Cyclooxygenase 2 Inhibitors

Name	AC	CK
Curcumin	70	103
Flavonoids	21	38
Resveratrol	20	31
Ginsenosides	18	29
Cannabis	7	22
Frankincense	3	22
Melatonin	10	20
Oleuropein	5	19
Phloretin	5	19
Vitamin C	6	18
Omega-3 Fatty Acids	6	17
Polyphenols	10	17
Sulforaphane	13	16
Thymoquinone	8	15
Berberine	9	14
Spirulina	3	14
Turmeric	5	14
Cannabinoids	4	13
Apples	2	12
DHA (Docosahexaenoic Acid)	3	12
Ginseng (Korean)	9	12
EPA (Eicosapentaenoic Acid)	2	11
Pomegranate	7	11
Banana	1	10
Eicosapentaenoic acid (EPA)	1	10
Grape	5	10
MSM (Methylsulfonylmethane)	1	10
Rose	7	10
Strawberry	1	10
Astaxanthin	5	9
Fisetin	7	9
Fucoxanthin	5	9
Ginger	5	9
Quercetin	6	9
Rosmarinic acid	5	9
Anthocyanins	4	8
Dandelion	6	8
Stilbenes	5	8
Gingerol	4	7
Ginkgo biloba	4	7
Hesperidin	4	7
Japanese cypress	4	7
Wogonin	5	7
Adlay	5	6
Cannabidiol	4	6
Chrysin	4	6
Citrus naringin	4	6
Honokiol	4	6
Indole-3-Carbinol	3	6
Lignans	3	6
Mangiferin	4	6
Myricetin	4	6
Punicalagin	4	6
Rutin	3	6
Antrodia camphorata	3	5
Apigenin	3	5
Beta-Caryophyllene	3	5
Citrus Peel	3	5
Diosmin	3	5
EGCG (Epigallocatechin gallate)	5	5
Genipin	3	5
Grape Seed Extract	3	5
Justicia gendarussa	3	5
Lotus	4	5
Luteolin	5	5
Naringenin	3	5
Noni	3	5
Palmitoylethanolamide	3	5
Pterostilbene	4	5
Sesamol	3	5
Vitex negundo	3	5
Zerumbone	3	5
Arginine	2	4
Astragaloside	2	4
Black Tea	3	4
Bromelain	4	4
Brown Rice	2	4
Chaga Mushroom (Inonotus obliquus)	3	4
D-Limonene	2	4
Delta-tetrahydrocannabinol (THC)	3	4
Ellagic Acid	3	4
Fermented Foods and Beverages	3	4
Flaxseed	2	4
Fucoidan	3	4
Geraniol	2	4
Isoliquiritigenin	3	4
Lactobacillus fermentum	2	4
Lychee	2	4
Medium Chain Triglycerides	2	4
Moringa oleifera	2	4
Nexrutine (Phellodendrom)	3	4
Nobiletin	3	4
Olive	3	4
Palm Oil	2	4
Piceatannol	3	4
Saturated fatty acids	2	4
Shikonin	2	4
Sweet Potato: Purple	2	4
Tangeretin	3	4
Tetrahydrocurcumin	2	4
Vitamin D	2	4
Walnut	2	4
18β-Glycyrrhetinic Acid	2	3
Aduki bean	2	3
Alpha-Lipoic Acid	2	3
Asiatic Acid	2	3
Avocado	2	3
Blueberry	2	3
Catechin	3	3
Chinese Skullcap	2	3
Daidzein	2	3
Diosgenin	2	3
Gastrodin	2	3
Ginseng (American)	2	3
Honey	2	3
Hydroxytyrosol	2	3
Lupeol	2	3
Medicinal Mushrooms	2	3
Mulberry	2	3
Nettle	2	3
P-Coumaric Acid	2	3
Perilla	2	3
Polyunsaturated Fatty Acids (PUFAs)	2	3
Red Sage	2	3
Rosemary	2	3
Saffron	2	3
Tanshinone IIA	3	3
Toona sinensis	2	3
Ursolic Acid	3	3
Water: Deuterium Depleted	2	3
6-Shogaol	1	2
ALA (Alpha-Linolenic Acid)	1	2
Acai	1	2
African Basil	1	2
Alpha Linolenic Acid	1	2
Apocynin	1	2
Apple Polyphenols	1	2
Arctigenin	1	2
Artemisia asiatica	1	2
Artemisinin	2	2
Asparagus	2	2
Bai Zhu	1	2
Barley	1	2
Bee Propolis	1	2
Bee Venom	2	2
Benzyl isothiocyanate	1	2
Bergamot	1	2
Bitter Orange	2	2
Boswellia	1	2
Burdock	1	2
Caffeic acid phenethyl ester	1	2
Camel Milk	1	2
Carnosol	1	2
Carrot	1	2
Carvacrol	1	2
Chickpea	2	2
Chlorogenic Acid	1	2
Chokeberry	1	2
Chrysanthemum Indicum	2	2
Cocoa	1	2
Coptis chinensis	1	2
Cranberry	1	2
Crocetin	1	2
Cyanidin 3-glucoside	1	2
Damnacanthal	1	2
Delphinidin	1	2
Demethoxycurcumin	1	2
Evening Primrose Oil	1	2
Garcinia indica	1	2
Gardenia	1	2
Garlic	1	2
Genistein	2	2
Ginseng	1	2
Gold (nanoparticles)	1	2
Graviola	1	2
Guggul	2	2
Hops	1	2
Horseradish	2	2
Hu Zhang (Polygonum cuspidatum)	1	2
Hydrogen Water	1	2
Isoflavones	1	2
Isoquercitrin	1	2
Kaempferia parviflora	1	2
Kaempferol	1	2
Krill	1	2
L-Carnitine	1	2
Lactobacillus paracasei	1	2
Lactobacillus rhamnosus	1	2
Ligustrazine	1	2
Lion's Mane (Hericium Erinaceus)	1	2
Loquat	1	2
Lycopene	2	2
Magnolol	1	2
Manuka Honey	1	2
Mint	1	2
Myo-inositol	1	2
Nigella sativa (aka Black Seed)	2	2
Noni leaf extract	1	2
Nutmeg	1	2
Oak	1	2
Olive leaf extract	1	2
Orange	1	2
Panax Ginseng	1	2
Patchouli	1	2
Pau D'Arco	1	2
Pelargonium sidoides	1	2
Peony	1	2
Pine Needle	1	2
Potato	1	2
Probiotics	1	2
Psychedelics:All	2	2
Puerarin	2	2
Raspberry	1	2
Red Wine	1	2
Reishi Mushroom	2	2
Rice Bran	1	2
Rosemaric Acid	1	2
Royal Jelly	1	2
Ruta Graveolens	1	2
Sea buckthorn	1	2
Selenium	1	2
Silibinin	1	2
Sour Cherry	1	2
Theaflavins	2	2
Thistle	1	2
Thuja	1	2
Thymol	1	2
Tongkat Ali	1	2
Turmeric: Fermented	1	2
Vanillin	2	2
Verbascoside	2	2
Watermelon	1	2
White Tea	1	2
Yam	1	2
Yeast	1	2
Zeaxanthin	1	2
Achillea fragrantissima	1	1
Amygdalin (laetrile)	1	1
Apple Pectin	1	1
Artesunate	1	1
Ashwagandha	1	1
Avacado	1	1
Avenanthramides	1	1
Bamboo	1	1
Beta-glucan	1	1
Betulinic acid	1	1
Bitter Melon	1	1
Black Pepper	1	1
Black Raspberry	1	1
Butterbur	1	1
Capsaicin	1	1
Carnosic Acid	1	1
Chamomile	1	1
Chlorella (Algae)	1	1
Coenzyme Q10	1	1
Coumestrol	1	1
Cucurbitacin B	1	1
Cumin	1	1
Cyanidin	1	1
Deguelin	1	1
Echinacea	1	1
False Black Pepper	1	1
Ferulic acid	1	1
Feverfew	1	1
Fish Oil	1	1
Fruit: All	1	1
Gleditsia sinensis	1	1
Guava	1	1
Homeopathic Medicine: All	1	1
Huperzine	1	1
Hyaluronic Acid	1	1
Isothiocyanates	1	1
Kahweol	1	1
Kava Kava	1	1
Kimchi	1	1
Lactobacillus rhamnosus GG	1	1
Long Pepper	1	1
Loquat Leaves	1	1
Lutein	1	1
Maitake Mushroom	1	1
Maqui	1	1
Modified Citrus Pectin	1	1
Mushrooms: All	1	1
Mussel: Green-lipped (Perna canaliculus)	1	1
Oats	1	1
Orange: Mandarin	1	1
Oranges	1	1
Paeoniflorin	1	1
Panax Notoginseng	1	1
Parthenolide	1	1
Passion Flower	1	1
Pea	1	1
Persimmon	1	1
Phenethyl isothiocyanate	1	1
Phyllanthus amarus	1	1
Pine Cone	1	1
Piperine	1	1
Piperlongumine	1	1
Plantago	1	1
Pomegranate Peel	1	1
Prickly Pear Cactus	1	1
Prunella vulgaris	1	1
Purple Carrots	1	1
Raisins	1	1
Rice: Black	1	1
Rooibos	1	1
Rose Hips	1	1
Saw Palmetto	1	1
Sesame Seeds	1	1
Shallot	1	1
Soy	1	1
Spikenard	1	1
Syrian rue	1	1
Tabebuia	1	1
Tart Cherry	1	1
Tocotrienol: Gamma	1	1
Truffles	1	1
Turmerones	1	1
Tyrosol	1	1
Unsaponifiables	1	1
Vegetables: All	1	1
Vitamin E: alpha tocopherol	1	1
Wasabi	2	1
White Button Mushroom	1	1
Wormwood	1	1
Yellow Sweet Clover (Melilotus officinalis)	1	1
beta-Carotene	1	1

[+]

A daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution of curcumin outside the gut.Jan 01, 2005

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Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):120-5. PMID: 15668484

Article Published Date : Jan 01, 2005

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Colorectal Cancer

Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors

Additional Keywords : Antineoplastic Agents

[+]

A formulation containing Frankincense and Turmeric extracts demonstrated a greater improvement in the treatment of OA than celecoxib.Oct 31, 2013

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Pubmed Data : Mol Med Rep. 2013 Nov ;8(5):1542-8. Epub 2013 Aug 29. PMID: 24002213

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Pubmed Data : Biomed Res Int. 2017 ;2017:3634915. Epub 2017 Nov 7. PMID: 29238715

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Diseases : Colorectal Cancer

Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

[+]

3,3'-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2.Jan 31, 2019

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Pubmed Data : Cancer Lett. 2019 Feb 1 ;448:20-30. Epub 2019 Feb 1. PMID: 30716361

Article Published Date : Jan 31, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Diseases : Colon Cancer

Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors

[+]

5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.Dec 31, 2015

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Pubmed Data : Drug Des Devel Ther. 2016 ;10:2239-53. Epub 2016 Jul 11. PMID: 27468227

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Pubmed Data : Hum Exp Toxicol. 2018 Jan 1:960327117751235. Epub 2018 Jan 1. PMID: 29350052

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Gingerol

Diseases : Ulcerative Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

[+]

6-Shogaol reduces progression of experimental endometriosis.Oct 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Korean J Physiol Pharmacol. 2018 Nov ;22(6):627-636. Epub 2018 Oct 25. PMID: 30402023

Article Published Date : Oct 31, 2018

Study Type : Animal Study

Additional Links

Substances : 6-Shogaol

Diseases : Endometriosis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation

[+]

A Burdock extract was able to reduce intestinal inflammation in an acute TNBS-induced experimental model of colitis in rats.Mar 06, 2013

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Pubmed Data : J Ethnopharmacol. 2013 Mar 7 ;146(1):300-10. Epub 2013 Jan 10. PMID: 23313393

Article Published Date : Mar 06, 2013

Study Type : Animal Study

Additional Links

Substances : Burdock

Diseases : Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2018 Jun 4 ;105:428-433. Epub 2018 Jun 4. PMID: 29879626

Article Published Date : Jun 03, 2018

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Drug-Induced Toxicity: Methotrexate

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 inducer, Hepatoprotective, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Amelioration of adjuvant induced arthritis in Sprague Dawley rats through modulation of inflammatory mediators by Ribes alpestre Decne.May 09, 2019

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Pubmed Data : J Ethnopharmacol. 2019 May 10 ;235:460-471. Epub 2019 Feb 13. PMID: 30771518

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Pubmed Data : Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419869489. PMID: 31462112

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Reishi Mushroom

Diseases : Cervical Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Bcl-2 protein down-regulation, Cyclooxygenase 2 Inhibitors

Additional Keywords : Polysaccharides

[+]

Antrodia camphorata extract, when combined with anti-tumor agents, showed adjuvant antiproliferative effects on multi-drug resistant hepatoma. Aug 13, 2008

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Pubmed Data : J Ethnopharmacol. 2008 Aug 13;118(3):387-95. Epub 2008 May 7. PMID: 18571350

Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.Sep 28, 2006

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Pubmed Data : Cancer Lett. 2006 Sep 28;241(2):275-80. Epub 2006 Jan 4. PMID: 16386831

Black Adzuki bean attenuates high-fat diet-induced colon inflammation.Mar 31, 2017

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Pubmed Data : J Med Food. 2017 Apr ;20(4):367-375. PMID: 28406732

Article Published Date : Mar 31, 2017

Study Type : Animal Study

Additional Links

Substances : Aduki bean

Diseases : Colitis, High Fat Diet, Inflammation, Lipopolysaccharide-Induced Toxicity, Obesity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

Black ginseng-enriched Chong-Myung-Tang extracts improve spatial learning behavior.Mar 31, 2017

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Pubmed Data : Carcinogenesis. 2010 Feb ;31(2):239-45. Epub 2009 Jul 22. PMID: 19625346

Article Published Date : Jan 31, 2010

Study Type : Animal Study

Additional Links

Substances : Indole-3-Carbinol, Myo-inositol

Diseases : Lung Cancer

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors

Problem Substances : Vinyl Carbamate

[+]

C-phycocyanin relieved symptoms associated with cyclophosphamide-induced cystitis.Dec 31, 2018

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Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:8424872. Epub 2019 Jul 29. PMID: 31467580

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Spirulina

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Cystitis

Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation

Additional Keywords : C-phycocyanin

[+]

C. obtusa essential oil may constitute a novel source of anti-inflammatory treatments. Jun 30, 2013

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Pubmed Data : Mol Med Rep. 2013 Jul ;8(1):255-9. Epub 2013 May 8. PMID: 23652412

[+]

Chemopreventive effects of Eryngium foetidum L. leaves on COX-2 reduction in mice induced colorectal carcinogenesis.Dec 31, 2015

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Pubmed Data : Nutr Cancer. 2016 ;68(1):144-53. Epub 2016 Jan 15. PMID: 26771664

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Thistle

Diseases : Colorectal Cancer

Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors

Additional Keywords : Phytotherapy

[+]

Chinese skullcap (Scutellaria baicalensis) significantly improves functional recovery from spinal cord injury in rats by inhibiting inflammation and oxidative stress after injury.Aug 01, 2009

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Pubmed Data : J Neurochem. 2009 Aug;110(4):1276-87. Epub 2009 Jun 10. PMID: 19519665

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Pubmed Data : J Nutr. 2006 May;136(5):1150-5. PMID: 16614396

Article Published Date : May 01, 2006

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Polyphenols

Diseases : Tumors

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

[+]

Combination of Pelargonium sidoides and Coptis chinensis root inhibits nuclear factor kappa B-mediated inflammatory responses.Jan 18, 2018

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Pubmed Data : Mediators Inflamm. 2017 ;2017:6280925. Epub 2017 Jan 11. PMID: 28167853

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Pubmed Data : Cancer Res. 2009 Dec 1;69(23):8958-66. Epub 2009 Nov 10. PMID: 19903839

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Pubmed Data : Clin Cancer Res. 2005 Oct 15;11(20):7490-8. PMID: 16243823

[+]

Dietary red raspberries attenuate dextran sulfate sodium-induced acute colitis.Dec 31, 2017

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Pubmed Data : J Nutr Biochem. 2018 01 ;51:40-46. Epub 2017 Sep 14. PMID: 29091813

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Raspberry

Diseases : Colitis, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-17 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Dietary saturated fatty acids down-regulate cyclooxygenase-2 and tumor necrosis factor alfa and reverse fibrosis in alcohol-induced liver disease in the rat.Dec 01, 1997

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Pubmed Data : Hepatology. 1997 Dec;26(6):1538-45. PMID: 9397995

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Pubmed Data : Int J Physiol Pathophysiol Pharmacol. 2014 ;6(1):23-36. Epub 2014 Mar 13. PMID: 24665356

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Evening Primrose Oil

Diseases : Myocardial Infarction

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Extracts of R. officinalis and rosmarinic acid through modulating neuro-inflammation might be potential candidates in treating neuropathic pain.Dec 21, 2016

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Pubmed Data : Biomed Pharmacother. 2016 Dec 22 ;86:441-449. Epub 2016 Dec 22. PMID: 28012923

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Pubmed Data : Mol Biol Rep. 2018 Oct 25. Epub 2018 Oct 25. PMID: 30362071

Article Published Date : Oct 24, 2018

Study Type : Animal Study

Additional Links

Substances : Fisetin

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Fisetin improved the hippocampal-dependent synaptic and memory functions in LPS-treated adult mice.Jun 13, 2019

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Pubmed Data : Int Immunopharmacol. 2011 Feb ;11(2):157-63. Epub 2010 Nov 26. PMID: 21084063

Article Published Date : Jan 31, 2011

Study Type : Animal Study

Additional Links

Substances : Fucoidan

Diseases : Aspirin-Induced Toxicity , Gastric Ulcer

Pharmacological Actions : Anti-Ulcer Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor

Problem Substances : Aspirin

Adverse Pharmacological Actions : Ulcerogenic

[+]

Fucoxanthin could be a novel adjuvant for preventing exacerbations associated with skin inflammation as well as protecting skin against UV radiation.Oct 09, 2018

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Pubmed Data : Carcinogenesis. 2008 Sep;29(9):1799-806. Epub 2008 Jun 20. PMID: 18567620

Article Published Date : Sep 01, 2008

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Colitis, Inflammation

Pharmacological Actions : Antioxidants, Apoptotic, Cyclooxygenase 2 Inhibitors

Additional Keywords : Plant Extracts

[+]

Ginkgo biloba extract protects against aging-associated mitochondrial dysfunction in platelets and hippocampi of mice.Jan 01, 2010

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Pubmed Data : Platelets. 2010;21(5):373-9. PMID: 20459350

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Pubmed Data : Environ Toxicol. 2018 Jul 2. Epub 2018 Jul 2. PMID: 29964319

Article Published Date : Jul 01, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Ginsenoside Rg3 alleviates lipopolysaccharide-induced learning and memory impairments. Sep 29, 2013

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Pubmed Data : Biochem Biophys Res Commun. 1996 Jul 16;224(2):358-61. PMID: 16534727

Article Published Date : Jul 16, 1996

Study Type : Animal Study

Additional Links

Substances : Hops

Diseases : Arthritis, Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation

Additional Keywords : Plant Extracts

[+]

Hydrogen rich water pre-treatment alleviated the aspirin-induced gastric lesions.Feb 13, 2014

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Pubmed Data : Biomed Pharmacother. 2016 Apr ;79:231-40. Epub 2016 Mar 11. PMID: 27044833

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Pubmed Data : Food Funct. 2016 Jan 14. Epub 2016 Jan 14. PMID: 26765787

Article Published Date : Jan 13, 2016

Study Type : Animal Study

Additional Links

Substances : Noni, Noni leaf extract

Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Antiproliferative , Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor, Immunomodulatory

Additional Keywords : Dose Response, Superiority of Natural Substances versus Drugs

[+]

Mulberry fruit suppressed the development of intestinal inflammation and tumorgenesis both in vitro and in vivo.Dec 31, 2014

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Pubmed Data : Environ Toxicol. 2018 Jan 18. Epub 2018 Jan 18. PMID: 29345053

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Food Nutr Res. 2016 ;60:30849. Epub 2016 Apr 26. PMID: 27121041

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Nutmeg

Diseases : Allodynia, Chronic Pain, Inflammation

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors

Additional Keywords : Superiority of Natural Substances versus Drugs

Problem Substances : Diclofenac

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Oleuropein has anti-inflammatory, analgesic and sedative effects both in vitro and in vivo.Jan 30, 2019

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Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2019 Jan 31 ;65(1):52-55. Epub 2019 Jan 31. PMID: 30782294

Article Published Date : Jan 30, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Oleuropein, Olive

Diseases : Inflammation, Insomnia

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hypnotics and Sedatives, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Oligonol ameliorates carbon tetrachloride induced liver injury in rats. Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

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View the Evidence: 743 Abstracts with Cyclooxygenase 2 Inhibitors Research

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A daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution of curcumin outside the gut.Jan 01, 2005

A formulation containing Frankincense and Turmeric extracts demonstrated a greater improvement in the treatment of OA than celecoxib.Oct 31, 2013

Carbohydrate ingestion from bananas had positive influence in attenuating metabolic perturbation and inflammation following 75-km cycling.Dec 31, 2017

Consumption of dried apple peel powder was associated with improved joint function and improved serum antioxidant protection status.Oct 31, 2014

Dietary strawberries significantly decreased the histologic grade of patients' precancerous esophageal lesions.Dec 31, 2011

Electroacupuncture may prevent ischemia-reperfusion-induced endothelial dysfunction via a COX-2 dependent mechanism.Dec 31, 2016

Electroacupuncture treatment alleviates central post-stroke pain.Dec 31, 2015

EPA supplementation significantly reduces Cox-2 enzyme expression in Barrett's esophagus.Apr 01, 2008

Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritisFeb 29, 2016

Omega-3 fatty acids cause a reduction in the mRNA levels for various proteins known to be important in the pathology of osteoarthritis. Jul 01, 2009

Phloretin inhibits the growth of P. acnes, P. granulosum, and S. epidermidis.Jan 31, 2016

Pycnogenol may be of value in treatment of MSU crystal-induced arthritis through its anti-inflammatory and anti-nitrosative activities.Feb 14, 2012

Sesamin can relieve clinical symptoms and pathological changes that caused by inflammatory impairment in patients with rheumatoid arthritis.Aug 31, 2019

Spirulina has favorable effects on lipid profiles, immune variables and antioxidant capacity in healthy individuals.Jan 01, 2008

The anti-inflammatory activity of Cannabis extracts on colon epithelial cells derives from a fraction of the extract that contains THCA.Dec 31, 2016

These new data support a potential role of oleuropein in the treatment of ulcerative colitis.Apr 14, 2017

Vitamin C attenuates aspirin-induced gastric damage. May 01, 2009

Cannabidiolic acid an active component in the cannabis plant offers potential therapeutic modality in the abrogation of cancer cell migration.Nov 14, 2012

Ginsenoside Rg1 can inhibit inflammatory responses in human chondrocytes in vitro and reduce articular cartilage damage in vivo.Mar 09, 2017

Melatonin as a novel selective ATF-6 inhibitor can sensitize human hepatoma cells to ER stress inducing apoptosis.Feb 13, 2017

Melatonin is a potential candidate compound for the treatment of proinflammatory disorders.Aug 31, 2012

Oleuropein might provide a basis for developing a new dietary strategy for the prevention and management of rheumatoid arthritis.Apr 19, 2017

Phloretin inhibits interleukin-1β-induced COX-2 and ICAM-1 in human lung epithelial cells.May 31, 2015

Resveratrol functions as a suppressor of particulate matter induced inflammatory signalling pathways.May 07, 2017

Sulforaphane combats colon cancer in vitro by inhibiting COX-2 and prostaglandin E1 synthase and exhibiting anti-angiogenic, anti-proliferative, and anti-metastatic properties.Jan 01, 2018

Berberin inhibited colorectal cancer invasion and metastasis via down regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway.Dec 31, 2014

"Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats."Feb 15, 2011

18β-Glycyrrhetinic acid significantly attenuated H. pylori-infected gastritis in gerbils.Dec 31, 2015

2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside may be a promising natural lead compound for treating early phases of colorectal cancer.Dec 31, 2016

3,3'-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2.Jan 31, 2019

5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.Dec 31, 2015

5-hydroxytryptophan attenuates imiquimod-induced psoriasiform dermatitis.Jan 10, 2018

6-Gingerol abates benzo[a]pyrene-induced colonic injury.Apr 17, 2019

6-gingerol prevented DSS-induced chronic ulcerative colitis via anti-inflammatory and antioxidative mechanisms.Dec 31, 2017

6-Shogaol reduces progression of experimental endometriosis.Oct 31, 2018

A Burdock extract was able to reduce intestinal inflammation in an acute TNBS-induced experimental model of colitis in rats.Mar 06, 2013

A combination of ginger and peony root may prevent memory impairment in AD by inhibiting Aβ accumulation and inflammation in the brain.Nov 29, 2015

A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer.Mar 26, 2019

A polyphenol-rich cranberry extract reverses insulin resistance and hepatic steatosis independently of body weight loss.Nov 30, 2017

Açaí demonstrated protective effects against AOM/DSS-induced colon carcinogenesis.Mar 14, 2017

Adlay bran ethanolic extract suppressed 1,2-dimethylhydrazine-indued preneoplastic lesions of the colon.Jul 13, 2010

Administration of chlorogenic acid alleviates spinal cord injury.Dec 31, 2017

Allylmethylsulfide (AMS), a volatile organosulfur derivative from garlic has radioprotective properties.Jun 01, 2009

Alpha linolenic fatty acid supplementation had a beneficial effect on tumor cell proliferation and cachexia parameters.May 25, 2015

Alpha lipoic acid has hepatoprotective effects against methotrexate-induced hepatic injury.Jun 03, 2018

Amelioration of adjuvant induced arthritis in Sprague Dawley rats through modulation of inflammatory mediators by Ribes alpestre Decne.May 09, 2019

American ginseng prevents and treats Ulcerative Colitis.Sep 18, 2008

Antarctic krill oil diet protects against lipopolysaccharide-induced oxidative stress, neuroinflammation and cognitive impairment.Nov 27, 2017

Anthocyanin-rich fractions from red raspberries attenuate inflammation both in vitro and in vivo.Dec 31, 2013

Anthocyanins from black chokeberry delayed aging-related degenerative changes of the brain.Jul 25, 2017

Anti-hyperuricemic and anti-gouty arthritis activities of polysaccharide purified from Lonicera japonica.Feb 14, 2019

Anti-inflammatory activity of hydroalcoholic extracts of Lavandula dentata L. and Lavandula stoechas L.Aug 21, 2016

Anti-inflammatory activity of Rg3-enriched Korean red ginseng extract in murine model of sepsis.Dec 31, 2017

Anti-inflammatory mechanisms could be involved in pomegranate-mediated prevention of breast cancer.Apr 27, 2017

Anti-inflammatory, antioxidant and anti-apoptotic activity of diosmin in acetic acid-induced ulcerative colitis.Dec 31, 2017

Antifibrotic effects of crocin on thioacetamide-induced liver fibrosis in mice.Apr 30, 2018

Antitumor activity of enzymatically hydrolyzed Ganoderma lucidum polysaccharide on U14 cervical carcinoma-bearing mice.Dec 31, 2018

Antrodia camphorata extract, when combined with anti-tumor agents, showed adjuvant antiproliferative effects on multi-drug resistant hepatoma. Aug 13, 2008

Apigenin and myricetin exhibited a protective and promising preventive strategy against cisplatin-induced nephrotoxicity.Nov 30, 2017

Apigenin, a dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation in mice. Jan 01, 2009

Apple polyphenols extract (APE) improves colon damage in a rat model of colitis.Feb 28, 2012

Apples rich polyphenols reduce colonic inflammation in rats. Dec 01, 2009

Arctigenin exerts protective effects against myocardial infarction.Feb 28, 2018

Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration.Dec 01, 2001

Artemisia extracts were mucoprotective by attenuating stress related mucosal damages.Feb 28, 2015

Artesunate affords protection against aspirin-induced gastric injury.Mar 31, 2018

Ascorbic acid contributes to the reduction of oxidative stress and inﬂammatory response in DSS-induced colitis.Dec 31, 2014

Asiatic acid is a potent nutraceutical agent against the progression of Parkinson's disease.Mar 31, 2016

Astaxanthin could be a promising agent for atopic dermatitis by inhibition of NF-κB signalling.Sep 07, 2017

Astaxanthin exhibits anti-inflammatory and anti-cancer activity in a rat model of colon cnacer.Apr 01, 2011

Astaxanthin had an anti-depressant effect on diabetic mice.Dec 21, 2016

Astaxanthin significantly suppressed the occurrence of esophageal cancer.Dec 31, 2018

Cyclooxygenase 2 Inhibitors

View the Evidence:
743 Abstracts with Cyclooxygenase 2 Inhibitors Research