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Cyclooxygenase 2 Inhibitors
Views 1180
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327 Substances Researched for Cyclooxygenase 2 Inhibitors
Name
AC
CK
Focus
Curcumin
70
103
Flavonoids
21
38
Resveratrol
20
31
Ginsenosides
18
29
Cannabis
7
22
Frankincense
3
22
Melatonin
10
20
Oleuropein
5
19
Phloretin
5
19
Vitamin C
6
18
Omega-3 Fatty Acids
6
17
Polyphenols
10
17
Sulforaphane
13
16
Thymoquinone
8
15
Berberine
9
14
Spirulina
3
14
Turmeric
5
14
Cannabinoids
4
13
Apples
2
12
DHA (Docosahexaenoic Acid)
3
12
Ginseng (Korean)
9
12
EPA (Eicosapentaenoic Acid)
2
11
Pomegranate
7
11
Banana
1
10
Eicosapentaenoic acid (EPA)
1
10
Grape
5
10
MSM (Methylsulfonylmethane)
1
10
Rose
7
10
Strawberry
1
10
Astaxanthin
5
9
Fisetin
7
9
Fucoxanthin
5
9
Ginger
5
9
Quercetin
6
9
Rosmarinic acid
5
9
Anthocyanins
4
8
Dandelion
6
8
Stilbenes
5
8
Gingerol
4
7
Ginkgo biloba
4
7
Hesperidin
4
7
Japanese cypress
4
7
Wogonin
5
7
Adlay
5
6
Cannabidiol
4
6
Chrysin
4
6
Citrus naringin
4
6
Honokiol
4
6
Indole-3-Carbinol
3
6
Lignans
3
6
Mangiferin
4
6
Myricetin
4
6
Punicalagin
4
6
Rutin
3
6
Antrodia camphorata
3
5
Apigenin
3
5
Beta-Caryophyllene
3
5
Citrus Peel
3
5
Diosmin
3
5
EGCG (Epigallocatechin gallate)
5
5
Genipin
3
5
Grape Seed Extract
3
5
Justicia gendarussa
3
5
Lotus
4
5
Luteolin
5
5
Naringenin
3
5
Noni
3
5
Palmitoylethanolamide
3
5
Pterostilbene
4
5
Sesamol
3
5
Vitex negundo
3
5
Zerumbone
3
5
Arginine
2
4
Astragaloside
2
4
Black Tea
3
4
Bromelain
4
4
Brown Rice
2
4
Chaga Mushroom (Inonotus obliquus)
3
4
D-Limonene
2
4
Delta-tetrahydrocannabinol (THC)
3
4
Ellagic Acid
3
4
Fermented Foods and Beverages
3
4
Flaxseed
2
4
Fucoidan
3
4
Geraniol
2
4
Isoliquiritigenin
3
4
Lactobacillus fermentum
2
4
Lychee
2
4
Medium Chain Triglycerides
2
4
Moringa oleifera
2
4
Nexrutine (Phellodendrom)
3
4
Nobiletin
3
4
Olive
3
4
Palm Oil
2
4
Piceatannol
3
4
Saturated fatty acids
2
4
Shikonin
2
4
Sweet Potato: Purple
2
4
Tangeretin
3
4
Tetrahydrocurcumin
2
4
Vitamin D
2
4
Walnut
2
4
18β-Glycyrrhetinic Acid
2
3
Aduki bean
2
3
Alpha-Lipoic Acid
2
3
Asiatic Acid
2
3
Avocado
2
3
Blueberry
2
3
Catechin
3
3
Chinese Skullcap
2
3
Daidzein
2
3
Diosgenin
2
3
Gastrodin
2
3
Ginseng (American)
2
3
Honey
2
3
Hydroxytyrosol
2
3
Lupeol
2
3
Medicinal Mushrooms
2
3
Mulberry
2
3
Nettle
2
3
P-Coumaric Acid
2
3
Perilla
2
3
Polyunsaturated Fatty Acids (PUFAs)
2
3
Red Sage
2
3
Rosemary
2
3
Saffron
2
3
Tanshinone IIA
3
3
Toona sinensis
2
3
Ursolic Acid
3
3
Water: Deuterium Depleted
2
3
6-Shogaol
1
2
ALA (Alpha-Linolenic Acid)
1
2
Acai
1
2
African Basil
1
2
Alpha Linolenic Acid
1
2
Apocynin
1
2
Apple Polyphenols
1
2
Arctigenin
1
2
Artemisia asiatica
1
2
Artemisinin
2
2
Asparagus
2
2
Bai Zhu
1
2
Barley
1
2
Bee Propolis
1
2
Bee Venom
2
2
Benzyl isothiocyanate
1
2
Bergamot
1
2
Bitter Orange
2
2
Boswellia
1
2
Burdock
1
2
Caffeic acid phenethyl ester
1
2
Camel Milk
1
2
Carnosol
1
2
Carrot
1
2
Carvacrol
1
2
Chickpea
2
2
Chlorogenic Acid
1
2
Chokeberry
1
2
Chrysanthemum Indicum
2
2
Cocoa
1
2
Coptis chinensis
1
2
Cranberry
1
2
Crocetin
1
2
Cyanidin 3-glucoside
1
2
Damnacanthal
1
2
Delphinidin
1
2
Demethoxycurcumin
1
2
Evening Primrose Oil
1
2
Garcinia indica
1
2
Gardenia
1
2
Garlic
1
2
Genistein
2
2
Ginseng
1
2
Gold (nanoparticles)
1
2
Graviola
1
2
Guggul
2
2
Hops
1
2
Horseradish
2
2
Hu Zhang (Polygonum cuspidatum)
1
2
Hydrogen Water
1
2
Isoflavones
1
2
Isoquercitrin
1
2
Kaempferia parviflora
1
2
Kaempferol
1
2
Krill
1
2
L-Carnitine
1
2
Lactobacillus paracasei
1
2
Lactobacillus rhamnosus
1
2
Ligustrazine
1
2
Lion's Mane (Hericium Erinaceus)
1
2
Loquat
1
2
Lycopene
2
2
Magnolol
1
2
Manuka Honey
1
2
Mint
1
2
Myo-inositol
1
2
Nigella sativa (aka Black Seed)
2
2
Noni leaf extract
1
2
Nutmeg
1
2
Oak
1
2
Olive leaf extract
1
2
Orange
1
2
Panax Ginseng
1
2
Patchouli
1
2
Pau D'Arco
1
2
Pelargonium sidoides
1
2
Peony
1
2
Pine Needle
1
2
Potato
1
2
Probiotics
1
2
Psychedelics:All
2
2
Puerarin
2
2
Raspberry
1
2
Red Wine
1
2
Reishi Mushroom
2
2
Rice Bran
1
2
Rosemaric Acid
1
2
Royal Jelly
1
2
Ruta Graveolens
1
2
Sea buckthorn
1
2
Selenium
1
2
Silibinin
1
2
Sour Cherry
1
2
Theaflavins
2
2
Thistle
1
2
Thuja
1
2
Thymol
1
2
Tongkat Ali
1
2
Turmeric: Fermented
1
2
Vanillin
2
2
Verbascoside
2
2
Watermelon
1
2
White Tea
1
2
Yam
1
2
Yeast
1
2
Zeaxanthin
1
2
Achillea fragrantissima
1
1
Amygdalin (laetrile)
1
1
Apple Pectin
1
1
Artesunate
1
1
Ashwagandha
1
1
Avacado
1
1
Avenanthramides
1
1
Bamboo
1
1
Beta-glucan
1
1
Betulinic acid
1
1
Bitter Melon
1
1
Black Pepper
1
1
Black Raspberry
1
1
Butterbur
1
1
Capsaicin
1
1
Carnosic Acid
1
1
Chamomile
1
1
Chlorella (Algae)
1
1
Coenzyme Q10
1
1
Coumestrol
1
1
Cucurbitacin B
1
1
Cumin
1
1
Cyanidin
1
1
Deguelin
1
1
Echinacea
1
1
False Black Pepper
1
1
Ferulic acid
1
1
Feverfew
1
1
Fish Oil
1
1
Fruit: All
1
1
Gleditsia sinensis
1
1
Guava
1
1
Homeopathic Medicine: All
1
1
Huperzine
1
1
Hyaluronic Acid
1
1
Isothiocyanates
1
1
Kahweol
1
1
Kava Kava
1
1
Kimchi
1
1
Lactobacillus rhamnosus GG
1
1
Long Pepper
1
1
Loquat Leaves
1
1
Lutein
1
1
Maitake Mushroom
1
1
Maqui
1
1
Modified Citrus Pectin
1
1
Mushrooms: All
1
1
Mussel: Green-lipped (Perna canaliculus)
1
1
Oats
1
1
Orange: Mandarin
1
1
Oranges
1
1
Paeoniflorin
1
1
Panax Notoginseng
1
1
Parthenolide
1
1
Passion Flower
1
1
Pea
1
1
Persimmon
1
1
Phenethyl isothiocyanate
1
1
Phyllanthus amarus
1
1
Pine Cone
1
1
Piperine
1
1
Piperlongumine
1
1
Plantago
1
1
Pomegranate Peel
1
1
Prickly Pear Cactus
1
1
Prunella vulgaris
1
1
Purple Carrots
1
1
Raisins
1
1
Rice: Black
1
1
Rooibos
1
1
Rose Hips
1
1
Saw Palmetto
1
1
Sesame Seeds
1
1
Shallot
1
1
Soy
1
1
Spikenard
1
1
Syrian rue
1
1
Tabebuia
1
1
Tart Cherry
1
1
Tocotrienol: Gamma
1
1
Truffles
1
1
Turmerones
1
1
Tyrosol
1
1
Unsaponifiables
1
1
Vegetables: All
1
1
Vitamin E: alpha tocopherol
1
1
Wasabi
2
1
White Button Mushroom
1
1
Wormwood
1
1
Yellow Sweet Clover (Melilotus officinalis)
1
1
beta-Carotene
1
1
Research Articles
645
Cumulative Knowledge Score
1043
Overall Research Rating
EXCELLENT
View the Evidence:
752 Abstracts with Cyclooxygenase 2 Inhibitors Research
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[+]
A daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution of curcumin outside the gut.
Jan 01, 2005
Click here to read the entire abstract
Pubmed Data
: Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):120-5. PMID:
15668484
Article Published Date
: Jan 01, 2005
Study Type
: Human Study
Additional Links
Substances
:
Curcumin
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Antineoplastic Agents
[+]
A formulation containing Frankincense and Turmeric extracts demonstrated a greater improvement in the treatment of OA than celecoxib.
Oct 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2013 Nov ;8(5):1542-8. Epub 2013 Aug 29. PMID:
24002213
Article Published Date
: Oct 31, 2013
Study Type
: Human Study
Additional Links
Substances
:
Frankincense
,
Turmeric
Diseases
:
Osteoarthritis: Knee
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Plant Extracts
,
Superiority of Natural Substances versus Drugs
Problem Substances
:
Celecoxib
,
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]
Carbohydrate ingestion from bananas had positive influence in attenuating metabolic perturbation and inflammation following 75-km cycling.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2018 ;13(3):e0194843. Epub 2018 Mar 22. PMID:
29566095
Article Published Date
: Dec 31, 2017
Study Type
: Human Study
Additional Links
Substances
:
Banana
Therapeutic Actions
:
Exercise: Cycling
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Consumption of dried apple peel powder was associated with improved joint function and improved serum antioxidant protection status.
Oct 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Med Food. 2014 Nov ;17(11):1204-13. Epub 2014 Oct 1. PMID:
25271471
Article Published Date
: Oct 31, 2014
Study Type
: Human Study
Additional Links
Substances
:
Apples
Diseases
:
Joint Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antinoceceptive
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Lipoxygenase Inhibitors
Additional Keywords
:
Plant Extracts
,
Significant Treatment Outcome
[+]
Dietary strawberries significantly decreased the histologic grade of patients' precancerous esophageal lesions.
Dec 31, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Prev Res (Phila). 2012 Jan ;5(1):41-50. Epub 2011 Dec 1. PMID:
22135048
Article Published Date
: Dec 31, 2011
Study Type
: Human Study
Additional Links
Substances
:
Strawberry
Diseases
:
Esophageal Cancer
Pharmacological Actions
:
Antiproliferative
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Nitric Oxide Inhibitor
Additional Keywords
:
Plant Extracts
,
Risk Reduction
[+]
Electroacupuncture may prevent ischemia-reperfusion-induced endothelial dysfunction via a COX-2 dependent mechanism.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2017 ;12(6):e0178838. Epub 2017 Jun 7. PMID:
28591155
Article Published Date
: Dec 31, 2016
Study Type
: Human Study
Additional Links
Diseases
:
Endothelial Dysfunction
,
Ischemia
Therapeutic Actions
:
Electroacupuncture
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
[+]
Electroacupuncture treatment alleviates central post-stroke pain.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Neural Plast. 2016 ;2016:1437148. Epub 2016 Aug 27. PMID:
27774321
Article Published Date
: Dec 31, 2015
Study Type
: Human Study
Additional Links
Diseases
:
Stroke: Attenuation/Recovery
Therapeutic Actions
:
Electroacupuncture
Pharmacological Actions
:
Analgesics
,
Cyclooxygenase 2 Inhibitors
[+]
EPA supplementation significantly reduces Cox-2 enzyme expression in Barrett's esophagus.
Apr 01, 2008
Click here to read the entire abstract
Pubmed Data
: Am J Clin Nutr. 2008 Apr;87(4):949-56. PMID:
18400718
Article Published Date
: Apr 01, 2008
Study Type
: Human Study
Additional Links
Substances
:
EPA (Eicosapentaenoic Acid)
Diseases
:
Barrett Esophagus
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
[+]
Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis
Feb 29, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Immunopathol Pharmacol. 2016 Mar ;29(1):140-6. Epub 2015 Dec 18. PMID:
26684635
Article Published Date
: Feb 29, 2016
Study Type
: Human Study
Additional Links
Substances
:
Frankincense
,
MSM (Methylsulfonylmethane)
Diseases
:
Osteoarthritis: Knee
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Omega-3 fatty acids cause a reduction in the mRNA levels for various proteins known to be important in the pathology of osteoarthritis.
Jul 01, 2009
Click here to read the entire abstract
Pubmed Data
: Osteoarthritis Cartilage. 2009 Jul;17(7):896-905. Epub 2009 Jan 13. PMID:
19217322
Article Published Date
: Jul 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
DHA (Docosahexaenoic Acid)
,
Eicosapentaenoic acid (EPA)
,
Omega-3 Fatty Acids
Diseases
:
Osteoarthritis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 alpha downregulation
,
Interleukin-1 beta downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Phloretin inhibits the growth of P. acnes, P. granulosum, and S. epidermidis.
Jan 31, 2016
Click here to read the entire abstract
Pubmed Data
: Int J Cosmet Sci. 2016 Feb ;38(1):85-92. Epub 2015 Aug 30. PMID:
26212527
Article Published Date
: Jan 31, 2016
Study Type
: Human In Vitro, Human Study
Additional Links
Substances
:
Phloretin
Diseases
:
Acne
Pharmacological Actions
:
Anti-Bacterial Agents
,
Antimicrobial
,
Cyclooxygenase 2 Inhibitors
,
Prostaglandin PGE2 downregulation
[+]
Pycnogenol may be of value in treatment of MSU crystal-induced arthritis through its anti-inflammatory and anti-nitrosative activities.
Feb 14, 2012
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2012 Feb 15 ;52(4):765-74. Epub 2011 Dec 13. PMID:
22198264
Article Published Date
: Feb 14, 2012
Study Type
: Human Study
Additional Links
Substances
:
Flavonoids
Diseases
:
Gout
,
Hyperuricemia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Sesamin can relieve clinical symptoms and pathological changes that caused by inflammatory impairment in patients with rheumatoid arthritis.
Aug 31, 2019
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2019 Sep ;33(9):2421-2428. Epub 2019 Jul 15. PMID:
31309643
Article Published Date
: Aug 31, 2019
Study Type
: Human Study
Additional Links
Substances
:
Sesamin
Diseases
:
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Spirulina has favorable effects on lipid profiles, immune variables and antioxidant capacity in healthy individuals.
Jan 01, 2008
Click here to read the entire abstract
Pubmed Data
: Ann Nutr Metab. 2008;52(4):322-8. Epub 2008 Aug 19. PMID:
18714150
Article Published Date
: Jan 01, 2008
Study Type
: Human Study
Additional Links
Substances
:
Spirulina
Diseases
:
High Cholesterol
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Interleukin-2 upregulation
,
Interleukin-6 Downregulation
[+]
The anti-inflammatory activity of Cannabis extracts on colon epithelial cells derives from a fraction of the extract that contains THCA.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cannabis Cannabinoid Res. 2017 ;2(1):167-182. Epub 2017 Jul 1. PMID:
29082314
Article Published Date
: Dec 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
Diseases
:
Inflammatory Bowel Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
These new data support a potential role of oleuropein in the treatment of ulcerative colitis.
Apr 14, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2017 Apr 15 ;9(4). Epub 2017 Apr 15. PMID:
28420140
Article Published Date
: Apr 14, 2017
Study Type
: Human Study
Additional Links
Substances
:
Oleuropein
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-17 downregulation
[+]
Vitamin C attenuates aspirin-induced gastric damage.
May 01, 2009
Click here to read the entire abstract
Pubmed Data
: Zhongguo Zhen Jiu. 2009 May;29(5):382-4. PMID:
17218764
Article Published Date
: May 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Aspirin-Induced Toxicity
,
NSAID-induced toxicity
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
[+]
Cannabidiolic acid an active component in the cannabis plant offers potential therapeutic modality in the abrogation of cancer cell migration.
Nov 14, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Toxicol Lett. 2012 Nov 15 ;214(3):314-9. Epub 2012 Sep 8. PMID:
22963825
Article Published Date
: Nov 14, 2012
Study Type
: Human In Vitro
Additional Links
Substances
:
Cannabis
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Anti-metastatic
,
Antineoplastic Agents
,
Antiproliferative
,
Cyclooxygenase 2 Inhibitors
,
Enzyme Inhibitors
[+]
Ginsenoside Rg1 can inhibit inflammatory responses in human chondrocytes in vitro and reduce articular cartilage damage in vivo.
Mar 09, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2017 Mar 10 ;9(3). Epub 2017 Mar 10. PMID:
28287423
Article Published Date
: Mar 09, 2017
Study Type
: Animal Study, Human In Vitro
Additional Links
Substances
:
Ginsenosides
Diseases
:
Osteoarthritis
Pharmacological Actions
:
Chondroprotective
,
Cyclooxygenase 2 Inhibitors
,
Matrix Metalloproteinase-13 (MMP-13) Inhibitor
,
Prostaglandin PGE2 downregulation
[+]
Melatonin as a novel selective ATF-6 inhibitor can sensitize human hepatoma cells to ER stress inducing apoptosis.
Feb 13, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: World J Gastroenterol. 2017 Feb 14 ;23(6):986-998. PMID:
28246472
Article Published Date
: Feb 13, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Apoptotic
,
Cyclooxygenase 2 Inhibitors
[+]
Melatonin is a potential candidate compound for the treatment of proinflammatory disorders.
Aug 31, 2012
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2012 Sep ;53(2):154-65. Epub 2012 Feb 21. PMID:
22348531
Article Published Date
: Aug 31, 2012
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
NF-kappaB Inhibitor
,
Nitric Oxide Inhibitor
,
Prostaglandin PGE2 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Dose Response
[+]
Oleuropein might provide a basis for developing a new dietary strategy for the prevention and management of rheumatoid arthritis.
Apr 19, 2017
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2017 Apr 20. Epub 2017 Apr 20. PMID:
28426090
Article Published Date
: Apr 19, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Oleuropein
Diseases
:
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Matrix metalloproteinase-1 (MMP-1) inhibitor
,
Matrix metalloproteinase-3 (MMP-3) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Phloretin inhibits interleukin-1β-induced COX-2 and ICAM-1 in human lung epithelial cells.
May 31, 2015
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2015 Jun ;6(6):1960-7. PMID:
25996641
Article Published Date
: May 31, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Phloretin
Diseases
:
Experimental Lung Inflammation
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Interleukin-8 downregulation
,
Prostaglandin PGE2 downregulation
[+]
Resveratrol functions as a suppressor of particulate matter induced inflammatory signalling pathways.
May 07, 2017
Click here to read the entire abstract
Pubmed Data
: Int J Biochem Cell Biol. 2017 May 8 ;88:113-123. Epub 2017 May 8. PMID:
28495310
Article Published Date
: May 07, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Resveratrol
Diseases
:
Air Pollution Linked Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Postaglandin PGE2 downregulation
[+]
Sulforaphane combats colon cancer in vitro by inhibiting COX-2 and prostaglandin E1 synthase and exhibiting anti-angiogenic, anti-proliferative, and anti-metastatic properties.
Jan 01, 2018
Click here to read the entire abstract
Pubmed Data
: Cells Tissues Organs. 2018 ;206(1-2):46-53. Epub 2018 Jul 24. PMID:
30041241
Article Published Date
: Jan 01, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Colon Cancer
Pharmacological Actions
:
Anti-Angiogenic
,
Anti-cancer
,
Anti-metastatic
,
Anti-Proliferative
,
Cyclooxygenase 2 Inhibitors
,
Hypoxia-inducible factor-1 (HIF-1) inhibitor
,
Prostaglandin E Synthase-1 (PGES-1) Down-Regulation
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
[+]
Berberin inhibited colorectal cancer invasion and metastasis via down regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(5):e0123478. Epub 2015 May 8. PMID:
25954974
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anti-metastatic
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Prostaglandin PGE2 downregulation
[+]
"Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats."
Feb 15, 2011
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2011 Feb 15 ;251(1):85-94. Epub 2010 Dec 15. PMID:
21167192
Article Published Date
: Feb 15, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Flavonoids
Diseases
:
Liver Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
,
Tumor Suppressor Protein p53 Upregulation
[+]
18β-Glycyrrhetinic acid significantly attenuated H. pylori-infected gastritis in gerbils.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Res Int. 2016 ;2016:4943793. Epub 2016 Feb 24. PMID:
27006947
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
18β-Glycyrrhetinic Acid
Diseases
:
Helicobacter Pylori Infection
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Gastroprotective
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside may be a promising natural lead compound for treating early phases of colorectal cancer.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Res Int. 2017 ;2017:3634915. Epub 2017 Nov 7. PMID:
29238715
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
[+]
3,3'-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2.
Jan 31, 2019
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2019 Feb 1 ;448:20-30. Epub 2019 Feb 1. PMID:
30716361
Article Published Date
: Jan 31, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Diseases
:
Colon Cancer
Pharmacological Actions
:
Cyclooxygenase 1 Inhibitor
,
Cyclooxygenase 2 Inhibitors
[+]
5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Drug Des Devel Ther. 2016 ;10:2239-53. Epub 2016 Jul 11. PMID:
27468227
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Thymoquinone
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Chemoprotective Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
,
Wnt/β-catenin signaling pathway modulation
Additional Keywords
:
Chemothapeutic Synergy: 5-flourouracil
,
Gene Expression Regulation
[+]
5-hydroxytryptophan attenuates imiquimod-induced psoriasiform dermatitis.
Jan 10, 2018
Click here to read the entire abstract
Pubmed Data
: Exp Dermatol. 2018 11 ;27(11):1273-1279. Epub 2018 Oct 9. PMID:
30221419
Article Published Date
: Jan 10, 2018
Study Type
: Animal Study
Additional Links
Substances
:
5-HTP (5-Hydroxytryptophan)
Diseases
:
Dermatitis
,
Psoriasis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
6-Gingerol abates benzo[a]pyrene-induced colonic injury.
Apr 17, 2019
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2019 Apr 18 ;307:1-7. Epub 2019 Apr 18. PMID:
31004597
Article Published Date
: Apr 17, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Gingerol
Diseases
:
Benzo[a]pyrene-induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Gastroprotective
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances
:
Benzo(a)pyrene
[+]
6-gingerol prevented DSS-induced chronic ulcerative colitis via anti-inflammatory and antioxidative mechanisms.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Hum Exp Toxicol. 2018 Jan 1:960327117751235. Epub 2018 Jan 1. PMID:
29350052
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Gingerol
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
[+]
6-Shogaol reduces progression of experimental endometriosis.
Oct 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Korean J Physiol Pharmacol. 2018 Nov ;22(6):627-636. Epub 2018 Oct 25. PMID:
30402023
Article Published Date
: Oct 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
6-Shogaol
Diseases
:
Endometriosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Postaglandin PGE2 downregulation
[+]
A Burdock extract was able to reduce intestinal inflammation in an acute TNBS-induced experimental model of colitis in rats.
Mar 06, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Ethnopharmacol. 2013 Mar 7 ;146(1):300-10. Epub 2013 Jan 10. PMID:
23313393
Article Published Date
: Mar 06, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Burdock
Diseases
:
Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
A combination of ginger and peony root may prevent memory impairment in AD by inhibiting Aβ accumulation and inflammation in the brain.
Nov 29, 2015
Click here to read the entire abstract
Pubmed Data
: J Alzheimers Dis. 2015 Nov 30. Epub 2015 Nov 30. PMID:
26639976
Article Published Date
: Nov 29, 2015
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Ginger
,
Peony
Diseases
:
Alzheimer's Disease
,
Brain Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Plant Extracts
[+]
A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer.
Mar 26, 2019
Click here to read the entire abstract
Pubmed Data
: Eur J Nutr. 2019 Mar 27. Epub 2019 Mar 27. PMID:
30919084
Article Published Date
: Mar 26, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Bergamot
,
Flavonoids
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-10 downregulation
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
[+]
A polyphenol-rich cranberry extract reverses insulin resistance and hepatic steatosis independently of body weight loss.
Nov 30, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Metab. 2017 Dec ;6(12):1563-1573. Epub 2017 Oct 18. PMID:
29107524
Article Published Date
: Nov 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Cranberry
Diseases
:
Insulin Resistance
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Extracts
[+]
Açaí demonstrated protective effects against AOM/DSS-induced colon carcinogenesis.
Mar 14, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Gut Liver. 2017 Mar 15 ;11(2):243-252. PMID:
27965474
Article Published Date
: Mar 14, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Acai
Diseases
:
Colon Cancer
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Adlay bran ethanolic extract suppressed 1,2-dimethylhydrazine-indued preneoplastic lesions of the colon.
Jul 13, 2010
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2010 Jul 14 ;58(13):7616-23. PMID:
20536243
Article Published Date
: Jul 13, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Adlay
Diseases
:
Colon Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Adlay
,
Anti-Inflammatory Agents
,
Chemopreventive
,
COLON CANCER
,
Cyclooxygenase 2 Inhibitors
,
Plant Extracts
[+]
Administration of chlorogenic acid alleviates spinal cord injury.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2018 Jan ;17(1):1340-1346. Epub 2017 Nov 6. PMID:
29115619
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Chlorogenic Acid
Diseases
:
Spinal Cord Injuries
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Neuroprotective Agents
,
NF-kappaB Inhibitor
[+]
Allylmethylsulfide (AMS), a volatile organosulfur derivative from garlic has radioprotective properties.
Jun 01, 2009
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2009 Jun;12(3):542-51. PMID:
19627202
Article Published Date
: Jun 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Garlic
Diseases
:
Lipid Peroxidation
,
Radiation Induced Illness
Pharmacological Actions
:
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Radioprotective
,
Vascular Cell Adhesion Molecule-1 Inhibitor
Additional Keywords
:
Plant Extracts
[+]
Alpha linolenic fatty acid supplementation had a beneficial effect on tumor cell proliferation and cachexia parameters.
May 25, 2015
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2015 May 26:1-8. Epub 2015 May 26. PMID:
26011096
Article Published Date
: May 25, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Alpha Linolenic Acid
Diseases
:
Breast Cancer
,
Cachexia
Pharmacological Actions
:
Antiproliferative
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Alpha lipoic acid has hepatoprotective effects against methotrexate-induced hepatic injury.
Jun 03, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 Jun 4 ;105:428-433. Epub 2018 Jun 4. PMID:
29879626
Article Published Date
: Jun 03, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Alpha-Lipoic Acid
Diseases
:
Drug-Induced Toxicity: Methotrexate
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Heme oxygenase-1 inducer
,
Hepatoprotective
,
Nrf2 activation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Amelioration of adjuvant induced arthritis in Sprague Dawley rats through modulation of inflammatory mediators by Ribes alpestre Decne.
May 09, 2019
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2019 May 10 ;235:460-471. Epub 2019 Feb 13. PMID:
30771518
Article Published Date
: May 09, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Black Currant
Diseases
:
Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-10 upregulation
,
Interleukin-1 beta downregulation
,
Interleukin-4 upregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Postaglandin PGE2 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Extracts
[+]
American ginseng prevents and treats Ulcerative Colitis.
Sep 18, 2008
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2008 Sep 18. [Epub ahead of print] PMID:
18802031
Article Published Date
: Sep 18, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Ginseng (American)
Diseases
:
Colitis: Pseudomembranous
,
Ulcerative Colitis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Nitric Oxide Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Antarctic krill oil diet protects against lipopolysaccharide-induced oxidative stress, neuroinflammation and cognitive impairment.
Nov 27, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2017 Nov 28 ;18(12). Epub 2017 Nov 28. PMID:
29182579
Article Published Date
: Nov 27, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Krill
Diseases
:
Alzheimer's Disease
,
Brain: Oxidative Stress
,
Brain Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Neuroprotective Agents
[+]
Anthocyanin-rich fractions from red raspberries attenuate inflammation both in vitro and in vivo.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2014 ;4:6234. Epub 2014 Aug 29. PMID:
25167935
Article Published Date
: Dec 31, 2013
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Anthocyanins
,
Raspberry
Diseases
:
Colitis
,
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
Additional Keywords
:
Plant Extracts
[+]
Anthocyanins from black chokeberry delayed aging-related degenerative changes of the brain.
Jul 25, 2017
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2017 Jul 26 ;65(29):5973-5984. Epub 2017 Jul 12. PMID:
28657734
Article Published Date
: Jul 25, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Anthocyanins
,
Chokeberry
Diseases
:
Aging: Brain
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Plant Extracts
[+]
Anti-hyperuricemic and anti-gouty arthritis activities of polysaccharide purified from Lonicera japonica.
Feb 14, 2019
Click here to read the entire abstract
Pubmed Data
: Int J Biol Macromol. 2019 Feb 15 ;123:801-809. Epub 2018 Nov 13. PMID:
30445085
Article Published Date
: Feb 14, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Honeysuckle
Diseases
:
Hyperuricemia
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
,
Uricosuric Agents
Additional Keywords
:
Polysaccharides
[+]
Anti-inflammatory activity of hydroalcoholic extracts of Lavandula dentata L. and Lavandula stoechas L.
Aug 21, 2016
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2016 Aug 22 ;190:142-58. Epub 2016 Jun 4. PMID:
27269390
Article Published Date
: Aug 21, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Lavender
Diseases
:
Colitis
,
Gastrointestinal Inflammation
,
Inflammatory Bowel Diseases
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
Anti-inflammatory activity of Rg3-enriched Korean red ginseng extract in murine model of sepsis.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2018 ;2018:6874692. Epub 2018 Oct 11. PMID:
30405742
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Ginseng (Korean)
Diseases
:
Sepsis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Anti-inflammatory mechanisms could be involved in pomegranate-mediated prevention of breast cancer.
Apr 27, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2017 Apr 28 ;9(5). Epub 2017 Apr 28. PMID:
28452959
Article Published Date
: Apr 27, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Pomegranate
Diseases
:
Breast Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Heat Shock Protein Down-Regulation
[+]
Anti-inflammatory, antioxidant and anti-apoptotic activity of diosmin in acetic acid-induced ulcerative colitis.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Hum Exp Toxicol. 2018 Jan ;37(1):78-86. Epub 2017 Feb 23. PMID:
29187079
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Diosmin
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Malondialdehyde Down-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Antifibrotic effects of crocin on thioacetamide-induced liver fibrosis in mice.
Apr 30, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Saudi J Biol Sci. 2018 May ;25(4):747-754. Epub 2016 Oct 13. PMID:
29740240
Article Published Date
: Apr 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Crocin
Diseases
:
Liver Fibrosis
Pharmacological Actions
:
Anti-Fibrotic
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Antitumor activity of enzymatically hydrolyzed Ganoderma lucidum polysaccharide on U14 cervical carcinoma-bearing mice.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419869489. PMID:
31462112
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Reishi Mushroom
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Polysaccharides
[+]
Antrodia camphorata extract, when combined with anti-tumor agents, showed adjuvant antiproliferative effects on multi-drug resistant hepatoma.
Aug 13, 2008
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2008 Aug 13;118(3):387-95. Epub 2008 May 7. PMID:
18571350
Article Published Date
: Aug 13, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Antrodia camphorata
Diseases
:
Cancers: Multi-Drug Resistant
,
Liver Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Cell cycle arrest
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Plant Extracts
[+]
Apigenin and myricetin exhibited a protective and promising preventive strategy against cisplatin-induced nephrotoxicity.
Nov 30, 2017
Click here to read the entire abstract
Pubmed Data
: Pharm Biol. 2017 Dec ;55(1):766-774. PMID:
28064632
Article Published Date
: Nov 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Apigenin
,
Flavonoids
,
Myricetin
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
,
Oxidative Stress
Pharmacological Actions
:
Chemoprotective Agents
,
Cyclooxygenase 1 Inhibitor
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Malondialdehyde Down-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Apigenin, a dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation in mice.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: Arthritis Res Ther. 2009;11(2):R59. Epub 2009 Apr 30. PMID:
19405952
Article Published Date
: Jan 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Apigenin
Diseases
:
Autoimmune Diseases
,
Lupus Erythematosus: Systemic
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
[+]
Apple polyphenols extract (APE) improves colon damage in a rat model of colitis.
Feb 28, 2012
Click here to read the entire abstract
Pubmed Data
: Dig Liver Dis. 2012 Feb 28. Epub 2012 Feb 28. PMID:
22381211
Article Published Date
: Feb 28, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Apple Polyphenols
Diseases
:
Colitis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Apples rich polyphenols reduce colonic inflammation in rats.
Dec 01, 2009
Click here to read the entire abstract
Pubmed Data
: Br J Nutr. 2009 Dec;102(11):1620-8. Epub 2009 Jul 22. PMID:
19622193
Article Published Date
: Dec 01, 2009
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Apples
,
Flavonoids
,
Polyphenols
Diseases
:
Inflammatory Bowel Diseases
,
Irritable Bowel Syndrome
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Arctigenin exerts protective effects against myocardial infarction.
Feb 28, 2018
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2018 Mar ;17(3):4839-4845. Epub 2018 Jan 10. PMID:
29328478
Article Published Date
: Feb 28, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Arctigenin
Diseases
:
Myocardial Infarction
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Heme oxygenase-1 up-regulation
Additional Keywords
:
Anti-Inflammatory Agents
,
Antioxidants
,
Arctigenin
,
Myocardial Infarction
[+]
Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration.
Dec 01, 2001
Click here to read the entire abstract
Pubmed Data
: J Pharmacol Exp Ther. 2001 Dec;299(3):832-9. PMID:
11714866
Article Published Date
: Dec 01, 2001
Study Type
: Animal Study
Additional Links
Substances
:
Arginine
Diseases
:
Alcoholic Liver Disease
,
Inflammation
,
Liver Fibrosis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Artemisia extracts were mucoprotective by attenuating stress related mucosal damages.
Feb 28, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Clin Biochem Nutr. 2015 Mar ;56(2):132-42. Epub 2014 Nov 28. PMID:
25759519
Article Published Date
: Feb 28, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Artemisia asiatica
Diseases
:
Gastrointestinal Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Gastroprotective
,
Nrf2 activation
Additional Keywords
:
Dose Response
[+]
Artesunate affords protection against aspirin-induced gastric injury.
Mar 31, 2018
Click here to read the entire abstract
Pubmed Data
: Pharmacol Rep. 2018 Apr ;70(2):390-397. Epub 2017 Jun 15. PMID:
29397336
Article Published Date
: Mar 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Artesunate
Diseases
:
Aspirin-Induced Toxicity
,
Gastric Ulcer
,
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Ulcer Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Malondialdehyde Down-regulation
,
Superoxide Dismutase Up-regulation
Additional Keywords
:
Natural Substances Versus Drugs
Problem Substances
:
Aspirin
[+]
Artesunate suppresses inflammation and oxidative stress in a rat model of colorectal cancer.
Aug 29, 2019
Click here to read the entire abstract
Pubmed Data
: Drug Dev Res. 2019 Aug 30. Epub 2019 Aug 30. PMID:
31471932
Article Published Date
: Aug 29, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Artesunate
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
NF-kappaB Inhibitor
[+]
Ascorbic acid contributes to the reduction of oxidative stress and inflammatory response in DSS-induced colitis.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Clin Exp Med. 2015 ;8(11):20245-53. Epub 2015 Nov 15. PMID:
26884937
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Gastrointestinal Inflammation
,
Ulcerative Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Superoxide Dismutase Up-regulation
[+]
Asiatic acid is a potent nutraceutical agent against the progression of Parkinson's disease.
Mar 31, 2016
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2016 Apr ;7(4):1999-2005. PMID:
26999333
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Asiatic Acid
Diseases
:
Parkinson's Disease
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Astaxanthin could be a promising agent for atopic dermatitis by inhibition of NF-κB signalling.
Sep 07, 2017
Click here to read the entire abstract
Pubmed Data
: Exp Dermatol. 2017 Sep 8. Epub 2017 Sep 8. PMID:
28887839
Article Published Date
: Sep 07, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Atopic Dermatitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Astaxanthin exhibits anti-inflammatory and anti-cancer activity in a rat model of colon cnacer.
Apr 01, 2011
Click here to read the entire abstract
Pubmed Data
: Invest New Drugs. 2011 Apr;29(2):207-24. Epub 2009 Oct 30. PMID:
19876598
Article Published Date
: Apr 01, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Cancer Metastasis
,
Colon Cancer
,
Colorectal Cancer
,
Inflammation
Pharmacological Actions
:
Apoptotic
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
[+]
Astaxanthin had an anti-depressant effect on diabetic mice.
Dec 21, 2016
Click here to read the entire abstract
Pubmed Data
: Brain Res. 2016 Dec 22. Epub 2016 Dec 22. PMID:
28017669
Article Published Date
: Dec 21, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Brain Inflammation
,
Depression
,
Diabetic Complications
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antidepressive Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Prophylactic Agents
[+]
Astaxanthin significantly suppressed the occurrence of esophageal cancer.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Onco Targets Ther. 2019 ;12:5087-5096. Epub 2019 Jul 1. PMID:
31308688
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Esophageal Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
[+]
Astragaloside IV protects rat gastric mucosa against aspirin-induced damage.
Nov 30, 2016
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2016 Dec ;41:47-55. Epub 2016 Nov 2. PMID:
27816726
Article Published Date
: Nov 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Astragaloside
Diseases
:
Aspirin-Induced Toxicity
,
Gastric Ulcer
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Cyclooxygenase 1 Inhibitor
,
Cyclooxygenase 2 Inhibitors
,
Gastroprotective
,
Superoxide Dismutase Up-regulation
Problem Substances
:
Aspirin
[+]
Astragaloside IV suppresses inflammatory mediator production in synoviocytes and collagen‑induced arthritic rats.
Mar 31, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2016 Apr ;13(4):3289-96. Epub 2016 Feb 22. PMID:
26936538
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Astragaloside
Diseases
:
Arthritis
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
[+]
Atractylodes macrocephala or Taraxacum herba extracts can be considered natural agents that can prevent inflammatory bowel disease relapse.
Sep 14, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Gut Liver. 2017 Sep 15 ;11(5):655-666. PMID:
28651306
Article Published Date
: Sep 14, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Bai Zhu
,
Dandelion
Diseases
:
Colitis
,
Inflammatory Bowel Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Heme oxygenase-1 up-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Extracts
,
Risk Reduction
,
Superiority of Natural Substances versus Drugs
[+]
Avocado may be used as a promising therapeutic against inflammatory bowel diseases.
Jan 04, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2019 Jan 5 ;20(1). Epub 2019 Jan 5. PMID:
30621304
Article Published Date
: Jan 04, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Avocado
Diseases
:
Colitis
,
Inflammatory Bowel Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
STAT3 Inhibitor
[+]
Barley sprouts have a protective effect against alcohol-induced liver injury.
Jul 20, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2016 Jul 21 ;8(7). Epub 2016 Jul 21. PMID:
27455313
Article Published Date
: Jul 20, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Barley
Diseases
:
Alcohol Toxicity
,
Chemically-Induced Liver Damage
,
Lipopolysaccharide-Induced Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Hepatoprotective
Additional Keywords
:
Plant Extracts
[+]
Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.
Sep 28, 2006
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2006 Sep 28;241(2):275-80. Epub 2006 Jan 4. PMID:
16386831
Article Published Date
: Sep 28, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Benzyl isothiocyanate
,
Sulforaphane
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Isothiocyanates
,
Stilbenes
[+]
Berberine attenuates arthritis in adjuvant-induced arthritis.
Feb 19, 2019
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2019 Feb 20. Epub 2019 Feb 20. PMID:
30796904
Article Published Date
: Feb 19, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-17 downregulation
,
NF-kappaB Inhibitor
[+]
Berberine chloride ameliorates oxidative stress, inflammation and apoptosis in the pancreas of Streptozotocin induced diabetic rats.
Aug 22, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Aug 23 ;95:175-185. Epub 2017 Aug 23. PMID:
28843149
Article Published Date
: Aug 22, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Hypoglycemic Agents
,
NF-kappaB Inhibitor
,
Pancreato Protective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Diabetes Mellitus: Type 1
[+]
Berberine has a preventive effect on experimental colon cancer.
Oct 01, 2010
Click here to read the entire abstract
Pubmed Data
: Zhongguo Zhong Yao Za Zhi. 2010 Oct;35(20):2768-73. PMID:
21246838
Article Published Date
: Oct 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Colon Cancer
Pharmacological Actions
:
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
[+]
Berberine prevents non-alcoholic steatohepatitis-derived hepatocellular carcinoma.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Am J Transl Res. 2019 ;11(5):2668-2682. Epub 2019 May 15. PMID:
31217846
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Liver Cancer
,
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Anti-Inflammatory Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
[+]
Berberine reduces neuroglia activation and inflammation in streptozotocin-induced diabetic mice.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419866379. PMID:
31337260
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine suppresses growth and metastasis of endometrial cancer cells.
Jun 30, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Pharmacother. 2018 Jul ;103:1287-1293. Epub 2018 May 7. PMID:
29864910
Article Published Date
: Jun 30, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Endometrial Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Cyclooxygenase 2 Inhibitors
,
Prostaglandin PGE2 downregulation
[+]
Beta-caryophyllene constitutes an alluring therapeutic molecule towards the treatment of multiple sclerosis.
Mar 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2017 Apr 1 ;18(4). Epub 2017 Apr 1. PMID:
28368293
Article Published Date
: Mar 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Beta-Caryophyllene
Diseases
:
Inflammation: Brain
,
Multiple Sclerosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Immunomodulatory
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
Additional Keywords
:
Cannabinoid Receptors
[+]
Black Adzuki bean attenuates high-fat diet-induced colon inflammation.
Mar 31, 2017
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2017 Apr ;20(4):367-375. PMID:
28406732
Article Published Date
: Mar 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Aduki bean
Diseases
:
Colitis
,
High Fat Diet
,
Inflammation
,
Lipopolysaccharide-Induced Toxicity
,
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Extracts
[+]
Black ginseng-enriched Chong-Myung-Tang extracts improve spatial learning behavior.
Mar 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Ginseng Res. 2017 Apr ;41(2):151-158. Epub 2016 Mar 25. PMID:
28413319
Article Published Date
: Mar 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ginseng
Diseases
:
Memory Disorders
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Neuroprotective Agents
[+]
Boswellia serrate extract has great potential to suppress colon tumorigenesis.
Feb 27, 2017
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2017 Feb 28. Epub 2017 Feb 28. PMID:
28245338
Article Published Date
: Feb 27, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Frankincense
Diseases
:
Colon Cancer
,
Colon Cancer: Prevention
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
[+]
Boswellic acid inhibits growth and metastasis of human colorectal cancer.
Apr 30, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Cancer. 2012 May 1 ;130(9):2176-84. Epub 2011 Sep 12. PMID:
21702037
Article Published Date
: Apr 30, 2012
Study Type
: Animal Study
Additional Links
Substances
:
acetyl-11-keto-beta-boswellic acid
,
Frankincense
Diseases
:
Cancer Metastasis
,
Colorectal Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anti-metastatic
,
Antiproliferative
,
Cyclooxygenase 2 Inhibitors
,
Enzyme Inhibitors
[+]
Boswellic acid suppresses growth and metastatis of human pancreatic tumors (nude mouse model).
Jan 01, 2011
Click here to read the entire abstract
Pubmed Data
: PLoS One. 2011 ;6(10):e26943. Epub 2011 Oct 31. PMID:
22066019
Article Published Date
: Jan 01, 2011
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Boswellia
Diseases
:
Cancer Metastasis
,
Pancreatic Cancer
Pharmacological Actions
:
Anti-metastatic
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Both indole-3-carbinol and myo-inositol inhibit the development of vinyl carbamate induced pulmonary adenocarcinoma in mice.
Jan 31, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Carcinogenesis. 2010 Feb ;31(2):239-45. Epub 2009 Jul 22. PMID:
19625346
Article Published Date
: Jan 31, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
,
Myo-inositol
Diseases
:
Lung Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
Problem Substances
:
Vinyl Carbamate
[+]
C-phycocyanin relieved symptoms associated with cyclophosphamide-induced cystitis.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2019 ;2019:8424872. Epub 2019 Jul 29. PMID:
31467580
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Spirulina
Diseases
:
Chemotherapy-Induced Toxicity: Cyclophosphamide
,
Cystitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Chemoprotective Agents
,
Cyclooxygenase 2 Inhibitors
,
Postaglandin PGE2 downregulation
Additional Keywords
:
C-phycocyanin
[+]
C. obtusa essential oil may constitute a novel source of anti-inflammatory treatments.
Jun 30, 2013
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2013 Jul ;8(1):255-9. Epub 2013 May 8. PMID:
23652412
Article Published Date
: Jun 30, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Japanese cypress
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Oils
[+]
Caffeic acid phenethyl ester, a compound found within propolis causes regression of experimental endometriosis.
Apr 01, 2007
Click here to read the entire abstract
Pubmed Data
: Reprod Sci. 2007 Apr;14(3):270-9. PMID:
17636241
Article Published Date
: Apr 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Bee Propolis
,
Caffeic acid phenethyl ester
Diseases
:
Endometriosis
Pharmacological Actions
:
Antioxidants
,
Cyclooxygenase 2 Inhibitors
[+]
Camel milk attenuates rheumatoid arthritis in animals.
Sep 19, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Physiol Biochem. 2017 Sep 20 ;43(2):540-552. Epub 2017 Sep 20. PMID:
28930753
Article Published Date
: Sep 19, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Camel Milk
Diseases
:
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-10 upregulation
,
NF-kappaB Inhibitor
,
Nitric Oxide Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Cannabidiol could be used to prevent experimental colitis in mice.
Oct 31, 2009
Click here to read the entire abstract
Pubmed Data
: J Mol Med (Berl). 2009 Nov ;87(11):1111-21. Epub 2009 Aug 20. PMID:
19690824
Article Published Date
: Oct 31, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
Diseases
:
Colitis
Pharmacological Actions
:
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-10 downregulation
,
Interleukin-1 beta downregulation
[+]
Carnosol protects against spinal cord injury through Nrf-2 upregulation.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: J Recept Signal Transduct Res. 2016 ;36(1):72-8. Epub 2015 Jul 6. PMID:
26791582
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Carnosol
Diseases
:
Oxidative Stress
,
Spinal Cord Injuries
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Nrf2 activation
[+]
Carrot seeds contain phytochemicals capable of inhibiting inflammatory enzymes.
Jun 01, 2007
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2007 Jun;28(6):1188-96. Epub 2006 Dec 6. PMID:
13680840
Article Published Date
: Jun 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Carrot
Pharmacological Actions
:
Cyclooxygenase 1 Inhibitor
,
Cyclooxygenase 2 Inhibitors
,
Cyclooxygenase Inhibitors
[+]
Carvacrol can be used as a protective agent against benzo(a)pyrene-induced lung toxicity and inflammation.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Hum Exp Toxicol. 2017 Jan 1:960327117735572. Epub 2017 Jan 1. PMID:
29019276
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Carvacrol
Diseases
:
Benzo[a]pyrene-induced Toxicity
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
Problem Substances
:
Benzo(a)pyrene
[+]
Carvacrol prevents the proconvulsant effect of LPS possibly through the inhibition of the COX-2 increased activity.
Jan 11, 2018
Click here to read the entire abstract
Pubmed Data
: Metab Brain Dis. 2018 12 ;33(6):2045-2050. Epub 2018 Sep 18. PMID:
30229386
Article Published Date
: Jan 11, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Carvacrol
Diseases
:
Lipopolysaccharide-Induced Toxicity
,
Seizures
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Chamaecyparis obtusa essential oil has anti-inflammatory and anti-nociceptive effects on arthritis in rats.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Biosci Biotechnol Biochem. 2015 ;80(1):203-9. Epub 2015 Aug 19. PMID:
26581235
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Japanese cypress
Diseases
:
Arthritis
Pharmacological Actions
:
Analgesics
,
Anti-Inflammatory Agents
,
Antinoceceptive
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Essential Oils
[+]
Chemopreventive effects of Eryngium foetidum L. leaves on COX-2 reduction in mice induced colorectal carcinogenesis.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2016 ;68(1):144-53. Epub 2016 Jan 15. PMID:
26771664
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Thistle
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Phytotherapy
[+]
Chinese skullcap (Scutellaria baicalensis) significantly improves functional recovery from spinal cord injury in rats by inhibiting inflammation and oxidative stress after injury.
Aug 01, 2009
Click here to read the entire abstract
Pubmed Data
: J Neurochem. 2009 Aug;110(4):1276-87. Epub 2009 Jun 10. PMID:
19519665
Article Published Date
: Aug 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Chinese Skullcap
Diseases
:
Brain: Microglial Activation
,
Spinal Cord Injuries
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Neuroprotective Agents
,
Nitric Oxide Inhibitor
Additional Keywords
:
Plant Extracts
[+]
Cloudy apple juice potentiates hepatoprotection during experimental liver injury.
Aug 20, 2019
Click here to read the entire abstract
Pubmed Data
: Int J Biol Macromol. 2019 Aug 21 ;140:1006-1017. Epub 2019 Aug 21. PMID:
31445146
Article Published Date
: Aug 20, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Apple
Diseases
:
Chemically-Induced Liver Damage
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Hepatoprotective
[+]
Cocoa may merit further clinical investigation as a chemopreventive agent that helps prevent colitis-associated cancer.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biofactors. 2015 Jan-Feb;41(1):1-14. Epub 2014 Dec 24. PMID:
25545372
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Cocoa
Diseases
:
Colorectal Cancer
,
Colorectal Cancer: Prevention
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Nrf2 activation
[+]
Cocoa polyphenols may inhibit tumor promotion through antioxidant and antiinflammatory mechanisms.
May 01, 2006
Click here to read the entire abstract
Pubmed Data
: J Nutr. 2006 May;136(5):1150-5. PMID:
16614396
Article Published Date
: May 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Flavonoids
,
Polyphenols
Diseases
:
Tumors
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
[+]
Coix lachryma-jobi extract ameliorates inflammation and oxidative stress in a complete Freund's adjuvant-induced rheumatoid arthritis model.
Nov 30, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pharm Biol. 2019 Dec ;57(1):792-798. PMID:
31747811
Article Published Date
: Nov 30, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Adlay
Diseases
:
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Combination of Pelargonium sidoides and Coptis chinensis root inhibits nuclear factor kappa B-mediated inflammatory responses.
Jan 18, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2018 Jan 19 ;18(1):20. Epub 2018 Jan 19. PMID:
29351747
Article Published Date
: Jan 18, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Coptis chinensis
,
Pelargonium sidoides
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Extracts
[+]
Combinational treatment effect of tetrahydrocurcumin and celecoxib on cervical cancer cell-induced tumor growth and tumor angiogenesis.
Jun 30, 2016
Click here to read the entire abstract
Pubmed Data
: J Med Assoc Thai. 2016 Jul ;99 Suppl 4:S23-31. PMID:
29916670
Article Published Date
: Jun 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Tetrahydrocurcumin
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Anti-Angiogenic
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
Compounds present in grape juice could reduce the inflammatory effects induced by experimental colitis.
Feb 28, 2014
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol Pharmacol. 2014 Mar ;37(2):819-27. Epub 2014 Feb 26. PMID:
24637249
Article Published Date
: Feb 28, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Grape
Diseases
:
Colitis
,
DNA damage
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
Cordyceps militaris protected against chronic kidney disease progression.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2019 ;2019:7850863. Epub 2019 Mar 31. PMID:
31049139
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cordyceps Militaris
Diseases
:
Chronic Kidney Disease (CKD)
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
COX2 expression in HPV16-induced lesions may be modulated by nutraceuticals.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Anticancer Res. 2018 03 ;38(3):1461-1466. PMID:
29491072
Article Published Date
: Dec 31, 2017
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Curcumin
,
Rutin
Diseases
:
Human Papillomavirus (HPV)
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
[+]
Crocetin supplementation in the MCA mice also showed protection against cervical cancer.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Res Int. 2015 ;2015:829513. Epub 2015 Mar 22. PMID:
25874230
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Crocetin
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Crocin, a carotenoid fround within Gardenia jasminoides and Crocus sativus (Safron) has significant anti-inflammatory activity.
Sep 23, 2009
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2009 Sep 23;57(18):8325-30. PMID:
19754168
Article Published Date
: Sep 23, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Gardenia
,
Saffron
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Cyclooxygenase Inhibitors
,
Prostaglandin Antagonists
[+]
Curcumin ameliorates doxorubicin-induced cardiotoxicity.
Jan 31, 2018
Click here to read the entire abstract
Pubmed Data
: J Biochem Mol Toxicol. 2018 Feb ;32(2). Epub 2018 Jan 5. PMID:
29315967
Article Published Date
: Jan 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Chemoprotective Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Curcumin ameliorates experimentally induced ulcerative colitis.
Mar 01, 2007
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2007 Mar;7(3):333-42. Epub 2006 Dec 18. PMID:
17276891
Article Published Date
: Mar 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Colitis
,
Ulcerative Colitis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Curcumin attenuated glucose intolerance and insulin resistance through its antioxidant and anti-inflammatory effects.
Dec 19, 2015
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2015 Dec 20. Epub 2015 Dec 20. PMID:
26713546
Article Published Date
: Dec 19, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
C-Reactive Protein
,
Diabetes Mellitus: Type 2
,
Inflammation
,
Insulin Resistance
,
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Malondialdehyde Down-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Curcumin can enhance postsynaptic electrical reactivity and cell viability in intact neural circuits with antidepressant-like effects.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mediators Inflamm. 2017 ;2017:6280925. Epub 2017 Jan 11. PMID:
28167853
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Antidepressive Agents
,
CURCUMIN
,
Cyclooxygenase 2 Inhibitors
,
depression
[+]
Curcumin has therapeutic effects in chemically-induced colitis.
Jun 28, 2006
Click here to read the entire abstract
Pubmed Data
: World J Gastroenterol. 2006 Jun 28;12(24):3848-53. PMID:
16804969
Article Published Date
: Jun 28, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Colitis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Prostaglandin PGE2 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Curcumin inhibits NF-kappaB activation and reduces the severity of experimental fatty liver in mice.
Dec 01, 2003
Click here to read the entire abstract
Pubmed Data
: Mech Ageing Dev. 2003 Dec;124(10-12):1025-34. PMID:
15582125
Article Published Date
: Dec 01, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Fatty Liver
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Enzyme Inhibitors
,
Hepatoprotective
,
NF-kappaB Inhibitor
[+]
Curcumin inhibits prostate cancer tumors.
Dec 01, 2009
Click here to read the entire abstract
Pubmed Data
: Peptides. 2009 Dec;30(12):2357-64. Epub 2009 Sep 20. PMID:
19772879
Article Published Date
: Dec 01, 2009
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats.
Aug 01, 2006
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2006 Aug;6(8):1233-42. Epub 2006 Apr 7. PMID:
16782535
Article Published Date
: Aug 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Colitis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Prostaglandin PGE2 downregulation
[+]
Curcumin may have therapeutic value in colon cancer prevention.
Oct 28, 1999
Click here to read the entire abstract
Pubmed Data
: Oncogene. 1999 Oct 28;18(44):6013-20. PMID:
10557090
Article Published Date
: Oct 28, 1999
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Cyclooxygenase 2 Inhibitors
,
Enzyme Inhibitors
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Curcumin might be useful in the chemoprevention of colorectal cancer in individuals consuming an high-protein diet.
Jul 31, 2015
Click here to read the entire abstract
Pubmed Data
: Nutr Res. 2015 Aug ;35(8):726-35. Epub 2015 Jun 1. PMID:
26094212
Article Published Date
: Jul 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Colorectal Cancer: Prevention
,
Gastrointestinal Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Nitric Oxide Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Curcumin potentiated significant increase in Nrf2 activation. It restored activity of phase-II antioxidant enzymes like GST, GR, NQO1, and tumour suppressor p53 level.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(4):e0124000. Epub 2015 Apr 10. PMID:
25860911
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Liver Cancer
,
Liver Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
MicroRNA modulator
,
Nrf2 activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer.
Dec 01, 2009
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 2009 Dec 1;69(23):8958-66. Epub 2009 Nov 10. PMID:
19903839
Article Published Date
: Dec 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Apoptotic
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Vascular Endothelial Growth Factor A Inhibitor
Additional Keywords
:
Drug Synergy
[+]
Curcumin prevents colon carcinogenesis.
Apr 01, 1999
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 1999 Apr;20(4):641-4. PMID:
10223193
Article Published Date
: Apr 01, 1999
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Colon Cancer
,
Colon Polyps
Pharmacological Actions
:
Anticarcinogenic Agents
,
Cyclooxygenase 2 Inhibitors
,
Enzyme Inhibitors
,
Nitric Oxide Inhibitor
[+]
Curcumin protects against necrotizing enterocolitis in neonatal rats.
Feb 01, 2010
Click here to read the entire abstract
Pubmed Data
: Zhongguo Dang Dai Er Ke Za Zhi. 2010 Feb;12(2):132-6. PMID:
20199731
Article Published Date
: Feb 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Infant Infections
,
Necrotising enterocolitis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Interleukin-10 downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Curcumin reduces oxidative and nitrative DNA damage associated with fluke infection.
Oct 01, 2009
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2009 Oct;53(10):1316-28. PMID:
19753608
Article Published Date
: Oct 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
DNA damage
,
Flukes
,
Oxidative Stress
,
Parasitic Diseases
Pharmacological Actions
:
Antimutagenic Agents
,
Antiparasitic Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
[+]
Curcumin retards the growth of intestinal polyps in a mouse model of familial adenomatous polyposis.
Feb 01, 2006
Click here to read the entire abstract
Pubmed Data
: Eur J Cancer. 2006 Feb;42(3):415-21. Epub 2006 Jan 4. PMID:
16387490
Article Published Date
: Feb 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Familial Adenomatous Polyposis
,
Intestinal Polyps
Pharmacological Actions
:
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
[+]
Curcumin reverses neurochemical, histological and immuno-histochemical alterations in the model of global brain ischemia.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Tradit Complement Med. 2017 Jan ;7(1):14-23. Epub 2016 Feb 11. PMID:
28053883
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Brain Ischemia
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Neuroprotective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Curcumin works synergistically with paclitaxel to inhibit breast cancer cell metastasis to the lung in a mouse model.
Oct 15, 2005
Click here to read the entire abstract
Pubmed Data
: Clin Cancer Res. 2005 Oct 15;11(20):7490-8. PMID:
16243823
Article Published Date
: Oct 15, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Breast Cancer
,
Breast Cancer: Lung Metastasis
,
Lung Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
NF-kappaB Inhibitor
Additional Keywords
:
Drug: Paclitaxel
,
Drug-Plant-Vitamin Synergies
[+]
Cyanidin-3-O-glucoside exerts pulmonary protective effects on CLP-induced ALI rats.
Jun 11, 2015
Click here to read the entire abstract
Pubmed Data
: J Surg Res. 2015 Jun 12. Epub 2015 Jun 12. PMID:
26152793
Article Published Date
: Jun 11, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cyanidin 3-glucoside
Diseases
:
Lung Injury: Acute
,
Sepsis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Malondialdehyde Down-regulation
,
Mitochondrial Superoxide Dismutase Upregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
D-limonene exhibits anti-inflammatory and antioxidant properties in an ulcerative colitis.
Mar 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2017 Apr ;15(4):2339-2346. Epub 2017 Feb 22. PMID:
28260017
Article Published Date
: Mar 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
D-Limonene
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Postaglandin PGE2 downregulation
[+]
D-limonene suppresses doxorubicin-induced oxidative stress and inflammation.
Mar 31, 2014
Click here to read the entire abstract
Pubmed Data
: Exp Biol Med (Maywood). 2014 Apr ;239(4):465-76. Epub 2014 Feb 28. PMID:
24586096
Article Published Date
: Mar 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
D-Limonene
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
,
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Chemoprotective Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Renoprotective
[+]
Daidzein attenuates abdominal aortic aneurysm through NF-κB, p38MAPK and TGF-β1 pathways.
Jun 30, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2016 Jul ;14(1):955-62. Epub 2016 May 18. PMID:
27222119
Article Published Date
: Jun 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Daidzein
,
Isoflavones
Diseases
:
Aneurysm: Aortic
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Demethoxycurcumin may decrease COX-2 expression and improve endothelial function in hypertension.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2016 ;2016:9045736. Epub 2016 Dec 25. PMID:
28105253
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Demethoxycurcumin
Diseases
:
Endothelial Dysfunction
,
Hypertension
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
[+]
Dendrosomal curcumin has a chemoprotective effect on the breast cancer metastasis through suppression of NF-κB and its regulated gene products.
Jul 04, 2015
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2015 Jul 5 ;758:188-96. Epub 2015 Apr 8. PMID:
25863259
Article Published Date
: Jul 04, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Breast Cancer
,
Breast Cancer: Metastatic
Pharmacological Actions
:
Anti-metastatic
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Dietary administration of garcinol effectively reduced the tumor size and incidence in the mouse colon.
Aug 31, 2014
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2014 Sep ;58(9):1820-9. Epub 2014 Jul 1. PMID:
24981158
Article Published Date
: Aug 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Garcinia indica
Diseases
:
Colon Cancer
,
Colon Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Chemopreventive
,
Cyclin D1 Down-Regulation
,
Cyclooxygenase 2 Inhibitors
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice.
May 20, 2011
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2011 May 20. Epub 2011 May 20. PMID:
21621527
Article Published Date
: May 20, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Colitis
,
Colon Cancer
Pharmacological Actions
:
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
[+]
Dietary feeding of grape seed extract prevents intestinal tumorigenesis in mice.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: Neoplasia. 2010 Jan;12(1):95-102. PMID:
20072658
Article Published Date
: Jan 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Grape Seed Extract
Diseases
:
Intestinal Cancer
,
Intestinal Polyps
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
[+]
Dietary flaxseed may be chemopreventive for intestinal and colon tumor development in mice possibly by increasing omega -3 fatty acid levels, lignans, and decreasing COX-1 and COX-2 levels.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2009;61(2):276-83. PMID:
19235044
Article Published Date
: Jan 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Flaxseed
,
Lignans
,
Omega-3 Fatty Acids
Diseases
:
Colon Cancer
,
Intestinal Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Cyclooxygenase 1 Inhibitor
,
Cyclooxygenase 2 Inhibitors
,
Cyclooxygenase Inhibitors
[+]
Dietary flaxseed meal containing high levels of omega-3 fatty acids and lignans is effective in preventing colon tumor development when compared with dietary corn meal possibly by increasing omega-3 fatty acid levels and decreasing COX-1 and COX-2 levels.
Jan 01, 2006
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2006;54(2):216-22. PMID:
16898866
Article Published Date
: Jan 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Flaxseed
,
Lignans
,
Omega-3 Fatty Acids
Diseases
:
Colon Cancer
Pharmacological Actions
:
Cyclooxygenase 1 Inhibitor
,
Cyclooxygenase 2 Inhibitors
[+]
Dietary intake of pterostilbene, a constituent of blueberries, inhibits colon carcinogenesis in rats.
Jul 01, 2010
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2010 Jul;31(7):1272-8. Epub 2010 Jan 8. PMID:
20061362
Article Published Date
: Jul 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Blueberry
,
Pterostilbene
Diseases
:
Colon Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Stilbenes
[+]
Dietary red raspberries attenuate dextran sulfate sodium-induced acute colitis.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2018 01 ;51:40-46. Epub 2017 Sep 14. PMID:
29091813
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Raspberry
Diseases
:
Colitis
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-17 downregulation
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Dietary saturated fatty acids down-regulate cyclooxygenase-2 and tumor necrosis factor alfa and reverse fibrosis in alcohol-induced liver disease in the rat.
Dec 01, 1997
Click here to read the entire abstract
Pubmed Data
: Hepatology. 1997 Dec;26(6):1538-45. PMID:
9397995
Article Published Date
: Dec 01, 1997
Study Type
: Animal Study
Additional Links
Substances
:
Medium Chain Triglycerides
,
Palm Oil
,
Saturated fatty acids
Diseases
:
Alcoholic Liver Disease
,
Liver Fibrosis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Beneficial Saturated Fats
,
Disease Reversal
[+]
Dietary supplementation of resveratrol attenuates chronic colonic inflammation in mice.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: Asia Pac J Clin Nutr. 2010;19(1):142-50. PMID:
20132809
Article Published Date
: Jan 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Resveratrol
,
Stilbenes
Diseases
:
Inflammation
,
Ulcerative Colitis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Nitric Oxide Inhibitor
,
P38 Mitogen-Activated Protein Kinase Modulator
,
Prostaglandin E Synthase-1 (PGES-1) Down-Regulation
[+]
Diosgenin prevented the atherosclerotic disease progression and concomitant suppression of inflammatory mediators in liver and brain.
Feb 28, 2018
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2018 Mar 1 ;196:28-37. Epub 2018 Jan 13. PMID:
29339101
Article Published Date
: Feb 28, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Diosgenin
Diseases
:
Atherosclerosis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Diosmin protects against ethanol-induced hepatic injury.
Feb 28, 2013
Click here to read the entire abstract
Pubmed Data
: Alcohol. 2013 Mar ;47(2):131-9. PMID:
23419394
Article Published Date
: Feb 28, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Diosmin
Diseases
:
Alcohol Toxicity
,
Alcoholic Liver Disease
,
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Hepatoprotective
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Effects of apple polyphenols on monocrotaline-induced pulmonary vascular remodeling in rats and its mechanism.
May 27, 2019
Click here to read the entire abstract
Pubmed Data
: Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2019 May 28 ;35(3):209-214. PMID:
31257800
Article Published Date
: May 27, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Apple Polyphenols
Diseases
:
Hypertension: Pulmonary
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Electroacupuncture was an effective analgesic and anti-inflammatory.
Oct 23, 2016
Click here to read the entire abstract
Pubmed Data
: Chin J Integr Med. 2016 Oct 24. Epub 2016 Aug 24. PMID:
27778263
Article Published Date
: Oct 23, 2016
Study Type
: Animal Study
Additional Links
Diseases
:
Neuropathic Pain
Therapeutic Actions
:
Electroacupuncture
Pharmacological Actions
:
Analgesics
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Ellagic acid exhibited a potent anti-inflammatory effect against carrageenan-induced inflammation.
Mar 31, 2014
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2014 Apr ;19(2):290-9. Epub 2014 Feb 15. PMID:
24534771
Article Published Date
: Mar 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Ellagic Acid
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Malondialdehyde Down-regulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Essential oils extracted from Chamaecyparis obtusa may be considered an effective therapeutic agent for the treatment of inflammatory diseases.
Mar 31, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2016 Apr ;13(4):3335-41. Epub 2016 Feb 18. PMID:
26936418
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Japanese cypress
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Nitric Oxide Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Essential Oils
[+]
Evening primrose oil ameliorates platelet aggregation and improves cardiac recovery in myocardial-infarct hypercholesterolemic rats.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Physiol Pathophysiol Pharmacol. 2014 ;6(1):23-36. Epub 2014 Mar 13. PMID:
24665356
Article Published Date
: Dec 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Evening Primrose Oil
Diseases
:
Myocardial Infarction
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cardioprotective
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Extracts of R. officinalis and rosmarinic acid through modulating neuro-inflammation might be potential candidates in treating neuropathic pain.
Dec 21, 2016
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2016 Dec 22 ;86:441-449. Epub 2016 Dec 22. PMID:
28012923
Article Published Date
: Dec 21, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Rosemary
,
Rosmarinic acid
Diseases
:
Brain Inflammation
,
Neuropathic Pain
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Nitric Oxide Inhibitor
,
Prostaglandin PGE2 downregulation
Additional Keywords
:
Plant Extracts
[+]
Fermented brown rice and rice bran have a chemopreventive effect on inflammation-related colorectal carcinogenesis in mice.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2010 Jan;23(1):53-9. PMID:
19956864
Article Published Date
: Jan 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Brown Rice
,
Fermented Foods and Beverages
,
Rice Bran
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Fermented C. longa might be a useful material for preventing impairment of learning and memory.
Jul 16, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2017 Jul 17 ;17(1):367. Epub 2017 Jul 17. PMID:
28716085
Article Published Date
: Jul 16, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Turmeric: Fermented
Diseases
:
Cognitive Decline/Dysfunction
,
Memory Disorders
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Neuroprotective Agents
,
Nitric Oxide Inhibitor
,
Postaglandin PGE2 downregulation
[+]
Fisetin can be considered as a potential cardioprotective agent during the management of carcinoma using doxorubicin anthracyclines.
Oct 24, 2018
Click here to read the entire abstract
Pubmed Data
: Mol Biol Rep. 2018 Oct 25. Epub 2018 Oct 25. PMID:
30362071
Article Published Date
: Oct 24, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Fisetin
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Chemoprotective Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Fisetin improved the hippocampal-dependent synaptic and memory functions in LPS-treated adult mice.
Jun 13, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Clin Med. 2019 Jun 14 ;8(6). Epub 2019 Jun 14. PMID:
31207963
Article Published Date
: Jun 13, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Fisetin
Diseases
:
Brain: Oxidative Stress
,
Lipopolysaccharide-Induced Toxicity
,
Memory Disorders
,
Neurodegenerative Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Neuroprotective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Fisetin may be a potential agent in the treatment of osteoarthritis.
Feb 13, 2017
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2017 Feb 14 ;45:135-147. Epub 2017 Feb 14. PMID:
28213268
Article Published Date
: Feb 13, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Fisetin
Diseases
:
Osteoarthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Matrix Metalloproteinase-13 (MMP-13) Inhibitor
,
Matrix metalloproteinase-3 (MMP-3) inhibitor
,
Prostaglandin PGE2 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Formononetin mediates the promising anti-traumatic brain injury effects against neurocyte damage.
Mar 14, 2014
Click here to read the entire abstract
Pubmed Data
: J Neurol Sci. 2014 Mar 15 ;338(1-2):112-7. Epub 2013 Dec 27. PMID:
24411660
Article Published Date
: Mar 14, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Formononetin
Diseases
:
Brain Injury: Traumatic
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Malondialdehyde Down-regulation
,
Neuroprotective Agents
,
Superoxide Dismutase Up-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Fucoidan exhibits a gastro-protective effect against aspirin-induced ulceration in rats.
Jan 31, 2011
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2011 Feb ;11(2):157-63. Epub 2010 Nov 26. PMID:
21084063
Article Published Date
: Jan 31, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Fucoidan
Diseases
:
Aspirin-Induced Toxicity
,
Gastric Ulcer
Pharmacological Actions
:
Anti-Ulcer Agents
,
Cyclooxygenase 1 Inhibitor
,
Cyclooxygenase 2 Inhibitors
,
Epidermal growth factor receptor (EGFR) inhibitor
Problem Substances
:
Aspirin
Adverse Pharmacological Actions
:
Ulcerogenic
[+]
Fucoxanthin could be a novel adjuvant for preventing exacerbations associated with skin inflammation as well as protecting skin against UV radiation.
Oct 09, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mar Drugs. 2018 Oct 10 ;16(10). Epub 2018 Oct 10. PMID:
30308980
Article Published Date
: Oct 09, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Fucoxanthin
Diseases
:
Erythema
,
Ultraviolet Radiation Induced Damage
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Heme oxygenase-1 up-regulation
,
Interleukin-6 Downregulation
,
Nrf2 activation
,
Photoprotective
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Fucoxanthin may have therapeutic potential as a treatment for patients with inflammatory diseases.
Sep 28, 2015
Click here to read the entire abstract
Pubmed Data
: J Biochem Mol Toxicol. 2015 Sep 29. Epub 2015 Sep 29. PMID:
26418808
Article Published Date
: Sep 28, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Fucoxanthin
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
[+]
Fucoxanthin prevents lipopolysaccharide-induced depressive-like behavior in mice.
Dec 14, 2018
Click here to read the entire abstract
Pubmed Data
: Metab Brain Dis. 2018 Dec 15. Epub 2018 Dec 15. PMID:
30554399
Article Published Date
: Dec 14, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Fucoxanthin
Diseases
:
Depression
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Gastrodin ameliorates subacute phase cerebral ischemia‑reperfusion injury by inhibiting inflammation and apoptosis.
Oct 31, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2016 Nov ;14(5):4144-4152. Epub 2016 Sep 26. PMID:
27748849
Article Published Date
: Oct 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Gastrodin
Diseases
:
Brain Ischemia
,
Inflammation
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
[+]
Genipin inhibits allergic responses in ovalbumin-induced asthmatic mice.
Nov 30, 2017
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2017 Dec ;53:49-55. Epub 2017 Oct 15. PMID:
29035815
Article Published Date
: Nov 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Genipin
Diseases
:
Asthma
Pharmacological Actions
:
Anti-Asthmatic Agents
,
Cyclooxygenase 2 Inhibitors
,
interleukin-13 down-regulation
,
Interleukin-5 downregulation
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Geniposide and genipin have a healthy promotion to eradicate H. pylori infections.
Nov 30, 2017
Click here to read the entire abstract
Pubmed Data
: J Food Sci. 2017 Dec ;82(12):3021-3028. Epub 2017 Nov 14. PMID:
29135040
Article Published Date
: Nov 30, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Genipin
Diseases
:
Helicobacter Pylori Infection
Pharmacological Actions
:
Anti-Bacterial Agents
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interferon Gamma Reducer
,
Interleukin-1 beta downregulation
[+]
Geraniol attenuates 4NQO-induced tongue carcinogenesis through downregulating the activation of NF-κB in rats.
Sep 30, 2017
Click here to read the entire abstract
Pubmed Data
: Mol Cell Biochem. 2017 Oct ;434(1-2):7-15. Epub 2017 Apr 10. PMID:
28397014
Article Published Date
: Sep 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Geraniol
Diseases
:
Tongue Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Geraniol could be a powerful treatment of intestinal inflammation and dysbiosis.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2016 ;7:38. Epub 2016 Mar 3. PMID:
26973525
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Geraniol
Diseases
:
Colitis
,
Dysbiosis
,
Gastrointestinal Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Germinated brown rice can be a promising dietary supplement in prevention of colon cancer.
Mar 25, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutr J. 2010 Mar 26 ;9:16. Epub 2010 Mar 26. PMID:
20346115
Article Published Date
: Mar 25, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Brown Rice
Diseases
:
Colon Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Ginger inhibits micoglial cell activiation associated with brain inflammation.
Jun 01, 2009
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2009 Jun;47(6):1190-7. Epub 2009 Feb 20. PMID:
19233241
Article Published Date
: Jun 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Ginger
Diseases
:
Brain: Microglial Activation
,
Brain Inflammation
,
Inflammation
,
Lipopolysaccharide-Induced Toxicity
,
Neurodegenerative Diseases
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Nitric Oxide Inhibitor
,
Prostaglandin Antagonists
[+]
Gingerol could protect against experimental liver fibrosis in rats.
Jan 25, 2016
Click here to read the entire abstract
Pubmed Data
: Naunyn Schmiedebergs Arch Pharmacol. 2016 Jan 26. Epub 2016 Jan 26. PMID:
26809353
Article Published Date
: Jan 25, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Gingerol
Diseases
:
Chemically-Induced Liver Damage
,
Liver Fibrosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Hepatoprotective
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Ginkgetin may be beneficial against chronic skin inflammatory disorders like atopic dermatitis.
Apr 30, 2006
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biol Pharm Bull. 2006 May ;29(5):1046-9. PMID:
16651744
Article Published Date
: Apr 30, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Ginkgo biloba
Diseases
:
Atopic Dermatitis
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
[+]
Ginkgo biloba extract anti-inflammatory properties and ameliorates colitis in mice.
Sep 01, 2008
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2008 Sep;29(9):1799-806. Epub 2008 Jun 20. PMID:
18567620
Article Published Date
: Sep 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Ginkgo biloba
Diseases
:
Colitis
,
Inflammation
Pharmacological Actions
:
Antioxidants
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Plant Extracts
[+]
Ginkgo biloba extract protects against aging-associated mitochondrial dysfunction in platelets and hippocampi of mice.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: Platelets. 2010;21(5):373-9. PMID:
20459350
Article Published Date
: Jan 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Ginkgo biloba
Diseases
:
Aging
,
Aging: Brain
,
Mitochondrial Dysfunction
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Neuroprotective Agents
Additional Keywords
:
Plant Extracts
[+]
Ginsenoside metabolite compound K exerts anti-inflammatory and analgesic effects via downregulating COX2.
Jan 31, 2019
Click here to read the entire abstract
Pubmed Data
: Inflammopharmacology. 2019 Feb ;27(1):157-166. Epub 2018 Jun 26. PMID:
29946770
Article Published Date
: Jan 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Inflammation
Pharmacological Actions
:
Analgesics
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Postaglandin PGE2 downregulation
[+]
Ginsenoside Rd inhibits the expressions of iNOS and COX-2 by suppressing NF-κB.
Feb 28, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Ginseng Res. 2013 Mar ;37(1):54-63. PMID:
23717157
Article Published Date
: Feb 28, 2013
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
[+]
Ginsenoside Rg1 might be an effective approach for the prevention against acute liver injury.
Jul 01, 2018
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol. 2018 Jul 2. Epub 2018 Jul 2. PMID:
29964319
Article Published Date
: Jul 01, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Chemically-Induced Liver Damage
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Hepatoprotective
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Nrf2 activation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Ginsenoside Rg3 alleviates lipopolysaccharide-induced learning and memory impairments.
Sep 29, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomol Ther (Seoul). 2013 Sep 30 ;21(5):381-90. PMID:
24244826
Article Published Date
: Sep 29, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Brain Inflammation
,
Lipopolysaccharide-Induced Toxicity
,
Memory Disorders
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Neuroprotective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Ginsenoside Rg3 attenuates microglia activation following systemic lipopolysaccharide treatment in mice.
Dec 31, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biol Pharm Bull. 2012 ;35(9):1546-52. PMID:
22975507
Article Published Date
: Dec 31, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Brain: Microglial Activation
,
Brain Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
Ginsenoside Rh3 metabolized from ginsenoside Rg5 may improve chronic dermatitis or psoriasis.
Jul 31, 2006
Click here to read the entire abstract
Pubmed Data
: Arch Pharm Res. 2006 Aug ;29(8):685-90. PMID:
16964764
Article Published Date
: Jul 31, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Dermatitis
,
Psoriasis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Ginsenosides from the leaves of Panax quinquefolius ameliorated acetaminophen-induced hepatotoxicity in mice.
May 09, 2017
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2017 May 10 ;65(18):3684-3692. Epub 2017 Apr 25. PMID:
28429935
Article Published Date
: May 09, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Acetaminophen (Tylenol) Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Hepatoprotective
,
Malondialdehyde Down-regulation
Problem Substances
:
Acetaminophen
,
Paracetamol
[+]
Grape juice concentrate is able to exert some chemopreventive activity on rat colon carcinogenesis.
Oct 31, 2015
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol Pharmacol. 2015 Nov ;40(3):870-5. Epub 2015 Sep 28. PMID:
26492449
Article Published Date
: Oct 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Grape
Diseases
:
Colon Cancer
Pharmacological Actions
:
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Plant Extracts
[+]
Grape stem extract reduces UVB-induced oxidative damage and hence can play a protective role in skin photo-damage.
Jul 31, 2017
Click here to read the entire abstract
Pubmed Data
: J Photochem Photobiol B. 2017 Aug ;173:551-559. Epub 2017 Jun 29. PMID:
28697472
Article Published Date
: Jul 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Grape
Diseases
:
Ultraviolet Radiation Induced Damage
Pharmacological Actions
:
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Heme oxygenase-1 inducer
,
Malondialdehyde Down-regulation
,
Nrf2 activation
,
Photoprotective
Additional Keywords
:
Plant Extracts
[+]
Graviola possesses analgesic effects through interaction with opioidergic pathway and anti-inflammatory properties through inhibition of chemical mediators of inflammation.
Nov 30, 2014
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2014 Dec ;17(12):1375-82. PMID:
25133801
Article Published Date
: Nov 30, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Graviola
Diseases
:
Arthritis
,
Rheumatism
Pharmacological Actions
:
Analgesics
,
Anti-Inflammatory Agents
,
Cyclooxygenase 1 Inhibitor
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Natural Substances Versus Drugs
Problem Substances
:
Carrageenan
[+]
Hesperidin may be a promising modulator in preventing renal cancer.
Aug 10, 2018
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol. 2018 Aug 11. Epub 2018 Aug 11. PMID:
30098279
Article Published Date
: Aug 10, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Hesperidin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Postaglandin PGE2 downregulation
,
Vascular Endothelial Growth Factor Regulator
[+]
Hesperidin protects against stress induced gastric ulcer.
Jun 22, 2018
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2018 Jun 23 ;291:153-161. Epub 2018 Jun 23. PMID:
29944876
Article Published Date
: Jun 22, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Hesperidin
Diseases
:
Diabetic Ulcer
,
Gastric Ulcer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anti-Ulcer Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Nrf2 activation
Additional Keywords
:
Natural Substances Versus Drugs
[+]
Hispolon could be useful in the treatment of breast cancers or other gynecologic diseases.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Int J Med Mushrooms. 2017 ;19(3):233-242. PMID:
28605338
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Medicinal Mushrooms
Diseases
:
Breast Cancer
Pharmacological Actions
:
Aromatase Inhibitors
,
Cyclooxygenase 2 Inhibitors
[+]
Honey protects against cisplatin-induced hepatic and renal toxicity.
Jun 12, 2018
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2018 Jun 13. Epub 2018 Jun 13. PMID:
29897076
Article Published Date
: Jun 12, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Honey
,
Manuka Honey
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions
:
Chemoprotective Agents
,
Cyclooxygenase 2 Inhibitors
,
Hepatoprotective
,
NF-kappaB Inhibitor
,
Renoprotective
[+]
Honokiol alleviates the degeneration of intervertebral disc.
May 19, 2018
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2018 May 20 ;120:368-379. Epub 2018 Apr 9. PMID:
29649568
Article Published Date
: May 19, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Honokiol
Diseases
:
Degenerative Disk Disease
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Matrix Metalloproteinase-13 (MMP-13) Inhibitor
,
Matrix metalloproteinase-3 (MMP-3) inhibitor
,
NF-kappaB Inhibitor
[+]
Honokiol has the ability to inhibit UVB-induced immunosuppression in preclinical model.
May 09, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2017 May 10 ;7(1):1657. Epub 2017 May 10. PMID:
28490739
Article Published Date
: May 09, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Honokiol
Diseases
:
Skin Cancer: Prevention
,
Ultraviolet Radiation Induced Damage
Pharmacological Actions
:
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Immunomodulatory
,
Postaglandin PGE2 downregulation
[+]
Hops (H. lupulus) has anti-inflammatory activity in a mouse model of athritis.
Jul 16, 1996
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 1996 Jul 16;224(2):358-61. PMID:
16534727
Article Published Date
: Jul 16, 1996
Study Type
: Animal Study
Additional Links
Substances
:
Hops
Diseases
:
Arthritis
,
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Postaglandin PGE2 downregulation
Additional Keywords
:
Plant Extracts
[+]
Hydrogen rich water pre-treatment alleviated the aspirin-induced gastric lesions.
Feb 13, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: World J Gastroenterol. 2014 Feb 14 ;20(6):1614-22. PMID:
24587639
Article Published Date
: Feb 13, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Hydrogen Water
Diseases
:
Aspirin-Induced Toxicity
,
Gastrointestinal Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Gastroprotective
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Malondialdehyde Down-regulation
,
Superoxide Dismutase Up-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances
:
Aspirin
[+]
Hydroxytyrosol represents an interesting molecule for the development of new nutraceuticals and functional food useful in chronic diseases prevention.
Dec 04, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2018 Dec 5 ;23(12). Epub 2018 Dec 5. PMID:
30563131
Article Published Date
: Dec 04, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Hydroxytyrosol
Diseases
:
DNA damage
,
Inflammation
,
Lipopolysaccharide-Induced Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Indole-3-carbinol enhances the sensitivity of murine breast adenocarcinoma cells to doxorubicin.
Jun 24, 2018
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2018 Jun 25 ;290:19-36. Epub 2018 May 15. PMID:
29775573
Article Published Date
: Jun 24, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Breast Cancer
,
Oxidative Stress
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Anti-Inflammatory Agents
,
Antioxidants
,
Apoptotic
,
Chemosensitizer
,
Cyclooxygenase 2 Inhibitors
,
Heme oxygenase-1 up-regulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Nrf2 activation
Additional Keywords
:
Chemotherapeutic Synergy: Doxorubicin
[+]
Inflammation and kidney injury attenuated by prior intake of Brazil nuts in the process of ischemia and reperfusion.
Sep 30, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Bras Nefrol. 2018 Oct-Dec;40(4):312-318. Epub 2018 Aug 16. PMID:
30118536
Article Published Date
: Sep 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Brazil nut
Diseases
:
Inflammation
,
Ischemia
,
Kidney Damage
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Renoprotective
,
Transforming growth factor beta (TGF-β) inhibitor
Additional Keywords
:
Phytotherapy
[+]
Influence of ferulic acid consumption in ameliorating the cadmium-induced liver and renal oxidative damage in rats.
Jun 30, 2019
Click here to read the entire abstract
Pubmed Data
: Environ Sci Pollut Res Int. 2019 Jul ;26(20):20631-20653. Epub 2019 May 18. PMID:
31104231
Article Published Date
: Jun 30, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Ferulic acid
Diseases
:
Chemically-Induced Liver Damage
,
Inflammation
,
Kidney Damage: Chemically-Induced
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Hepatoprotective
,
Renoprotective
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Inhibitory effect of carnosol on phthalic anhydride-induced atopic dermatitis via inhibition of STAT3.
Aug 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomol Ther (Seoul). 2017 Sep 1 ;25(5):535-544. PMID:
28655070
Article Published Date
: Aug 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Carnosol
Diseases
:
Atopic Dermatitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
STAT3 Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Intragastric administration of curcumin inhibited the experimentally induced murine colitis.
Feb 28, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Cancer Prev. 2018 Mar ;23(1):18-24. Epub 2018 Mar 30. PMID:
29629345
Article Published Date
: Feb 28, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
STAT3 Inhibitor
[+]
Isoliquiritigenin has a protective effect against carbon tetrachloride-induced liver damage.
Jan 04, 2015
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2015 Jan 5 ;225:13-20. Epub 2014 Nov 6. PMID:
25450236
Article Published Date
: Jan 04, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Isoliquiritigenin
Diseases
:
Chemically-Induced Liver Damage
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Enzyme Inhibitors
,
Hepatoprotective
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Isoquercitrin may be effective in the prevention of acute colitis.
Nov 30, 2016
Click here to read the entire abstract
Pubmed Data
: Pharmacol Rep. 2016 Dec ;68(6):1197-1204. Epub 2016 Sep 19. PMID:
27657482
Article Published Date
: Nov 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Isoquercitrin
Diseases
:
Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Korean Red Ginseng extracts exhibited anti-inflammatory effects by ameliorating the symptoms of gastric ulcer in a gastritis mouse model.
Sep 30, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Ginseng Res. 2016 Oct ;40(4):437-444. Epub 2016 Aug 24. PMID:
27746698
Article Published Date
: Sep 30, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ginseng (Korean)
Diseases
:
Gastric Ulcer
,
Gastritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Gastrointestinal Agents
,
Gastroprotective
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Lactobacillus fermentum HY01 had significant preventive effects in dextran sulfate sodium induced-colitis.
May 24, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2017 May 25 ;9(6). Epub 2017 May 25. PMID:
28587089
Article Published Date
: May 24, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Lactobacillus fermentum
Diseases
:
Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interferon Gamma Reducer
,
Interleukin-12 downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Lactobacillus fermentum IM12 attenuates inflammation in mice.
May 29, 2017
Click here to read the entire abstract
Pubmed Data
: Benef Microbes. 2017 May 30 ;8(3):407-419. Epub 2017 May 15. PMID:
28504577
Article Published Date
: May 29, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Lactobacillus fermentum
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
[+]
Lactobacillus paracasei GMNL-32 exerts a therapeutic effect on cardiac abnormalities in mice.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2017 ;12(9):e0185098. Epub 2017 Sep 21. PMID:
28934296
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Lactobacillus paracasei
Diseases
:
Cardiovascular Disease
,
Lupus Erythematosus: Systemic
Pharmacological Actions
:
Anti-Apoptotic
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
LED therapy provides an analgesic effect and modifies the expression of COX-2, PGE2, and proinflammatory cytokines in incised skin.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pain Res Manag. 2017 ;2017:4792489. Epub 2017 Apr 2. PMID:
28469528
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Diseases
:
Wound Healing
Therapeutic Actions
:
Light-Emitting Diodes (LEDs) Therapy
Pharmacological Actions
:
Analgesics
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Postaglandin PGE2 downregulation
[+]
Lion's mane has antitumor effects in tumor-bearing mice.
Sep 28, 2011
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2011 Sep 28 ;59(18):9861-9. Epub 2011 Aug 25. PMID:
21846141
Article Published Date
: Sep 28, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Lion's Mane (Hericium Erinaceus)
Diseases
:
Colon Cancer
,
Low Immune Function: Natural Killer Cells
,
Tumors
Pharmacological Actions
:
5-Lipoxygenase Inhibitor
,
Anti-Angiogenic
,
Antineoplastic Agents
,
Cyclooxygenase 2 Inhibitors
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Liver injury induced by carbon tetrachloride in mice is prevented by the antioxidant capacity of white tea polyphenols.
Mar 13, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Antioxidants (Basel). 2019 Mar 14 ;8(3). Epub 2019 Mar 14. PMID:
30875793
Article Published Date
: Mar 13, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Polyphenols
,
White Tea
Diseases
:
Chemically-Induced Liver Damage
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Hepatoprotective
,
Interleukin-1 beta downregulation
[+]
Lupeol acetate significantly improves the symptoms of RA by down-regulating expressions of inflammatory cytokines and osteoclastogenesis.
Mar 31, 2016
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2016 Apr ;79:231-40. Epub 2016 Mar 11. PMID:
27044833
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Lupeol
Diseases
:
Arthritis
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Dose Response
[+]
L‑carnitine ameliorated liver inflammation and serum pro‑inflammatory markers in cancer cachexia.
Dec 03, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2015 Dec 4. Epub 2015 Dec 4. PMID:
26647854
Article Published Date
: Dec 03, 2015
Study Type
: Animal Study
Additional Links
Substances
:
L-Carnitine
Diseases
:
Cachexia: Cancer
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Prostaglandin PGE2 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
M. oleifera containing Vicenin-2 active compound may accelerate wound healing in hyperglycemic conditions.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Drug Des Devel Ther. 2016 ;10:1715-30. Epub 2016 May 24. PMID:
27307703
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Moringa oleifera
Diseases
:
Diabetic Complications
,
Wound Healing: Delayed
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Mangiferin is potent anti-inflammatory compound that reduces inflammation.
Feb 19, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2017 Feb 20 ;7:42683. Epub 2017 Feb 20. PMID:
28218280
Article Published Date
: Feb 19, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Mangiferin
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Melatonin and pycnogenol have a therapeutic role in the treatment fo endothelial dysfunction.
Aug 01, 2003
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2003 Aug;12(2):269-73. PMID:
20421515
Article Published Date
: Aug 01, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Flavonoids
,
Melatonin
Diseases
:
Endothelial Dysfunction
,
Hypertension
Pharmacological Actions
:
Antihypertensive Agents
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Melatonin causes regression and atrophy of the endometriotic lesions in rats.
Apr 01, 2008
Click here to read the entire abstract
Pubmed Data
: Fertil Steril. 2008 Apr;89(4):934-42. Epub 2007 Jun 19. PMID:
17582405
Article Published Date
: Apr 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Endometriosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
[+]
Molecular characterization of the grape seeds extract's effect against chemically induced liver cancer.
Jan 18, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2018 Jan 19 ;8(1):1270. Epub 2018 Jan 19. PMID:
29352129
Article Published Date
: Jan 18, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Grape Seed Extract
Diseases
:
Liver Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Antiproliferative
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
[+]
Morinda citrifolia leaf was more effective than the erlotinib in suppressing lung adenocarcinoma in mice.
Jan 13, 2016
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2016 Jan 14. Epub 2016 Jan 14. PMID:
26765787
Article Published Date
: Jan 13, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Noni
,
Noni leaf extract
Diseases
:
Carcinoma: Non-Small-Cell Lung
,
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Cyclooxygenase 2 Inhibitors
,
Epidermal growth factor receptor (EGFR) inhibitor
,
Immunomodulatory
Additional Keywords
:
Dose Response
,
Superiority of Natural Substances versus Drugs
[+]
Mulberry fruit suppressed the development of intestinal inflammation and tumorgenesis both in vitro and in vivo.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2015 ;5:17348. Epub 2015 Nov 30. PMID:
26615818
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Mulberry
Diseases
:
Colitis
,
Colorectal Cancer: Prevention
,
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
[+]
Myricetin has protective cardiovascular effects against ischemia/reperfusion-induced myocardial injury.
Aug 01, 2016
Click here to read the entire abstract
Pubmed Data
: Cardiovasc Toxicol. 2016 Aug 2. Epub 2016 Aug 2. PMID:
27484498
Article Published Date
: Aug 01, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Myricetin
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Antioxidants
,
Cardioprotective
,
Cyclooxygenase 2 Inhibitors
,
Malondialdehyde Down-regulation
[+]
Nano-gold displayed anti-inflammatory properties.
Mar 18, 2018
Click here to read the entire abstract
Pubmed Data
: Artif Cells Nanomed Biotechnol. 2018 Mar 19:1-10. Epub 2018 Mar 19. PMID:
29553845
Article Published Date
: Mar 18, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Gold (nanoparticles)
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
[+]
Naringenin ameliorates learning and memory impairment following systemic lipopolysaccharide challenge.
Mar 04, 2018
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2018 Mar 5. Epub 2018 Mar 5. PMID:
29518393
Article Published Date
: Mar 04, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Naringenin
Diseases
:
Lipopolysaccharide-Induced Toxicity
,
Memory Disorders
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Neuroprotective Agents
,
NF-kappaB Inhibitor
,
Nrf2 activation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Anti-Inflammatory Agents
,
Lipopolysaccharide-Induced Toxicity
,
Memory Disorders
,
Naringenin
[+]
Naringenin suppresses the development of precancerous lesions via controlling hyperproliferation and inflammation in the colon.
Jan 17, 2018
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol. 2018 Jan 18. Epub 2018 Jan 18. PMID:
29345053
Article Published Date
: Jan 17, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Naringenin
Diseases
:
Colon Cancer: Prevention
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
Additional Keywords
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Colon Cancer: Prevention
,
Naringenin
[+]
Naringin protects against cyclophosphamide-induced hepatotoxicity and nephrotoxicity.
May 14, 2018
Click here to read the entire abstract
Pubmed Data
: Environ Sci Pollut Res Int. 2018 May 15. Epub 2018 May 15. PMID:
29766429
Article Published Date
: May 14, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Citrus naringin
Diseases
:
Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Chemoprotective Agents
,
Cyclooxygenase 2 Inhibitors
,
Hepatoprotective
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Renoprotective
[+]
Naringin protects against the liver damage caused by streptozotocin-induced diabetes.
Aug 31, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 Sep ;105:95-102. Epub 2018 May 28. PMID:
29852394
Article Published Date
: Aug 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Citrus naringin
Diseases
:
Diabetes Mellitus: Type 1: Prevention
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Hepatoprotective
,
Interleukin-6 Downregulation
[+]
Neferine ameliorates dextran sulfate sodium-induced ulcerative colitis.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Am J Chin Med. 2018 ;46(6):1263-1279. Epub 2018 Aug 27. PMID:
30149754
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Lotus
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Phytotherapy
[+]
Nexrutine could be useful candidate agent for colon cancer chemoprevention and treatment.
Jul 31, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Carcinog. 2016 Aug ;55(8):1262-74. Epub 2015 Aug 10. PMID:
26259065
Article Published Date
: Jul 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Nexrutine (Phellodendrom)
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
[+]
Nobiletin may serve as a potential approach to alleviate neuroinflammation-related diseases.
May 07, 2019
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2019 May 8 ;67(18):5122-5134. Epub 2019 Apr 24. PMID:
30995031
Article Published Date
: May 07, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Nobiletin
Diseases
:
Brain Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Nobiletin restored intestinal barrier function, which had been damaged after TNBS administration, through the inhibition of the Akt-NF-κB-MLCK pathway.
Apr 30, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2015 May ;59(5):829-42. Epub 2015 Mar 16. PMID:
25655748
Article Published Date
: Apr 30, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Citrus Peel
,
Nobiletin
Diseases
:
Colitis
,
Inflammation
,
Intestinal Permeability
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Noni, and its major bioactive component damnacanthal, exhibits anti-inflammatory properties.
Nov 01, 2011
Click here to read the entire abstract
Pubmed Data
: Inflamm Allergy Drug Targets. 2011 Nov 1. Epub 2011 Nov 1. PMID:
21999179
Article Published Date
: Nov 01, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Damnacanthal
,
Noni
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Nitric Oxide Inhibitor
[+]
Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Food Nutr Res. 2016 ;60:30849. Epub 2016 Apr 26. PMID:
27121041
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Nutmeg
Diseases
:
Allodynia
,
Chronic Pain
,
Inflammation
Pharmacological Actions
:
Analgesics
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Superiority of Natural Substances versus Drugs
Problem Substances
:
Diclofenac
[+]
Oleuropein has anti-inflammatory, analgesic and sedative effects both in vitro and in vivo.
Jan 30, 2019
Click here to read the entire abstract
Pubmed Data
: Cell Mol Biol (Noisy-le-grand). 2019 Jan 31 ;65(1):52-55. Epub 2019 Jan 31. PMID:
30782294
Article Published Date
: Jan 30, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Oleuropein
,
Olive
Diseases
:
Inflammation
,
Insomnia
Pharmacological Actions
:
Analgesics
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Hypnotics and Sedatives
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Oligonol ameliorates carbon tetrachloride induced liver injury in rats.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2016 ;2016:3935841. Epub 2015 Dec 21. PMID:
26798422
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Lychee
Diseases
:
Chemically-Induced Liver Damage
,
Lipid Peroxidation
Pharmacological Actions
:
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Hepatoprotective
,
Interleukin-1 beta downregulation
,
Malondialdehyde Down-regulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Extracts
[+]
Oligonol is effective in protecting against DSS-induced mouse colitis and colon carcinogenesis.
Jul 09, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Antioxid Redox Signal. 2013 Jul 10 ;19(2):102-14. Epub 2013 May 15. PMID:
23394584
Article Published Date
: Jul 09, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Lychee
Diseases
:
Colitis
,
Colon Cancer
,
Inflammation
,
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Colitis
,
COLON CANCER
,
Inflammation
,
Lipid Peroxidation
,
Lychee
,
oxidative stress
[+]
Olive leaf methanolic extract prevents ethanol-induced gastritis.
Jun 30, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Jul ;91:338-349. Epub 2017 May 2. PMID:
28463797
Article