Pancreato Protective Agents

Name	AC	CK
Anthocyanins	2	3
Chokeberry	2	3
Alpha-Lipoic Acid	1	2
Apigenin	1	2
Caffeic acid phenethyl ester	1	2
Chaga Mushroom (Inonotus obliquus)	1	2
Chrysin	1	2
Cordyceps sinensis	1	2
Curcumin	2	2
Dates	1	2
Fucoidan	1	2
Jambul	1	2
Kombucha Tea	1	2
Nettle	1	2
Parsley	1	2
Propolis: Bee	1	2
Prunella vulgaris.	1	2
Quercetin	1	2
Yarrow	1	2
Banaba	1	1
Resveratrol	1	1
Selenium	1	1
Spirulina	1	1
Thymoquinone	1	1

Diseases : Diabetes Mellitus: Type 1

Pharmacological Actions : Antioxidants, Hepatoprotective, Hypoglycemic Agents, Hypolipidemic, Pancreato Protective Agents, Renoprotective

Additional Keywords : Antioxidants, Diabetes Mellitus: Type 1, Hepatoprotective, Honeydew (melon), Hypoglycemic Agents

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Aqueous extract of unfermented honeybush attenuates STZ-induced diabetes and β-cell cytotoxicity.May 31, 2014

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Pubmed Data : Planta Med. 2014 Jun ;80(8-9):622-9. Epub 2014 May 22. PMID: 24853761

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Pubmed Data : Biomed Pharmacother. 2017 Aug 23 ;95:175-185. Epub 2017 Aug 23. PMID: 28843149

Article Published Date : Aug 22, 2017

Study Type : Animal Study

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Substances : Berberine

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Hypoglycemic Agents, NF-kappaB Inhibitor, Pancreato Protective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Diabetes Mellitus: Type 1

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Pubmed Data : J Nutr Biochem. 2018 Dec 21 ;66:17-28. Epub 2018 Dec 21. PMID: 30708236

Article Published Date : Dec 20, 2018

Study Type : Animal Study

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Substances : Pomegranate

Diseases : Pancreatitis

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Nrf2 activation, Pancreato Protective Agents

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Early dietary supplementation with n-6 and n-3 PUFAs can be powerfully used for protection against metabolic dysfunctions.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Endocrinol. 2016 ;2016:9242319. Epub 2016 Dec 5. PMID: 28050167

Article Published Date : Dec 31, 2015

Study Type : Animal Study

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Substances : Essential Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)

Diseases : Metabolic Diseases, Obesity

Pharmacological Actions : Antioxidants, Pancreato Protective Agents

Problem Substances : Monosodium Glutamate (MSG)

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Effects of alpha-tocopherol on acute pancreatitis.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Ulus Travma Acil Cerrahi Derg. 2019 Jan ;25(1):1-6. PMID: 30742296

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Vitamin E: alpha tocopherol

Diseases : Pancreatitis

Pharmacological Actions : Pancreato Protective Agents

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Emodin may be an efficient candidate natural product for severe acute pancreatitis treatment.Nov 01, 2018

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Pubmed Data : Oncol Rep. 2018 Nov 2. Epub 2018 Nov 2. PMID: 30542707

Article Published Date : Nov 01, 2018

Study Type : Animal Study

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Substances : Emodin

Diseases : Pancreatitis

Pharmacological Actions : Anti-Inflammatory Agents, Pancreato Protective Agents

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Experimental cannabidiol treatment reduces early pancreatic inflammation in type 1 diabetes.Oct 17, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2018 Oct 3 ;10(10). Epub 2018 Oct 3. PMID: 30282902

Article Published Date : Oct 02, 2018

Study Type : Animal Study

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Substances : Luteolin

Diseases : Fibrosis, Hepatic Steatosis, Insulin Resistance, Obesity

Pharmacological Actions : Anti-Fibrotic, Pancreato Protective Agents

Additional Keywords : Anti-Obesity Agents

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Mangiferin induces islet regeneration in aged mice.Feb 28, 2018

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Pubmed Data : Int J Mol Med. 2018 Mar 1. Epub 2018 Mar 1. PMID: 29512742

Article Published Date : Feb 28, 2018

Study Type : Animal Study

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Substances : Mangiferin

Pharmacological Actions : Anti-Apoptotic, Pancreato Protective Agents

Additional Keywords : Anti-Apoptotic, Mangiferin, Pancreato Protective Agents

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Maternal folate supplementation counteracts bisphenol A induced Igf2 DNA hypermethylation in the offspring.Feb 05, 2017

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Pubmed Data : J Appl Toxicol. 2017 Feb 6. Epub 2017 Feb 6. PMID: 28165156

Article Published Date : Feb 05, 2017

Study Type : Animal Study

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Substances : Folate, Folate: Dietary

Diseases : Bisphenol Toxicity, Prenatal Chemical Exposures

Pharmacological Actions : Pancreato Protective Agents

Additional Keywords : Bisphenol A, Bisphenol Toxicity, Folate, Prenatal Chemical Exposures, Risk Reduction

Problem Substances : Bisphenol A

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Momordica charantia reverses type II diabetes in animals.Aug 22, 2019

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Pubmed Data : J Food Biochem. 2019 Aug 23:e13021. Epub 2019 Aug 23. PMID: 31441956

Article Published Date : Aug 22, 2019

Study Type : Animal Study

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Substances : Bitter Melon

Diseases : Diabetes Mellitus: Type 2: Prevention

Pharmacological Actions : Hypoglycemic Agents, Pancreato Protective Agents

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N. sativa and thymoquinone may prove clinically useful in the treatment of diabetics and in the protection of β-cells against oxidative stress.Nov 30, 2010

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Diabetes. 2010 Dec ;2(4):256-66. PMID: 20923501

Article Published Date : Nov 30, 2010

Study Type : Animal Study

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Substances : Nigella sativa (aka Black Seed), Thymoquinone

Diseases : Diabetes: Oxidative Stress

Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Pancreato Protective Agents, Superoxide Dismutase Up-regulation

Additional Keywords : Antioxidants, Diabetes: Oxidative Stress, Nigella sativa (aka Black Seed), Phytotherapy, Plant Extracts, thymoquinone

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Nardostachys jatamansi treatment increased the pancreatic acinar cell survival and reduced collagen deposition and pancreatic stellate cell activation.Jun 30, 2012

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Pubmed Data : BMB Rep. 2012 Jul ;45(7):402-7. PMID: 22831975

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Pubmed Data : Drug Res (Stuttg). 2018 Sep 12. Epub 2018 Sep 12. PMID: 30208495

Article Published Date : Sep 11, 2018

Study Type : Animal Study

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Substances : Rhubarb

Diseases : Diabetes: Oxidative Stress

Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Pancreato Protective Agents

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Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Basic Med Sci. 2017 Sep ;20(9):1009-1015. PMID: 29085595

Article Published Date : Aug 31, 2017

Study Type : Animal Study

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Substances : Genistein

Diseases : Hyperglycemia, Postmenopausal Disorders

Pharmacological Actions : Hypoglycemic Agents, Pancreato Protective Agents

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Click here to read the entire abstract

Pubmed Data : J Med Food. 2018 Mar ;21(3):244-253. Epub 2018 Feb 22. PMID: 29470134

Article Published Date : Feb 28, 2018

Study Type : Animal Study, In Vitro Study

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Substances : Chokeberry

Diseases : Diabetes Mellitus: Type 1

Pharmacological Actions : Hypoglycemic Agents, Pancreato Protective Agents

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This study provided new evidence supporting beneficial effects of coenzyme Q10 and L-carnitine on statin-induced pancreatic toxicity.Nov 30, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Res Pharm Sci. 2017 Dec ;12(6):434-443. PMID: 29204172

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Chin Med J (Engl). 2013 ;126(9):1647-53. PMID: 23652045

Article Published Date : Dec 31, 2012

Study Type : Animal Study

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Substances : Prunella vulgaris

Diseases : Diabetes Mellitus: Type 2, Hyperglycemia

Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Pancreato Protective Agents, Superoxide Dismutase Up-regulation

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Virgin olive oil and Nigella sativa seeds had antihyperlipidemic and hypoglycemic effects.Feb 27, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Affect Disord. 2014 Sep ;166:6-13. Epub 2014 May 4. PMID: 25012404

Article Published Date : Aug 31, 2014

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Pubmed Data : J Ethnopharmacol. 2018 Aug 16 ;227:8-17. Epub 2018 Aug 16. PMID: 30120944

Article Published Date : Aug 15, 2018

Study Type : In Vitro Study

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Substances : Hibiscus rosa-sinensis

Diseases : Diabetic Complications

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Pancreato Protective Agents

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HM-chromanone could be useful for the protection of pancreatic β-cells against oxidative stress and apoptosis induced by high glucose.Feb 13, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Cell Mol Med. 2016 Oct ;20(10):1803-12. Epub 2016 Jul 22. PMID: 27444655

Article Published Date : Sep 30, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Endocrinol. 2014 Nov ;223(2):107-17. PMID: 25297556

Article Published Date : Oct 31, 2014

Study Type : In Vitro Study

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Substances : Curcumin, Resveratrol

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Pancreato Protective Agents, Phosphodiesterase Inhibitors

Additional Keywords : Dose Response, Gene Expression Regulation

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This study demonstrates the therapeutic potential and action mechanism of cirsimaritin for the prevention and treatment of type 1 diabetes mellitus.Jun 30, 2017

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Pubmed Data : J Pharm Pharmacol. 2017 Jul ;69(7):875-883. Epub 2017 Apr 11. PMID: 28397263

Article Published Date : Jun 30, 2017

Study Type : In Vitro Study

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Substances : Thistle

Diseases : Diabetes Mellitus: Type 1: Prevention, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Pancreato Protective Agents

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This study that examines the impact of ginsenosides on human pancreatic islets in vitro.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Eur J Pharm Med Res. 2016 Jan ;3(1):110-119. PMID: 27547829

View the Evidence: 133 Abstracts with Pancreato Protective Agents Research

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Cytoprotective effects of ginsenoside Rd on apoptosis-associated cell death in the isolated human pancreatic islets.Dec 31, 2018

6-shogaol can be used as a therapeutic agent for preventing complications in diabetic patients.Dec 31, 2018

A hot-water extract of rose hip exerted an anti-prediabetic effect in a rat model.Feb 08, 2017

A. vera extract exhibited pancreatic islet cell rejuvenation.Nov 30, 2017

Achillea Millefolium hydro alcoholic extract protects pancreatic cells.Dec 31, 2013

Aegle marmelos fruit extract exhibits protective effects on the pancreas.Dec 31, 2004

Alpha lipoic acid had ameliorative effects against HFCS induced pancreatic lesions.Mar 09, 2016

Amygdalin improves microcirculatory disturbance and attenuates pancreatic fibrosis.Nov 08, 2017

Anthocyanin-rich purple corn extract exerted anti-diabetic effects through protection of pancreatic β-cells and increase of insulin secretion.Jan 31, 2015

Antidiabetic activity and chemical composition of Sanbai melon seed oil.Dec 31, 2017

Aqueous extract of unfermented honeybush attenuates STZ-induced diabetes and β-cell cytotoxicity.May 31, 2014

Astaxanthin ameliorates cerulein-induced acute pancreatitis in mice.Jan 08, 2018

Baicalein protects from pancreatic injury in rats with severe acute pancreatitis.Oct 29, 2015

Balanites aegyptiaca and Petroselinum sativum aqueous extracts have antidiabetic and antioxidant effects in diabetic rats.Dec 31, 2015

Berberine chloride ameliorates oxidative stress, inflammation and apoptosis in the pancreas of Streptozotocin induced diabetic rats.Aug 22, 2017

Blueberry supplementation has the potential to protect and improve health conditions for both type 1 and type 2 diabetes patients.Dec 31, 2018

Bone marrow-derived mesenchymal stem cells and N.sativa ameliorate the histological, biochemical and immunohistochemical changes induced by energy drink.Jun 30, 2019

Both resveratrol and garlic have similar property to increase insulin secretion from beta cells.Dec 31, 2015

Broccoli reduces oxidative damage to pancreatic tissue and combats hyperglycaemia in diabetic rats.Nov 30, 2017

Cabbage extracts have a pancreato-protective effect.Jan 19, 2017

Caffeic acid phenethyl ester could be used for supportive and protective therapy against pesticide intoxication.Jun 29, 2016

Chrysin treatment improves diabetes and its complications in liver, brain, and pancreasMay 12, 2015

Coenzyme Q10 protects against β-cell toxicity induced by pravastatin treatment of hypercholesterolemia.Jun 30, 2019

Compound K protects pancreatic islet cells against apoptosisJun 26, 2014

Cordyceps sinensis could protect pancreatic beta cells from the pro-apoptotic endoplasmic reticulum stress induced by HFD-STZ.Apr 28, 2016

Crocin can improve oxidative stress in pancreatic cells by potentiating the anti-oxidant defense system.May 31, 2019

Crocin suppressed atrophic change of the pancreas by decrease of LOX-1 and RAGE mRNA expression in diabetic rats.Sep 17, 2019

Crocin, an active constituent of Crocus sativus ameliorates cerulein induced pancreatic inflammation and oxidative stress.Nov 24, 2019

Dietary d-limonene alleviates insulin resistance and oxidative stress-induced liver injury in high-fat diet.Jan 31, 2012

Dietary intake of kaempferol ameliorated hyperglycemia and improved insulin levels in middle-aged obese diabetic mice.Dec 31, 2014

Dietary pomegranate supplement alleviates murine pancreatitis.Dec 20, 2018

Early dietary supplementation with n-6 and n-3 PUFAs can be powerfully used for protection against metabolic dysfunctions.Dec 31, 2015

Effects of alpha-tocopherol on acute pancreatitis.Dec 31, 2018

Emodin may be an efficient candidate natural product for severe acute pancreatitis treatment.Nov 01, 2018

Experimental cannabidiol treatment reduces early pancreatic inflammation in type 1 diabetes.Oct 17, 2016

Fenugreek ethanolic extract can serve as an antidote for dimethoate-induced pancreatic insult.Nov 24, 2017

Formononetin treatment reduces insulin resistance and attenuate hyperglycemia in type 2 diabetes.Dec 31, 2017

Fucoidan exhibits an anti-diabetic effect mainly through attenuation of β-cell death.May 10, 2017

Fucoidan may stimulate insulin secretion and provide pancreatic protection via the cAMP signaling pathway, in vivo and in vitro.Aug 31, 2015

Ginseng extract reduces tacrolimus-induced oxidative stress by modulating autophagy in pancreatic beta cells.Jul 30, 2017

Ginsenoside Rg1 can be effective antagonistic structure and function of the pancreas injury induced by D-gal. Jun 30, 2017

Hesperidin may have the potential to protect pancreatic β-cells and improve their function.Oct 14, 2019

Hibiscus sabdariffa renews pancreatic β-cells in experimental type 1 diabetic model.May 31, 2019

Histopathologically beneficial changes in the pancreases were detected when grape seed extract was given to diabetic rats.Mar 30, 2018

Honokiol protects pancreatic β cell against high glucose and intermittent hypoxia-induced injury.Dec 31, 2017

Intermittent fasting preserves beta-cell mass in obesity-induced diabetes.Aug 29, 2017

Isolated mangiferin and naringenin exert antidiabetic effects.Jan 24, 2018

Isoliquiritigenin protects against pancreatic injury and intestinal dysfunction after severe acute pancreatitis.Dec 31, 2017

Kombucha tea attenuated oxidative stress mediated tissue damage in alloxan induced diabetic rats.Sep 30, 2013

Litchi semen constituents can improve glycolipid metabolism and insulin resistance, and increase insulin sensitivity to cure T2DM.Jun 30, 2015

Luteolin ameliorates diet-induced obesity and its comorbidities.Oct 02, 2018

Mangiferin induces islet regeneration in aged mice.Feb 28, 2018

Maternal folate supplementation counteracts bisphenol A induced Igf2 DNA hypermethylation in the offspring.Feb 05, 2017

Momordica charantia reverses type II diabetes in animals.Aug 22, 2019

N. sativa and thymoquinone may prove clinically useful in the treatment of diabetics and in the protection of β-cells against oxidative stress.Nov 30, 2010

Nardostachys jatamansi treatment increased the pancreatic acinar cell survival and reduced collagen deposition and pancreatic stellate cell activation.Jun 30, 2012

Naringenin could be a good anti-diabetic agent.Dec 31, 2017

Naringenin protects against acute pancreatitis in two experimental models.Dec 31, 2017

Naringin was found to upregulate the FoxM1 transcription factor in diabetic animals, which influenced the proliferation and functional status of beta cells.May 07, 2019

Nettle distillate regenerates pancreatic beta cells in streptozotocin-Induced diabetic rats.Feb 28, 2018

Nettle extract treatment was associated with less apoptosis in an experimental acute pancreatitis model in rats.Dec 31, 2013

Nigella sativa exerts a therapeutic protective effect in diabetes by decreasing oxidative stress and preserving pancreatic beta-cell integrity.Jun 30, 2004

Nigella sativa may be clinically useful for protecting beta-cells against oxidative stress.Sep 30, 2009

Nigerian propolis confers protection against hyperglycemia-induced oxidative stress in both liver and pancreas of adult Wistar rats.Mar 31, 2015

Oligonol protects the pancreas from Bax and PDX-1 via oxidative stress for the prevention or delaying of diabetes mellitus.Jul 12, 2016

Opuntia humifusa ameliorated cerulein-induced acute pancreatitis.Dec 31, 2013

P. alata has anti-inflammatory properties, contributing to the protection of beta cells in pancreatic islets in NOD mice.May 31, 2016

P. oleracea extract is a general tissue protective and regenerative agent and may be a novel therapeutic agent for diabetes prevention.Jan 10, 2017

Palmitoylethanolamide could be effective in type 1-diabetic patients not only as pain reliever but also in controlling the development of pathology.Dec 31, 2014

Phenylpropenoic acid glucoside from rooibos protects the beta cell mass exposed to acute diabetogenic stress.Dec 31, 2015

Polysaccharides from Inonotus obliquus may provide a valuable therapeutic option against diabetes.Dec 31, 2013

Protective efficacy of Tinospora sinensis against streptozotocin induced pancreatic islet cell injuries.Oct 24, 2019

Pancreato Protective Agents

View the Evidence:
133 Abstracts with Pancreato Protective Agents Research