new and novel treatment for melanoma.
Feb 28, 2019
Click here to read the entire abstract
Pubmed Data
: J Surg Res. 2019 Mar ;235:210-215. Epub 2018 Oct 30. PMID:
30691796
Article Published Date
: Feb 28, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Melanoma
Pharmacological Actions
:
Antiproliferative
,
Chemopreventive
[+]
Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis.
Apr 30, 2009
Click here to read the entire abstract
Pubmed Data
: Neurobiol Dis. 2009 May ;34(2):300-7. PMID:
19385063
Article Published Date
: Apr 30, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Aging
,
Aging: Brain
,
Brain Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Calcium Channel Blockers
,
Neuritogenic
,
Neuroprotective Agents
[+]
Cannabinoids can prime glioma cells to respond better to ionizing radiation and suggest a potential clinical benefit for glioma patients by using these two treatment modalities.
Nov 30, 2014
Click here to read the entire abstract
Pubmed Data
: Mol Cancer Ther. 2014 Dec ;13(12):2955-67. Epub 2014 Nov 14. PMID:
25398831
Article Published Date
: Nov 30, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabidiol
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Glioma
Pharmacological Actions
:
Radiosensitizer
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
Cannabinoids control spasticity and tremor in a multiple sclerosis model.
Mar 02, 2000
Click here to read the entire abstract
Pubmed Data
: Nature. 2000 Mar 2;404(6773):84-7. PMID:
10716447
Article Published Date
: Mar 02, 2000
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
Diseases
:
Multiple Sclerosis
,
Muscle Spasticity
,
Tremor
Pharmacological Actions
:
Antispasmodic
[+]
Cannabinoids could be a novel clinical therapy for corneal pain and inflammation resulting from ocular surface injury.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cannabis Cannabinoid Res. 2018 ;3(1):11-20. Epub 2018 Feb 1. PMID:
29450258
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabinoids
Diseases
:
Eye Damage
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antinoceceptive
[+]
Cannabinoids demonstrated antinociceptive effects in this mouse model of diabetic peripheral neuropathy.
Mar 16, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Pain. 2010 Mar 17 ;6:16. Epub 2010 Mar 17. PMID:
20236533
Article Published Date
: Mar 16, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabinoids
Diseases
:
Brain: Microglial Activation
,
Diabetic Neuropathies
,
Hyperalgesia
,
Neuropathic Pain
Pharmacological Actions
:
Analgesics
,
Antinoceceptive
[+]
Cannabinoids for the treatment of neuropsychiatric symptoms, pain and weight loss in dementia.
Feb 28, 2018
Click here to read the entire abstract
Pubmed Data
: Curr Opin Psychiatry. 2018 Mar ;31(2):140-146. PMID:
29256923
Article Published Date
: Feb 28, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Dementia
Additional Keywords
:
Risk Reduction
[+]
Cannabinoids have anti-tumoral action against liver cancer.
Sep 01, 2010
Click here to read the entire abstract
Pubmed Data
: Iran J Allergy Asthma Immunol. 2010 Sep;9(3):157-62. PMID:
21475304
Article Published Date
: Sep 01, 2010
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Liver Cancer
Pharmacological Actions
:
Anti-Tumor
,
Autophagy Up-regulation
[+]
Cannabinoids inhibit the growth of gliomas in vivo by targeting both tumor cells and vascular endothelial cells.
Feb 28, 2003
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: FASEB J. 2003 Mar ;17(3):529-31. Epub 2003 Jan 2. PMID:
12514108
Article Published Date
: Feb 28, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Cancers: All
,
Gliomas
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Vascular Endothelial Growth Factor Regulator
Additional Keywords
:
Disease Regression
[+]
Cannabinoids inhibit the growth of melanoma cells but not of normal melanocytes.
Nov 30, 2006
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: FASEB J. 2006 Dec ;20(14):2633-5. Epub 2006 Oct 25. PMID:
17065222
Article Published Date
: Nov 30, 2006
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabinoids
,
Cannabinoids: Synthetic
Diseases
:
Melanoma
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Anti-metastatic
,
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemotherapeutic
Additional Keywords
:
Cannabinoid Receptors
,
Selective Cytotoxicity
[+]
Cannabinoids may have therapeutic value in neurodegenerative conditions by preventing and/or reducing neuroinflammation.
Feb 22, 2007
Click here to read the entire abstract
Pubmed Data
: Neuroscience. 2007 Feb 23 ;144(4):1516-22. Epub 2006 Dec 18. PMID:
17178196
Article Published Date
: Feb 22, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Brain: Microglial Activation
,
Brain Inflammation
,
Lipopolysaccharide-Induced Toxicity
,
Memory Disorders
Pharmacological Actions
:
Analgesics
,
Anti-Inflammatory Agents
,
Neuroprotective Agents
[+]
Cannabinoids prevent depressive-like symptoms and alterations in BDNF expression in a rat model of PTSD.
Feb 16, 2018
Click here to read the entire abstract
Pubmed Data
: Prog Neuropsychopharmacol Biol Psychiatry. 2018 Feb 17 ;84(Pt A):129-139. Epub 2018 Feb 17. PMID:
29458190
Article Published Date
: Feb 16, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Depressive Disorder
Pharmacological Actions
:
Antidepressive Agents
,
Brain-derived neurotrophic factor modulator
[+]
Cannabinoids seem to protect neurons against NMDA toxicity.
Feb 28, 2006
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Pharmacol. 2006 Mar ;69(3):691-6. Epub 2005 Nov 18. PMID:
16299067
Article Published Date
: Feb 28, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
,
Delta-tetrahydrocannabinol (THC)
Pharmacological Actions
:
Neuroprotective Agents
,
Nitric Oxide Inhibitor
[+]
Cannabinol may have therapeutic value in ameliorating symptoms in ALS.
Sep 01, 2005
Click here to read the entire abstract
Pubmed Data
: Amyotroph Lateral Scler Other Motor Neuron Disord. 2005 Sep;6(3):182-4. PMID:
16183560
Article Published Date
: Sep 01, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
Diseases
:
Amyotrophic Lateral Sclerosis
[+]
Cannabis based medicine could be used as a neuroprotective agent capable of delaying disease progression in Huntington's disease.
Aug 31, 2011
Click here to read the entire abstract
Pubmed Data
: J Neurosci Res. 2011 Sep ;89(9):1509-18. Epub 2011 Jun 14. PMID:
21674569
Article Published Date
: Aug 31, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Huntington Disease
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Plant Extracts
[+]
Cannabis cannabinoids can achieve analgesic effects against cisplatin neuropathy.
May 22, 2016
Click here to read the entire abstract
Pubmed Data
: Planta Med. 2016 May 23. Epub 2016 May 23. PMID:
27214593
Article Published Date
: May 22, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions
:
Analgesics
[+]
Cannabis contains a number of compounds which may have therapeutic value in delaying the progression of ALS.
Mar 01, 2004
Click here to read the entire abstract
Pubmed Data
: Amyotroph Lateral Scler Other Motor Neuron Disord. 2004 Mar;5(1):33-9. PMID:
15204022
Article Published Date
: Mar 01, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
Diseases
:
Amyotrophic Lateral Sclerosis
Pharmacological Actions
:
Neuroprotective Agents
[+]
Cannabis extracts could be capable of attenuating experimental autoimmune encephalitis progression in a multiple sclerosis model.
Oct 31, 2015
Click here to read the entire abstract
Pubmed Data
: Mult Scler Relat Disord. 2015 Nov ;4(6):505-11. Epub 2015 Aug 5. PMID:
26590655
Article Published Date
: Oct 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
,
Delta-tetrahydrocannabinol (THC)
Additional Keywords
:
Plant Extracts
[+]
Cannabis extracts could be neuroprotective agents, delaying disease progression in a proinflammatory model of Huntington’s disease.
May 15, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: ACS Chem Neurosci. 2012 May 16 ;3(5):400-6. Epub 2012 Feb 9. PMID:
22860209
Article Published Date
: May 15, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
Diseases
:
Huntington Disease
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
Cannabis extracts have therapeutic potential to slow multiple sclerosis progression and repair the central nervous system.
Jun 30, 2015
Click here to read the entire abstract
Pubmed Data
: Br J Pharmacol. 2015 Jul ;172(14):3579-95. Epub 2015 May 20. PMID:
25857324
Article Published Date
: Jun 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Multiple Sclerosis
Pharmacological Actions
:
Immunomodulatory
Additional Keywords
:
Plant Extracts
[+]
Cannabis may provide support as a novel disease-modifying therapy in ALS.
Aug 31, 2014
Click here to read the entire abstract
Pubmed Data
: CNS Neurosci Ther. 2014 Sep ;20(9):809-15. Epub 2014 Apr 7. PMID:
24703394
Article Published Date
: Aug 31, 2014
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Amyotrophic lateral sclerosis (ALS)
[+]
Cannabis sativa extract has an antihyperalgesic effect in a rat model of neuropathic pain.
Jul 31, 2008
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2008 Aug ;22(8):1017-24. PMID:
18618522
Article Published Date
: Jul 31, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabinoids
,
Cannabis
Diseases
:
Hyperalgesia
Pharmacological Actions
:
Analgesics
Additional Keywords
:
Plant Extracts
[+]
CBD administration attenuated spinal cord injury induced sublesional cancellous bone loss.
May 03, 2017
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2017 May 4. Epub 2017 May 4. PMID:
28479140
Article Published Date
: May 03, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Spinal Cord Injuries
Pharmacological Actions
:
Osteoprotective
[+]
CBD both acutely inhibited fear expression and enhanced extinction to produce longer lasting reductions in fear.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2016 ;7:493. Epub 2016 Dec 16. PMID:
28018227
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Psychiatric Disorder: Conditioned Fear
,
Traumatic Memory Formation
[+]
CBD can attenuate both behavioural and dopaminergic neuronal correlates of mesolimbic dopaminergic sensitization.
May 03, 2016
Click here to read the entire abstract
Pubmed Data
: J Neurosci. 2016 May 4 ;36(18):5160-9. PMID:
27147666
Article Published Date
: May 03, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Amphetamine Addiction/Withdrawal
,
Schizophrenia
Pharmacological Actions
:
Neuroprotective Agents
Problem Substances
:
Amphetamine
[+]
CBD can be considered an agent that reduces the risk of the drug relapse.
Aug 31, 2017
Click here to read the entire abstract
Pubmed Data
: Prog Neuropsychopharmacol Biol Psychiatry. 2017 Sep 1. Epub 2017 Sep 1. PMID:
28870635
Article Published Date
: Aug 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Drug Addiction
[+]
CBD can be used as a novel therapeutic option to inhibit growth and metastasis of highly aggressive breast cancer subtypes including TNBC.
Mar 31, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Oncol. 2015 Apr ;9(4):906-19. Epub 2015 Jan 19. PMID:
25660577
Article Published Date
: Mar 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Epidermal growth factor receptor (EGFR) inhibitor
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
[+]
CBD could be an interesting pharmacological approach to reduce the anxiogenic effects of stress and promote the extinction of fear memories.
Nov 30, 2008
Click here to read the entire abstract
Pubmed Data
: Eur Neuropsychopharmacol. 2008 Dec ;18(12):849-59. Epub 2008 Aug 15. PMID:
18706790
Article Published Date
: Nov 30, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Anxiety
,
Traumatic Memory Formation
Pharmacological Actions
:
Anti-Anxiety Agents
[+]
CBD exerts protective effects against Doxorubicin induced cardiotoxicity and cardiac dysfunction by attenuating oxidative and nitrative stress.
Jan 05, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med. 2015 Jan 6. Epub 2015 Jan 6. PMID:
25569804
Article Published Date
: Jan 05, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cardioprotective
,
Chemoprotective Agents
,
Hepatoprotective
[+]
CBD has neuroprotective effects in middle-aged diabetic rats subjected to chronic cerebral hypoperfusion.
Nov 13, 2018
Click here to read the entire abstract
Pubmed Data
: Neurotox Res. 2018 Nov 14. Epub 2018 Nov 14. PMID:
30430393
Article Published Date
: Nov 13, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Cerebral Hypoperfusion
,
Diabetes: Memory Problems
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
[+]
CBD has therapeutic potential to attenuate contextual memories associated with drugs of abuse and consequently to reduce the risk of relapse.
Jan 31, 2016
Click here to read the entire abstract
Pubmed Data
: Addict Biol. 2016 Feb 1. Epub 2016 Feb 1. PMID:
26833888
Article Published Date
: Jan 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Drug Abuse
Additional Keywords
:
Risk Reduction
[+]
CBD induced a robust increase in ROS, which led to the inhibition of cell survival, phosphorylated (p)-AKT, self-renewal and a significant increase in the survival of GSC bearing mice.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Death Dis. 2015 ;6:e1601. Epub 2015 Jan 15. PMID:
25590811
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Glioblastoma
Pharmacological Actions
:
Anticarcinogenic Agents
,
Apoptotic
,
Redox Modulator
Additional Keywords
:
Cancer Stem Cells
,
Significant Treatment Outcome
[+]
CBD induces antidepressant-like effects comparable to those of imipramine.
Dec 31, 2009
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Br J Pharmacol. 2010 Jan ;159(1):122-8. Epub 2009 Dec 4. PMID:
20002102
Article Published Date
: Dec 31, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
Additional Keywords
:
Natural Substances Versus Drugs
[+]
CBD leads to improvement in fracture healing and demonstrate the critical mechanical role of collagen crosslinking enzymes.
Mar 18, 2015
Click here to read the entire abstract
Pubmed Data
: J Bone Miner Res. 2015 Mar 19. Epub 2015 Mar 19. PMID:
25801536
Article Published Date
: Mar 18, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Bone Fractures
Pharmacological Actions
:
Enzyme Activators
[+]
CBD markedly improved the clinical signs of experimental autoimmune encephalomyelitis and reduced infiltration, demyelination and axonal damage.
Aug 30, 2017
Click here to read the entire abstract
Pubmed Data
: Exp Neurol. 2017 Aug 31. Epub 2017 Aug 31. PMID:
28867485
Article Published Date
: Aug 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Encephalomyelitis
Pharmacological Actions
:
Immunomodulatory
,
Interleukin-6 Downregulation
[+]
CBD may be beneficial for the treatment of clinical depression and other states with prominent anhedonia.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Neuropsychobiology. 2016 ;73(2):123-9. Epub 2016 Mar 25. PMID:
27010632
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
[+]
CBD may be potent and effective at preventing the development of chemotherapy-induced peripheral neuropathy.
May 25, 2017
Click here to read the entire abstract
Pubmed Data
: Br J Pharmacol. 2017 May 26. Epub 2017 May 26. PMID:
28548225
Article Published Date
: May 25, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Chemotherapy and Radiation Toxicity
,
Chemotherapy-Induced Toxicity: Oxaliplatin
,
Chemotherapy-Induced Toxicity: Paclitaxel
,
Chemotherapy-Induced Toxicity: Vincristine
,
Neuropathic Pain
Pharmacological Actions
:
Chemoprotective Agents
[+]
CBD may be useful to control bone resorption during progression of experimental periodontitis in rats.
Jan 31, 2009
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2009 Feb ;9(2):216-22. Epub 2008 Dec 12. PMID:
19070683
Article Published Date
: Jan 31, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Periodontitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
CBD may represent a promising novel treatment for management of autoimmune myocarditis and possibly other autoimmune disorders
Jan 07, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Med. 2016 Jan 8. Epub 2016 Jan 8. PMID:
26772776
Article Published Date
: Jan 07, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Autoimmune Diseases
,
Myocarditis: Autoimmune
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Immunomodulatory
[+]
CBD treatment attenuated the development of thermal sensitivity following spinal cord injury.
Mar 07, 2018
Click here to read the entire abstract
Pubmed Data
: Cell Immunol. 2018 Mar 8. Epub 2018 Mar 8. PMID:
29784129
Article Published Date
: Mar 07, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Spinal Cord Inflammation
,
Spinal Cord Injuries
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
CBD's anti-inflammatory effects are linked to the inhibition of adenosine uptake.
Nov 30, 2008
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Invest Ophthalmol Vis Sci. 2008 Dec ;49(12):5526-31. Epub 2008 Jul 18. PMID:
18641283
Article Published Date
: Nov 30, 2008
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Diabetic Retinopathy
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Daily treatment with topical 1 % CBD-cream may exert neuroprotective effects against autoimmune encephalomyelitis.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Daru. 2015 ;23(1):48. Epub 2015 Oct 21. PMID:
26489494
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Multiple Sclerosis
Pharmacological Actions
:
Neuroprotective Agents
[+]
Delta-tetrahydrocannabinol, cannabidiol, and cannabichromene exert antidepressant-like actions in animal models.
May 31, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pharmacol Biochem Behav. 2010 Jun ;95(4):434-42. Epub 2010 Mar 21. PMID:
20332000
Article Published Date
: May 31, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabinoids
,
Cannabis
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
[+]
Distinct interactions of cannabidiol and morphine in three nociceptive behavioral models in mice.
Mar 31, 2015
Click here to read the entire abstract
Pubmed Data
: Behav Pharmacol. 2015 Apr ;26(3):304-14. PMID:
25485642
Article Published Date
: Mar 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
Effects of cannabidiol in males and females in two different rat models of depression.
Dec 16, 2018
Click here to read the entire abstract
Pubmed Data
: Physiol Behav. 2018 Dec 17. Epub 2018 Dec 17. PMID:
30571957
Article Published Date
: Dec 16, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
[+]
Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms.
Apr 26, 2019
Click here to read the entire abstract
Pubmed Data
: J Chem Neuroanat. 2019 Apr 27 ;98:104-116. Epub 2019 Apr 27. PMID:
31039391
Article Published Date
: Apr 26, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
,
Brain-derived neurotrophic factor modulator
[+]
Experimental cannabidiol treatment reduces early pancreatic inflammation in type 1 diabetes.
Oct 17, 2016
Click here to read the entire abstract
Pubmed Data
: Clin Hemorheol Microcirc. 2016 Oct 18. Epub 2016 Aug 18. PMID:
27767974
Article Published Date
: Oct 17, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Diabetes Mellitus: Type 1
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Pancreato Protective Agents
[+]
Maternal administration of cannabidiol promotes an anti-inflammatory effect on the intestinal wall in a gastroschisis rat model.
Mar 14, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Braz J Med Biol Res. 2018 Mar 15 ;51(5):e7132. Epub 2018 Mar 15. PMID:
29561958
Article Published Date
: Mar 14, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Gastroschisis
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs have been identified.
Jul 31, 2013
Click here to read the entire abstract
Pubmed Data
: Neuropharmacology. 2013 Aug ;71:282-91. Epub 2013 Apr 12. PMID:
23587650
Article Published Date
: Jul 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabinoids
Diseases
:
Brain Damage: Hypoxic Ischemic Insult
,
Brain Ischemia
Pharmacological Actions
:
Neuroprotective Agents
[+]
Neurodegenerative diseases linked directly to mitochondrial malfunction may benefit greatly from CBD-based medicines.
Feb 17, 2009
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Neurosci. 2009 Feb 18 ;29(7):2053-63. PMID:
19228959
Article Published Date
: Feb 17, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Friedreich Ataxia
,
Huntington Disease
,
Mitochondrial Dysfunction
,
Neurodegenerative Diseases
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol in hypoxic-ischemic newborn piglets has been observed.
Nov 30, 2008
Click here to read the entire abstract
Pubmed Data
: Pediatr Res. 2008 Dec ;64(6):653-8. PMID:
18679164
Article Published Date
: Nov 30, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Brain Damage: Hypoxic Ischemic Insult
,
Brain Ischemia
Pharmacological Actions
:
Neuroprotective Agents
[+]
Novel insights into mitochondrial molecular targets of iron-induced neurodegeneration: Reversal by cannabidiol.
Jan 28, 2018
Click here to read the entire abstract
Pubmed Data
: Brain Res Bull. 2018 Jan 29 ;139:1-8. Epub 2018 Jan 29. PMID:
29374603
Article Published Date
: Jan 28, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Neurodegenerative Diseases
Pharmacological Actions
:
Neuroprotective Agents
[+]
O-1602 decreased acquisition and expression of morphine CPP and inhibited development of morphine-induced physical dependence.
May 31, 2016
Click here to read the entire abstract
Pubmed Data
: Pharmacol Rep. 2016 Jun ;68(3):592-7. Epub 2016 Jan 11. PMID:
26971034
Article Published Date
: May 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Morphine Tolerance/Dependence
[+]
O-1602 is protective against experimentally induced colitis and inhibits neutrophil recruitment independently of CB1, CB2 and GPR55 receptors.
Jul 31, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Inflamm Bowel Dis. 2011 Aug ;17(8):1651-64. Epub 2010 Nov 15. PMID:
21744421
Article Published Date
: Jul 31, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Colitis
,
Inflammation: Neutrophil-Mediated
Additional Keywords
:
Dose Response
[+]
O-1602 mediates its vasorelaxant effects partly by an endothelium-dependent pathway involving rimonabant- and O-1918-sensitive targets.
Oct 14, 2015
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2015 Oct 15 ;765:107-14. Epub 2015 Aug 18. PMID:
26297305
Article Published Date
: Oct 14, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
Pharmacological Actions
:
Vasodilator Agents
[+]
Ondansetron and delta9-THC both dose-dependently suppressed cisplatin-induced vomiting and retching.
Jun 30, 2004
Click here to read the entire abstract
Pubmed Data
: Psychopharmacology (Berl). 2004 Jul ;174(2):254-9. PMID:
14740147
Article Published Date
: Jun 30, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabinoids
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions
:
Chemoprotective Agents
[+]
Oral cannabidiol has a beneficial action on two symptoms of established inflammation: edema and hyperalgesia.
Feb 29, 2004
Click here to read the entire abstract
Pubmed Data
: Naunyn Schmiedebergs Arch Pharmacol. 2004 Mar ;369(3):294-9. Epub 2004 Feb 12. PMID:
14963641
Article Published Date
: Feb 29, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
Diseases
:
Hyperalgesia
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Prostaglandin PGE2 downregulation
[+]
Oral cannabidiol prevents allodynia and neurological dysfunctions in a mouse model of mild traumatic brain injury.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2019 ;10:352. Epub 2019 Apr 16. PMID:
31040777
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Allodynia
,
Brain Injury: Traumatic
Pharmacological Actions
:
Neuroprotective Agents
[+]
Oral treatment with a low dose of THC inhibits atherosclerosis progression in this mouse model.
Apr 06, 2005
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nature. 2005 Apr 7 ;434(7034):782-6. PMID:
15815632
Article Published Date
: Apr 06, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Arteriosclerosis
,
Inflammation
Pharmacological Actions
:
Anti-atherogenic
,
Anti-Inflammatory Agents
,
Interferon Gamma Reducer
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Our results indicate that CBD exhibits neuroprotective effects in a cerebral malaria model and might be useful as an adjunctive therapy to prevent neurological symptoms.
Mar 18, 2015
Click here to read the entire abstract
Pubmed Data
: Neuroscience. 2015 Mar 19 ;289:166-80. Epub 2015 Jan 13. PMID:
25595981
Article Published Date
: Mar 18, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Malaria
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Neuroprotective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Malaria Complications
[+]
Pharmacokinetics of oral and intravenous cannabidiol and its antidepressant-like effects in chronic mild stress model.
May 29, 2019
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol Pharmacol. 2019 May 30 ;70:103202. Epub 2019 May 30. PMID:
31173966
Article Published Date
: May 29, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
,
Brain-derived neurotrophic factor modulator
[+]
Pretreatment of mice with cannabidiol attenuated the amphetamine induced disruptive effects on prepulse inhibition (PPI).
May 05, 2015
Click here to read the entire abstract
Pubmed Data
: Psychopharmacology (Berl). 2015 May 6. Epub 2015 May 6. PMID:
25943166
Article Published Date
: May 05, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Schizophrenia
Pharmacological Actions
:
Antipsychotic Agents
Problem Substances
:
Amphetamine
[+]
Short-term cannabidiol treatment results in global functional recovery in ischemic mice.
Nov 22, 2016
Click here to read the entire abstract
Pubmed Data
: Prog Neuropsychopharmacol Biol Psychiatry. 2016 Nov 23. Epub 2016 Nov 23. PMID:
27889412
Article Published Date
: Nov 22, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Brain Inflammation
,
Brain Ischemia
Pharmacological Actions
:
Neuroplasticity enhancement
,
Neuroprotective Agents
[+]
Tetrahdrocannabivarin has therapeutic potential for ameliorating some of the negative, cognitive and positive symptoms of schizophrenia.
Feb 28, 2015
Click here to read the entire abstract
Pubmed Data
: Br J Pharmacol. 2015 Mar ;172(5):1305-18. PMID:
25363799
Article Published Date
: Feb 28, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Schizophrenia
[+]
Tetrahydrocannabivarin could be used for delaying disease progression in PD and also for ameliorating parkinsonian symptoms.
Jul 31, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Br J Pharmacol. 2011 Aug ;163(7):1495-506. PMID:
21323909
Article Published Date
: Jul 31, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Parkinson's Disease
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
Tetrahydrocannabivarin is a new potential treatment against obesity-associated glucose intolerance.
Dec 31, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutr Diabetes. 2013 ;3:e68. Epub 2013 May 27. PMID:
23712280
Article Published Date
: Dec 31, 2012
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Insulin Resistance
,
Metabolic Diseases
,
Obesity
Pharmacological Actions
:
Hypoglycemic Agents
[+]
THC and cannabidiol may have therapeutic value in reducing damage and inflammation associated with colitis.
Jun 01, 2010
Click here to read the entire abstract
Pubmed Data
: Br J Pharmacol. 2010 Jun;160(3):712-23. PMID:
20590574
Article Published Date
: Jun 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Colitis
,
Inflammatory Bowel Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
THC and CBD could be therapeutic in mitigating a dysfunctional aversive memory through reconsolidation disruption in PTSD patients.
May 31, 2015
Click here to read the entire abstract
Pubmed Data
: Eur Neuropsychopharmacol. 2015 Jun ;25(6):958-65. Epub 2015 Feb 16. PMID:
25799920
Article Published Date
: May 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Memory Disorders
,
Post-Traumatic Stress Disorders (PTSD)
Additional Keywords
:
Extinction Of Fear Conditioning
[+]
THC mediates neuroprotection via PPARγ-dependent restoration of mitochondrial content which may be beneficial for PD treatment.
Jun 26, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2016 Jun 27. Epub 2016 Jun 27. PMID:
27366949
Article Published Date
: Jun 26, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Parkinson's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
THCV and CBD might be used as new therapeutic agents for the treatment of obesity- and metabolic syndrome-related NAFLD/hepatosteatosis.
May 31, 2015
Click here to read the entire abstract
Pubmed Data
: J Hepatol. 2015 Jun ;62(6):1382-90. Epub 2015 Jan 13. PMID:
25595882
Article Published Date
: May 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabidiol
,
Cannabinoids
Diseases
:
Metabolic Syndrome X
,
Nonalcoholic fatty liver disease (NAFLD)
,
Obesity
Pharmacological Actions
:
Hepatoprotective
[+]
The activation of the endocannabinoid system promotes white and gray matter recovery after neonatal HI injury.
Nov 30, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Stroke. 2010 Dec ;41(12):2956-64. PMID:
21115947
Article Published Date
: Nov 30, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Brain Ischemia
,
Neonatal Stroke
,
Stroke: Attenuation/Recovery
Pharmacological Actions
:
Neurogenesis
Additional Keywords
:
Endocannabinoid System
,
Neuro-repair
[+]
The anti-Inflammatory properties of terpenoids from cannabis.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Cannabis Cannabinoid Res. 2018 ;3(1):282-290. Epub 2018 Dec 26. PMID:
30596146
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Immunomodulatory
[+]
The antitumorigenic effects of O-1602 are multiple in that it reduces viability and proliferation of cancer cells and further promotes their apoptosis.
Mar 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Mol Med (Berl). 2013 Apr ;91(4):449-58. Epub 2012 Sep 11. PMID:
22965195
Article Published Date
: Mar 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Colitis
,
Colon Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Chemopreventive
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
The anxiolytic effects of cannabidiol in chronically stressed mice are mediated by the endocannabinoid system.
Mar 02, 2018
Click here to read the entire abstract
Pubmed Data
: Neuropharmacology. 2018 Mar 3 ;135:22-33. Epub 2018 Mar 3. PMID:
29510186
Article Published Date
: Mar 02, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Anxiety
Pharmacological Actions
:
Anti-Anxiety Agents
[+]
The CB2 cannabinoid agonist AM-1241 prolongs survival (56%) in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset.
Jul 01, 2005
Click here to read the entire abstract
Pubmed Data
: Curr Eye Res. 2005 Jul;30(7):583-91. PMID:
17241118
Article Published Date
: Jul 01, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Amyotrophic Lateral Sclerosis
Pharmacological Actions
:
Neuroprotective Agents
[+]
The combination of THC and CBD exhibits a better therapeutic profile than each cannabis component alone against Alzheimer's disease.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: J Alzheimers Dis. 2015 ;43(3):977-91. PMID:
25125475
Article Published Date
: Dec 31, 2014
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
,
Delta-tetrahydrocannabinol (THC)
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Gene Expression
,
Natural Substance Synergy
[+]
The combination of TRAIL and cannabidiol decreased tumor growth in xenograft models.
May 08, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancers (Basel). 2019 May 9 ;11(5). Epub 2019 May 9. PMID:
31075907
Article Published Date
: May 08, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Chemosensitizer
[+]
The data from this study supports the view that inhibition of microglial activation may improve schizophrenia symptoms.
Apr 30, 2015
Click here to read the entire abstract
Pubmed Data
: Schizophr Res. 2015 May ;164(1-3):155-63. Epub 2015 Feb 10. PMID:
25680767
Article Published Date
: Apr 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Brain Inflammation
,
Schizophrenia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antipsychotic Agents
,
Neuroprotective Agents
Additional Keywords
:
Clozapine
,
Natural Substances Versus Drugs
[+]
The data support a promising therapeutic profile for CBD as a new fast-acting antidepressant treatment.
Jun 03, 2018
Click here to read the entire abstract
Pubmed Data
: Mol Neurobiol. 2018 Jun 4. Epub 2018 Jun 4. PMID:
29869197
Article Published Date
: Jun 03, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
,
Brain-derived neurotrophic factor modulator
Additional Keywords
:
Antidepressive Agents
,
Brain-derived neurotrophic factor modulator
,
Cannabidiol
,
depression
[+]
The discovery of IL-12-induced CB2 overexpression in thyroid cancer cells may offer a new target for anaplastic thyroid cancer treatment
Jan 31, 2008
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Gene Ther. 2008 Feb ;15(2):101-7. Epub 2007 Dec 21. PMID:
18197164
Article Published Date
: Jan 31, 2008
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabinoids
,
Cannabinoids: Synthetic
Diseases
:
Thyroid Cancer
Pharmacological Actions
:
Apoptotic
,
Cannabinoid Receptor Antagonist/Inverse Agonist
,
Chemosensitizer
Additional Keywords
:
Cannabinoid Receptors
,
Chemothapeutic Synergy: Paclitaxel
[+]
The in vivo administration of microencapsulated cannabinoids efficiently reduces tumor growth.
Dec 31, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2013 ;8(1):e54795. Epub 2013 Jan 22. PMID:
23349970
Article Published Date
: Dec 31, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabinoids
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Glioblastoma Multiforme
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Antiproliferative
,
Apoptotic
1
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