Proanthocyanidins

Name	AC	CK
Urinary Tract Infections	4	40
Escherichia coli Infections	2	20
Oxidative Stress	5	17
Aging	4	16
DNA damage	2	12
Neurodegenerative Diseases	2	12
Cardiovascular Diseases	2	11
Esophageal Cancer	2	11
Aging Skin	1	10
Aging: Brain	5	10
Alzheimer's Disease	1	10
Chloasma	1	10
Cholesterol: Oxidation	1	10
Diesel Exhaust Particle Toxicity	1	10
Endothelial Dysfunction	1	10
HDL: Low	1	10
Helicobacter Pylori Infection	1	10
Hypertension	1	10
Leg Edema	1	10
Neurogenic Bladder	1	10
Sitting Sickness	1	10
Spinal Cord Injuries	1	10
Memory Disorders	4	8
Cataract	2	4
Cognitive Decline/Dysfunction	2	4
Diabetes Mellitus: Type 1	3	4
Inflammation	3	3
Acetaminophen (Tylenol) Toxicity	1	2
Advanced Glycation End products (AGE)	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Clotting	1	2
Colon Cancer	2	2
Diabetes Mellitus: Type 2	2	2
Diabetes: Cardiovascular Illness	1	2
Diabetes: Oxidative Stress	1	2
Diabetic Complications	1	2
Food Allergies	1	2
HIV Infections	2	2
Inflammatory Bowel Diseases	1	2
Lipid Peroxidation	1	2
Allergies	1	1
Bladder Cancer	1	1
Cancers: All	1	1
Epstein-Barr Virus Infections	1	1
Gout	1	1
Hepatitis A	1	1
Hepatoma	1	1
Hodgkin Lymphoma	1	1
Lipopolysaccharide-Induced Toxicity	1	1
Liver Cancer	1	1
Malaria	1	1
Nasopharyngeal Cancer	1	1
Norovirus	1	1
Oral Cancer	1	1
Ovarian Cancer	1	1
Peroxynitrite Toxicity	1	1
Skin Cancer	1	1
Skin Cancer: Squamous Cell	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Tumors	1	1

Name	AC	CK
Catechin	15	61
Flavonoids	16	55
Grape Seed Extract	10	32
Anthocyanins	4	23
Cranberry	3	21
Apples	6	17
Polyphenols	6	17
Pycnogenol (Pine Bark)	4	13
Chokeberry	2	11
Persimmon	2	11
Chlorogenic Acid	1	10
Lotus	4	8
Astaxanthin	1	2
Flowers	2	2
Garlic	1	2
Longan	2	2
OPC (Oligomeric Proanthocyanidins)	1	2
Tannic Acid	1	2
Blueberry	1	1
Cranberry Proanthocyanidins	1	1
Loquat	1	1
Loquat Leaves	1	1
Pine Bark Extract	1	1
Pinus Massoniana Bark	1	1
Pomegranate Polyphenols	1	1
Proanthocyanidins	1	1
Procyanidin B2	1	1
Roseoside	1	1

Name	AC	CK	Focus
Placebo Effect	1	10

Name	AC	CK
Antioxidants	21	81
Anti-Bacterial Agents	4	31
Anti-Apoptotic	2	12
Leukotriene Antagonists	1	10
Neuroprotective Agents	5	10
Apoptotic	7	7
Anti-Inflammatory Agents	3	3
Antineoplastic Agents	3	3
Cell cycle arrest	3	3
NF-kappaB Inhibitor	3	3
Anti-HIV Agents	2	2
Antiproliferative	2	2
Enzyme Inhibitors	2	2
Platelet Aggregation Inhibitors	1	2
5-lipoxygenase Inhibitor	1	1
Alpha-amylase inhibitor	1	1
Alpha-glucosidase inhibitor	1	1
Anti-Allergic Agents	1	1
Anti-metastatic	1	1
Bcl-2 protein down-regulation	1	1
Immunomodulatory	1	1
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	1
Mitogen-activated protein kinase kinase 4 (MEK4)	1	1
Nitric Oxide Inhibitor	1	1
Prophylactic Agents	1	1
Xanthine oxidase inhibitor	1	1

[+]

Oral intake of proanthocyanidin-rich grape seed extract up to 2500 mg for 4 weeks was found to be generally safe and well tolerated in humans.Sep 30, 2017

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Pubmed Data : Food Chem Toxicol. 2017 Oct ;108(Pt B):519-523. Epub 2016 Nov 24. PMID: 27889390

Article Published Date : Sep 30, 2017

Study Type : Human Study

Additional Links

Substances : Grape Seed Extract

Additional Keywords : Proanthocyanidins, Safety of Natural Substances

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Persimmon peel extract has a protective effect against oxidative damage under H2O2-induced cellular senescence.Jun 01, 2008

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Pubmed Data : Biol Pharm Bull. 2008 Jun;31(6):1265-9. PMID: 18520066

Article Published Date : Jun 01, 2008

Study Type : Human Study

Additional Links

Substances : Persimmon

Diseases : Aging, DNA damage

Pharmacological Actions : Antioxidants

Additional Keywords : Proanthocyanidins

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Proanthocyanidin-rich grape seed extract reduces leg swelling in healthy women during prolonged sitting.Jan 31, 2013

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Pubmed Data : J Sci Food Agric. 2013 Feb ;93(3):457-62. Epub 2012 Jul 2. PMID: 22752876

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Pubmed Data : Can J Physiol Pharmacol. 2009 Aug;87(8):633-40. PMID: 19767888

Article Published Date : Aug 01, 2009

Study Type : Animal Study

Additional Links

Substances : Garlic, Grape Seed Extract

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Antioxidants

Additional Keywords : Drug: Doxorubicin, Plant Extracts, Proanthocyanidins

[+]

Anthocyanins may exhibit protective effects against high glucose induced renal injury in diabetic nephropathy via antioxidant activity.Feb 28, 2018

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Pubmed Data : Int J Mol Med. 2018 Mar ;41(3):1608-1618. Epub 2018 Jan 10. PMID: 29328429

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Exp Ther Med. 2018 Jan ;15(1):1053-1061. Epub 2017 Nov 13. PMID: 29403553

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Diabetic Complications

Pharmacological Actions : Antioxidants, Nitric Oxide Inhibitor, Nrf2 activation

Additional Keywords : Proanthocyanidins

[+]

Grape seed proanthocyanidin extract supplementation has anti-hypertrophic and hyperplasic activities in rats with established obesity.Apr 03, 2017

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Pubmed Data : Int J Obes (Lond). 2017 Apr 4. Epub 2017 Apr 4. PMID: 28373675

Grape seed procyanidin extract can protect against the toxicity of titanium dioxide nanoparticles.Sep 24, 2017

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Pubmed Data : Chem Biol Interact. 2017 Sep 25 ;275:133-144. Epub 2017 Aug 2. PMID: 28780322

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Pubmed Data : J Neuroinflammation. 2017 04 4 ;14(1):74. Epub 2017 Apr 4. PMID: 28376889

Article Published Date : Jan 03, 2017

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Gout, Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

Additional Keywords : Proanthocyanidins

[+]

Grape-seed proanthocyanidins are able to reverse intestinal dysfunction and metabolic endotoxemia induced by a cafeteria diet.Apr 28, 2019

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Pubmed Data : Nutrients. 2019 Apr 29 ;11(5). Epub 2019 Apr 29. PMID: 31035432

Pubmed Data : Food Funct. 2013 Aug ;4(8):1252-62. PMID: 23764910

Article Published Date : Aug 01, 2013

Proanthocyanidin and vitamin E have protective effects against toxic effects of formaldehyde in kidney tissue.Dec 31, 2014

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Pubmed Data : Biotech Histochem. 2015 Jan ;90(1):69-78. Epub 2014 Sep 16. PMID: 25225844

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Vitamin E

Diseases : Formaldehyde Toxicity, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Malondialdehyde Down-regulation, Renoprotective, Superoxide Dismutase Up-regulation

Additional Keywords : Proanthocyanidins

Problem Substances : Formaldehyde

[+]

Procyanidin B2 protects against diet-induced obesity and non-alcoholic fatty liver disease.Feb 27, 2019

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View the Evidence: 101 Abstracts with Proanthocyanidins Research

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Apple peel extract inhibits the growth of Helicobacter pylori, and attenuates damage to the gastric mucosa caused by neutrophils. Sep 09, 2009

Black chokeberry juice lowered the incidence of Urinary tract infections by 55% and a reduction in antibiotics use in patients. May 31, 2014

Cacao liquor proanthocyanidins inhibit lung injury induced by diesel exhaust particles.Apr 01, 2008

Chocolate procyanidins may inhibit vascular and inflammatory processes that contribute to cardiovascular disease. Jan 01, 2001

Cocoa powder and dark chocolate may favorably affect cardiovascular disease risk status by modestly reducing LDL oxidation susceptibility and increasing serum total antioxidant capacity and HDL-cholesterol concentrations.Nov 01, 2001

Cocoa procyanidins attenuate lipid peroxidation associated neuronal cell death in a manner relevant to Alzheimer's disease.May 15, 2009

Cranberry extract has inhibitory activity on the bacterial adhesiveness of pathogenic E. Coli. Apr 01, 2010

Cranberry extract prevents urinary tract infections in spinal cord injured patients with neurogenic bladder. Sep 01, 2008

Cranberry has significant bacterial anti-adhesion activity against uropathogenic Escherica coli. Jan 01, 2010

Flavonoid consumption reduces the risk of esophageal cancer.Jun 01, 2007

Grape seed procyanidin extract mediates antineoplastic effects against lung cancer.Nov 30, 2016

Oral administration of French maritime pine bark extract (Flavangenol(®)) improves clinical symptoms in photoaged facial skin.Dec 31, 2011

Oral intake of proanthocyanidin-rich extract from grape seeds improves chloasma.Oct 31, 2004

Oral intake of proanthocyanidin-rich grape seed extract up to 2500 mg for 4 weeks was found to be generally safe and well tolerated in humans.Sep 30, 2017

Persimmon peel extract has a protective effect against oxidative damage under H2O2-induced cellular senescence.Jun 01, 2008

Proanthocyanidin-rich grape seed extract reduces leg swelling in healthy women during prolonged sitting.Jan 31, 2013

The high intake of flavanol-rich cocoa by the Kuna Indians may be responsible for their low blood pressure.Jan 01, 2006

Oligonol has strong preventative potential in diabetes mellitus and in Alzheimer's disease.Feb 29, 2016

Aged garlic extract and grape seed proanthocyanidin protect against doxorubicin-induced cardiotoxicity.Aug 01, 2009

Anthocyanins may exhibit protective effects against high glucose induced renal injury in diabetic nephropathy via antioxidant activity.Feb 28, 2018

Apple procyanidins protect against experimental inflammatory bowel disease in mice.Dec 20, 2008

Astaxanthin has an inhibitory effect on oxidative stress in diabetic rats. Jul 01, 2008

Boysenberry seed polyphenols have antihypertensive effects.Dec 31, 2011

Cocoa flavanol and procyanidin supplementation inhibits platelet function.Jun 01, 2003

Dietary grape seed proanthocyanidin extract may be a protector against lead-induced metabolic dysfunction and liver injury.May 31, 2018

Dietary unripe apple polyphenol inhibits the development of food allergies in the mouse model. Aug 15, 2005

Enhancement of berberine hypoglycemic activity by oligomeric proanthocyanidins.Dec 13, 2018

Grape proanthocyanidin inhibit pancreatic cancer cell growth in vitro and in vivo.Dec 31, 2011

Grape seed extract has inhibiting effect on the accumulation of age-related oxidative DNA damages in the central nervous system of rats. Feb 15, 2006

Grape seed extract prevents acetaminophen-induced cell death in the mouse liver. Sep 01, 1999

Grape seed proanthocyanidin ameliorates cardiac toxicity induced by boldenone undecylenate.Dec 31, 2017

Grape seed proanthocyanidin extract alleviates urethral dysfunction in diabetic rats.Dec 31, 2017

Grape seed proanthocyanidin extract supplementation has anti-hypertrophic and hyperplasic activities in rats with established obesity.Apr 03, 2017

Grape seed proanthocyanidin inhibit advanced glycation end products in diabetic rats. Jun 01, 2009

Grape seed proanthocyanidin reverses pulmonary vascular remodeling in monocrotaline-induced pulmonary arterial hypertension.Apr 30, 2018

Grape seed proanthocyanidine extract administration may decrease periodontal inflammation and alveolar bone loss.May 31, 2018

Grape seed proanthocyanidins improve white adipose tissue expansion during diet-induced obesity development.Sep 04, 2018

Grape seed proanthocyanidins inactivate Treg cells by promoting DNA repair in dendritic cells in UVB-exposed skin.Jul 24, 2017

Grape seed procyanidin extract can protect against the toxicity of titanium dioxide nanoparticles.Sep 24, 2017

Grape seed procyanidin extract may represent a new therapeutical direction for the treatment of ischemia-reperfusion brain injury.Jun 09, 2017

Grape seed procyanidin extract reduces arsenic-induced renal inflammatory injury in male mice.Jun 30, 2017

Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression.Jan 03, 2017

Grape-seed proanthocyanidins are able to reverse intestinal dysfunction and metabolic endotoxemia induced by a cafeteria diet.Apr 28, 2019

Lotus procyanidins reverse memory impairments in cognitivitely impaired aged rats.Sep 01, 2010

Lotus seed extract improves memory in cognitively impaired aged rats.Dec 01, 2009

Lotus seed skin proanthocyanidin extract exhibits potent antioxidant property via activation of the Nrf2-ARE pathway.Dec 31, 2018

Lotus seedpod proanthyocyanins have an ameliorative effect on cognitive deficits and oxidative damage in senescence-accelerated mice.Dec 01, 2008

Lotus seedpod procyanidins mitigate the oxidative effects and learning and memory damage caused by extremely low frequency electromagnetic fields onAug 01, 2013

Mechanistic insights into anticancer properties of oligomeric proanthocyanidins from grape seeds in colorectal cancer.May 27, 2018

Nephrin loss is reduced by grape seed proanthocyanidins in the experimental diabetic nephropathy model.Nov 30, 2017

Novel antihypertensive prodrug from grape Seed proanthocyanidin extract via acid-mediated depolymerization in the presence of captopril.Apr 10, 2018

Oligomeric proanthocyanidins improve memory in age-accelerated mice. Feb 01, 2010

Oral administration of apple procyanidins inhibits the proliferation of tumor cells by inducing apoptosis through the intrinsic mitochondrial pathway.Feb 29, 2008

Oral grape seed extract prevents selenite-induced oxidative stress in experimental cataract.Jun 01, 2006

Polyphenols derived from lychee seed suppress amyloid-β-induced neuroinflammation.Jul 19, 2018

Proanthocyanidin and vitamin E have protective effects against toxic effects of formaldehyde in kidney tissue.Dec 31, 2014

Procyanidin B2 protects against diet-induced obesity and non-alcoholic fatty liver disease.Feb 27, 2019

Procyanidins extracted from the lotus seedpod ameliorate scopolamine-induced memory impairment in mice.Jan 13, 2010

Thioredoxin is implicated in the anti‑apoptotic effects of grape seed proanthocyanidin extract during hyperglycemia.Oct 31, 2017

Treatments with lotus seedpod oligomeric procyanidins could be beneficial in diabetic treatments.May 16, 2017

"Antibacterial effects of plant-derived extracts on methicillin-resistant Staphylococcus aureus."May 31, 2012

Apple polyphenols activate programmed cell death in human colon cancer cells. Oct 16, 2009

Apple-derived procyanidin may possess chemotherapeutic effects against esophageal cancer. Dec 01, 2008

Berries and their phenolics selectively inhibit the growth of human pathogenic bacteria.Dec 31, 2004

Blueberry juice and blueberry proanthocyanidins shows preventive potential against infection.Jun 13, 2016

Cinnamtannin B1 was a potent cancer cell proliferation inhibitor and a good intracellular antioxidant.Jun 30, 2015

Cocoa procyanidins suppress neoplastic cell transformation by suppressing mitogen-activated protein kinase.Jan 01, 2006

Combinational proanthocyanidins and resveratrol synergistically inhibit human breast cancer cells. Jul 26, 2018

Cranberry may have a favorable role to play in the prevention of cardiovascular disease.Nov 01, 2007

Flavanols and procyanidins of cocoa and chocolate inhibit growth and polyamine biosynthesis of human colonic cancer cells.Jan 25, 2002

Flavonoids of cocoa inhibit recombinant human 5-lipoxygenase.Jul 01, 2002

Grape seed extract dowregulates HIV-1 entry in normal peripheral blood mononuclear cells. Jan 01, 2002

Proanthocyanidins

View the Evidence:
101 Abstracts with Proanthocyanidins Research