Dose Response

Name	AC	CK
Meat	2	40
Fluoride	1	10
Sugar	1	10
Sugar Sweetened Beverages	1	10
Tamoxifen	1	10
Zolpidem (trade name Ambien)	1	10
Sodium Fluoride	3	8
Bisphenol A	4	7
Acetaminophen	3	5
Paracetamol	3	5
Dexamethasone	1	2
Diclofenac	1	2
Donepezil (trade name Aricept)	1	2
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	2
Paraquat	1	2
Thimerosal	2	2
Aflatoxin	1	1
Arsenite	1	1
Mercury	1	1
Monosodium Glutamate (MSG)	1	1
Nanoparticles	1	1
Streptozotocin	1	1

Name	AC	CK
Breast Cancer	57	129
Cardiovascular Diseases	6	81
Diabetes Mellitus: Type 2	15	61
Inflammation	33	61
All-Cause Mortality	3	60
Cardiac Mortality	3	60
Hypertension	8	58
Liver Cancer	29	55
Breast Cancer: Triple Negative	27	51
Alzheimer's Disease	17	50
Colon Cancer	29	49
Prostate Cancer	15	42
Hypercholesterolemia	4	41
Oxidative Stress	20	37
Lung Cancer	28	35
Dementia	4	34
Cancers: All	11	32
Diabetes Mellitus: Type 2: Prevention	2	30
Prediabetes	3	30
Bladder Cancer	6	29
Gastric Cancer	19	27
Alcohol Toxicity	3	23
Basal Cell Carcinoma	2	22
Inflammatory Bowel Diseases	2	22
Kidney Cancer	2	21
Prostate Cancer: Prevention	2	21
Anxiety Disorders	1	20
Cancer Mortality	1	20
Heart Disease	1	20
Kidney Cancer: Prevention	1	20
Nasopharyngeal Cancer	1	20
Triglycerides: Elevated	1	20
Lipopolysaccharide-Induced Toxicity	10	18
Colorectal Cancer	14	17
Melanoma	10	16
Aging Skin	2	15
High Cholesterol	2	15
Influenza A	3	13
Acute Myeloid Leukemia	7	12
Advanced Glycation End products (AGE)	3	12
Atherosclerosis	2	12
Multiple Sclerosis	2	12
Pancreatic Cancer	7	12
Cervical Cancer	10	11
Glioma	8	11
Neurodegenerative Diseases	4	11
Obesity	6	11
Atopic Dermatitis	1	10
Attention Deficit Disorder with Hyperactivity	1	10
Bone Fractures	1	10
Breast Cancer: Estrogen	1	10
C-Reactive Protein	1	10
Cardiovascular Disease: Prevention	1	10
Cholesterol: Oxidation	1	10
Coronary Artery Disease	1	10
Dental Caries	1	10
Diabetic Neuropathies	1	10
Erythema	1	10
Influenza B	1	10
Lower Urinary Tract Symptoms	1	10
Mycobacterium tuberculosis	1	10
Myelodysplastic Syndromes	1	10
Oral Cancer	9	10
Osteopenia	1	10
Osteoporosis	1	10
Rectal Cancer	1	10
Skin Diseases	1	10
Skin Diseases: Photo-Aging	1	10
Wrinkles	1	10
Depression	4	8
Neuropathic Pain	4	8
Osteosarcoma	8	8
Cancer Metastasis	2	7
Carcinoma: Non-Small-Cell Lung	6	7
Esophageal Cancer	5	7
Gastrointestinal Inflammation	2	7
Lipid Peroxidation	4	7
Ovarian Cancer	5	7
Arthritis	3	6
Brain Inflammation	4	6
Cerebral Ischemia	4	6
Cholangiocarcinoma	2	6
Cognitive Decline/Dysfunction	3	6
DNA damage	6	6
High Fat Diet	3	6
Osteoarthritis	2	6
Parkinson's Disease	4	6
Squamous cell carcinoma	5	6
Staphylococcus aureus: Methicillin-resistant (MRSA)	2	6
Acetaminophen (Tylenol) Toxicity	3	5
Bladder Cancer: Prevention	1	5
Cancers: Drug Resistant	5	5
Chemically-Induced Liver Damage	3	5
Chemotherapy-Induced Toxicity: Cisplatin	3	5
Colon Cancer: Prevention	3	5
Fluoride Toxicity	1	5
Leukemia: Chronic Lymphocytic Leukemia (CLL)	1	5
Malignant Melanoma	1	5
Neuromyelitis Optica	1	5
Prostate Cancer Stem Cells	1	5
Radiotherapy	1	5
Retinoblastoma	1	5
Tongue Cancer	1	5
Ultraviolet Radiation Induced Damage	1	5
Wound Healing	1	5
Acute lymphoblastic leukemia (ALL)	4	4
Allodynia	2	4
Amnesia: Drug-Induced	2	4
Bisphenol Toxicity	2	4
Candida Albicans	4	4
Cataract	3	4
Chemotherapy-Induced Toxicity: Paclitaxel	2	4
Colitis	2	4
Gallbladder Cancer	2	4
Infertility	2	4
Liver Fibrosis	2	4
Nonalcoholic fatty liver disease (NAFLD)	2	4
Pain	2	4
Pesticide Toxicity	2	4
Pneumonia	3	4
Staphylococcus aureus infection	3	4
Adrenal Hyperplasia: Congenital	1	3
Aging	2	3
Diabetic Complications	2	3
Endothelial Dysfunction	2	3
HIV Infections	3	3
Head and Neck Cancer	2	3
Hepatitis B	3	3
Hydrogen Peroxide Induced Toxicity	2	3
Hyperglycemia	2	3
Insulin Resistance	2	3
Leukemia	3	3
Leukemia: Acute promyelocytic leukemia	3	3
Leukemia: Chronic myelogenous leukemia (CML)	3	3
Mesothelioma	2	3
Non-Small-Cell Lung Carcinoma	3	3
Prostate Cancer: Metastatic	2	3
Retinal Diseases	2	3
Thyroid Cancer	3	3
Anthrax	1	2
Autism Spectrum Disorders	1	2
Autoimmune Diseases	1	2
Brain Edema	1	2
Brain: Oxidative Stress	1	2
Breast Cancer: HER-2 Overexpressed	1	2
Cachexia: Cancer	1	2
Cancers: Multi-Drug Resistant	2	2
Chemotherapy-Induced Kidney Damage	1	2
Chemotherapy-Induced Liver Toxicity	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Cholera	1	2
Choriocarcinoma	2	2
Chronic Pain	1	2
Colorectal Cancer: Prevention	1	2
Cough	1	2
Degenerative Disk Disease	1	2
Delayed Sleep Phase Disorder	1	2
Diabetes	1	2
Diabetes Mellitus: Type 1	1	2
Diabetic Nephropathy	1	2
Dyslipidemias	1	2
Ehrlich carcinoma	1	2
Encephalomyelitis	1	2
Endometriosis	1	2
Endometritis	1	2
Enteropathy	1	2
Epilepsy	1	2
Fetal Origin of Adult Disease	1	2
Fever	1	2
Fibrosis	1	2
Gastric Ulcer	1	2
Giardiasis	1	2
Glioblastoma	1	2
Hair Loss	1	2
Hepatic Steatosis	1	2
Hepatitis C	2	2
Herbicide Toxicity	1	2
Hyperalgesia	1	2
Hyperammonemia	1	2
Hyperhomocysteinemia	1	2
Hypoglycemia	1	2
Immune Disorders	1	2
Inflammation: Neutrophil-Mediated	1	2
Insomnia	1	2
Intracerebral Hemorrhage	1	2
Leptin Resistance	1	2
Liver Cirrhosis	1	2
Lung Cancer: Metastatic	1	2
Lymphoma	2	2
Melanoma: Metastasis	1	2
Morphine Tolerance/Dependence	1	2
Neuroblastoma	2	2
Neurologic Disorders	1	2
Neurotoxicity	1	2
Pancreatic Cancer: Metastatic	2	2
Pancreatic Diseases	1	2
Pancreatitis	1	2
Pancreatitis: Chronic	1	2
Peripheral Neuropathies	1	2
Prenatal Chemical Exposures	1	2
Respiratory Syncytial Virus Infections	1	2
Respiratory Tract Infections	1	2
Rheumatoid Arthritis	1	2
Sleep Disorders	1	2
Snake Bite: Venom Toxicity	1	2
Steptococcus Mutans Infections	2	2
Stress	1	2
Stroke: Attenuation/Recovery	1	2
Substance Withdrawal Syndrome	1	2
Ulcerative Colitis	1	2
Urolithiasis	1	2
Vitamin D Deficiency	1	2
Advanced Glycation Endproduct (AGE) Formation	1	1
Allergies	1	1
Alphavirus Infections	1	1
Asbestos Toxicity	1	1
Aspergillosis	1	1
Bisphenol-A Toxicity	1	1
Bone Diseases	1	1
Brain: Microglial Activation	1	1
Breast Cancer: Drug Resistant	1	1
Burkitt Lymphoma	1	1
Cardiac Hypertrophy	1	1
Chemotherapy-Induced Toxicity: Bleomycin	1	1
Chikungunya Virus	1	1
Chlamydia pneumoniae	1	1
Chlamydia trachomatis	1	1
Chondrosarcoma	1	1
Common Cold	1	1
Diabetes: Oxidative Stress	1	1
Echinococcosis	1	1
Escherichia coli Infections	1	1
Fusobacterium Infections	1	1
Gram-Positive Bacterial Infections	1	1
H1N1 Infection	1	1
Halitosis	1	1
Helicobacter Pylori Infection	1	1
Herpes Simplex Virus Type 1	1	1
Hodgkin Lymphoma	1	1
Hydatid Cyst	1	1
Hypersensitivity	1	1
Hypoxia	1	1
Leishmaniasis	1	1
Leukemia: Monocytic	1	1
Leukemia: Multi-Drug Resistant	1	1
Liver Damage: Aflatoxin-Induced	1	1
Lung Cancer: Prevention	1	1
Melanoma: Metastatic	1	1
Multiple Myeloma	1	1
Myocardial Ischemia	1	1
Oral Cancer: Prevention	1	1
Periodontal Diseases	1	1
Pseudomonas aeruginosa	1	1
Salmonella Infections	1	1
Sepsis	1	1
Skin Cancer	1	1
Tetanus	1	1
Tumors	1	1
Urothelial Tumors	1	1

Name	AC	CK	Focus
Low Dose Ionizing Radiation	1	5

Name	AC	CK
Neurotoxic	3	4
Anti-Fertility	1	2
Oxidant	1	1

Name	AC	CK
Coffee	7	74
Fiber	3	60
Curcumin	36	59
Fruit: All	2	40
Vegetables: All	2	40
Black Tea	4	33
Delta-tetrahydrocannabinol (THC)	8	33
Green Tea	4	33
Melatonin	6	32
Vitamin C	6	28
Vitamin D	2	22
Black Raspberry	3	21
Caffeine	3	21
Resveratrol	10	21
Delphinidin	2	20
Green Leafy Vegetables	1	20
Legumes	1	20
Nuts	1	20
Yoghurt	1	20
Apigenin	9	19
Quercetin	7	19
Polyphenols	6	17
Shikonin	10	17
White Mulberry	3	17
EGCG (Epigallocatechin gallate)	15	16
Ginkgo biloba	5	16
Anthocyanins	5	15
Cocoa	5	15
Pomegranate	4	15
Fig	4	14
Thymoquinone	5	14
Cranberry	2	12
DHA (Docosahexaenoic Acid)	2	12
Cannabinoids	5	11
Cannabis	2	11
EPA (Eicosapentaenoic Acid)	2	11
Apple Pectin	1	10
Broccoli Sprouts	1	10
Caffeic Acid	1	10
Cannabinoids: Synthetic	1	10
Chrysin	7	10
Cyanidin 3-glucoside	1	10
Evening Primrose Oil	1	10
Huaier (Trametes robiniophila murr)	8	10
Lemon Balm	1	10
Lichens	6	10
Lutein	1	10
Maqui	1	10
Omega-3 Fatty Acids	1	10
Silibinin	7	10
Tea	1	10
Turmeric	6	10
Water	1	10
Berberine	8	9
Cannabidiol	6	9
Cucurbitacin B	7	9
Honokiol	6	9
Ashwagandha	2	8
Baicalein	6	8
Nigella sativa (aka Black Seed)	3	8
Sulforaphane	7	8
Fucoidan	5	7
Garcinia Mangostana	2	7
Luteolin	5	7
Lycopene	2	7
Pterostilbene	5	7
Puerarin	4	7
Fisetin	4	6
Genistein	6	6
Licorice	3	6
Lotus	4	6
Piperine	4	6
Rosemary	2	6
Acai	1	5
Anandamide	1	5
Apple Polyphenols	3	5
Bee Venom	4	5
Blueberry	3	5
Citral	1	5
Fennel	1	5
Flavonoids	4	5
Goji	1	5
Jujube	1	5
Lemongrass	1	5
Lychee	1	5
Mushrooms: All	4	5
Neem	1	5
Piperlongumine	1	5
Propolis: Bee	1	5
Propolis: Brazillian	1	5
Rice	1	5
Sea buckthorn	1	5
Spirulina	3	5
Tocotrienol: Delta	3	5
Wogonin	1	5
Yarrow	1	5
Apples	2	4
Bacopa	2	4
Betulinic acid	2	4
Crocin	3	4
Hibiscus sabdariffa	2	4
Naringenin	4	4
Noni	2	4
Oridonin	3	4
Plantago	3	4
Prunella vulgaris	3	4
Strawberry	2	4
Barberry	2	3
Bee Propolis	3	3
Bisdemethoxycurcumin	2	3
Carrot	2	3
Celery	2	3
Chamomile	2	3
Cinnamon	2	3
Dandelion	2	3
Garlic	2	3
Ginger	2	3
Ginseng (Korean)	2	3
Hesperidin	3	3
Kaempferol	3	3
Mangiferin	2	3
Mistletoe	2	3
Oak	2	3
Phellinus Linteus	3	3
Phyllanthus urinaria	3	3
Pumpkin	2	3
Rambutan	2	3
Rice: Black	3	3
Salvia divinorum	2	3
St. Johns Wort	2	3
Ursolic Acid	2	3
Acacia arabica	1	2
Aloe Vera	2	2
Amla Fruit	1	2
Anise	1	2
Artemisia asiatica	1	2
Artemisinin	2	2
Astaxanthin	2	2
Banana Leaf	1	2
Burdock	2	2
Cafestol	2	2
Carnosic Acid	1	2
Carnosol	1	2
Carotenoids	1	2
Carvacrol	2	2
Catechin	1	2
Chaga Mushroom (Inonotus obliquus)	2	2
Chokeberry	2	2
Chrysanthemum Indicum	2	2
Coenzyme Q10	1	2
Cranberry Proanthocyanidins	1	2
Crocetin	1	2
Cucumber	1	2
Cucurbitacin E	2	2
Curcuma Purpurascens	1	2
Curcumol	1	2
Curry Leaves	1	2
Ellagic Acid	2	2
Emodin	2	2
Feijoa	1	2
Fenugreek	1	2
Fermented Foods and Beverages	2	2
Fruit Peel	1	2
Gac	1	2
Garcinia dulcis	1	2
Garden Cress (Lepidium sativum)	1	2
Garlic: Aged	1	2
Ginseng	1	2
Graviola	2	2
Holy Basil	1	2
Honey	2	2
Horehound	1	2
Kahweol	2	2
Limonoids	1	2
Lion's Mane (Hericium Erinaceus)	1	2
Loquat	1	2
Lupeol	1	2
Magnolol	2	2
Mangosteen	2	2
Morelloflavone	1	2
Moringa oleifera	1	2
Noni leaf extract	1	2
Okra	1	2
Olive leaf extract	1	2
Oregano	1	2
Panax Ginseng	1	2
Panax Notoginseng	1	2
Patchouli	1	2
Peanut	1	2
Pelargonium sidoides	1	2
Pine Bark Extract	1	2
Prickly Pear Cactus	1	2
Punicalagin	1	2
Purslane	2	2
Pycnogenol (Pine Bark)	2	2
Raspberry	1	2
Reishi Mushroom	1	2
Rhodiola (Tibetan Ginseng)	1	2
Rhubarb	2	2
Rosemaric Acid	1	2
Rosmarinic acid	1	2
Royal Jelly	1	2
Saffron	1	2
Schisandra	2	2
Sesamin	1	2
Shemamruthaa	1	2
Shiitake Mushroom	2	2
Solanum Glaucophyllum	1	2
Sophora Flavescens	1	2
Spikenard	1	2
Sweet Potato: Purple	2	2
Tangeretin	1	2
Thistle	2	2
Tocotrienol: Gamma	2	2
Tongkat Ali	1	2
Turmerones	1	2
Vitamin D3	1	2
Vitamin E	1	2
Vitamin K	1	2
Wasabi	1	2
Wormwood	2	2
Alpha-Lipoic Acid	1	1
Alpinia galanga	1	1
Antrodia camphorata	1	1
Arctigenin	1	1
Argan Oil	1	1
Artesunate	1	1
Asparagus	1	1
Avenanthramides	1	1
Banaba	1	1
Berbamine	1	1
Berries: All	1	1
Beta-Caryophyllene	1	1
Betaine	1	1
Black Pepper	1	1
Bloodroot	1	1
Cabbage	1	1
Calcium	1	1
Capparis spinosa (caper)	1	1
Carpolobia lutea	1	1
Chickpea	1	1
Chlorella (Algae)	1	1
Citrus naringin	1	1
Cleavers	1	1
Cryptomeria japonica	1	1
Cumin	1	1
Cyanidin	1	1
D-Limonene	1	1
Daidzein	1	1
Diallyl sulfide	1	1
Docosahexaenoic acid (DHA)	1	1
Essential Oils: Unspecified	1	1
Evodiamine	1	1
False Black Pepper	1	1
Gallic Acid	1	1
Gingerol	1	1
Ginsenosides	1	1
Guava	1	1
Gymnema Sylvestre	1	1
Hawthorn	1	1
Hemp Seed	1	1
Hibiscus rosa-sinensis	1	1
Horsetail	1	1
Ice Man Fungus	1	1
Isoflavones	1	1
Isothiocyanates	1	1
Japanese mugwort	1	1
Kefir	1	1
Lemon	1	1
Lignans	1	1
Lithospermum erythrorhizon	1	1
Magnesium	1	1
Magnolia	1	1
Mango Seed	1	1
Medicinal Mushrooms	1	1
Mulberry	1	1
Myrtle (Myrtus communis L.)	1	1
Nobiletin	1	1
Oats	1	1
Oleanolic acid	1	1
Oleuropein	1	1
Palm Oil	1	1
Parsley	1	1
Peach	1	1
Phloretin	1	1
Phyllanthus amarus	1	1
Phyllanthus niruri (Stonebreaker)	1	1
Pine Needle	1	1
Plant Sterols/Stanols	1	1
Plum	1	1
Polyunsaturated Fatty Acids (PUFAs)	1	1
Pomegranate Peel	1	1
Pterocarpus marsupium	1	1
Purple Carrots	1	1
Red Sage	1	1
Rice Bran	1	1
Rutin	1	1
Sage	1	1
Sembung Leaf	1	1
Soup	1	1
Star Anise (Illicium anisatum)	1	1
Stevia	1	1
Sweet Potato	1	1
Tannic Acid	1	1
Tetrahydrocurcumin	1	1
Theaflavins	1	1
Thymol	1	1
Trichosanthes Kirilowii	1	1
Vitamin E: Gamma-tocotrienol	1	1
Vitamin E: alpha tocopherol	1	1
Vitamin K2	1	1
Walnut	1	1
Water: Deep Sea	1	1
Xanthohumol	1	1
Xanthones	1	1

Name	AC	CK
Yoga	1	20
Exercise	3	14
Light-Emitting Diodes (LEDs) Therapy	2	11
Dietary Modification: Mediterranean Diet	1	10
Exercise: Cycling	1	10
Exercise: Green	1	10
Integrative Medicine	2	2
Laser Treatment: Low-Level	1	1

Name	AC	CK
Antiproliferative	195	275
Apoptotic	177	275
Anti-Inflammatory Agents	72	172
Chemopreventive	41	137
Antioxidants	62	129
Cell cycle arrest	60	93
Anti-metastatic	49	75
Cardioprotective	7	73
Neuroprotective Agents	31	62
NF-kappaB Inhibitor	30	56
Hypoglycemic Agents	12	47
Bcl-2 protein down-regulation	24	41
Interleukin-1 beta downregulation	14	41
Tumor Necrosis Factor (TNF) Alpha Inhibitor	23	41
Antihypertensive Agents	7	37
Interleukin-6 Downregulation	13	35
Tumor Suppressor Protein p53 Upregulation	18	34
Anticholesteremic Agents	4	29
Cyclooxygenase 2 Inhibitors	18	29
Anticarcinogenic Agents	17	28
Hypolipidemic	4	26
Immunomodulatory	8	26
MicroRNA modulator	20	26
Analgesics	9	25
Chemosensitizer	12	25
Caspase-3 Activation	15	23
Malondialdehyde Down-regulation	8	23
Antiviral Agents	11	22
Cardiovascular Agents	2	22
Anti-Anxiety Agents	1	20
Hepatoprotective	11	20
Antinoceceptive	10	19
Matrix metalloproteinase-9 (MMP-9) inhibitor	16	19
Alpha-glucosidase inhibitor	5	18
Nrf2 activation	11	18
Antineoplastic Agents	12	17
Matrix metalloproteinase-2 (MMP-2) inhibitor	14	16
P21 Activation	7	16
Alpha-amylase inhibitor	4	14
Caspase-9 Activation	10	14
Superoxide Dismutase Up-regulation	9	14
Angiogenesis Inhibitors	7	13
Anti-Apoptotic	9	13
Chemotherapeutic	11	13
Prophylactic Agents	4	13
Anti-Glycation Agents	3	12
Anti-Tumor	3	12
Nitric Oxide Inhibitor	6	12
Prostaglandin PGE2 downregulation	6	12
Renoprotective	6	12
Immunostimulatory	2	11
Osteogenic	2	11
Anti-Bacterial Agents	6	10
Anti-collagenase	1	10
Autophagy Up-regulation	8	10
Chemoprotective Agents	5	10
Cytoprotective	6	10
Estrogen Receptor Modulators	1	10
Insulin-Like Growth Factor Inhibition/Downregulation	1	10
PER2 Protein Expression Up-regulation	1	10
Vascular Cell Adhesion Molecule-1 Inhibitor	1	10
Antimicrobial	8	9
Cyclin D1 Down-Regulation	7	9
Cytotoxic	7	9
Enzyme Inhibitors	6	9
Vascular Endothelial Growth Factor Inhibitors	6	9
Antidepressive Agents	4	8
Gastroprotective	4	8
Genoprotective	4	8
Pancreato Protective Agents	5	8
Radioprotective	3	8
Caspase-8 activation	6	7
Multidrug Resistance Gene Modulators	3	7
Neuritogenic	2	7
Acetylcholinesterase Inhibitor	2	6
Histone deacetylase inhibitor	2	6
Vasodilator Agents	3	6
Wnt/β-catenin pathway down-regulation	5	6
Anti-Angiogenic	3	5
Bax/Bcl2 ratio: Increase	4	5
Epidermal growth factor receptor (EGFR) inhibitor	3	5
Heme oxygenase-1 up-regulation	4	5
Photoprotective	1	5
Anti-Ulcer Agents	2	4
Anti-pyretic	2	4
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	2	4
Neuromodulatory	2	4
Radiosensitizer	2	4
Bax/Bcl2 Ratio: Decrease	2	3
Catalase Up-Regulation	2	3
Glutathione Upregulation	2	3
Heat Shock Protein Down-Regulation	2	3
Interleukin-10 upregulation	2	3
Redox Modulator	2	3
Topoisomerase I inhibitor	2	3
Topoisomerase II Inhibitor	2	3
Tumor Suppressor Protein p73 Upregulation	2	3
5-alpha reductase inhibitor	1	2
Anti-Fibrotic	1	2
Antidiarrheals	1	2
Antifungal Agents	2	2
Antiprotozoal Agents	1	2
Antitussive Agents	1	2
Antiurolithiatic	1	2
Autophagy Inhibitors	1	2
Bcl-xL down-regulation	1	2
Cyclooxygenase Inhibitors	1	2
Cytotoxicity	2	2
Fertility Agents	1	2
Gastrointestinal Agents	1	2
Heme oxygenase-1 inducer	1	2
Immunomodulatory: Th17 downregulation	1	2
Immunosuppressive Agents	1	2
Insulin-releasing	1	2
Lipoxygenase Inhibitors	1	2
Malonaldehyde (MDA) Down-Regulation	1	2
Matrix Metalloproteinase-7 (MMP-7) Inhibitor	2	2
Matrix Metalloproteinases Inhibitors	1	2
Neurogenesis	1	2
Postaglandin PGE2 downregulation	2	2
Proteasome Inhibitors	1	2
STAT3 Inhibitor	2	2
Survivin Down-Regulation	1	2
5-Lipoxygenase Inhibitor	1	1
Adiponectin upregulation	1	1
Angiotensin-Converting Enzyme Inhibitors	1	1
Anti-Allergic Agents	1	1
Caspase-7 Activation	1	1
Chelating Agents	1	1
Enzyme Activators	1	1
HIV Protease Inhibitors	1	1
Interferon Gamma Reducer	1	1
Interleukin-10 downregulation	1	1
Interleukin-18 down-regulation	1	1
Leishmanicidal	1	1
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	1	1
Nitric Oxide Enhancer	1	1
Osteoprotective	1	1
PI3K/Akt/signaling suppression	1	1
Paraptosis	1	1
Phosphodiesterase Inhibitors	1	1
Reverse Transcriptase Inhibitors	1	1
Scolicidal	1	1
Telomerase Inhibitor	1	1
Trypsin Inhibitors	1	1
Wnt/β-catenin signaling pathway modulation	1	1

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Pubmed Data : Can J Physiol Pharmacol. 2016 Nov 25. Epub 2016 Nov 25. PMID: 28177691

Article Published Date : Nov 24, 2016

Study Type : Human Study

Additional Links

Substances : Caffeine

Diseases : Alzheimer's Disease

Additional Keywords : Dose Response

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Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans.Jan 31, 2006

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Pubmed Data : Eur J Neurosci. 2006 Feb ;23(4):1082-6. PMID: 16519674

Article Published Date : Jan 31, 2006

Study Type : Human Study

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Therapeutic Actions : Light-Emitting Diodes (LEDs) Therapy

Pharmacological Actions : PER2 Protein Expression Up-regulation

Additional Keywords : Circadian Rhythm, Dose Response, PER2 Protein

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Evening primrose oil might be effective in treating atopic dermatitis.Jul 31, 2013

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Inhaled cannabis demonstrated a dose dependent reduction in diabetic peripheral neuropathy pain in patients with treatment refractory pain.Jun 30, 2015

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Pubmed Data : J Pain. 2015 Jul ;16(7):616-27. Epub 2015 Apr 3. PMID: 25843054

Article Published Date : Jun 30, 2015

Study Type : Human Study

Additional Links

Substances : Cannabis, Delta-tetrahydrocannabinol (THC)

Diseases : Diabetic Neuropathies

Pharmacological Actions : Analgesics

Additional Keywords : Dose Response, Significant Treatment Outcome

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The present study identifies an augmented post-exercise hypotensive effect for children following green exercise compared to exercise alone.Mar 31, 2014

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Pubmed Data : Int J Environ Res Public Health. 2014 Apr ;11(4):3678-88. Epub 2014 Apr 2. PMID: 24699030

Article Published Date : Mar 31, 2014

Study Type : Human Study

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Diseases : Hypertension

Therapeutic Actions : Exercise: Green

Pharmacological Actions : Antihypertensive Agents

Additional Keywords : Dose Response

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The results from a population sample of cyclists suggest that additional cardiovascular health benefits can be achieved beyond the current minimum physical activity recommendation.Mar 31, 2015

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Pubmed Data : J Hum Hypertens. 2015 Apr ;29(4):219-23. Epub 2014 Oct 2. PMID: 25273856

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Pubmed Data : Phytother Res. 2016 Jun 9. Epub 2016 Jun 9. PMID: 27279471

Article Published Date : Jun 08, 2016

Study Type : Human Study

Additional Links

Substances : Black Raspberry

Diseases : Prediabetes

Pharmacological Actions : Anti-Inflammatory Agents, Hypoglycemic Agents

Additional Keywords : Dose Response, Plant Extracts

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This study demonstrates the feasibility for development of high dose EPA and DHA ethyl esters for primary prevention of breast cancer.Aug 13, 2015

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Pubmed Data : Cancer Prev Res (Phila). 2015 Aug 14. Epub 2015 Aug 14. PMID: 26276744

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Pubmed Data : J Recept Signal Transduct Res. 2015 Jun 8:1-8. Epub 2015 Jun 8. PMID: 26053510

Article Published Date : Jun 07, 2015

Study Type : Human In Vitro

Additional Links

Substances : Curcumin

Diseases : Alzheimer's Disease, Neurodegenerative Diseases

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Dose Response

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Curcumin reduced Akt expression, cell proliferation, and migration in MDA-MB-231 breast cancer cells.Dec 31, 2015

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Pubmed Data : Food Funct. 2011 Jun ;2(6):320-7. Epub 2011 Jun 6. PMID: 21779570

Article Published Date : May 31, 2011

Study Type : Animal Study

Additional Links

Diseases : Amnesia: Drug-Induced, Cognitive Decline/Dysfunction, Oxidative Stress

Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation

Additional Keywords : Dose Response, Plant Extracts

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A polyphenol-rich strawberry extract exerts important biological activities against a highly invasive breast cancer cell line.Aug 07, 2016

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Artemisia extracts were mucoprotective by attenuating stress related mucosal damages.Feb 28, 2015

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Pubmed Data : J Clin Biochem Nutr. 2015 Mar ;56(2):132-42. Epub 2014 Nov 28. PMID: 25759519

Article Published Date : Feb 28, 2015

Study Type : Animal Study

Additional Links

Substances : Artemisia asiatica

Diseases : Gastrointestinal Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Gastroprotective, Nrf2 activation

Additional Keywords : Dose Response

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Bacopa Monniera extract alleviates depression induced by chronic unpredictable stress.Jun 30, 2014

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Pubmed Data : Psychiatry Investig. 2014 Jul ;11(3):297-306. Epub 2014 Jul 21. PMID: 25110503

Article Published Date : Jun 30, 2014

Study Type : Animal Study

Additional Links

Substances : Bacopa

Diseases : Depression, Stress

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Dose Response

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Additional Keywords : Dose Response

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CCGG stimulated lipid metabolism in HED-induced obese rats, which is attributable to fat mobilization from adipose tissue.Dec 31, 2015

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Pubmed Data : BMC Complement Altern Med. 2016 ;16(1):100. Epub 2016 Mar 12. PMID: 26968378

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Cocoa, Coffee, Garcinia Mangostana, Green Tea

Diseases : Obesity

Pharmacological Actions : Anticholesteremic Agents

Additional Keywords : Anti-Obesity Agents, Dose Response

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Celery extracts were found to have vasorelaxant and antihypertensive effects.Sep 30, 2013

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Pubmed Data : Biomed Pharmacother. 2016 Aug ;82:345-54. Epub 2016 May 24. PMID: 27470372

Article Published Date : Jul 31, 2016

Study Type : Animal Study

Additional Links

Substances : Chrysin

Diseases : Hyperammonemia

Pharmacological Actions : Antioxidants, Cytoprotective

Additional Keywords : Dose Response

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Chrysin treatment improves diabetes and its complications in liver, brain, and pancreasMay 12, 2015

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Pubmed Data : Can J Physiol Pharmacol. 2015 May 13:1-6. Epub 2015 May 13. PMID: 26863330

Article Published Date : May 12, 2015

Study Type : Animal Study

Additional Links

Substances : Chrysin

Diseases : Diabetes Mellitus: Type 1, Diabetic Complications

Pharmacological Actions : Hepatoprotective, Neuroprotective Agents, Pancreato Protective Agents

Additional Keywords : Dose Response

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Coenzyme Q10 has a coloprotective effect against experimentally induced ulcerative colitis.Jan 02, 2017

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Pubmed Data : Inflammopharmacology. 2017 Jan 3. Epub 2017 Jan 3. PMID:

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View the Evidence: 634 Abstracts with Dose Response Research

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Coffee consumption is inversely associated with all cause and cardiovascular disease mortality.Oct 14, 2014

Coffee consumption is inversely associated with liver cancer risk.Dec 01, 2016

Consumption of dietary fiber is inversely associated with risk of coronary heart disease, especially for fiber from cereals and fruits.Jul 31, 2015

Dietary fiber intake, especially vegetable and legume fiber, may be associated with reduced renal cell carcinoma risk.Jul 31, 2014

Hatha yoga is a promising method for treating anxiety. May 19, 2016

High intake of total red or total processed meat is associated with a significantly increased risk of nasopharyngeal carcinoma.Jul 31, 2016

Higher consumption of fruit and vegetables is associated with a lower risk of all cause mortality, particularly cardiovascular mortality.Dec 31, 2013

Higher fruit or green leafy vegetables intake is associated with a significantly reduced risk of type 2 diabetes.Dec 31, 2013

Higher level of yogurt consumption was associated with a lower incident risk of cardiovascular disease in the dose-response analysis.Mar 21, 2017

Increased consumption of fruit and vegetables could be beneficial in preventing the risk of developing hypertension.Sep 30, 2016

Light alcohol intake may protect against dementia, while excessive drinking may instead increase the risk.Jan 16, 2017

Tea consumption could lower the risk associated with CVD mortality and for all cause mortality.Jul 22, 2015

The present meta-analysis showed that intake of vitamin C from food was inversely associated with prostate cancer risk. Dec 31, 2014

There is a highly significant linear dose-response relationship between circulating 25-OH-D levels and overall survival in patients with breast cancer.Apr 30, 2017

This meta-analysis indicated that the intake of dietary fiber was significantly associated with a decreased risk of inflammatory bowel disease.Aug 31, 2015

This meta-analysis suggested that caffeinated coffee might have chemopreventive effects against basal cell carcinoma.Nov 28, 2016

This meta-analysis suggests that processed meat may be associated with bladder cancer risk.Dec 21, 2016

Tree nut intake lowers total cholesterol, LDL cholesterol, apolipoprotein B, and triglycerides. Nov 30, 2015

A diet that includes cruciferous vegetables could be an important modifiable risk factor for ovarian cancer.Apr 24, 2018

A dose-response relationship was found between sugar-sweetened beverages intake and ADHD.Dec 31, 2015

An anthocyanin mixture reduced the inflammatory response in hypercholesterolemic subjects.Aug 31, 2013

Application of melatonin cream 12.5% protects against natural sunlight induced erythema.Aug 08, 2016

Broccoli sprouts powder led to a significant decrease in oxidative stress and oxidized low density lipoprotein cholesterol in type 2 diabetes patients.Jul 31, 2011

Caffeine given at breakfast significantly stimulated ketone production in a dose-dependent manner.Nov 24, 2016

Coffee consumption was associated with 26% lower odds of developing colorectal cancer.Mar 31, 2016

Cranberry fruit powder showed a clinically relevant, dose-dependent, and significant reduction in lower urinary tract symptoms in men over 45.Jun 06, 2015

Delphinol significantly and dose-dependently lowered basal glycemia and insulinemia. Dec 31, 2015

Drinking cocoa could activate natural immunity. Feb 29, 2016

Drinking either black or green tea was associated with a dose-dependent reduction in tuberculosis risk.May 24, 2017

Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans.Jan 31, 2006

Evening primrose oil might be effective in treating atopic dermatitis.Jul 31, 2013

Exercise reduced neuropsychiatric symptoms in patients with mild Alzheimer's disease.Dec 09, 2015

Fig fruit extracts is a possible adjunctive treatment for glycemic management of chronic metabolic disorders.Jul 30, 2019

Fried food consumption has a positive, dose-dependent association with coronary artery disease.Jun 04, 2019

Habitual tea consumption is associated with a reduced risk of type 2 diabetes among Vietnamese adults.Dec 31, 2017

High sugar intakes leads to high levels of caries in adults even in those with widespread water fluoridation and the use of fluoridated toothpastes.Dec 31, 2013

Increases in dietary polyphenols are associated with decreased inflammatory biomarkers.Apr 20, 2016

Inhaled cannabis demonstrated a dose dependent reduction in diabetic peripheral neuropathy pain in patients with treatment refractory pain.Jun 30, 2015

Lemon balm has the potential to provide health benefits with regard to glycation-associated tissue damage in blood vessels and skin of healthy adults.Dec 31, 2016

Lutein exerts anti-inflammatory effects in patients with coronary artery disease.May 05, 2017

Moderate coffee intake was associated with smaller invasive primary tumors and lower proportions of ER positive tumors compared with patients with low consumption.Feb 16, 2015

one-year treatment with melatonin increased bone mineral density at femoral neck in a dose-dependent manner, while high dose melatonin increased vBMD in the spine.Jun 02, 2015

Resveratrol supplementation increased PTX3 and TAS levels in a dose-dependent manner in T2DM patients.Feb 24, 2017

Sulforaphane detoxifies benzene, an air pollutant, in a dose-dependent manner and may attentuate attenuate associated long-term health risks of air pollution. Jul 03, 2019

The combined formulation of fruit extracts showed excellent antioxidative and anti-collagenase activity as well as a significant effect on anti-wrinkle activity on human skin.Dec 31, 2014

The present study identifies an augmented post-exercise hypotensive effect for children following green exercise compared to exercise alone.Mar 31, 2014

The results from a population sample of cyclists suggest that additional cardiovascular health benefits can be achieved beyond the current minimum physical activity recommendation.Mar 31, 2015

The study suggests that regular tea consumption may reduce the risk of de novo myelodysplastic syndromes.Jan 31, 2015

These results elucidated that apple pectin immediately enhanced quercetin absorption in human subjects.May 27, 2015

These results support the beneficial effects of black raspberry on the control of glycemia and vascular inflammation in prediabetic patients.Jun 08, 2016

These results support the beneficial effects of black raspberry on the control of glycemia and vascular inflammation in prediabetic patients.Jun 08, 2016

This study demonstrates the feasibility for development of high dose EPA and DHA ethyl esters for primary prevention of breast cancer.Aug 13, 2015

This study found that plain water intake had a significant negative correlation with T2D risk score; and regression analysis suggested that water may have a role in reducing T2D risk.Jul 01, 2015

This study may support the experimental and biological evidence for a neuroprotective effect by the endocannabinoid system in MS.Dec 23, 2014

Zolpidem use might be associated with increased risk for dementia in elderly population.Apr 30, 2015

A water extract of Withania somnifera has potent cytotoxic effect on human malignant melanoma A375 cells.Dec 31, 2014

An extract of Rosmarinus officinals L. was able to efficiently reduce the proliferation of the human melanoma A375 cells.Dec 31, 2014

Anandamide is a potent and selective inhibitor of the proliferation of breast cancer cells.Jul 06, 1998

Apigenin could be a useful compound to prevent proliferation and migration of cancer cells as well as cancer stem cells.Aug 24, 2016

Curcumin and citral in combination may be a useful therapeutic intervention for breast cancer.Aug 31, 2015

Curcumin inhibits Aβ-induced neuronal damage and cell death involving the prevention from intracellular Ca2+ elevation mediated by the NMDA receptor.Jun 07, 2015

Curcumin reduced Akt expression, cell proliferation, and migration in MDA-MB-231 breast cancer cells.Dec 31, 2015

Extracts of Yarrow can contribute to reduce genotoxicity induced by ionizing radiation in human lymphocytes.Dec 31, 2014

Fennel is a potential botanical agent for the treatment of skin damage induced by UV irradiation.Nov 14, 2016

Glycyrrhizic acid may be a promising novel therapeutic agent against neuromyelitis optica.Jul 24, 2016

Goji berry extracts have chemopreventive potential in breast cancer treatment.Nov 01, 2015

Makgeolli reduced the tumor size and volume in gastric adenocarcinoma tumor xenografts.Aug 31, 2015

Malaysian and Brazilian red propolis show potential to assist in wound healing.Dec 31, 2014

Melatonin in combination with sorafenib synergistically inhibits proliferation and induces apoptosis in human liver cancer cells.Feb 07, 2017

Melatonin is a potential candidate compound for the treatment of proinflammatory disorders.Aug 31, 2012

Morus alba flavonoid extract and doxorubicin induce a dose dependent cell death in HT-29 cell line.Mar 30, 2016

N. sativa oil could be used against multi-drug resistant S. aureus in the treatment of diabetic wounds.Oct 31, 2015

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View the Evidence:
634 Abstracts with Dose Response Research