Renoprotective

Name	AC	CK
Curcumin	48	90
Magnesium	7	62
Thymoquinone	25	45
Sodium Bicarbonate	5	42
Vitamin C	19	42
Nigella sativa (aka Black Seed)	18	33
Melatonin	13	24
Ginger	11	22
Resveratrol	12	22
Omega-3 Fatty Acids	3	21
DHA (Docosahexaenoic Acid)	2	20
EPA (Eicosapentaenoic Acid)	2	20
Fiber	1	20
Green Tea	10	20
Quercetin	10	20
Spirulina	10	20
Ginsenosides	7	19
Astragaloside	9	17
Berberine	9	16
EGCG (Epigallocatechin gallate)	8	16
Puerarin	8	15
Vitamin E	8	15
Astaxanthin	7	14
Grape Seed Extract	7	14
Pomegranate	7	13
Stevia	2	12
Polyphenols	6	11
Activated Charcoal	1	10
Anthocyanins	5	10
B-complex	1	10
Citrus naringin	5	10
Garlic	5	10
Hesperidin	5	10
Hibiscus sabdariffa	1	10
Luteolin	5	10
S-Adenosylmethionine (SAMe)	1	10
Thiamine (B-1)	1	10
Vitamin B-12	1	10
Vitamin B-6	1	10
Honey	5	9
Moringa oleifera	5	9
Naringenin	5	9
Allicin	4	8
Caffeic acid phenethyl ester	4	8
Camel Milk	4	8
Diosmin	4	8
Ginkgo biloba	4	8
Ginseng	5	8
Pterostilbene	4	8
Selenium	4	8
Sesamol	4	8
Apigenin	4	7
Astragalus	2	7
Chrysanthemum Indicum	2	7
Chrysin	4	7
Olive leaf extract	4	7
Rhubarb	4	7
Rosemary	4	7
Tetrahydrocurcumin	4	7
Bacopa	3	6
Bee Propolis	3	6
Crocin	3	6
Ellagic Acid	3	6
Fenugreek	3	6
Gingerol	3	6
Grape	3	6
Honokiol	3	6
Lycopene	3	6
Mangiferin	3	6
Nettle	3	6
Oleuropein	3	6
Paeoniflorin	3	6
Royal Jelly	3	6
Rutin	3	6
Silymarin	3	6
Sulforaphane	4	6
Tanshinone IIA	3	6
Zinc	3	6
Angelica	1	5
Flavonoids	3	5
Prunella vulgaris	1	5
Red Sage	3	5
Soy	1	5
Amla Fruit	2	4
Asiatic Acid	2	4
Bee Venom	2	4
Bilberry	2	4
Black Tea	2	4
Caffeic Acid	2	4
Chaga Mushroom (Inonotus obliquus)	2	4
Chlorogenic Acid	2	4
Chokeberry	2	4
Corn: Purple	2	4
Dates	2	4
Fucoidan	2	4
Gallic Acid	2	4
Hydrogen Water	2	4
Lactobacillus plantarum	2	4
Mangosteen	2	4
Myricetin	2	4
NAC (N-acetyl-L-cysteine)	2	4
Nordihydroguaiaretic acid (NDGA)	2	4
Palm Oil	2	4
Palmitoylethanolamide	2	4
Plantago	2	4
Pomegranate Peel	2	4
Pomegranate Seed	2	4
Prickly Pear Cactus	2	4
Propolis: Bee	2	4
Silibinin	2	4
St. Johns Wort	2	4
Strawberry	2	4
Sweet Potato: Purple	2	4
Taurine	2	4
Tocotrienols	2	4
Vanillin	2	4
Vitamin D	2	4
Walnut	2	4
White Tea	2	4
Cannabidiol	2	3
Cordyceps sinensis	2	3
Fermented Foods and Beverages	2	3
Onion	2	3
Turmeric	2	3
White Mulberry	2	3
Wogonin	2	3
6-Shogaol	1	2
Acai	1	2
Aduki bean	1	2
Aloe Vera	1	2
Alpha-Lipoic Acid	1	2
Amygdalin	1	2
Andrographis	1	2
Apple Cider Vinegar	1	2
Arabic gum	1	2
Arctigenin	1	2
Arginine	1	2
Artichoke	1	2
Asparagus	1	2
Avacado	1	2
Bael	1	2
Baicalein	1	2
Bamboo	1	2
Banaba	1	2
Basil	1	2
Bee Pollen	1	2
Betanin	1	2
Betulinic acid	1	2
Bifidobacterium Longum	1	2
Bisdemethoxycurcumin	1	2
Bitter Apple	1	2
Bitter Melon	1	2
Bitter Orange	1	2
Blackberry	1	2
Boerhaavia diffusa	1	2
Brazil nut	1	2
Brussels Sprouts	1	2
Burdock	1	2
Butyrate	1	2
Calcium	1	2
Carnitine	1	2
Carotenoids	1	2
Carrot	1	2
Carvacrol	1	2
Catechols	1	2
Chamomile	1	2
Chinese Medicine: Modified Simiao Decoction	1	2
Cinnamon	1	2
Citral	1	2
Cocoa	1	2
Coconut Oil	1	2
Cordyceps Militaris	1	2
Corn Silk	1	2
Curry Leaves	1	2
Cysteine (see N-Acetylcysteine)	1	2
D-Limonene	1	2
Dandelion	1	2
Date Seeds	1	2
Diallyl sulfide	1	2
False Black Pepper	1	2
Feijoa	1	2
Ferulic acid	1	2
Feverfew	1	2
Fig	1	2
Fish Oil	1	2
Garlic: Aged	1	2
Genipin	1	2
Goji	1	2
Gold (nanoparticles)	1	2
Gynostemma	1	2
Honeydew (melon)	1	2
Hops	1	2
Horse Chestnut	1	2
Huaier (Trametes robiniophila murr)	1	2
Hydroxytyrosol	1	2
Krill	1	2
Lavender: Essential Oil	1	2
Ligustrazine	1	2
Litchi	1	2
Loquat Seeds	1	2
Lotus	1	2
Lychee	1	2
Manuka Honey	1	2
Milk Thistle	1	2
Neem	1	2
Nobiletin	1	2
Nutmeg	1	2
Olive	1	2
Olive Oil	1	2
P-Coumaric Acid	1	2
Palash	1	2
Panax Notoginseng	1	2
Passion Flower	1	2
Peppermint	1	2
Perilla	1	2
Persimmon	1	2
Piceatannol	1	2
Pine Bark Extract	1	2
Piperine	1	2
Plantago asiatica	1	2
Plantago major	1	2
Pomegranate flower	1	2
Proanthocyanidins	1	2
Probiotics	1	2
Propolis: Brazillian	1	2
Pterocarpus marsupium	1	2
Punicalagin	1	2
Pycnogenol (Pine Bark)	1	2
Rambutan	1	2
Red Yeast Rice	1	2
Rice Bran	1	2
Rooibos	1	2
Rose	1	2
Rosemaric Acid	1	2
Rosmarinic acid	1	2
Saffron	1	2
Salacia oblonga	1	2
Salvia miltiorrhiza	1	2
Sesamin	1	2
Soy Protein	1	2
Syrian rue	1	2
Tamarind	1	2
Tangeretin	1	2
Thyme	1	2
Thymol	1	2
Tocotrienol: Delta	1	2
Toona sinensis	1	2
Traditional Chinese Medicine: Wen-pi-tang-Hab-Wu-ling-san	1	2
Triphala	1	2
Tripterygium wilfordii	1	2
Triptolide	1	2
Ubiquinol	1	2
Ursolic Acid	1	2
Vitamin C: Intravenous	1	2
Vitamin E: alpha tocopherol	1	2
Vitamin K	1	2
Vitamin K2	1	2
Wheat Grass	1	2
Zataria multiflora	1	2
2,3,5,4'-tetrahydroxystilbene-2-O-β -D-glucoside (THSG)	1	1
Apocynin	1	1
Bergamot orange	1	1
Beta-Caryophyllene	1	1
Coenzyme Q10	1	1
Daidzein	1	1
Diosgenin	1	1
Emodin	1	1
Isoflavones	1	1
Licorice	1	1
Mustard: Field/Turnip	1	1
Okra	1	1
Purslane	1	1
Red Wine Extract	1	1
Riboflavin (Vitamin B-2)	1	1

[+]

A systematic review and meta-analysis of Abelmoschus manihot for diabetic nephropathy.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Ren Fail. 2004 Jul;26(4):453-9. PMID: 15462115

Article Published Date : Jul 01, 2004

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid), Omega-3 Fatty Acids

Diseases : IgA Nephropathy

Pharmacological Actions : Renoprotective

[+]

A 12-month therapy with omega-3 fatty acids improves renal vascular function and tubule function in IgA nephropathy patients.Sep 01, 2004

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Pubmed Data : Am J Nephrol. 2004 Sep-Oct;24(5):474-82. Epub 2004 Sep 1. PMID: 15340256

Article Published Date : Sep 01, 2004

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid), Omega-3 Fatty Acids

Pharmacological Actions : Renoprotective

[+]

A manihot is a promising therapy for patients with primary kidney disease.Jun 30, 2014

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Pubmed Data : Medicine (Baltimore). 2016 Feb ;95(7):e2715. PMID: 26886610

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Pubmed Data : J Am Soc Nephrol. 2016 Jan 28. Epub 2016 Jan 28. PMID: 26823552

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Pubmed Data : Am J Chin Med. 2017 Mar 30:1-21. Epub 2017 Mar 30. PMID: 28359196

Article Published Date : Mar 29, 2017

Study Type : Human In Vitro

Additional Links

Substances : Prunella vulgaris

Diseases : Diabetic Nephropathy

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor, Renoprotective

[+]

"Curcumin ameliorates cisplatin-induced nephrotoxicity by inhibiting renal inflammation in mice."Dec 11, 2012

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Pubmed Data : J Biosci Bioeng. 2012 Dec 12. Epub 2012 Dec 12. PMID: 23245727

Article Published Date : Dec 11, 2012

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Chemotherapy-Induced Toxicity: Kidney

Pharmacological Actions : Renoprotective

Additional Keywords : Drug: Cisplatin

[+]

"Pomegranate Extract Attenuates Gentamicin-Induced Nephrotoxicity in Rats by Reducing Oxidative Stress."Nov 25, 2012

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Pubmed Data : Ren Fail. 2012 Nov 26. Epub 2012 Nov 26. PMID: 23176634

Article Published Date : Nov 25, 2012

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Chemotherapy-Induced Toxicity: Gentamicin, Kidney Damage: Chemically-Induced

Pharmacological Actions : Antioxidants, Renoprotective

Additional Keywords : Drug: Gentamicin

Problem Substances : Gentamicin

Adverse Pharmacological Actions : Nephrotoxic

[+]

2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside exerted protective effects on diabetic nephropathy.Nov 08, 2016

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Pubmed Data : Food Funct. 2016 Nov 9 ;7(11):4628-4636. PMID: 27747335

Article Published Date : Nov 08, 2016

Study Type : Animal Study

Additional Links

Diseases : Diabetic Nephropathy

Pharmacological Actions : Renoprotective

[+]

6-shogaol can be used as a therapeutic agent for preventing complications in diabetic patients.Dec 31, 2018

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Pubmed Data : Diabetol Metab Syndr. 2019 ;11:15. Epub 2019 Feb 12. PMID: 30805033

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Pubmed Data : J Ethnopharmacol. 2012 Jun 26 ;142(1):248-52. Epub 2012 May 8. PMID: 22575704

Article Published Date : Jun 25, 2012

Study Type : Animal Study

Additional Links

Substances : Chinese Medicine: Modified Simiao Decoction

Diseases : Hyperuricemia, Uric Acid Nephropathy

Pharmacological Actions : Malondialdehyde Down-regulation, Renoprotective, Superoxide Dismutase Up-regulation

Additional Keywords : Phytotherapy

[+]

A combination of ascorbate with Amphotericin B is a potentially effective treatment that may reduce nephrotoxicity in patients with systemic candidiasis.Jul 31, 2015

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Pubmed Data : Am J Physiol Regul Integr Comp Physiol. 2015 Aug 1 ;309(3):R223-34. PMID: 25994956

[+]

A purple corn extract may be a potent therapeutic agent targeting abnormal angiogenesis in diabetic nephropathy leading to kidney failure.Dec 31, 2012

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Pubmed Data : PLoS One. 2013 ;8(11):e79823. Epub 2013 Nov 20. PMID: 24278186

Article Published Date : Dec 31, 2012

Study Type : Animal Study

Additional Links

Substances : Anthocyanins, Corn: Purple

Diseases : Diabetic Nephropathy

Pharmacological Actions : Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Renoprotective, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Plant Extracts

[+]

A spice mixture containing garlic, ginger and nutmeg possesses both therapeutic and prophylactic effect against Cd-induced organ damage.May 31, 2016

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Pubmed Data : J Food Drug Anal. 2019 Jan ;27(1):135-144. Epub 2018 Aug 14. PMID: 30648566

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Okra

Diseases : Diabetes Mellitus: Type 2, Diabetic Nephropathy

Pharmacological Actions : Antioxidants, Renoprotective

[+]

Açaí seed extract substantially reduced renal injury and prevented renal dysfunction.Jan 19, 2017

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Pubmed Data : Eur J Nutr. 2017 Jan 20. Epub 2017 Jan 20. PMID: 28105508

Article Published Date : Jan 19, 2017

Study Type : Animal Study

Additional Links

Substances : Acai

Diseases : Diabetic Nephropathy

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

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Pubmed Data : Chem Biol Interact. 2016 Feb 5 ;245:1-11. Epub 2015 Dec 8. PMID: 26680107

Article Published Date : Feb 04, 2016

Study Type : Animal Study

Additional Links

Substances : Thymol

Diseases : Diabetic Nephropathy, High Fat Diet

Pharmacological Actions : Renoprotective, Vascular Endothelial Growth Factor Inhibitors

[+]

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Pubmed Data : Hum Exp Toxicol. 2017 Jul ;36(7):681-691. Epub 2016 Sep 5. PMID: 27596067

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Pubmed Data : Biomed Pharmacother. 2018 Feb ;98:242-251. Epub 2017 Dec 27. PMID: 29268245

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Pubmed Data : Nagoya J Med Sci. 2015 Feb ;77(1-2):145-53. PMID: 25797979

Article Published Date : Jan 31, 2015

Study Type : Animal Study

Additional Links

Substances : Amla Fruit

Diseases : Arsenic Poisoning

Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective

Additional Keywords : Plant Extracts

Problem Substances : Arsenite

[+]

Amygdalin is a potent antifibrotic agent that may have therapeutic potential for patients with fibrotic kidney diseases.Apr 30, 2013

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Pubmed Data : Mol Med Rep. 2013 May ;7(5):1453-7. Epub 2013 Mar 22. PMID: 23525378

Article Published Date : Apr 30, 2013

Study Type : Animal Study

Additional Links

Substances : Amygdalin

Diseases : Chronic Kidney Disease (CKD), Kidney Fibrosis

Pharmacological Actions : Antiproliferative , Renoprotective

[+]

An experimetal evaluation of nephroprotective potential of Butea monosperma extract in albino rats.Dec 31, 2013

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Pubmed Data : Indian J Pharmacol. 2014 Jan-Feb;46(1):109-12. PMID: 24550595

Pubmed Data : J Med Food. 2018 Sep ;21(9):887-898. Epub 2018 Aug 15. PMID: 30109956

Article Published Date : Aug 31, 2018

Study Type : Animal Study

Additional Links

Substances : Angelica

Diseases : Chemically-Induced Liver Damage, Inflammation, Kidney Damage, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective, Malondialdehyde Down-regulation, Renoprotective

[+]

Anthocyanins may exhibit protective effects against high glucose induced renal injury in diabetic nephropathy via antioxidant activity.Feb 28, 2018

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Pubmed Data : Int J Mol Med. 2018 Mar ;41(3):1608-1618. Epub 2018 Jan 10. PMID: 29328429

Article Published Date : Feb 28, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Anthocyanins, Grape Seed Extract

Diseases : Diabetes: Oxidative Stress, Diabetic Nephropathy

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Renoprotective

Additional Keywords : Proanthocyanidins

[+]

Anti-inflammatory and renal protective effect of gingerol in high-fat diet/streptozotocin-induced diabetic rats via inflammatory mechanism.Mar 01, 2019

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Pubmed Data : Inflammopharmacology. 2019 Mar 2. Epub 2019 Mar 2. PMID: 30826930

Article Published Date : Mar 01, 2019

Study Type : Animal Study

Additional Links

Substances : Gingerol

Diseases : Diabetes Mellitus: Type 2, Diabetic Complications, Hyperglycemia

Pharmacological Actions : Anti-Inflammatory Agents, Hypoglycemic Agents, Renoprotective

[+]

Antidiabetic activity and chemical composition of Sanbai melon seed oil.Dec 31, 2017

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Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:5434156. Epub 2018 May 2. PMID: 29853958

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Pubmed Data : J Membr Biol. 2014 Aug ;247(8):667-73. Epub 2014 Jun 4. PMID: 24894721

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Pubmed Data : J Antimicrob Chemother. 2012 Feb ;67(2):452-9. Epub 2011 Nov 28. PMID: 22127588

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Pubmed Data : Int Urol Nephrol. 2018 Jan 24. Epub 2018 Jan 24. PMID: 29368247

Article Published Date : Jan 23, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Astaxanthin

Diseases : Kidney Damage

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Renoprotective

[+]

Astaxanthin promotes Nrf2/ARE signalling to alleviate renal fibronectin and collagen IV accumulation in diabetic rats.Dec 31, 2017

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Pubmed Data : J Diabetes Res. 2018 ;2018:6730315. Epub 2018 Mar 21. PMID: 29744366

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Diabetic Nephropathy

Pharmacological Actions : Antioxidants, Nrf2 activation, Renoprotective

[+]

Astaxanthin promotes Nrf2/ARE signalling to inhibit high glucose induced renal fibrosis in GMCs.Apr 04, 2018

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Pubmed Data : Mar Drugs. 2018 Apr 5 ;16(4). Epub 2018 Apr 5. PMID: 29621130

B. diffusa exerted protection against structural and functional damage induced by gentamicin.Mar 31, 2015

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Pubmed Data : Heliyon. 2016 Feb ;2(2):e00068. Epub 2016 Feb 15. PMID: 27441247

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Pubmed Data : J Complement Integr Med. 2018 Oct 12. Epub 2018 Oct 12. PMID: 30312166

Article Published Date : Oct 11, 2018

Study Type : Animal Study

Additional Links

Substances : Basil

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Bee venom may be a useful therapeutic agent for the prevention of fibrosis that characterizes progression of chronic kidney disease.May 31, 2015

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Pubmed Data : Toxins (Basel). 2015 Jun ;7(6):1917-28. Epub 2015 May 29. PMID: 26035488

Pubmed Data : IUBMB Life. 2019 Oct 6. Epub 2019 Oct 6. PMID: 31587481

Article Published Date : Oct 05, 2019

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Bisphenol Toxicity, Ischemia

Pharmacological Actions : Renoprotective

Additional Keywords : Increased Risk

Problem Substances : Bisphenol A

[+]

Bitter apple extracts could be a potential adjuvant in cisplatin-based chemotherapy.Dec 12, 2017

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Pubmed Data : J Complement Integr Med. 2017 Dec 13. Epub 2017 Dec 13. PMID: 29236674

Article Published Date : Dec 12, 2017

Study Type : Animal Study

Additional Links

Substances : Bitter Apple

Diseases : Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Chemoprotective Agents, Hepatoprotective, Renoprotective

[+]

Blackberry juice and quercetin together significantly reduced sodium fluoride induced oxidative and histological changes in rats.Apr 30, 2015

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Pubmed Data : J Basic Clin Physiol Pharmacol. 2015 May 1 ;26(3):237-51. PMID: 25918918

Article Published Date : Apr 30, 2015

Study Type : Animal Study

Additional Links

Substances : Blackberry, Quercetin

Diseases : Fluoride Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Cytoprotective, Hepatoprotective, Renoprotective

Additional Keywords : Natural Substance Synergy

Problem Substances : Sodium Fluoride

[+]

Blackberry juice anthocyanidins limit cisplatin-induced renal pathophysiology in mice.May 31, 2019

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Pubmed Data : Pathophysiology. 2019 Jun ;26(2):137-143. Epub 2019 Apr 19. PMID: 31040041

Article Published Date : May 31, 2019

Study Type : Animal Study

Additional Links

Substances : Anthocyanins, Blackberry

Diseases : Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Chemoprotective Agents, Renoprotective

[+]

Both Nigella sativa and date reduce the toxic effects of aflatoxin-B1 in liver and kidney.Jun 30, 2008

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Carnosic acid attenuates cadmium induced nephrotoxicity.Nov 17, 2019

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Pubmed Data : Molecules. 2019 Nov 18 ;24(22). Epub 2019 Nov 18. PMID: 31752142

Article Published Date : Nov 17, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Carnosic Acid

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective

Problem Substances : Cadmium

[+]

Chrysin inhibits advanced glycation end products-induced kidney fibrosis.Jul 08, 2018

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Pubmed Data : Niger J Physiol Sci. 2019 Jun 30 ;34(1):11-16. Epub 2019 Jun 30. PMID: 31449266

Article Published Date : Jun 29, 2019

Study Type : Animal Study

Additional Links

Substances : Coconut Water

Diseases : Prenatal Chemical Exposures

Pharmacological Actions : Hepatoprotective, Renoprotective

Problem Substances : Monosodium Glutamate (MSG)

[+]

Combination of berberine with pentoxifylline illustrated a synergistic effect in attenuation of diclofenac-induced acute kidney injury.Mar 31, 2019

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Pubmed Data : Int J Crit Illn Inj Sci. 2019 Apr-Jun;9(2):69-74. PMID: 31334048

Article Published Date : Mar 31, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Kidney Damage: Drug-Induced

Pharmacological Actions : Renoprotective

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Diclofenac

[+]

[+]

Crocin has a renoprotective effects against the development of oxidative stress and inflammation in the kidney of old rats.Jun 08, 2016

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Pubmed Data : Phytother Res. 2016 Jun 9. Epub 2016 Jun 9. PMID: 27279282

Article Published Date : Jun 08, 2016

Study Type : Animal Study

Additional Links

Substances : Crocin

Diseases : Kidney Damage, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective

[+]

Crocin has anti-inflammatory and protective effects in ischemia-reperfusion induced renal injuries.Jun 30, 2017

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Curcumin attenuates high glucose-induced podocyte apoptosis in vitro and diabetic nephropathy in vivo.Jan 31, 2016

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Pubmed Data : Acta Pharmacol Sin. 2016 Feb 1. Epub 2016 Feb 1. PMID: 26838071

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Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:917435. Epub 2015 Aug 5. PMID: 26345660

Article Published Date : Dec 31, 2014

Study Type : Animal Study

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Substances : Curcumin

Diseases : Chemotherapy-Induced Toxicity: Gentamicin

Pharmacological Actions : Chemoprotective Agents, Nrf2 activation, Renoprotective

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Curcumin could protect against the synergistic toxicity of ethanol and atrazine.Oct 31, 2017

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Pubmed Data : Ren Fail. 2017 Nov ;39(1):588-596. PMID: 28741978

Article Published Date : Oct 31, 2017

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Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:827472. Epub 2015 Oct 11. PMID: 26539236

Article Published Date : Dec 31, 2014

Study Type : Animal Study

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Substances : Curcumin

Diseases : Glomerulosclerosis, Leptin: Elevated Levels, Obesity

Pharmacological Actions : Renoprotective, Wnt/β-catenin pathway down-regulation

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Curcumin may be effective in the management of diet-induced oxidative stress.Dec 31, 2014

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Curcumin reduced the side effects of mitomycin C in the treatment of breast cancer.Nov 01, 2009

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Pubmed Data : Cancer Sci. 2009 Nov;100(11):2040-5. Epub 2009 Jul 23. PMID: 19703194

Effects of delta-tocotrienol on ochratoxin A-induced nephrotoxicity.Oct 31, 2018

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Pubmed Data : J Cell Physiol. 2018 Nov ;233(11):8731-8739. Epub 2018 May 18. PMID: 29775204

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Pubmed Data : Zhonghua Yi Xue Za Zhi. 2016 May 10 ;96(17):1330-5. PMID: 27180749

Article Published Date : May 09, 2016

Study Type : Animal Study

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Substances : EGCG (Epigallocatechin gallate)

Diseases : Diabetes: Oxidative Stress, Diabetes Mellitus: Type 2

Pharmacological Actions : Antioxidants, Renoprotective

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EGCG treatment can decrease renal ischemia-reperfusion injury by suppressing inflammation and cell apoptosis.Jun 27, 2015

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Pubmed Data : Int Urol Nephrol. 2015 Jun 28. Epub 2015 Jun 28. PMID: 26122117

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : EXCLI J. 2013 ;12:858-71. Epub 2013 Sep 24. PMID: 26622220

Article Published Date : Dec 31, 2012

Study Type : Animal Study

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Substances : False Black Pepper

Diseases : Diabetes Mellitus: Type 2, Diabetic Nephropathy, Lipid Peroxidation

Pharmacological Actions : Antihypertensive Agents, Antioxidants, Catalase Up-Regulation, Glutathione Upregulation , Insulin Sensitizers, Renoprotective, Superoxide Dismutase Up-regulation

Additional Keywords : Plant Extracts

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Emerging evidence further suggests the protective benefits of melatonin against BPA nephrotoxicity.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:3082438. Epub 2018 Feb 18. PMID: 29670679

Article Published Date : Dec 31, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Melatonin

Diseases : Bisphenol Toxicity

Pharmacological Actions : Antioxidants, Renoprotective

Problem Substances : Bisphenol A

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Fermented camel milk prevents carbon tetrachloride induced acute injury in kidney of mice.Apr 30, 2018

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Pubmed Data : J Dairy Res. 2018 May ;85(2):251-256. PMID: 29785914

Article Published Date : Apr 30, 2018

Study Type : Animal Study

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Substances : Camel Milk , Fermented Foods and Beverages

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Renoprotective

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Ferulic acid may have future therapeutic relevance in the prevention of lead acetate-induced testicular and renal toxicity.Sep 03, 2019

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Pubmed Data : Environ Sci Pollut Res Int. 2019 Sep 4. Epub 2019 Sep 4. PMID: 31482528

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Pubmed Data : Biomed Pharmacother. 2018 Nov ;107:1786-1794. Epub 2018 Sep 13. PMID: 30257398

Article Published Date : Oct 31, 2018

Study Type : Animal Study

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Substances : Gallic Acid

Diseases : Bisphenol Toxicity

Pharmacological Actions : Cardioprotective, Renoprotective

Problem Substances : Bisphenol A

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Gamma-linolenic acid has a protective and restorative effect on the kidney's of diabetic rats. Dec 01, 2001

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Pubmed Data : J Nutr. 2001 Dec;131(12):3160-5. PMID: 11739860

Article Published Date : Dec 01, 2001

Study Type : Animal Study

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Diseases : Diabetes: Kidney Function

Pharmacological Actions : Renoprotective

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Garden cress has a protective effect on aluminium induced impairment of the liver and kidneys. Dec 31, 2018

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Pubmed Data : Biomed Res Int. 2019 ;2019:4516730. Epub 2019 Jul 18. PMID: 31396529

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Pubmed Data : Int J Immunopathol Pharmacol. 2015 Mar ;28(1):122-8. PMID: 25816415

Article Published Date : Feb 28, 2015

Study Type : Animal Study

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Substances : Ginger, Zinc

Diseases : Chemical Exposure, Chemically-Induced Liver Damage, Kidney Damage: Chemically-Induced

Pharmacological Actions : Hepatoprotective, Renoprotective

Additional Keywords : Malathion Toxicity, Zinc Chloride

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Ginger extracts could have a potent protective effects against nephrotoxicity induced by various toxicants.Jan 31, 2019

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Pubmed Data : Saudi J Biol Sci. 2019 Feb ;26(2):382-389. Epub 2017 Aug 18. PMID: 31485182

Article Published Date : Jan 31, 2019

Study Type : Animal Study

Additional Links

Substances : Ginger

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Antioxidants, Renoprotective

Problem Substances : Cadmium

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Ginger has a protective effect against kidney damage associated with diabetes.Apr 30, 2011

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Pubmed Data : Chin J Physiol. 2011 Apr 30 ;54(2):79-86. PMID: 21789888

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Pubmed Data : Life Sci. 2016 Jul 15 ;157:82-90. Epub 2016 Jun 1. PMID: 27262790

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Pubmed Data : Basic Clin Pharmacol Toxicol. 2006 Sep;99(3):230-6. PMID: 16930296

Article Published Date : Sep 01, 2006

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Chemotherapy Induced Myelotoxicity , Chemotherapy-Induced Toxicity: Gentamicin, Kidney Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Genoprotective, Renoprotective

Additional Keywords : Plant Extracts

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Grape seed procyanidin extract reduces arsenic-induced renal inflammatory injury in male mice.Jun 30, 2017

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Pubmed Data : Biomed Environ Sci. 2017 Jul ;30(7):535-539. PMID: 28756814

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Open Access Maced J Med Sci. 2019 Feb 28 ;7(4):536-542. Epub 2019 Feb 27. PMID: 30894908

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Honey protects against cisplatin-induced hepatic and renal toxicity.Jun 12, 2018

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Pubmed Data : Food Funct. 2018 Jun 13. Epub 2018 Jun 13. PMID: 29897076

Article Published Date : Jun 12, 2018

Study Type : Animal Study

Additional Links

Substances : Honey, Manuka Honey

Diseases : Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, NF-kappaB Inhibitor, Renoprotective

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Honokiol alleviates sepsis-induced acute kidney injury.Dec 31, 2018

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Pubmed Data : J Bras Nefrol. 2018 Oct-Dec;40(4):312-318. Epub 2018 Aug 16. PMID: 30118536

Article Published Date : Sep 30, 2018

Study Type : Animal Study

Additional Links

Substances : Brazil nut

Diseases : Inflammation, Ischemia, Kidney Damage

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Renoprotective, Transforming growth factor beta (TGF-β) inhibitor

Additional Keywords : Phytotherapy

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Influence of ferulic acid consumption in ameliorating the cadmium-induced liver and renal oxidative damage in rats.Jun 30, 2019

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Pubmed Data : Environ Sci Pollut Res Int. 2019 Jul ;26(20):20631-20653. Epub 2019 May 18. PMID: 31104231

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View the Evidence: 730 Abstracts with Renoprotective Research

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A systematic review and meta-analysis of Abelmoschus manihot for diabetic nephropathy.Dec 31, 2018

Alpha-tocopherol pre-treatment is associated with reduction of incidence of contrast-induced nephropathy.Jan 23, 2019

These results highlight the potential protective effect of magnesium supplementation on cisplatin-induced acute nephrotoxicity.Aug 18, 2019

This study summarizes the potential beneficial effects of dietary fiber in the CKD population demonstrating a reduction in serum urea and creatinine.Jun 30, 2015

A "very low dose" of omega-3 fatty acids slows renal progression in high-risk patients with IgA nephropathy.Jul 01, 2004

A 12-month therapy with omega-3 fatty acids improves renal vascular function and tubule function in IgA nephropathy patients.Sep 01, 2004

A manihot is a promising therapy for patients with primary kidney disease.Jun 30, 2014

An intravenous hydration regimen supplemented with magnesium prevented cisplatin-induced nephrotoxicity in patients with head and neck cancer.Feb 01, 2018

Combined sodium bicarbonate and ascorbic acid could prevent contrast-induced nephropathy following catheterization in CKD patients.Jan 24, 2017

Effects of Brazilian green propolis on proteinuria and renal function in patients with chronic kidney disease.Apr 24, 2019

Ginsenoside Rb1 treatment was effective in reducing the extent of oxidative stress and inflammation in chronic kidney disease patients.Jan 31, 2017

Hibiscus sabdariffa consumption improved indices of renal function in patients with mild to moderate hypertension.May 23, 2016

High-volume hydration and magnesium supplementation can reduce the renal toxicity induced by cisplatin.Dec 31, 2013

Hydration with sodium bicarbonate reduces contrast-induced renal impairment compared to hydration with saline.Apr 30, 2016

Intravenous magnesium supplementation conferred protective effects against cisplatin-induced nephrotoxicity.Dec 31, 2017

Lower dietary magnesium intake was independently associated with greater odds of rapid kidney function decline.Oct 21, 2016

Magnesium deficiency is associated with increased risk of diabetic retinopathy and poor glycemic control.Apr 30, 2019

Magnesium supplementation during cisplatin-containing chemotherapy was associated with less cisplatin-induced nephrotoxicity.Apr 19, 2018

Magnesium was found to provide nephroprotective effects among patients with cervical cancer undergoing chemotherapy with cisplatin alone.Mar 31, 2015

Oral activated charcoal effectively delays the onset of hyperphosphatemia in patients with chronic kidney disease.Dec 25, 2018

S-adenosylmethionine has nephroprotective properties.Nov 30, 2017

Sodium bicarbonate reduces the incidence of contrast-induced acute kidney injury.Jan 31, 2016

Sodium bicarbonate supplementation is associated with a decrease in electronegative LDL in chronic kidney disease patients.Sep 30, 2017

Stevia has the potential for a significant improvement of some biochemical parameters in chronic kidney disease patients.Nov 30, 2018

The ketogenic diet seems nutritionally safe and could defer dialysis initiation in some patients with chronic kidney disease.Jan 27, 2016

Vitamin B complex improved glycemic control and renal function through decreasing homocysteine.Jan 16, 2019

Angelica and Astragalus could protect against oxidative stress-induced apoptosis in kidney epithelium.Feb 16, 2016

Glycine max and Chrysanthemum indicum extracts exhibited a promising protective effect on cisplatin-induced nephrotoxicity.Nov 30, 2011

Prunella vulgaris attenuates diabetic renal injury.Mar 29, 2017

"Curcumin ameliorates cisplatin-induced nephrotoxicity by inhibiting renal inflammation in mice."Dec 11, 2012

"Pomegranate Extract Attenuates Gentamicin-Induced Nephrotoxicity in Rats by Reducing Oxidative Stress."Nov 25, 2012

2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside exerted protective effects on diabetic nephropathy.Nov 08, 2016

6-shogaol can be used as a therapeutic agent for preventing complications in diabetic patients.Dec 31, 2018

6-shogaol may be of value in protection against diabetic complications in kidney and heart.Aug 31, 2018

6-Shogaol protects against ischemic acute kidney injury by modulating NFκB and heme oxygenase-1 pathways.Jul 16, 2019

A Chinese formula Modified Simiao Decoction regulates renal urate transporters and enhancing antioxidant enzymes activities to improve renal dysfunction in hyperuricemic mice.Jun 25, 2012

A combination of ascorbate with Amphotericin B is a potentially effective treatment that may reduce nephrotoxicity in patients with systemic candidiasis.Jul 31, 2015

A compound in ginger known as 6-Gingerol prevents cisplatin-induced acute renal failure in rats.Apr 06, 2005

A compound in mangosteen prevents cisplatin-induced toxicity to the kidneys of rats.Oct 06, 2010

A compound within Andrographis prevent diabetic nephropathy in an animal model. Aug 30, 2010

A dietary supplement of nuciferine rich in lotus leaf may have potential for the prevention and treatment of hyperuricemia with kidney inflammation.Jan 14, 2015

A pomegranate flower extract could ameliorate gentamicin induced renal toxicity in male rats.Dec 31, 2014

A purple corn extract may be a potent therapeutic agent targeting abnormal angiogenesis in diabetic nephropathy leading to kidney failure.Dec 31, 2012

A spice mixture containing garlic, ginger and nutmeg possesses both therapeutic and prophylactic effect against Cd-induced organ damage.May 31, 2016

A tocotrienol rich fraction of palm oil protects against chemically-induced kidney damage.Jul 30, 2010

A virgin coconut oil supplementary diet could be a therapy for kidney problems.May 31, 2019

Abelmoschus esculentus subfractions improved nephropathy with regulating dipeptidyl peptidase-4 and type 1 glucagon-like peptide receptor.Dec 31, 2018

Açaí seed extract substantially reduced renal injury and prevented renal dysfunction.Jan 19, 2017

Administration of 6-gingerol during gentamicin therapy has a significant reno-protective effect in a rat model of gentamicin-induced renal damage.Mar 16, 2016

Administration of astragaloside containing fluid led to a dramatic improvement in survival following crush syndrome.Sep 03, 2017

Administration of calcium to female rats can ameliorate the hazardous effects of fluoride observed in the biochemical, hormonal, and histological parameters.Jul 22, 2015

Administration of camel milk exerts significant hepatoprotective and nephroprotective effects in gentamicin-treated rats.Dec 31, 2013

Administration of Curcumin during 72-h reperfusion following 30 minutes of ischemia can decrease renal oxidative stress and leukocytes infiltration.Oct 31, 2015

Administration of thymol afforded remarkable protection against high fat diet induced diabetic nephropathy.Feb 04, 2016

Aegle marmelos Correa leaf extract prevents secondary complications in streptozotocin-induced diabetic rats.May 31, 2013

AGE has an ameliorative effect against CP-induced oxidative stress and renal damage through its antioxidant, anti-inflammatory and antiapoptotic properties. Dec 31, 2013

Aged garlic extract has the ability to ameliorate kidney damage in diabetic rats and the renoprotective effect of AGE may be attributed to its anti-glycation and hypolipidemic activities.Dec 31, 2012

Allicin administration has the potential to protect against cyclosporine-A induced renal injury.Jun 30, 2017

Allicin showed an antihypertensive, nephroprotective, cardioprotective, and antioxidant effects.Dec 31, 2015

Ameliorating efficacy of eugenol against metanil yellow induced toxicity.Feb 06, 2019

Ameliorative effect of Ecklonia cava polyphenol extract on renal inflammation.May 16, 2017

Ameliorative effect of pumpkin seed oil against emamectin induced toxicity in mice.Jan 31, 2018

Ameliorative Potentials of Ginger (Z. officinale Roscoe) on Relative Organ Weights in Streptozotocin induced Diabetic Rats.May 31, 2013

Amla exhibits antihyperglycemic and hepato-renal protective properties in fluoride induced toxicity.Jun 30, 2012

Amla leaf extract might have therapeutic application for protecting against arsenic-mediated toxicity.Jan 31, 2015

Amygdalin is a potent antifibrotic agent that may have therapeutic potential for patients with fibrotic kidney diseases.Apr 30, 2013

An experimetal evaluation of nephroprotective potential of Butea monosperma extract in albino rats.Dec 31, 2013

An extract of Bacopa monniera effectively protects the kidney from hypercholesterolemia-mediated oxido-lipidemic damage.Sep 30, 2014

An extract of Ginkgo biloba leaves can prevent renal fibrosis in rats with diabetic nephropathy.Nov 14, 2015

An extract of moringa oleifera seeds ameliorated gentamicin-induced nephrotoxicity.Aug 31, 2019

An extract of R. ribes root improves renal dysfunction in alloxan-induced diabetic rats.Oct 31, 2014

An extract of Zataria multiflora and carvacrol had protective effects on the renal damage induced by Adriamycin.Aug 08, 2019

Renoprotective

View the Evidence:
730 Abstracts with Renoprotective Research