Tumor Microenvironment

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2 Problem Substances Researched for Tumor Microenvironment

Name	AC	CK	Focus
Ethanol	1	1
Phthalates	1	1

23 Diseases Researched for Tumor Microenvironment

Name	AC	CK
Breast Cancer	4	10
Breast Cancer: Metastatic	2	7
Breast Cancer Stem Cells	2	6
Ovarian Cancer	3	5
Lung Cancer	3	4
Cancers: All	3	3
Inflammation	2	3
Cancer Stem Cells	2	2
Colon Cancer	1	2
Colon Cancer: Prevention	1	2
Colorectal Cancer	2	2
Glioblastoma	1	2
High Fat Diet	1	2
Hypoxia	2	2
Liver Cancer	2	2
Lung Cancer: Metastatic	1	2
Obesity	1	2
Prostate Cancer	1	2
Cancer Metastasis	1	1
Cancers: Drug Resistant	1	1
Liver Cancer Stem Cells	1	1
Ovarian Cancer Stem Cell	1	1
Pancreatic Cancer	1	1

2 Problematic Actions Researched for Tumor Microenvironment

Name	AC	CK	Focus
Hypoxia	2	2
Surgical Procedures	1	1

1 Adverse Pharmacological Actions Researched for Tumor Microenvironment

Name	AC	CK	Focus
Cancer Stemness Inducer	2	2

18 Substances Researched for Tumor Microenvironment

Name	AC	CK
Curcumin	4	5
Genistein	3	5
Amla Fruit	1	2
Flaxseed	1	2
Tomato	1	2
Wogonin	1	2
Antrodia camphorata	1	1
Berberine	1	1
Beta-glucan	1	1
EGCG (Epigallocatechin gallate)	1	1
NAC (N-acetyl-L-cysteine)	1	1
Naringenin	1	1
Piperine	1	1
Prunella vulgaris.	1	1
Reishi Mushroom	1	1
Resveratrol	1	1
Tocotrienols	1	1
Vitamin E	1	1

1 Therapeutic Actions Researched for Tumor Microenvironment

Name	AC	CK	Focus
Exercise	1	2

24 Pharmacological Actions Researched for Tumor Microenvironment

Name	AC	CK
Anti-metastatic	8	15
Antiproliferative	8	12
Anti-Inflammatory Agents	5	7
NF-kappaB Inhibitor	2	7
Chemopreventive	2	4
Immunomodulatory	2	3
Interleukin-6 Downregulation	2	3
Vascular Endothelial Growth Factor Inhibitors	2	3
Anti-Angiogenic	1	2
Anticarcinogenic Agents	1	2
Apoptotic	2	2
Heme oxygenase-1 inducer	1	2
MicroRNA modulator	1	2
NF-E2-Related Factor-2 (Nrf2) Modulator	1	2
Tumor Necrosis Factor (TNF) Alpha Inhibitor	1	2
Angiogenesis Inhibitors	1	1
Cell cycle arrest	1	1
Chemosensitizer	1	1
Cyclooxygenase 2 Inhibitors	1	1
Interleukin-10 downregulation	1	1
Interleukin-12 upregulation	1	1
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	1
Tumor Suppressor Protein p53 Upregulation	1	1
Wnt/β-catenin pathway down-regulation	1	1

Research Articles 21
Cumulative Knowledge Score 33
Overall Research Rating GOOD

View the Evidence:
35 Abstracts with Tumor Microenvironment Research

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View the Evidence: 35 Abstracts with Tumor Microenvironment Research

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Amla extract modulates cancer cells and the tumor microenvironment.Apr 24, 2016

Benzyl isothiocyanate suppresses high-fat diet-stimulated mammary tumor progression.Dec 31, 2014

Early life BPA exposure can contribute to breast cancer development and progression by modulating the anti-tumoral immune response.Sep 04, 2017

Fasting inhibits colorectal cancer growth by reducing M2 polarization of tumor-associated macrophages.Sep 25, 2017

Flaxseed reduces the pro-carcinogenic micro-environment in the ovaries of normal hens by altering the PG and oestrogen pathways in a dose-dependent manner.Apr 07, 2015

Genistein mediated upregulation of CHOP impeded C/EBPβ interaction with the IL-6 promoter, thus disturbing the angiogenic microenvironment which inhibited tumor proliferation.May 31, 2015

Genistein regulates tumor microenvironment and exhibits anticancer effects in experimental colon carcinogenesis model.Jun 02, 2016

Human marrow stromal cells secrete microRNA-375-containing exosomes to regulate glioma progression.Feb 06, 2019

The tomato diet significantly inhibited TNFα stimulated NF-κB activity in cultured PC3 cells, and modulated the expression of genes associated with inflammation, apoptosis, and cancer progression.Dec 31, 2014

This study indicates the protective effects of a dendrosomal curcumin formulation on mice metastatic breast cancer.Dec 31, 2014

Voluntary physical activity represents a means to counteract the proliferative effects of adipose tissue on breast cancers in obese patients.May 04, 2016

Wogonin suppresses tumor cells migration in inflammatory microenvironment by inactivating STAT3 signaling.Jun 28, 2014

"Cancer stem cell niche: the place to be."Jan 31, 2011

"The hypoxic microenvironment upgrades stem-like properties of ovarian cancer cells."Dec 31, 2011

"The niche of hepatic cancer stem cell and cancer recurrence."Feb 15, 2013

Anthocyanins, delphinidin-3-O-glucoside and cyanidin-3-O-glucoside, inhibit immune checkpoints in human colorectal cancer cells.Aug 08, 2019

Anti-tumor and anti-metastatic roles of cordycepin, one bioactive compound of Cordyceps militaris.Jun 30, 2018

Arctigenin shows preferential cytotoxicity to acidity-tolerant prostate carcinoma PC-3 cells.Nov 09, 2018

Benzyl butyl phthalate influences the efficacy of chemotherapy by remodelling the tumor microenvironment of breast cancer.Nov 30, 2015

Berberine reversed the epithelial-mesenchymal transition of normal colonic epithelial cells induced by SW480 cells.Dec 09, 2018

Curcumin potentiates and chemosensitizes HCT116R cells to 5-FU-based chemotherapyDec 31, 2014

Curcumin targets numerous therapeutically important cancer signalling pathways.Jul 27, 2016

Ethanol exposure many induce phenotypes associated with cancer cell stemness and NAC may protect against these adverse changes.Jan 14, 2012

Ginsenoside Rh2 exerts anti-metastasis activity in hypoxic tumor microenvironment in lung adenocarcinoma cells via mir-491.Jul 03, 2019

Gold nanoparticles disrupt tumor microenvironment.Jun 18, 2019

Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction.Jun 30, 2008

Mushroom polysaccharides are efficacious in ameliorating the immune suppression in the tumor microenvironment.Dec 31, 2014

Oligo-Fucoidan supplementation increases cancer cell death and attenuates the adverse effects induced by etoposideSep 18, 2017

Prostate cancer cells and exosomes in acidic condition show increased carbonic anhydrase IX expression and activity.Nov 30, 2019

Prunella vulgaris may have the therapeutic potential to inhibit the migration and invasion of liver cancer.Dec 31, 2015

The anti-inflammatory effect of unsaturated tocotrienols could be highly promising in the regulation of tumor microenvironments.Mar 06, 2016

This manuscript deals with discussions concerning the direct cytotoxic effect of heat, heat-induced alterations of the tumor microenvironment.Jun 30, 2002

This review highlights specific biological processes that could be exploited as targets for the prevention and therapy of cancer.Apr 09, 2015

This review outlines the principal biological activities of piceatannol.Dec 31, 2015

This reviews how inflammation conspires with KRAS signalling to fuel carcinogenesis.Jun 09, 2016

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Tumor Microenvironment

View the Evidence:
35 Abstracts with Tumor Microenvironment Research

Arctigenin shows preferential cytotoxicity to acidity-tolerant prostate carcinoma PC-3 cells.Nov 09, 2018