Interleukin-6 Downregulation

Name	AC	CK
Curcumin	62	145
Coenzyme Q10	11	116
Vitamin C	16	96
Probiotics	11	74
Berberine	25	56
Ginsenosides	28	53
Resveratrol	24	42
Vitamin D	8	37
Spirulina	5	36
Melatonin	6	35
Alpha-Lipoic Acid	4	34
Lycopene	4	33
Astaxanthin	12	32
Garlic	3	32
Polyphenols	19	32
Thymoquinone	16	32
Omega-3 Fatty Acids	4	31
Tomato	2	30
Ginger	15	28
Lactobacillus plantarum	6	27
Fish Oil	4	26
Flavonoids	15	26
Anthocyanins	9	25
Green Tea	13	24
Red Sage	9	24
Vitamin E	4	24
Paeoniflorin	13	23
Puerarin	9	23
Quercetin	14	23
Sesame Seeds	4	23
Tanshinone IIA	15	23
Luteolin	12	22
Strawberry	3	22
Gastrodin	7	21
Turmeric	9	21
Hesperidin	11	20
Isoflavones	2	20
Purslane	11	20
Soy Protein	2	20
Vitamin B-12	2	20
Rose	12	19
Citrus naringin	10	18
EGCG (Epigallocatechin gallate)	10	18
Asiatic Acid	11	17
Lactobacillus fermentum	5	17
Sulforaphane	12	17
Astragaloside	10	16
Genistein	5	16
Lactobacillus casei	4	16
Moringa oleifera	10	16
Vitamin E: alpha tocopherol	4	16
DHA (Docosahexaenoic Acid)	4	15
Black Raspberry	4	14
Dandelion	8	14
Nettle	3	14
Phloretin	7	14
Pomegranate	5	14
Silibinin	3	14
Whey	3	14
Black Currant	3	13
Cannabidiol	7	13
Fisetin	5	13
Ginkgo biloba	3	13
Lychee	5	13
Oleuropein	5	13
Panax Notoginseng	7	13
Rosmarinic acid	5	13
Burdock	2	12
Caffeic acid phenethyl ester	2	12
Cyanidin 3-glucoside	2	12
Fucoidan	6	12
Honey	2	12
Indole-3-Carbinol	6	12
Lactobacillus probiotics	2	12
Magnolol	6	12
NAC (N-acetyl-L-cysteine)	2	12
Olive Oil	2	12
Tart Cherry	2	12
Yerba Mate	2	12
Astragalus	2	11
Boswellia	2	11
Chrysanthemum Indicum	6	11
Ellagic Acid	7	11
Ginseng (Korean)	7	11
Lactobacillus delbrueckii Subsp	2	11
Lotus	6	11
Lutein	2	11
Nobiletin	7	11
Nuts	2	11
Punicalagin	5	11
Sesamin	2	11
Almond	1	10
Antioxidant formulas	1	10
Ashwagandha	6	10
Bacillus coagulans	1	10
Baicalein	5	10
Bee Venom	6	10
Bilberry	1	10
Blueberry	6	10
Broccoli Sprouts	1	10
Carnitine	1	10
Chocolate	1	10
Cruciferous Vegetables	1	10
Delphinidin	1	10
Flaxseed	1	10
Folate	1	10
Folic Acid	1	10
Hydrogen Water	5	10
Isothiocyanate	1	10
Kaempferol	6	10
Lactobacillus Acidophilus	1	10
Lactobacillus reuteri	5	10
Mastic gum	1	10
Pumpkin Seeds	1	10
Raisins	1	10
Soup	1	10
Thunder god vine	1	10
Tripterygium wilfordii	1	10
Ubiquinol	1	10
Vitamin A	1	10
Water: Electrolyzed Reduced	1	10
beta-Carotene	1	10
Carnosol	3	9
Fucoxanthin	5	9
Grape Seed Extract	5	9
Honokiol	5	9
Lactobacillus rhamnosus GG	5	9
Bamboo	3	8
Chrysin	6	8
Crocin	4	8
Ferulic acid	4	8
Myricetin	5	8
Tangeretin	5	8
Wogonin	6	8
Apigenin	4	7
Chokeberry	4	7
Diosmin	4	7
Genipin	4	7
Ginseng	2	7
Ligustrazine	4	7
Naringenin	4	7
Piceatannol	5	7
Sea buckthorn	4	7
Selenium	4	7
Stilbenes	4	7
Vitexins	2	7
6-Shogaol	3	6
Agaricus Blazei	3	6
Allicin	3	6
Carnosic Acid	3	6
Chlorogenic Acid	3	6
Eucalyptus	3	6
Hibiscus sabdariffa	3	6
Histidine	3	6
Kefir	3	6
Mangiferin	4	6
Manuka Honey	4	6
Rooibos	3	6
Rosemaric Acid	4	6
Sweet Potato: Purple	4	6
Verbascoside	4	6
Yellow Tea	3	6
Adlay	4	5
Beta-Elemene	3	5
Betulinic acid	3	5
Gallic Acid	3	5
Garlic: Aged	1	5
Gingerol	3	5
Gotu Kola	3	5
Guduchi	3	5
Hops	3	5
Isoliquiritigenin	3	5
Japanese cypress	3	5
Lactobacillus rhamnosus	3	5
Olive	3	5
Piperine	3	5
Rutin	3	5
Saffron	3	5
Shikonin	3	5
Acai	2	4
Aloe Vera	2	4
Amygdalin	2	4
Bifidobacterium Longum	2	4
Bitter Apple	2	4
Bitter Melon	2	4
Camel Milk	2	4
Carnosine	2	4
Chinese Skullcap	2	4
Cocoa	2	4
Diosgenin	2	4
EPA (Eicosapentaenoic Acid)	2	4
Emodin	2	4
Hu Zhang (Polygonum cuspidatum)	2	4
Huperzine	2	4
Isothiocyanates	3	4
Mulberry	2	4
Patchouli	2	4
Propolis: Bee	2	4
Purple Carrots	3	4
Red Yeast Rice	2	4
Sesamol	2	4
Soy	2	4
St. Johns Wort	2	4
Vanillin	3	4
White Tea	2	4
Xanthohumol	2	4
Zerumbone	2	4
Arctigenin	2	3
Artichoke	2	3
Bacopa	2	3
Bergamot	2	3
Bitter Orange	2	3
Black Tea	2	3
Chamomile	2	3
Cucurbitacin B	2	3
Curcumin: Degradiation byproducts	2	3
Echinacea	3	3
Eugenol	2	3
Garcinia Mangostana	2	3
Geraniol	2	3
Glycyrrhizin	2	3
Hemp Seed	2	3
Jujube	2	3
Justicia gendarussa	2	3
Lignans	2	3
Lion's Mane (Hericium Erinaceus)	2	3
Loquat Leaves	2	3
MSM (Methylsulfonylmethane)	2	3
Nigella sativa (aka Black Seed)	2	3
Oats	2	3
P-Coumaric Acid	2	3
Parthenolide	2	3
Perilla	2	3
Persimmon	2	3
Plantago	2	3
Procyanidin B2	2	3
Raspberry	2	3
Reishi Mushroom	3	3
Soybean: Black	2	3
Theaflavins	2	3
Thyme	2	3
Thymol	2	3
Vitex negundo	2	3
Yoghurt	2	3
Zeaxanthin	2	3
ALA (Alpha-Linolenic Acid)	1	2
Aduki bean	1	2
African Basil	1	2
Alpha Linolenic Acid	1	2
Angelica	1	2
Antrodia Camphorate	1	2
Apocynin	1	2
Arginine	1	2
Artesunate	1	2
Bael	1	2
Banaba	1	2
Banana	1	2
Barberry	1	2
Barley	1	2
Basil	1	2
Beans: All	1	2
Beta-Caryophyllene	1	2
Bifidobacterium	1	2
Bifidobacterium Infantis	1	2
Billygoat Weed	1	2
Blackberry	1	2
Blue Honeysuckle	1	2
Boron	1	2
Brown Rice	1	2
Brown Rice: Pre-Germinated	1	2
Buckwheat	1	2
Butyrate	1	2
Caffeic Acid	1	2
Cardamonin	1	2
Carnosine	1	2
Catechin	1	2
Celadrin	1	2
Chaenomeles speciosa	1	2
Chaga Mushroom (Inonotus obliquus)	1	2
Chia	1	2
Cinnamaldehyde	2	2
Cinnamon	1	2
Citrulline	1	2
Citrus Peel	1	2
Coconut Oil	1	2
Coffee: Green/Unroasted	1	2
Corn: Purple	1	2
Cranberry	1	2
Crocetin	1	2
Cystine	1	2
Diallyl sulfide	1	2
Elderberry	1	2
Elm tree	1	2
Evening Primrose Oil	1	2
FOS (Fructooligosaccharides)	1	2
Flaxseed Oil	1	2
Garden Cress (Lepidium sativum)	1	2
Gold (nanoparticles)	1	2
Grape	1	2
Gymnema Sylvestre	1	2
Hawthorn	1	2
Helenalin	1	2
Kaempferia parviflora	1	2
Krill	1	2
L-Carnitine	1	2
Lactobacillus Brevis	1	2
Lactobacillus paracasei	1	2
Lactobacillus salivarius	1	2
Lemon Verbena	1	2
Litchi	1	2
Loquat	1	2
Lupeol	1	2
Maca	1	2
Maitake Mushroom	1	2
Milk Thistle	1	2
Milk: Fermented	1	2
Mint	1	2
Mosla scabra	1	2
Moxibustion	1	2
Mucuna pruriens (aka Velvet Beans)	1	2
Mussel: Green-lipped (Perna canaliculus)	1	2
Myrrh	1	2
Nattokinase	1	2
Neem	1	2
Oleanolic acid	1	2
Olive leaf extract	1	2
Onion	1	2
Oolong tea	1	2
Palmitoylethanolamide	1	2
Peony	1	2
Perillaldehyde	1	2
Phosphatidylcholine	1	2
Phytosterols	1	2
Pine Needle	2	2
Piper cubeba (Cubeb)	1	2
Pomegranate Peel	1	2
Potato	1	2
Prunella vulgaris	1	2
Pterostilbene	1	2
Rice	1	2
Satsuma	1	2
Sembung Leaf	1	2
Sesame Seed Oil	1	2
Shiitake Mushroom	1	2
Silymarin	1	2
Sour Cherry	2	2
Spikenard	2	2
Stevia	1	2
Suma (Pfaffia Paniculata)	1	2
Tea	1	2
Tetrahydrocurcumin	1	2
Theanine	1	2
Tocotrienols	1	2
Velvet antler	1	2
Vitamin K	1	2
Vitamin K2: (MK-4)	1	2
White Mulberry	2	2
Yeast	1	2
Acorus calamus	1	1
Agrimony	1	1
Amino Acids	1	1
Amygdalin (laetrile)	1	1
Andrographis	1	1
Antrodia camphorata	1	1
Apple Cider Vinegar	1	1
Apple Pectin	1	1
Avocado	1	1
Ayahuasca	1	1
Basil: Sweet	1	1
Beta-glucan	1	1
Bisdemethoxycurcumin	1	1
Bromelain	1	1
Caffeoylquinic Acids	1	1
Carotenoids	1	1
Celery seed	1	1
Chlorella (Algae)	1	1
Coriandrum sativum	1	1
Cranberry Proanthocyanidins	1	1
Cryptomeria japonica	1	1
Cucurbitacin E	1	1
Curcumin: Lipidated	1	1
Daidzein	1	1
Damnacanthal	1	1
Delta-tetrahydrocannabinol (THC)	1	1
Devils Claw	1	1
Frankincense	1	1
Fruit: All	1	1
Gynostemma	1	1
Hirudin (from Medicinal Leaches)	1	1
Horseradish	1	1
Horsetail	1	1
Juniper	1	1
Kombucha Tea	1	1
Maple	1	1
Maple Syrup	1	1
Meadowsweet	1	1
Medicinal Mushrooms	1	1
Motherwort	1	1
Mushrooms: All	1	1
Oak	1	1
Palash	1	1
Phellinus Linteus	1	1
Pine Cone	1	1
Polyacetylenes	1	1
Polyunsaturated Fatty Acids (PUFAs)	1	1
Pomegranate flower	1	1
Prickly Pear Cactus	1	1
Progesterone	1	1
Red Clover	1	1
Rhubarb	1	1
Riboflavin (Vitamin B-2)	1	1
Rice: Black	1	1
Royal Jelly	1	1
Saccharomyces Boulardii	1	1
Salicylic acid	1	1
Sessile Joyweed	1	1
Sophora Flavescens	1	1
Sumac	1	1
Syrian rue	1	1
Thistle	1	1
Ursolic Acid	1	1
Vegetables: All	1	1
Vitamin E: Gamma-tocotrienol	1	1
Wasabi	1	1
Willow Bark	1	1
Wormwood	1	1
Zataria multiflora	1	1

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Alpha-lipoic acid supplementation had beneficial effects on inflammatory markers among patients with metabolic syndrome and related disorders.Dec 31, 2017

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Pubmed Data : Nutr Metab Cardiovasc Dis. 2013 Sep ;23(9):843-9. Epub 2012 Aug 17. PMID: 22906565

Article Published Date : Aug 31, 2013

Study Type : Human Study

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Substances : Anthocyanins, Cyanidin 3-glucoside, Delphinidin

Diseases : Atherosclerosis, C-Reactive Protein, High Cholesterol, Hypercholesterolemia

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Vascular Cell Adhesion Molecule-1 Inhibitor

Additional Keywords : Dose Response, Natural Substance Synergy

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An elemental diet reduces mucosal inflammation in patients with active Crohn's disease with remission occuring in 71% of patients. Jun 01, 2005

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Pubmed Data : Inflamm Bowel Dis. 2005 Jun;11(6):580-8. PMID: 15905706

Article Published Date : Jun 01, 2005

Study Type : Human Study

Additional Links

Diseases : Inflammation

Therapeutic Actions : Dietary Modification: Elemental Diet

Pharmacological Actions : Interleukin-1 receptor antagonist, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Pubmed Data : Am J Clin Nutr. 2009 Mar ;89(3):773-7. Epub 2009 Jan 21. PMID: 19158207

Article Published Date : Mar 01, 2009

Study Type : Human Study

Additional Links

Diseases : C-Reactive Protein, Cholesterol: Oxidation, Lipid Peroxidation

Pharmacological Actions : Interleukin-6 Downregulation

Problem Substances : Acrylamide , Potato, Potato Chips

Adverse Pharmacological Actions : Atherogenic, Inflammatory

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Chronic insomnia is associated with a shift of interleukin-6 and tumor necrosis factor secretion from nighttime to daytime.Jul 01, 2002

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Pubmed Data : Metabolism. 2002 Jul;51(7):887-92. PMID: 12077736

Article Published Date : Jul 01, 2002

Study Type : Human Study

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Diseases : Insomnia

Pharmacological Actions : Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Pubmed Data : Nephrol Dial Transplant. 2006 Aug;21(8):2239-46. Epub 2006 Jun 9. PMID: 16766544

Article Published Date : Aug 01, 2006

Study Type : Human Study

Additional Links

Substances : Isoflavones

Diseases : C-Reactive Protein, Hemodialysis, Inflammation, Kidney Failure

Pharmacological Actions : Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Dietary strawberries may have significant analgesic and anti-inflammatory effects in obese adults with established knee osteoarthritis.Aug 27, 2017

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Pubmed Data : Nutrients. 2017 Aug 28 ;9(9). Epub 2017 Aug 28. PMID: 28846633

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Pubmed Data : Eur J Appl Physiol. 2003 May ;89(3-4):393-400. Epub 2003 Apr 1. PMID: 12682838

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Pubmed Data : Mediators Inflamm. 2016 ;2016:5912146. Epub 2016 Jun 2. PMID: 27340344

Article Published Date : Dec 31, 2015

Study Type : Human Study

Additional Links

Substances : Folic Acid , Vitamin B-12

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Forest bathing has therapeutic effects on human hypertension and induces inhibition of the renin–angiotensin system and inflammation.Nov 30, 2012

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Article Publish Status : This is a free article. Click here to read the complete article.

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Lactobacillus acidophilus modulates inflammatory activity by regulating the TLR4 and NF-κB expression in porcine peripheral blood mononuclear cells.Feb 27, 2016

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Pubmed Data : Neurol Sci. 2017 May ;38(Suppl 1):173-175. PMID: 28527073

Article Published Date : Apr 30, 2017

Study Type : Human Study

Additional Links

Diseases : Headache: Migraine, Inflammation

Therapeutic Actions : Meditation , Mindfullness Training

Pharmacological Actions : Analgesics, Interleukin-6 Downregulation

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

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Mindfulness meditation training is associated with improvements in a marker of inflammatory disease risk.Jun 30, 2016

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Pubmed Data : Biol Psychiatry. 2016 Jul 1 ;80(1):53-61. Epub 2016 Jan 29. PMID: 27021514

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Pubmed Data : Ann Surg. 2006 Nov;244(5):706-14. PMID: 17060763

Article Published Date : Nov 01, 2006

Study Type : Human Study

Additional Links

Substances : Lactobacillus casei, Lactobacillus probiotics, Probiotics

Diseases : Biliary Obstruction , Biliary Tract Diseases, Liver Cancer

Pharmacological Actions : Interleukin-6 Downregulation

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Phototherapy can be an important tool in the obesity, mostly considering its potential effects associated to exercise training in attenuating inflammation in women.May 09, 2015

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Pubmed Data : Lasers Med Sci. 2015 May 10. Epub 2015 May 10. PMID: 25958170

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Pubmed Data : Zhong Xi Yi Jie He Xue Bao. 2007 Jan;5(1):28-31. PMID: 17214932

Article Published Date : Jan 01, 2007

Study Type : Human Study

Additional Links

Substances : Red Sage

Diseases : Pancreatitis

Pharmacological Actions : Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Sesame seed is a natural and safe substance that may have beneficial effects in patients with knee osteoarthritis.Dec 31, 2014

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Pubmed Data : Oman Med J. 2016 Jul ;31(4):263-9. PMID: 27403238

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Pubmed Data : J Physiol Pharmacol. 2016 Dec ;67(6):859-866. PMID: 28195066

Article Published Date : Nov 30, 2016

Study Type : Human Study

Additional Links

Diseases : C-Reactive Protein, Clostridium Infections, Diarrhea, Inflammation

Therapeutic Actions : Microbiota Transfer Therapy

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-12 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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The combined application of berberine in patients with metabolic syndrome can effectively regulate blood glucose and blood lipid of patients.Mar 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

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Vitamin C inhibited oxidative stress and proinflammatory mediators in severe pneumonia.Dec 31, 2013

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Pubmed Data : Nutr Res Pract. 2013 Feb ;7(1):9-14. Epub 2013 Feb 4. PMID: 23422838

Article Published Date : Jan 31, 2013

Study Type : Human In Vitro

Additional Links

Substances : Bamboo

Diseases : Cardiovascular Diseases, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

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Carnosol inhibits pro-inflammatory and catabolic mediators of cartilage breakdown in human osteoarthritic chondrocytes.Dec 31, 2014

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Pubmed Data : PLoS One. 2015 ;10(4):e0124903. Epub 2015 Apr 9. PMID: 25856395

Article Published Date : Dec 31, 2014

Study Type : Human In Vitro

Additional Links

Substances : Curcumin

Diseases : Herpes Simplex Virus Type 2, HIV Infections, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Anti-Retroviral Agents, Antiviral Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Ginsenoside 20(S)-Rh2 has therapeutic potential for the treatment with colorectal cancer.Dec 23, 2016

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Pubmed Data : J Ethnopharmacol. 2016 Dec 24 ;194:83-90. Epub 2016 Aug 23. PMID: 27566200

Punicalagin and EGCG can rescue keratinocyte viability and attenuate the inflammatory responses of cells due to airborne particles.Mar 21, 2018

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Pubmed Data : Skin Pharmacol Physiol. 2018 Mar 22 ;31(3):134-143. Epub 2018 Mar 22. PMID: 29566388

Article Published Date : Mar 21, 2018

Study Type : Human In Vitro

Additional Links

Substances : EGCG (Epigallocatechin gallate), Punicalagin

Diseases : Air Pollution Linked Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Pubmed Data : Eur J Nutr. 2019 Mar 27. Epub 2019 Mar 27. PMID: 30919084

Article Published Date : Mar 26, 2019

Study Type : Animal Study

Additional Links

Substances : Bergamot, Flavonoids

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Interleukin-10 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation

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A purified dry extract of ginseng may improve cancer related fatigue via regulation of inflammatory responses and hematopoiesis.Dec 31, 2014

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Pubmed Data : Gut Liver. 2017 Mar 15 ;11(2):243-252. PMID: 27965474

Article Published Date : Mar 14, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Acai

Diseases : Colon Cancer, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Açaí seed extract substantially reduced renal injury and prevented renal dysfunction.Jan 19, 2017

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Pubmed Data : Eur J Nutr. 2017 Jan 20. Epub 2017 Jan 20. PMID: 28105508

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Allicin attenuates lipopolysaccharide‑induced acute lung injury.Mar 06, 2018

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Pubmed Data : Mol Med Rep. 2018 Mar 7. Epub 2018 Mar 7. PMID: 29512749

Article Published Date : Mar 06, 2018

Study Type : Animal Study

Additional Links

Substances : Allicin

Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Allicin attenuates liver oxidative stress and inflammation.Sep 27, 2016

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Pubmed Data : J Agric Food Chem. 2016 Sep 28 ;64(38):7104-13. Epub 2016 Sep 19. PMID: 27584700

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mediators Inflamm. 2014 ;2014:640746. Epub 2014 Apr 13. PMID: 24829522

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Pubmed Data : Nutr Cancer. 2015 Jul 2:1-9. Epub 2015 Jul 2. PMID: 26133950

Article Published Date : Jul 01, 2015

Study Type : Animal Study

Additional Links

Substances : Whey

Diseases : Cachexia: Cancer

Pharmacological Actions : Anti-Cachexic Agents, Chemotherapeutic, Interleukin-6 Downregulation, Prostaglandin PGE2 downregulation, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Drug: 5-flourouracil

[+]

An iso-α-acid-rich extract from hops attenuates acute alcohol-induced liver steatosis in mice.Dec 31, 2017

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Pubmed Data : Nutrition. 2018 Jan ;45:68-75. Epub 2017 Jul 27. PMID: 29129239

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Hops

Diseases : Alcoholic Liver Disease

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation

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An isocaloric carbohydrate restriction diet and natural AMPK activating agents induce synergistic anticancer effects.Mar 18, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Eur J Cancer Prev. 2015 Mar 19. Epub 2015 Mar 19. PMID: 25747515

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2017 Apr 27 ;17(1):233. Epub 2017 Apr 27. PMID: 28449676

Article Published Date : Apr 26, 2017

Study Type : Animal Study

Additional Links

Substances : Curcumin, Ligustrazine, Resveratrol

Diseases : Arthritis, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Anti-inflammatory effects of aspalathin and nothofagin from rooibos.Jul 31, 2015

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Pubmed Data : Inflammation. 2015 Aug ;38(4):1502-16. PMID: 25655391

Article Published Date : Jul 31, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Rooibos

Diseases :

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View the Evidence: 1390 Abstracts with Interleukin-6 Downregulation Research

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Alpha-lipoic acid supplementation had beneficial effects on inflammatory markers among patients with metabolic syndrome and related disorders.Dec 31, 2017

Coenzyme Q10 could have significant inflammatory lowering effects.Feb 04, 2017

Coenzyme Q10 supplementation may partly improve the process of inflammatory state.Dec 31, 2016

Garlic supplementation reduces circulating C-reactive protein, tumor necrosis factor, and interleukin-6 in adults.Mar 31, 2019

Meta-analysis: curcumin down-regulates inteleukin-6. Jul 04, 2016

Mind-body therapies reduce markers of inflammation and influence virus-specific immune responses to vaccination.Dec 31, 2013

Probiotic supplementation significantly reduced serum concentrations of pro-inflammatory cytokines.Mar 10, 2019

Probiotics lowered pro-inflammatory cytokines IL-6 in rheumatoid arthritis.Sep 14, 2017

Prolonged vitamin C supplementation has some modest beneficial effects on recovery from unaccustomed exercise.Nov 30, 2001

Spirulina maxima improves insulin sensitivity, lipid profile, and total antioxidant status in obese patients with well-treated hypertension.Apr 30, 2017

Supplementation of fish oil may reduce the circulating levels of TNF-α, IL-1 and IL-6 in patients with chronic heart failure.Dec 31, 2011

This meta-analysis showed the promising effect of melatonin administration on reducing CRP and IL-6 among patients with MetS and related disorders.Jun 14, 2018

This suggests that CQ10 supplementation likely attenuates subclinical inflammation.Aug 24, 2017

Tomato products and lycopene supplementation have positive effects on blood lipids, blood pressure and endothelial function.Jan 12, 2017

A combination of gastrodin, folate, and vitamin-B12 in addition to standard antiepileptic treatment can effectively control epileptic seizures.Oct 31, 2017

A dietary mixture of sesame, pumpkin and flax seed added to a habitual diet lowered triglyceride and CRP, TNF-alpha, IL-6 levelsDec 31, 2013

A hydro alcoholic extract of nettle could decrease the levels of IL-6 and hs-CRP in patients with type 2 diabetes.Jul 31, 2011

A standardized preparation of curcuminoids compares favorably with atorvastatin on endothelial dysfunction in association with reductions in inflammatory cytokines and markers of oxidative stress. Jan 01, 2008

Active polymyalgia rheumatica is characterized by increased serum levels of Interleukin-6 probably originating in inflamed tissue. Mar 01, 2009

Adherence to the mediterranean diet is inversely associated with inflammation (circulating interleukin-6) among middle-aged men. Jan 15, 2008

An anthocyanin mixture reduced the inflammatory response in hypercholesterolemic subjects.Aug 31, 2013

An elemental diet reduces mucosal inflammation in patients with active Crohn's disease with remission occuring in 71% of patients. Jun 01, 2005

Association of endodontic infection with detection of an initial lesion to the cardiovascular system.Nov 30, 2011

Astaxanthin addition improves human neutrophils function.Dec 01, 2010

Astragalus improves cardiac function in aged patients with Chronic Heart Failure.Sep 01, 2005

Beneficial effects of Lactobacillus plantarum on glycemia and homocysteine levels in postmenopausal women with metabolic syndrome.Jun 30, 2014

Beneficial effects of probiotic combination with omega-3 fatty acids in NAFLD.Nov 30, 2018

Berberine promoted myocardial protection of postoperative patients through regulating myocardial autophagy.Aug 31, 2018

Brief mindfulness training reduces salivary IL-6 and TNF-α in young women with depressive symptomatology.Sep 30, 2016

Burdock root tea improves inflammatory status and oxidative stress in patients with knee osteoarthritis.Oct 27, 2014

Cardamonin is a potential candidate for controlling inflammation during primary Sjögren's syndrome.Mar 31, 2018

Cashew may have anti-inflammatory activity in rheumatoid arthritis patients.Dec 06, 2006

Chaihu Shihuang soup can significantly regulate cytokine and improve early recovery of severe acute pancratitis.May 31, 2009

Chronic ingestion of acrylamide-containing products (potato chips) induces a proinflammatory state, a risk factor for progression of atherosclerosis.Mar 01, 2009

Chronic insomnia is associated with a shift of interleukin-6 and tumor necrosis factor secretion from nighttime to daytime.Jul 01, 2002

Coenzyme Q10 might have a role as a good supplement in young children with Down syndrome to ameliorate the neurological symptoms.Oct 18, 2016

Combined therapy regulates the inflammatory process and oxidative stress and contributes to immune protection on patients with T2D.May 07, 2018

Consumption of black currant nectar prior to and after a bout of eccentric exercise attenuates muscle damage and inflammation.Dec 31, 2015

Consumption of cruciferous and apiaceous vegetables reduced circulating IL-6.Oct 31, 2014

CoQ10 supplementation at a dosage of 500 mg appears to decrease inflammatory markers in patients with MS.Apr 30, 2015

Curcumin and Boswellia serrata are safe and tolerable and helped to improvethe levels of an inflammatory cytokine (IL-6).Dec 31, 2012

Curcumin supplementation effectively mitigates inflammation in patients suffering from chronic SM-induced cutaneous complications. Oct 31, 2012

Curcumin supplementation significantly decreases serum concentrations of pro-inflammatory cytokines in subjects with MetS.Jun 05, 2016

Daily consumption of BC30 by adult’s aged 65-80 y can increase beneficial groups of bacteria in the human gut.Jun 30, 2015

Daily supplementation of coenzyme Q10 can be effective in decreasing some pro-inflammatory factors in hypertensive patients. Nov 30, 2015

Dark chocolate has beneficial effects on serum adiponectin, biochemical and inflammatory parameters in diabetic patients.Dec 31, 2017

Dietary soy improves the inflammatory and nutritional status in end-stage renal disease patients on chronic hemodialysisAug 01, 2006

Dietary strawberries may have significant analgesic and anti-inflammatory effects in obese adults with established knee osteoarthritis.Aug 27, 2017

Dietary supplementation with pressurized whey may potentiate the effects of exercise training on exercise tolerance and quality of life in patients with COPD.Jun 01, 2010

Effect of diosmin administration in patients with chronic venous disorders on selected factors affecting angiogenesis.Sep 11, 2019

Either free radicals are not involved in delaying the recovery process following a bout of unaccustomed exercise or the consumption of VitaminC wholly after exercise is unable to deliver this antioxidant to the appropriate sites with sufficient expediencyApr 30, 2003

Electroacupuncture can effectively decrease the proinflammatory cytokine of IL-1 and IL-6 and increase the inhibition cytokine of IL-4 and IL-10 and improve the internal environment of occurrence and progression of rheumatoid arthritis.Oct 01, 2010

Electrolyzed reduced water (i.e. structured water) reduces hemodialysis-induced oxidative stress in end-stage kidney disease patients.Aug 01, 2003

Exercise decreases C-reactive protein with with increased exercise time.Nov 23, 2015

Folic acid supplementation mitigates Alzheimer's disease by reducing inflammation.Dec 31, 2015

Forest bathing has therapeutic effects on human hypertension and induces inhibition of the renin–angiotensin system and inflammation.Nov 30, 2012

Forest bathing is beneficial to human health.May 31, 2012

Frequent nut consumption was associated with a healthy profile of inflammatory biomarkers.Jul 26, 2016

Garlic extract had beneficial effects on serum inflammatory markers of peritoneal dialysis patients.Jan 24, 2019

Genistein can reduce insulin resistance, oxidative and inflammatory indices along with improvement in fat metabolism in patients with NAFLD.May 31, 2017

Ginkgo is effective in treating pulmonary interstitial fibrosis.Mar 01, 2005

Honey reduce the probable aggravating effects of intensive cycling training on spermatogenesis and fertility capacity in road cyclists.Apr 30, 2012

Horticultural therapy by reducing plasma IL-6 may prevent inflammatory disorders.Aug 08, 2018

IL-6 levels significantly decreased with 70 days of broccoli consumption.Mar 12, 2018

Impact of resveratrol supplementation on inflammatory, antioxidant, and periodontal markers in type 2 diabetic patients with chronic periodontitis.Jul 31, 2019

In patients with stable coronary artery disease, an independent and inverse association exists between n-3 fatty acid levels and inflammatory biomarkers.Aug 01, 2009

Including almonds in diets as a snack may help healthy overweight and obese individuals improve nutritional status and reduce their risk for CVD.Jul 09, 2017

Inclusion of dried grapes in diet was beneficial in NAFLD patients with non-significant fibrosis.Nov 08, 2016

Increased production of Interleukin-6 is a characteristic of patients with polymyalgia rheumatica and giant cell arteritis. Sep 01, 1993

Increasing tomato intake may provide a useful approach for reducing the risk of inflammatory diseases such as CVD and diabetes, which are associated with obesity.May 31, 2013

Inflammation may link obesity with asthma. Jan 01, 2008

Intake of bilberries has an ameliorating effect on some markers of gingival inflammation reducing gingivitis to a similar extent compared to standard of care.Dec 31, 2014

Interleukin-6 Downregulation

View the Evidence:
1390 Abstracts with Interleukin-6 Downregulation Research