Wnt/β-catenin signaling pathway modulation

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20 Substances Researched for Wnt/β-catenin signaling pathway modulation
NameACCKFocus
Curcumin916Locked
Bee Propolis12Locked
Caffeic acid phenethyl ester12Locked
EGCG (Epigallocatechin gallate)12Locked
Grape Seed Extract12Locked
Resveratrol12Locked
Sulforaphane22Locked
Theaflavins12Locked
Thymoquinone12Locked
Broccoli11Locked
Broccoli Sprouts11Locked
Chlorophyllin11Locked
Ellagic Acid11Locked
Ginger11Locked
Honey11Locked
Luteolin11Locked
Pomegranate11Locked
Quercetin11Locked
Silymarin11Locked
Urolithin A 11Locked

View the Evidence:
96 Abstracts with Wnt/β-catenin signaling pathway modulation Research

[+]

Light-emitting diodes have a potential to stimulate human dermal papilla cell proliferation.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Dermatol. 2017 Dec ;29(6):747-754. Epub 2017 Oct 30. PMID: 29200764
Article Published Date : Nov 30, 2017
Study Type : Human In Vitro
Additional Links
Diseases : Hair Loss
Therapeutic Actions : Light-Emitting Diode Therapy
Pharmacological Actions : Wnt/β-catenin signaling pathway modulation
[+]

Resveratrol may represent a new interesting therapeutic approach, in order to affect glioma stem cell proliferation and motility.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(1):e0169854. Epub 2017 Jan 12. PMID: 28081224
Article Published Date : Dec 31, 2016
Study Type : Human In Vitro
Additional Links
Substances : Resveratrol
Diseases : Glioblastoma Multiforme
Pharmacological Actions : Antiproliferative , Apoptotic, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Cancer Stem Cells
[+]

5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2016 ;10:2239-53. Epub 2016 Jul 11. PMID: 27468227
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Gene Expression Regulation
[+]

Arctigenin attenuates tumor metastasis of hepatocellular carcinoma.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:937. Epub 2019 Aug 29. PMID: 31555129
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Arctigenin
Diseases : Cancer Metastasis, Liver Cancer
Pharmacological Actions : Anti-metastatic, Cyclin D1 Down-Regulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, Wnt/β-catenin signaling pathway modulation
[+]

Benzyl isothiocyanate suppresses development and metastasis of murine mammary carcinoma by regulating the Wnt/β‑catenin pathway.Jul 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2019 Aug ;20(2):1808-1818. Epub 2019 Jun 18. PMID: 31257529
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic, Wnt/β-catenin signaling pathway modulation
[+]

Berberine combined with HMQ1611 exhibited potential antitumor activities against human liver cancer in vitro and in vivo.Dec 17, 2018

Pubmed Data : Phytother Res. 2018 Dec 18. Epub 2018 Dec 18. PMID: 30565332
Article Published Date : Dec 17, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Berberine
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Wnt/β-catenin signaling pathway modulation
[+]

Caffeic acid phenethyl ester may be a potential therapeutic agent for patients with advanced PCa.May 14, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 May 15. Epub 2016 May 15. PMID: 27191743
Article Published Date : May 14, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bee Propolis, Caffeic acid phenethyl ester
Diseases : Cancer Metastasis, Prostate Cancer
Pharmacological Actions : Anti-metastatic, Chemotherapeutic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Wnt/β-catenin signaling pathway modulation
[+]

Cinnamaldehyde enhances apoptotic effect of oxaliplatin and reverses epithelial-mesenchymal transition and stemnness in hypoxic colorectal cancer cells.Jul 11, 2019

Pubmed Data : Exp Cell Res. 2019 Jul 12:111500. Epub 2019 Jul 12. PMID: 31306656
Article Published Date : Jul 11, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Cinnamaldehyde
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Chemotherapeutic Synergy: Oxaliplatin
[+]

Curcumin affects β-catenin pathway in HSCs and might suggest a possible new explanation for the effects of curcumin on HSC activation and liver fibrosis.Oct 31, 2014

Pubmed Data : J Pharm Pharmacol. 2014 Nov ;66(11):1615-22. Epub 2014 Jun 19. PMID: 24945564
Article Published Date : Oct 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Liver Cirrhosis
Pharmacological Actions : Hepatoprotective, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Plant Extracts
[+]

Curcumin may be a potential therapeutic agent for the treatment of glucocorticoid induced osteoporosis.Dec 10, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2015 Dec 11. Epub 2015 Dec 11. PMID: 26677102
Article Published Date : Dec 10, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Osteoporosis
Pharmacological Actions : Wnt/β-catenin signaling pathway modulation
Problem Substances : Dexamethasone
[+]

Curcumin nanoparticles may offer a therapeutic approach to treating neurodegenerative diseases by enhancing brain self-repair mechanisms.Jan 27, 2014

Pubmed Data : ACS Nano. 2014 Jan 28 ;8(1):76-103. Epub 2013 Dec 10. PMID: 24467380
Article Published Date : Jan 27, 2014
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Neurodegenerative Diseases
Pharmacological Actions : Neurogenesis, Neuroprotective Agents, Wnt/β-catenin signaling pathway modulation
[+]

Curcumin provides neuroprotection against BPA-mediated impaired neurogenesis via activation of the Wnt/β-catenin signaling pathway.May 11, 2015

Pubmed Data : Mol Neurobiol. 2015 May 12. Epub 2015 May 12. PMID: 25963729
Article Published Date : May 11, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Bisphenol-A Toxicity
Pharmacological Actions : Neurogenesis, Neuroprotective Agents, Wnt/β-catenin signaling pathway modulation
Problem Substances : Bisphenol A
Adverse Pharmacological Actions : Neurotoxic
[+]

Ellagic acid may be used in functional foods or medicines to help treat nerve dysfunction, neurodegenerative disease and aging.Oct 28, 2016

Pubmed Data : Mol Nutr Food Res. 2016 Oct 29. Epub 2016 Aug 29. PMID: 27794200
Article Published Date : Oct 28, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ellagic Acid
Diseases : Neurodegenerative Diseases, Traumatic Brain Injury
Pharmacological Actions : Wnt/β-catenin signaling pathway modulation
[+]

Epigallocatechin gallete and theaflavin restrict mouse liver carcinogenesis through modulation of self-renewal Wnt and hedgehog pathways.Aug 20, 2015

Pubmed Data : J Nutr Biochem. 2015 Aug 21. Epub 2015 Aug 21. PMID: 26386739
Article Published Date : Aug 20, 2015
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Theaflavins
Diseases : Liver Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Wnt/β-catenin signaling pathway modulation
[+]

Gastrodin treatment markedly preserved the Wnt/β-Catenin signalling pathway, which could promote neurogenesis and provide neuroprotection brain injury.May 31, 2019

Pubmed Data : Brain Res. 2019 Jun 1 ;1712:7-15. Epub 2019 Feb 1. PMID: 30716287
Article Published Date : May 31, 2019
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Cerebral Stroke
Pharmacological Actions : Neurogenesis, Neuroprotective Agents, Wnt/β-catenin signaling pathway modulation
[+]

Geraniol represents a valuable asset against colitis alone or in combination with the conventional anti-colitic therapies.Aug 31, 2015

Pubmed Data : Life Sci. 2015 Sep 1 ;136:142-50. Epub 2015 Jul 10. PMID: 26165751
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Substances : Geraniol
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Immunosuppressive Agents, NF-kappaB Inhibitor, Wnt/β-catenin signaling pathway modulation
[+]

Ginsenoside Rb1 ameliorates chronic kidney disease-associated vascular calcification by inhibiting the Wnt/β-catenin pathway.Aug 18, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2019 Aug 19. Epub 2019 Aug 19. PMID: 31423730
Article Published Date : Aug 18, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Diseases : Chronic Kidney Disease (CKD), Vascular Calcification
Pharmacological Actions : Wnt/β-catenin signaling pathway modulation
[+]

Ginsenoside Rg1 could exert its therapeutic effects on intestinal intestinal ischemia/reperfusion injury.Jan 01, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 12 2 ;6:38480. Epub 2016 Dec 2. PMID: 27910952
Article Published Date : Jan 01, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Intestinal Ischemia
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Gastroprotective, Wnt/β-catenin signaling pathway modulation
[+]

Guava fruit extract and its triterpene constituents have osteoanabolic effect.Mar 07, 2017

Pubmed Data : J Nutr Biochem. 2017 Mar 8 ;44:22-34. Epub 2017 Mar 8. PMID: 28343085
Article Published Date : Mar 07, 2017
Study Type : Animal Study
Additional Links
Substances : Guava
Diseases : Osteopenia
Pharmacological Actions : Osteogenic, Wnt/β-catenin signaling pathway modulation
[+]

Hesperidin has a prophylactic effect against hepatocarcinogenesis.Jul 24, 2017

Pubmed Data : Life Sci. 2017 Jul 25. Epub 2017 Jul 25. PMID: 28754618
Article Published Date : Jul 24, 2017
Study Type : Animal Study
Additional Links
Substances : Hesperidin
Diseases : Liver Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Wnt/β-catenin signaling pathway modulation
[+]

Intranasal administration of nasal gel huperzine A may represent a safe and noninvasive therapeutic strategy for the treatment of Alzheimer's disease.Mar 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neuropsychopharmacology. 2011 Apr ;36(5):1073-89. Epub 2011 Feb 2. PMID: 21289607
Article Published Date : Mar 31, 2011
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Huperzine
Diseases : Alzheimer's Disease
Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants, Wnt/β-catenin signaling pathway modulation
[+]

Isoliquiritigenin suppresses the proliferation and induced apoptosis via miR-32/LATS2/Wnt in nasopharyngeal carcinoma.Aug 04, 2019

Pubmed Data : Eur J Pharmacol. 2019 Aug 5 ;856:172352. Epub 2019 Apr 17. PMID: 31004603
Article Published Date : Aug 04, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Isoliquiritigenin
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, MicroRNA modulator, Wnt/β-catenin signaling pathway modulation
[+]

Micellar curcumin in combination with cisplatin can be a promising strategy for treatment of pediatric hepatocellular carcinoma.Oct 18, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2015 Oct 19. Epub 2015 Oct 19. PMID: 26515460
Article Published Date : Oct 18, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, NF-kappaB Inhibitor, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Oral curcumin intake could inhibit androgen receptor expression and probably PSA activity.Aug 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Korean J Urol. 2015 Sep ;56(9):656-65. Epub 2015 Aug 31. PMID: 26366279
Article Published Date : Aug 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Prostate Cancer
Pharmacological Actions : Androgen Antagonists, Antiproliferative , Wnt/β-catenin signaling pathway modulation
Additional Keywords : Gene Expression Regulation
[+]

Regulation of Wnt activity by curcumin is a feasible alternative strategy to rescue diabetic renal injury.Feb 29, 2016

Pubmed Data : Am J Med Sci. 2016 Mar ;351(3):286-95. PMID: 26992258
Article Published Date : Feb 29, 2016
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Diabetic Nephropathy, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Wnt/β-catenin signaling pathway modulation
[+]

Resveratrol and grape seed extract combination eliminates colon CSCs in vivo and in vitro.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2016 ;16:278. Epub 2016 Aug 9. PMID: 27506388
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Grape Seed Extract, Resveratrol
Diseases : Colon Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Cancer Stem Cells
[+]

Salvia miltiorrhiza protects against diabetic nephropathy.Nov 01, 2018

Pubmed Data : Pharmacol Res. 2018 Nov 2. Epub 2018 Nov 2. PMID: 30395946
Article Published Date : Nov 01, 2018
Study Type : Animal Study
Additional Links
Substances : Salvia miltiorrhiza
Diseases : Diabetic Nephropathy
Pharmacological Actions : Renoprotective, Wnt/β-catenin signaling pathway modulation
[+]

These findings suggest crocin as a promising complementary antimetastatic herbal medicine for treatment of triple-negative breast cancer.Oct 22, 2018

Pubmed Data : DNA Cell Biol. 2018 Oct 23. Epub 2018 Oct 23. PMID: 30351203
Article Published Date : Oct 22, 2018
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Wnt/β-catenin signaling pathway modulation
[+]

These results suggest that electro-acupuncture therapy may promote spinal cord recovery following injury.Jun 18, 2017

Pubmed Data : Mol Med Rep. 2017 Jun 19. Epub 2017 Jun 19. PMID: 28627669
Article Published Date : Jun 18, 2017
Study Type : Animal Study
Additional Links
Diseases : Spinal Cord Injuries
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Wnt/β-catenin signaling pathway modulation
[+]

This study revealed that cotreatment of cardamonin and 5-FU could strongly potentiate the antitumor activity of 5-FU.May 16, 2019

Pubmed Data : Invest New Drugs. 2019 May 17. Epub 2019 May 17. PMID: 31102118
Article Published Date : May 16, 2019
Study Type : Animal Study
Additional Links
Substances : Cardamonin
Diseases : Gastric Cancer
Pharmacological Actions : Chemosensitizer, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Treadmill exercise alleviates Alzheimer disease-associated memory loss by increasing neurogenesis.Jul 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exerc Rehabil. 2016 Aug ;12(4):276-83. Epub 2016 Aug 31. PMID: 27656623
Article Published Date : Jul 31, 2016
Study Type : Animal Study
Additional Links
Diseases : Alzheimer's Disease, Diabetic Complications
Therapeutic Actions : Exercise
Pharmacological Actions : Neurogenesis, Neuroprotective Agents, Wnt/β-catenin signaling pathway modulation
[+]

Treatment with curcumin alleviates sublesional bone loss following spinal cord injury in rats.Aug 19, 2015

Pubmed Data : Eur J Pharmacol. 2015 Aug 20 ;765:209-216. Epub 2015 Aug 20. PMID: 26300394
Article Published Date : Aug 19, 2015
Study Type : Animal Study
Additional Links
Diseases : Spinal Cord Injuries
Pharmacological Actions : MicroRNA modulator, NF-kappaB Inhibitor, Wnt/β-catenin signaling pathway modulation
[+]

Vitamin D3 and 5-FU synergise together and exhibit better anticancer effects by modulating Wnt/β-catenin pathway.Jul 24, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Clin Cancer Res. 2015 Jul 25 ;34:71. Epub 2015 Jul 25. PMID: 26205949
Article Published Date : Jul 24, 2015
Study Type : Animal Study
Additional Links
Substances : Vitamin D
Diseases : Colon Cancer
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Heat Shock Protein Down-Regulation, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

20(S)-ginsenoside Rh2 inhibits the proliferation and induces the apoptosis of KG-1a cells through the Wnt/β-catenin signaling pathway.Jun 30, 2016

Pubmed Data : Oncol Rep. 2016 Jul ;36(1):137-46. Epub 2016 Apr 27. PMID: 27121661
Article Published Date : Jun 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Leukemia
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Wnt/β-catenin signaling pathway modulation
[+]

A comparative study on anti-invasion, antimigration, and anti-adhesion effects of the bioactive carotenoids of saffron on 4T1 breast cancer cells.Jul 31, 2018

Pubmed Data : DNA Cell Biol. 2018 Aug ;37(8):697-707. Epub 2018 Jul 3. PMID: 29969282
Article Published Date : Jul 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Crocetin, Crocin, Saffron
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Wnt/β-catenin signaling pathway modulation
[+]

A review of targeting oncogenic transcription factors by polyphenols.Jan 03, 2018

Pubmed Data : Pharmacol Res. 2018 Jan 4. Epub 2018 Jan 4. PMID: 29305909
Article Published Date : Jan 03, 2018
Study Type : Review
Additional Links
Substances : 4-Shogaol, 6-Shogaol, Apigenin, Berberine, Caffeic Acid, Capsaicin, Cardamonin, Chrysin, Curcumin, EGCG (Epigallocatechin gallate), Ellagic Acid, Fisetin, Gingerol , Luteolin, Mangiferin, Piperlongumine , Polyphenols, Pterostilbene, Quercetin, Resveratrol, Rutin, Sesamin, Ursolic Acid, Wogonin, Xanthohumol
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive, Chemotherapeutic, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, NF-kappaB Inhibitor, STAT3 Inhibitor, Wnt/β-catenin signaling pathway modulation
[+]

A review of the possible use of Punica granatum in cancer therapy.May 01, 2018

Pubmed Data : Pharmacol Res. 2018 May 2. Epub 2018 May 2. PMID: 29729421
Article Published Date : May 01, 2018
Study Type : Review
Additional Links
Substances : Pomegranate
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive, Chemotherapeutic, NF-kappaB Inhibitor, Wnt/β-catenin signaling pathway modulation
[+]

A vanillin derivative suppresses the growth of HT29 cells through the Wnt/β-catenin signaling pathway.Jan 28, 2019

Pubmed Data : Eur J Pharmacol. 2019 Jan 29 ;849:43-49. Epub 2019 Jan 29. PMID: 30707959
Article Published Date : Jan 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Vanillin
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Wnt/β-catenin signaling pathway modulation
[+]

Activation of Wnt/β-catenin signaling is involved in hair growth-promoting effect of 655-nm red light and LED.Mar 31, 2018

Pubmed Data : Lasers Med Sci. 2018 Apr ;33(3):637-645. Epub 2018 Feb 21. PMID: 29468283
Article Published Date : Mar 31, 2018
Study Type : In Vitro Study
Additional Links
Diseases : Alopecia
Therapeutic Actions : Light-Emitting Diode Therapy
Pharmacological Actions : Wnt/β-catenin signaling pathway modulation
Additional Keywords : Hair Regeneration
[+]

An ellagic acid derivative efficiently inhibits colon cancer cell growth through a mechanism involving WNT16.Apr 30, 2015

Pubmed Data : J Pharmacol Exp Ther. 2015 May ;353(2):433-44. Epub 2015 Mar 10. PMID: 25758919
Article Published Date : Apr 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Ellagic Acid
Diseases : Cancers: Drug Resistant, Colon Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Wnt/β-catenin signaling pathway modulation
Additional Keywords : Drug: 5-flourouracil, Selective Antiproliferation
[+]

Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells.Oct 14, 2013

Pubmed Data : Bioorg Med Chem Lett. 2013 Oct 15 ;23(20):5511-4. Epub 2013 Aug 22. PMID: 24018191
Article Published Date : Oct 14, 2013
Study Type : In Vitro Study
Additional Links
Substances : Honeysuckle, Lignans
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Wnt/β-catenin signaling pathway modulation
[+]

Apigenin was noted to upregulate miR-520b and miR-101 in different cancers to inhibit tumor growth. Oct 01, 2018

Pubmed Data : J Cell Biochem. 2018 Oct 2. Epub 2018 Oct 2. PMID: 30278099
Article Published Date : Oct 01, 2018
Study Type : In Vitro Study
Additional Links
Substances : Apigenin
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative , Apoptotic, MicroRNA modulator, Wnt/β-catenin signaling pathway modulation
[+]

Baicalein may represent a potential candidate for periodontitis therapy.May 31, 2017

Pubmed Data : Arch Oral Biol. 2017 Jun ;78:100-108. Epub 2017 Feb 7. PMID: 28222387
Article Published Date : May 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Baicalein
Diseases : Periodontitis
Pharmacological Actions : Osteogenic, Wnt/β-catenin signaling pathway modulation
[+]

Benzyl isothiocyanate inhibits breast cancer cell tumorigenesisDec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Med. 2015 ;8(10):17601-11. Epub 2015 Oct 15. PMID: 26770350
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Chemopreventive, Wnt/β-catenin signaling pathway modulation
[+]

Berbamine suppresses cell proliferation and promotes apoptosis in ovarian cancer.Apr 25, 2018

Pubmed Data : Acta Biochim Biophys Sin (Shanghai). 2018 Apr 26. Epub 2018 Apr 26. PMID: 29701777
Article Published Date : Apr 25, 2018
Study Type : In Vitro Study
Additional Links
Substances : Berbamine
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Wnt/β-catenin signaling pathway modulation
[+]

Berberine accelerates odontoblast differentiation by Wnt/β-catenin activation.Mar 31, 2019

Pubmed Data : Cell Reprogram. 2019 Apr ;21(2):108-114. PMID: 30969881
Article Published Date : Mar 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Dental Caries
Pharmacological Actions : Wnt/β-catenin signaling pathway modulation
[+]

Berberine promotes osteogenic differentiation of mesenchymal stem cells with therapeutic potential in periodontal regeneration.Feb 14, 2019

Pubmed Data : Eur J Pharmacol. 2019 Feb 15. Epub 2019 Feb 15. PMID: 30776366
Article Published Date : Feb 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Periodontal Diseases
Pharmacological Actions : Regenerative, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Bodily Tissue Regeneration, Mesenchymal Stem Cells
[+]

Beta-elemene increases chemosensitivity to 5-fluorouracil in colorectal carcinoma cells.Jul 31, 2018

Pubmed Data : J Cell Biochem. 2018 Aug ;119(8):7032-7039. Epub 2018 May 8. PMID: 29737579
Article Published Date : Jul 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Beta-Elemene
Diseases : Colorectal Cancer
Pharmacological Actions : Chemosensitizer, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

CBD suppresses pro-inflammatory signalling and may be a potential new candidate for Alzheimer's disease therapy.Sep 30, 2017

Pubmed Data : Acta Biochim Biophys Sin (Shanghai). 2017 Oct 1 ;49(10):853-866. PMID: 28981597
Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol
Diseases : Alzheimer's Disease, Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Wnt/β-catenin signaling pathway modulation
[+]

Coumestrol modulates Akt and Wnt/β-catenin signaling during the attenuation of adipogenesis.Dec 06, 2016

Pubmed Data : Food Funct. 2016 Dec 7 ;7(12):4984-4991. PMID: 27868125
Article Published Date : Dec 06, 2016
Study Type : In Vitro Study
Additional Links
Substances : Coumestrol
Diseases : Cancers: All
Pharmacological Actions : Anti-Adipogenic, Wnt/β-catenin signaling pathway modulation
[+]

Curcumin exhibits a neuroprotective effect through the classical wnt signaling pathway.Nov 30, 2014

Pubmed Data : J Surg Res. 2014 Dec ;192(2):298-304. Epub 2014 Jun 19. PMID: 25033705
Article Published Date : Nov 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents, Wnt/β-catenin signaling pathway modulation
[+]

Curcumin inhibits the growth via Wnt/β-catenin pathway in non-small-cell lung cancer cells.Oct 31, 2018

Pubmed Data : Eur Rev Med Pharmacol Sci. 2018 Nov ;22(21):7492-7499. PMID: 30468498
Article Published Date : Oct 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Non-Small-Cell Lung Carcinoma
Pharmacological Actions : Antiproliferative , Wnt/β-catenin signaling pathway modulation
[+]

Deep-sea water has some promise in improving cancer survival by preventing tumor metastasis.Oct 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2013 Nov ;43(5):1691-700. Epub 2013 Sep 4. PMID: 24008507
Article Published Date : Oct 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Water: Deep Sea
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-9 (MMP-9) inhibitor, Wnt/β-catenin signaling pathway modulation
[+]

Deguelin inhibits growth of breast cancer cells by modulating the expression of key members of the Wnt signaling pathway.Oct 31, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Prev Res (Phila). 2009 Nov ;2(11):942-50. Epub 2009 Oct 27. PMID: 19861542
Article Published Date : Oct 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Deguelin
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Wnt/β-catenin signaling pathway modulation
[+]

Delphinidin is a potent inhibitor of Wnt/β-catenin signaling in prostate cancer cells.May 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer Prev. 2016 Jun ;21(2):110-4. Epub 2016 Jun 30. PMID: 27390740
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Delphinidin
Diseases : Prostate Cancer
Pharmacological Actions : Wnt/β-catenin signaling pathway modulation
[+]

Delphinidin suppresses breast carcinogenesis through HOTAIR/microRNA-34a axis.Jul 18, 2019

Pubmed Data : Cancer Sci. 2019 Jul 19. Epub 2019 Jul 19. PMID: 31325197
Article Published Date : Jul 18, 2019
Study Type : In Vitro Study
Additional Links
Substances : Delphinidin
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Anticarcinogenic Agents, Chemoprotective Agents, MicroRNA modulator, Wnt/β-catenin signaling pathway modulation
[+]

Diallyl trisulfide inhibits breast cancer stem cells via suppression of Wnt/β-catenin pathway.Dec 14, 2017

Pubmed Data : J Cell Biochem. 2017 Dec 15. Epub 2017 Dec 15. PMID: 29243835
Article Published Date : Dec 14, 2017
Study Type : In Vitro Study
Additional Links
Substances : Garlic
Diseases : Breast Cancer
Pharmacological Actions : Wnt/β-catenin signaling pathway modulation
Additional Keywords : Cancer Stem Cells
[+]

Ganoderic acid A inhibits the proliferation, viability, and intracellular ROS of pancreatic cancer RIN-5F cells.Aug 21, 2016

Pubmed Data : Interdiscip Sci. 2016 Aug 22. Epub 2016 Aug 22. PMID: 27549815
Article Published Date : Aug 21, 2016
Study Type : In Vitro Study
Additional Links
Substances : Reishi Mushroom
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Wnt/β-catenin signaling pathway modulation
[+]

Gastrodin attenuates proliferation and inflammatory responses in activated microglia through Wnt/β-catenin signaling pathway.Aug 14, 2019

Pubmed Data : Brain Res. 2019 Aug 15 ;1717:190-203. Epub 2019 Apr 24. PMID: 31026457
Article Published Date : Aug 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Gastrodin
Diseases : Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Wnt/β-catenin signaling pathway modulation
[+]

Genistein inhibits invasion and migration of colon cancer cells by recovering WIF1 expression.Apr 30, 2018

Pubmed Data : Mol Med Rep. 2018 May ;17(5):7265-7273. Epub 2018 Mar 16. PMID: 29568950
Article Published Date : Apr 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Genistein
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Cyclin D1 Down-Regulation, Wnt/β-catenin signaling pathway modulation
[+]

Ginkgetin suppresses the growth of medulloblastoma.Mar 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nat Prod Bioprospect. 2015 Mar 29. Epub 2015 Mar 29. PMID: 25821199
Article Published Date : Mar 28, 2015
Study Type : In Vitro Study
Additional Links
Substances : Ginkgo biloba
Diseases : Medulloblastoma
Pharmacological Actions : Antiproliferative , Wnt/β-catenin signaling pathway modulation
[+]

Ginsenoside Rh2 inhibits proliferation and migration of medulloblastoma Daoy by down-regulation of microRNA-31.Jul 31, 2018

Pubmed Data : J Cell Biochem. 2018 Aug ;119(8):6527-6534. Epub 2018 Apr 19. PMID: 29377269
Article Published Date : Jul 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Medulloblastoma
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, MicroRNA modulator, Wnt/β-catenin signaling pathway modulation
[+]

Green tea polyphenols protect PC12 cells against H2O2-induced damages by upregulating lncRNA MALAT1.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419872624. PMID: 31456460
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Green Tea
Diseases : Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Anti-Apoptotic, Wnt/β-catenin signaling pathway modulation
[+]

In this review, they highlight the efficacy of curcumin and its analogues in targeting colorectal CSC and also the underlying molecular mechanism involved.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Cell Int. 2015 ;15:96. Epub 2015 Oct 9. PMID: 26457069
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Colorectal Cancer
Pharmacological Actions : Chemosensitizer, MicroRNA modulator, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Cancer Stem Cells
[+]

Korean Red ginseng extract inhibits glioblastoma propagation by blocking the Wnt signaling pathway.Mar 12, 2019

Pubmed Data : J Ethnopharmacol. 2019 Mar 13 ;236:393-400. Epub 2019 Mar 13. PMID: 30878548
Article Published Date : Mar 12, 2019
Study Type : In Vitro Study
Additional Links
Substances : Ginseng (Korean)
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative , Chemotherapeutic, Wnt/β-catenin signaling pathway modulation
[+]

Lupeol inhibits growth and migration in two human colorectal cancer cell lines by suppression of Wnt-β-catenin pathway.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2018 ;11:7987-7999. Epub 2018 Nov 9. PMID: 30519040
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Wnt/β-catenin signaling pathway modulation
[+]

Luteolin can be considered as a potential drug to treat colorectal cancer.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2014 ;15(14):5501-8. PMID: 25081655
Article Published Date : Dec 31, 2013
Study Type : Review
Additional Links
Substances : Luteolin
Diseases : Colorectal Cancer, Oxidative Stress
Pharmacological Actions : Antineoplastic Agents, Antioxidants, Apoptotic, Wnt/β-catenin signaling pathway modulation
[+]

MAP30 markedly induces apoptosis in U87 and U251 cell lines.Mar 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2018 Apr ;15(4):5833-5840. Epub 2018 Feb 16. PMID: 29556310
Article Published Date : Mar 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Bitter Melon
Diseases : Glioma
Pharmacological Actions : Apoptotic, Wnt/β-catenin signaling pathway modulation
[+]

Myricetin enhances osteogenic differentiation through the activation of canonical Wnt/β-catenin signaling in human bone marrow stromal cells.Sep 04, 2014

Pubmed Data : Eur J Pharmacol. 2014 Sep 5 ;738:22-30. Epub 2014 May 27. PMID: 24876056
Article Published Date : Sep 04, 2014
Study Type : In Vitro Study
Additional Links
Substances : Myricetin
Diseases : Osteoporosis
Pharmacological Actions : Osteoprotective , Wnt/β-catenin signaling pathway modulation
[+]

Nobiletin inhibits hypoxia-induced epithelial-mesenchymal transition in renal cell carcinoma cells.Sep 10, 2018

Pubmed Data : J Cell Biochem. 2018 Sep 11. Epub 2018 Sep 11. PMID: 30203502
Article Published Date : Sep 10, 2018
Study Type : In Vitro Study
Additional Links
Substances : Nobiletin
Diseases : Kidney Cancer
Pharmacological Actions : Anti-metastatic, NF-kappaB Inhibitor, Wnt/β-catenin signaling pathway modulation
[+]

Noni leaf extract might be a novel alternative medicine for bone and periodontal regeneration in patients with periodontal diseases.Dec 31, 2017

Pubmed Data : J Med Food. 2018 Jan ;21(1):57-69. Epub 2017 Oct 5. PMID: 28981378
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Noni
Diseases : Periodontal Diseases, Wound Healing: Periodontal
Pharmacological Actions : Regenerative, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Bone Regeneration
[+]

Phenethyl isothiocyanate inhibits colorectal cancer stem cells by suppressing Wnt/β-catenin pathway.Nov 30, 2018

Pubmed Data : Phytother Res. 2018 Dec ;32(12):2447-2455. Epub 2018 Aug 30. PMID: 30159926
Article Published Date : Nov 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Wnt/β-catenin signaling pathway modulation
Additional Keywords : Cancer Stem Cells
[+]

Piceatannol exhibits selective toxicity to multiple myeloma cells.Nov 30, 2014

Pubmed Data : Hematol Oncol. 2014 Dec ;32(4):197-204. Epub 2014 Jan 27. PMID: 24470348
Article Published Date : Nov 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Piceatannol
Diseases : Multiple Myeloma
Pharmacological Actions : Antiproliferative , Apoptotic, Wnt/β-catenin signaling pathway modulation
[+]

Puerarin may exert protective effects against Alzheimer's disease.Nov 30, 2017

Pubmed Data : Mol Med Rep. 2017 Dec ;16(6):9081-9085. Epub 2017 Oct 3. PMID: 28990074
Article Published Date : Nov 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Puerarin
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents, Wnt/β-catenin signaling pathway modulation
[+]

Quercetin as a potent inhibitor of Wnt signaling may be an effective therapeutic agent in cancers with aberrant activation of the Wnt pathway. Sep 30, 2014

Pubmed Data : Food Funct. 2014 Oct ;5(10):2564-73. Epub 2014 Aug 20. PMID: 25138740
Article Published Date : Sep 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Cancers: All, Teratoma
Pharmacological Actions : Antiproliferative , Apoptotic, Chemotherapeutic, Wnt/β-catenin signaling pathway modulation
[+]

Quercetin can inhibit the proliferation K562 and K562R cells.Sep 30, 2019

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Oct ;27(5):1409-1415. PMID: 31607291
Article Published Date : Sep 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Chemosensitizer, Wnt/β-catenin signaling pathway modulation
[+]

Quercetin suppresses the tumorigenesis of oral squamous cell carcinoma.May 03, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Sci. 2019 May 4. Epub 2019 May 4. PMID: 31257059
Article Published Date : May 03, 2019
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Oral Cancer, Squamous cell carcinoma
Pharmacological Actions : Chemopreventive, MicroRNA modulator, Wnt/β-catenin signaling pathway modulation
[+]

Several pomegranate phytochemicals exhibited synergistic effects in suppressing growth of tumor cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2015;20(12):22315-22328. Epub 2015 Dec 12. PMID: 26703530
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate
Diseases : Breast Cancer, Breast Cancer: Chemically-Induced, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Cyclin D1 Down-Regulation, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Natural Substance Synergy
[+]

Silymarin-mediated downregulation of β-catenin and TCF4 may result in the inhibition of Wnt signalling in human colorectal cancer cells.Apr 10, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2016 Apr 11. Epub 2016 Apr 11. PMID: 27068260
Article Published Date : Apr 10, 2016
Study Type : In Vitro Study
Additional Links
Substances : Silymarin
Diseases : Colorectal Cancer
Pharmacological Actions : Wnt/β-catenin signaling pathway modulation
[+]

Sulforaphane could be considered as a potential adjuvant therapeutic agent in treating glioblastoma patients combined with temozolomide.May 19, 2015

Pubmed Data : J Neurochem. 2015 May 20. Epub 2015 May 20. PMID: 25991372
Article Published Date : May 19, 2015
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Glioblastoma
Pharmacological Actions : Chemopreventive, Chemotherapeutic, MicroRNA modulator, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Chemotherapeutic Synergy: Temozolomide
[+]

Sulforaphane could suppress the growth of nasopharyngeal carcinoma cells via the DNMT1/WIF1 axis.Jul 28, 2019

Pubmed Data : Phytomedicine. 2019 Jul 29 ;63:153058. Epub 2019 Jul 29. PMID: 31394414
Article Published Date : Jul 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Antiproliferative , Wnt/β-catenin signaling pathway modulation
[+]

Tanshinone IIA can inhibit the expression of COX-2 and activate the Wnt/β-catenin signalling pathway in colon cancer cells.Aug 31, 2018

Pubmed Data : J BUON. 2018 Sep-Oct;23(5):1337-1342. PMID: 30570856
Article Published Date : Aug 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Colon Cancer
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Vascular Endothelial Growth Factor Inhibitors, Wnt/β-catenin signaling pathway modulation
[+]

The Anti-cancer effect of quercetin: Molecular implications in cancer metabolism.Jun 27, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Jun 28 ;20(13). Epub 2019 Jun 28. PMID: 31261749
Article Published Date : Jun 27, 2019
Study Type : Review
Additional Links
Substances : Quercetin
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation, Wnt/β-catenin signaling pathway modulation
[+]

The anticancer efficiency of Citrullus colocynthis toward the colorectal cancer therapy.Aug 28, 2019

Pubmed Data : J Gastrointest Cancer. 2019 Aug 29. Epub 2019 Aug 29. PMID: 31463888
Article Published Date : Aug 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Bitter Apple
Diseases : Colorectal Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Anti-metastatic, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Wnt/β-catenin signaling pathway modulation
[+]

The combination of Gelam honey and ginger may serve as a potential therapy in the treatment of colorectal cancer.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(15):6549-56. PMID: 26434873
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Ginger, Honey
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Chemopreventive, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Dose Response, Gene Expression Regulation, Plant Extracts
[+]

The plant sesquiterpene lactone parthenolide inhibits Wnt/β-catenin signalling.Apr 05, 2018

Pubmed Data : J Biol Chem. 2018 Apr 6 ;293(14):5335-5344. Epub 2018 Feb 9. PMID: 29462785
Article Published Date : Apr 05, 2018
Study Type : In Vitro Study
Additional Links
Substances : Parthenolide
Diseases : Cancers: All
Pharmacological Actions : Wnt/β-catenin signaling pathway modulation
[+]

The study also highlights mangiferin as a promising Wnt inhibitor for liver cancer treatment.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2018 ;47(5):1819-1834. Epub 2018 Jun 28. PMID: 29953980
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Mangiferin
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Wnt/β-catenin signaling pathway modulation
Additional Keywords : Xanthones
[+]

Therapeutic effects of β-elemene via attenuation of the Wnt/β-catenin signaling pathway in cervical cancer cells.Feb 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2018 Mar ;17(3):4299-4306. Epub 2018 Jan 18. PMID: 29363722
Article Published Date : Feb 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Beta-Elemene
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Tumor Suppressor Protein p53 Upregulation, Wnt/β-catenin signaling pathway modulation
[+]

These findings demonstrate the effect of diosgenin on inhibiting the resilient breast cancer stem cells.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2017 ;8:124. Epub 2017 Mar 20. PMID: 28373842
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Diosgenin
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Cancer Stem Cells
[+]

These results demonstrate that Notoginsenoside R1 promotes growth of cultured cortical neurons.Dec 31, 2017

Pubmed Data : CNS Neurol Disord Drug Targets. 2018 ;17(7):547-556. PMID: 29992896
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Panax Notoginseng
Pharmacological Actions : Neurogenesis, Wnt/β-catenin signaling pathway modulation
[+]

These studied flavonoids significantly enhances doxorubicin-mediated cell death.Nov 25, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Cancer. 2018 Nov 26 ;18(1):1168. Epub 2018 Nov 26. PMID: 30477461
Article Published Date : Nov 25, 2018
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Flavonoids, Quercetin, Rutin, Theaflavins
Diseases : Cancers: Multi-Drug Resistant
Pharmacological Actions : Chemosensitizer, Chemotherapeutic, Wnt/β-catenin signaling pathway modulation
[+]

This article focuses on the effects of sulforaphane on CSCs and self-renewal pathways.Jul 31, 2013

Pubmed Data : Future Oncol. 2013 Aug ;9(8):1097-103. PMID: 23902242
Article Published Date : Jul 31, 2013
Study Type : Review
Additional Links
Substances : Broccoli, Broccoli Sprouts, Sulforaphane
Diseases : Cancers: All
Pharmacological Actions : Anticarcinogenic Agents, NF-kappaB Inhibitor, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Cancer Stem Cells, Isothiocyanates
[+]

This review concludes that luteolin can be a molecule for the therapy of both cancer and diabetes by acting on broad signaling pathway.Jan 21, 2018

Pubmed Data : Brief Funct Genomics. 2018 07 22 ;18(4):230-239. PMID: 30462152
Article Published Date : Jan 21, 2018
Study Type : Review
Additional Links
Substances : Luteolin
Diseases : Colon Cancer, Diabetes Mellitus: Type 2
Pharmacological Actions : Antioxidants, Matrix metalloproteinase-9 (MMP-9) inhibitor, Tumor Suppressor Protein p53 Upregulation, Wnt/β-catenin signaling pathway modulation
[+]

This review provides insights into the molecular mechanisms of the anticancer effects of dietary chlorophyllin.Dec 31, 2014

Pubmed Data : Nutr Cancer. 2015 ;67(2):203-11. Epub 2015 Feb 4. PMID: 25650669
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : Chlorophyllin
Diseases : Cancers: All
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, NF-kappaB Inhibitor, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Risk Reduction
[+]

Urolithin A could inhibit cell proliferation and reduce oxidative stress status in liver cancer. Jul 31, 2015

Pubmed Data : Toxicol In Vitro. 2015 Aug ;29(5):1107-15. Epub 2015 Apr 21. PMID: 25910917
Article Published Date : Jul 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Liver Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Antiproliferative , Chemopreventive, Superoxide Dismutase Up-regulation, Tumor Suppressor Protein p53 Upregulation, Wnt/β-catenin signaling pathway modulation
[+]

Vicenin-2 inhibits Wnt/β-catenin signaling and induces apoptosis in HT-29 human colon cancer cell lineDec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2018 ;12:1303-1310. Epub 2018 May 18. PMID: 29849451
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Apigenin
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Wnt/β-catenin signaling pathway modulation

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Broccoli Can Stimulate Brain Regeneration, New Research Suggests
Written by Sayer Ji, Founder
For decades it was believed that brain regeneration was not possible. But an accumulating body of research now reveals that common foods such as broccoli contain compounds capable of stimulating the repair and renewal of nerve tissue.

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