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Dose Response
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22 Problem Substances Researched for Dose Response
Name
AC
CK
Focus
Meat
2
40
Fluoride
1
10
Sugar
1
10
Sugar Sweetened Beverages
1
10
Tamoxifen
1
10
Zolpidem (trade name Ambien)
1
10
Sodium Fluoride
3
8
Bisphenol A
4
7
Acetaminophen
3
5
Paracetamol
3
5
Dexamethasone
1
2
Diclofenac
1
2
Donepezil (trade name Aricept)
1
2
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
1
2
Paraquat
1
2
Thimerosal
2
2
Aflatoxin
1
1
Arsenite
1
1
Mercury
1
1
Monosodium Glutamate (MSG)
1
1
Nanoparticles
1
1
Streptozotocin
1
1
260 Diseases Researched for Dose Response
Name
AC
CK
Focus
Breast Cancer
57
129
Cardiovascular Diseases
6
81
Diabetes Mellitus: Type 2
15
61
Inflammation
33
61
All-Cause Mortality
3
60
Cardiac Mortality
3
60
Hypertension
8
58
Liver Cancer
29
55
Breast Cancer: Triple Negative
27
51
Alzheimer's Disease
17
50
Colon Cancer
29
49
Prostate Cancer
15
42
Hypercholesterolemia
4
41
Oxidative Stress
20
37
Lung Cancer
28
35
Dementia
4
34
Cancers: All
11
32
Diabetes Mellitus: Type 2: Prevention
2
30
Prediabetes
3
30
Bladder Cancer
6
29
Gastric Cancer
19
27
Alcohol Toxicity
3
23
Basal Cell Carcinoma
2
22
Inflammatory Bowel Diseases
2
22
Kidney Cancer
2
21
Prostate Cancer: Prevention
2
21
Anxiety Disorders
1
20
Cancer Mortality
1
20
Heart Disease
1
20
Kidney Cancer: Prevention
1
20
Nasopharyngeal Cancer
1
20
Triglycerides: Elevated
1
20
Lipopolysaccharide-Induced Toxicity
10
18
Colorectal Cancer
14
17
Melanoma
10
16
Aging Skin
2
15
High Cholesterol
2
15
Influenza A
3
13
Acute Myeloid Leukemia
7
12
Advanced Glycation End products (AGE)
3
12
Atherosclerosis
2
12
Multiple Sclerosis
2
12
Pancreatic Cancer
7
12
Cervical Cancer
10
11
Glioma
8
11
Neurodegenerative Diseases
4
11
Obesity
6
11
Atopic Dermatitis
1
10
Attention Deficit Disorder with Hyperactivity
1
10
Bone Fractures
1
10
Breast Cancer: Estrogen
1
10
C-Reactive Protein
1
10
Cardiovascular Disease: Prevention
1
10
Cholesterol: Oxidation
1
10
Coronary Artery Disease
1
10
Dental Caries
1
10
Diabetic Neuropathies
1
10
Erythema
1
10
Influenza B
1
10
Lower Urinary Tract Symptoms
1
10
Mycobacterium tuberculosis
1
10
Myelodysplastic Syndromes
1
10
Oral Cancer
9
10
Osteopenia
1
10
Osteoporosis
1
10
Rectal Cancer
1
10
Skin Diseases
1
10
Skin Diseases: Photo-Aging
1
10
Wrinkles
1
10
Depression
4
8
Neuropathic Pain
4
8
Osteosarcoma
8
8
Cancer Metastasis
2
7
Carcinoma: Non-Small-Cell Lung
6
7
Esophageal Cancer
5
7
Gastrointestinal Inflammation
2
7
Lipid Peroxidation
4
7
Ovarian Cancer
5
7
Arthritis
3
6
Brain Inflammation
4
6
Cerebral Ischemia
4
6
Cholangiocarcinoma
2
6
Cognitive Decline/Dysfunction
3
6
DNA damage
6
6
High Fat Diet
3
6
Osteoarthritis
2
6
Parkinson's Disease
4
6
Squamous cell carcinoma
5
6
Staphylococcus aureus: Methicillin-resistant (MRSA)
2
6
Acetaminophen (Tylenol) Toxicity
3
5
Bladder Cancer: Prevention
1
5
Cancers: Drug Resistant
5
5
Chemically-Induced Liver Damage
3
5
Chemotherapy-Induced Toxicity: Cisplatin
3
5
Colon Cancer: Prevention
3
5
Fluoride Toxicity
1
5
Leukemia: Chronic Lymphocytic Leukemia (CLL)
1
5
Malignant Melanoma
1
5
Neuromyelitis Optica
1
5
Prostate Cancer Stem Cells
1
5
Radiotherapy
1
5
Retinoblastoma
1
5
Tongue Cancer
1
5
Ultraviolet Radiation Induced Damage
1
5
Wound Healing
1
5
Acute lymphoblastic leukemia (ALL)
4
4
Allodynia
2
4
Amnesia: Drug-Induced
2
4
Bisphenol Toxicity
2
4
Candida Albicans
4
4
Cataract
3
4
Chemotherapy-Induced Toxicity: Paclitaxel
2
4
Colitis
2
4
Gallbladder Cancer
2
4
Infertility
2
4
Liver Fibrosis
2
4
Nonalcoholic fatty liver disease (NAFLD)
2
4
Pain
2
4
Pesticide Toxicity
2
4
Pneumonia
3
4
Staphylococcus aureus infection
3
4
Adrenal Hyperplasia: Congenital
1
3
Aging
2
3
Diabetic Complications
2
3
Endothelial Dysfunction
2
3
HIV Infections
3
3
Head and Neck Cancer
2
3
Hepatitis B
3
3
Hydrogen Peroxide Induced Toxicity
2
3
Hyperglycemia
2
3
Insulin Resistance
2
3
Leukemia
3
3
Leukemia: Acute promyelocytic leukemia
3
3
Leukemia: Chronic myelogenous leukemia (CML)
3
3
Mesothelioma
2
3
Non-Small-Cell Lung Carcinoma
3
3
Prostate Cancer: Metastatic
2
3
Retinal Diseases
2
3
Thyroid Cancer
3
3
Anthrax
1
2
Autism Spectrum Disorders
1
2
Autoimmune Diseases
1
2
Brain Edema
1
2
Brain: Oxidative Stress
1
2
Breast Cancer: HER-2 Overexpressed
1
2
Cachexia: Cancer
1
2
Cancers: Multi-Drug Resistant
2
2
Chemotherapy-Induced Kidney Damage
1
2
Chemotherapy-Induced Liver Toxicity
1
2
Chemotherapy-Induced Toxicity: Cyclophosphamide
1
2
Chemotherapy-Induced Toxicity: Gentamicin
1
2
Cholera
1
2
Choriocarcinoma
2
2
Chronic Pain
1
2
Colorectal Cancer: Prevention
1
2
Cough
1
2
Degenerative Disk Disease
1
2
Delayed Sleep Phase Disorder
1
2
Diabetes
1
2
Diabetes Mellitus: Type 1
1
2
Diabetic Nephropathy
1
2
Dyslipidemias
1
2
Ehrlich carcinoma
1
2
Encephalomyelitis
1
2
Endometriosis
1
2
Endometritis
1
2
Enteropathy
1
2
Epilepsy
1
2
Fetal Origin of Adult Disease
1
2
Fever
1
2
Fibrosis
1
2
Gastric Ulcer
1
2
Giardiasis
1
2
Glioblastoma
1
2
Hair Loss
1
2
Hepatic Steatosis
1
2
Hepatitis C
2
2
Herbicide Toxicity
1
2
Hyperalgesia
1
2
Hyperammonemia
1
2
Hyperhomocysteinemia
1
2
Hypoglycemia
1
2
Immune Disorders
1
2
Inflammation: Neutrophil-Mediated
1
2
Insomnia
1
2
Intracerebral Hemorrhage
1
2
Leptin Resistance
1
2
Liver Cirrhosis
1
2
Lung Cancer: Metastatic
1
2
Lymphoma
2
2
Melanoma: Metastasis
1
2
Morphine Tolerance/Dependence
1
2
Neuroblastoma
2
2
Neurologic Disorders
1
2
Neurotoxicity
1
2
Pancreatic Cancer: Metastatic
2
2
Pancreatic Diseases
1
2
Pancreatitis
1
2
Pancreatitis: Chronic
1
2
Peripheral Neuropathies
1
2
Prenatal Chemical Exposures
1
2
Respiratory Syncytial Virus Infections
1
2
Respiratory Tract Infections
1
2
Rheumatoid Arthritis
1
2
Sleep Disorders
1
2
Snake Bite: Venom Toxicity
1
2
Steptococcus Mutans Infections
2
2
Stress
1
2
Stroke: Attenuation/Recovery
1
2
Substance Withdrawal Syndrome
1
2
Ulcerative Colitis
1
2
Urolithiasis
1
2
Vitamin D Deficiency
1
2
Advanced Glycation Endproduct (AGE) Formation
1
1
Allergies
1
1
Alphavirus Infections
1
1
Asbestos Toxicity
1
1
Aspergillosis
1
1
Bisphenol-A Toxicity
1
1
Bone Diseases
1
1
Brain: Microglial Activation
1
1
Breast Cancer: Drug Resistant
1
1
Burkitt Lymphoma
1
1
Cardiac Hypertrophy
1
1
Chemotherapy-Induced Toxicity: Bleomycin
1
1
Chikungunya Virus
1
1
Chlamydia pneumoniae
1
1
Chlamydia trachomatis
1
1
Chondrosarcoma
1
1
Common Cold
1
1
Diabetes: Oxidative Stress
1
1
Echinococcosis
1
1
Escherichia coli Infections
1
1
Fusobacterium Infections
1
1
Gram-Positive Bacterial Infections
1
1
H1N1 Infection
1
1
Halitosis
1
1
Helicobacter Pylori Infection
1
1
Herpes Simplex Virus Type 1
1
1
Hodgkin Lymphoma
1
1
Hydatid Cyst
1
1
Hypersensitivity
1
1
Hypoxia
1
1
Leishmaniasis
1
1
Leukemia: Monocytic
1
1
Leukemia: Multi-Drug Resistant
1
1
Liver Damage: Aflatoxin-Induced
1
1
Lung Cancer: Prevention
1
1
Melanoma: Metastatic
1
1
Multiple Myeloma
1
1
Myocardial Ischemia
1
1
Oral Cancer: Prevention
1
1
Periodontal Diseases
1
1
Pseudomonas aeruginosa
1
1
Salmonella Infections
1
1
Sepsis
1
1
Skin Cancer
1
1
Tetanus
1
1
Tumors
1
1
Urothelial Tumors
1
1
1 Problematic Actions Researched for Dose Response
Name
AC
CK
Focus
Low Dose Ionizing Radiation
1
5
3 Adverse Pharmacological Actions Researched for Dose Response
Name
AC
CK
Focus
Neurotoxic
3
4
Anti-Fertility
1
2
Oxidant
1
1
315 Substances Researched for Dose Response
Name
AC
CK
Focus
Coffee
7
74
Fiber
3
60
Curcumin
36
59
Fruit: All
2
40
Vegetables: All
2
40
Black Tea
4
33
Delta-tetrahydrocannabinol (THC)
8
33
Green Tea
4
33
Melatonin
6
32
Vitamin C
6
28
Vitamin D
2
22
Black Raspberry
3
21
Caffeine
3
21
Resveratrol
10
21
Delphinidin
2
20
Green Leafy Vegetables
1
20
Legumes
1
20
Nuts
1
20
Yoghurt
1
20
Apigenin
9
19
Quercetin
7
19
Polyphenols
6
17
Shikonin
10
17
White Mulberry
3
17
EGCG (Epigallocatechin gallate)
15
16
Ginkgo biloba
5
16
Anthocyanins
5
15
Cocoa
5
15
Pomegranate
4
15
Fig
4
14
Thymoquinone
5
14
Cranberry
2
12
DHA (Docosahexaenoic Acid)
2
12
Cannabinoids
5
11
Cannabis
2
11
EPA (Eicosapentaenoic Acid)
2
11
Apple Pectin
1
10
Broccoli Sprouts
1
10
Caffeic Acid
1
10
Cannabinoids: Synthetic
1
10
Chrysin
7
10
Cyanidin 3-glucoside
1
10
Evening Primrose Oil
1
10
Huaier (Trametes robiniophila murr)
8
10
Lemon Balm
1
10
Lichens
6
10
Lutein
1
10
Maqui
1
10
Omega-3 Fatty Acids
1
10
Silibinin
7
10
Tea
1
10
Turmeric
6
10
Water
1
10
Berberine
8
9
Cannabidiol
6
9
Cucurbitacin B
7
9
Honokiol
6
9
Ashwagandha
2
8
Baicalein
6
8
Nigella sativa (aka Black Seed)
3
8
Sulforaphane
7
8
Fucoidan
5
7
Garcinia Mangostana
2
7
Luteolin
5
7
Lycopene
2
7
Pterostilbene
5
7
Puerarin
4
7
Fisetin
4
6
Genistein
6
6
Licorice
3
6
Lotus
4
6
Piperine
4
6
Rosemary
2
6
Acai
1
5
Anandamide
1
5
Apple Polyphenols
3
5
Bee Venom
4
5
Blueberry
3
5
Citral
1
5
Fennel
1
5
Flavonoids
4
5
Goji
1
5
Jujube
1
5
Lemongrass
1
5
Lychee
1
5
Mushrooms: All
4
5
Neem
1
5
Piperlongumine
1
5
Propolis: Bee
1
5
Propolis: Brazillian
1
5
Rice
1
5
Sea buckthorn
1
5
Spirulina
3
5
Tocotrienol: Delta
3
5
Wogonin
1
5
Yarrow
1
5
Apples
2
4
Bacopa
2
4
Betulinic acid
2
4
Crocin
3
4
Hibiscus sabdariffa
2
4
Naringenin
4
4
Noni
2
4
Oridonin
3
4
Plantago
3
4
Prunella vulgaris
3
4
Strawberry
2
4
Barberry
2
3
Bee Propolis
3
3
Bisdemethoxycurcumin
2
3
Carrot
2
3
Celery
2
3
Chamomile
2
3
Cinnamon
2
3
Dandelion
2
3
Garlic
2
3
Ginger
2
3
Ginseng (Korean)
2
3
Hesperidin
3
3
Kaempferol
3
3
Mangiferin
2
3
Mistletoe
2
3
Oak
2
3
Phellinus Linteus
3
3
Phyllanthus urinaria
3
3
Pumpkin
2
3
Rambutan
2
3
Rice: Black
3
3
Salvia divinorum
2
3
St. Johns Wort
2
3
Ursolic Acid
2
3
Acacia arabica
1
2
Aloe Vera
2
2
Amla Fruit
1
2
Anise
1
2
Artemisia asiatica
1
2
Artemisinin
2
2
Astaxanthin
2
2
Banana Leaf
1
2
Burdock
2
2
Cafestol
2
2
Carnosic Acid
1
2
Carnosol
1
2
Carotenoids
1
2
Carvacrol
2
2
Catechin
1
2
Chaga Mushroom (Inonotus obliquus)
2
2
Chokeberry
2
2
Chrysanthemum Indicum
2
2
Coenzyme Q10
1
2
Cranberry Proanthocyanidins
1
2
Crocetin
1
2
Cucumber
1
2
Cucurbitacin E
2
2
Curcuma Purpurascens
1
2
Curcumol
1
2
Curry Leaves
1
2
Ellagic Acid
2
2
Emodin
2
2
Feijoa
1
2
Fenugreek
1
2
Fermented Foods and Beverages
2
2
Fruit Peel
1
2
Gac
1
2
Garcinia dulcis
1
2
Garden Cress (Lepidium sativum)
1
2
Garlic: Aged
1
2
Ginseng
1
2
Graviola
2
2
Holy Basil
1
2
Honey
2
2
Horehound
1
2
Kahweol
2
2
Limonoids
1
2
Lion's Mane (Hericium Erinaceus)
1
2
Loquat
1
2
Lupeol
1
2
Magnolol
2
2
Mangosteen
2
2
Morelloflavone
1
2
Moringa oleifera
1
2
Noni leaf extract
1
2
Okra
1
2
Olive leaf extract
1
2
Oregano
1
2
Panax Ginseng
1
2
Panax Notoginseng
1
2
Patchouli
1
2
Peanut
1
2
Pelargonium sidoides
1
2
Pine Bark Extract
1
2
Prickly Pear Cactus
1
2
Punicalagin
1
2
Purslane
2
2
Pycnogenol (Pine Bark)
2
2
Raspberry
1
2
Reishi Mushroom
1
2
Rhodiola (Tibetan Ginseng)
1
2
Rhubarb
2
2
Rosemaric Acid
1
2
Rosmarinic acid
1
2
Royal Jelly
1
2
Saffron
1
2
Schisandra
2
2
Sesamin
1
2
Shemamruthaa
1
2
Shiitake Mushroom
2
2
Solanum Glaucophyllum
1
2
Sophora Flavescens
1
2
Spikenard
1
2
Sweet Potato: Purple
2
2
Tangeretin
1
2
Thistle
2
2
Tocotrienol: Gamma
2
2
Tongkat Ali
1
2
Turmerones
1
2
Vitamin D3
1
2
Vitamin E
1
2
Vitamin K
1
2
Wasabi
1
2
Wormwood
2
2
Alpha-Lipoic Acid
1
1
Alpinia galanga
1
1
Antrodia camphorata
1
1
Arctigenin
1
1
Argan Oil
1
1
Artesunate
1
1
Asparagus
1
1
Avenanthramides
1
1
Banaba
1
1
Berbamine
1
1
Berries: All
1
1
Beta-Caryophyllene
1
1
Betaine
1
1
Black Pepper
1
1
Bloodroot
1
1
Cabbage
1
1
Calcium
1
1
Capparis spinosa (caper)
1
1
Carpolobia lutea
1
1
Chickpea
1
1
Chlorella (Algae)
1
1
Citrus naringin
1
1
Cleavers
1
1
Cryptomeria japonica
1
1
Cumin
1
1
Cyanidin
1
1
D-Limonene
1
1
Daidzein
1
1
Diallyl sulfide
1
1
Docosahexaenoic acid (DHA)
1
1
Essential Oils: Unspecified
1
1
Evodiamine
1
1
False Black Pepper
1
1
Gallic Acid
1
1
Gingerol
1
1
Ginsenosides
1
1
Guava
1
1
Gymnema Sylvestre
1
1
Hawthorn
1
1
Hemp Seed
1
1
Hibiscus rosa-sinensis
1
1
Horsetail
1
1
Ice Man Fungus
1
1
Isoflavones
1
1
Isothiocyanates
1
1
Japanese mugwort
1
1
Kefir
1
1
Lemon
1
1
Lignans
1
1
Lithospermum erythrorhizon
1
1
Magnesium
1
1
Magnolia
1
1
Mango Seed
1
1
Medicinal Mushrooms
1
1
Mulberry
1
1
Myrtle (Myrtus communis L.)
1
1
Nobiletin
1
1
Oats
1
1
Oleanolic acid
1
1
Oleuropein
1
1
Palm Oil
1
1
Parsley
1
1
Peach
1
1
Phloretin
1
1
Phyllanthus amarus
1
1
Phyllanthus niruri (Stonebreaker)
1
1
Pine Needle
1
1
Plant Sterols/Stanols
1
1
Plum
1
1
Polyunsaturated Fatty Acids (PUFAs)
1
1
Pomegranate Peel
1
1
Pterocarpus marsupium
1
1
Purple Carrots
1
1
Red Sage
1
1
Rice Bran
1
1
Rutin
1
1
Sage
1
1
Sembung Leaf
1
1
Soup
1
1
Star Anise (Illicium anisatum)
1
1
Stevia
1
1
Sweet Potato
1
1
Tannic Acid
1
1
Tetrahydrocurcumin
1
1
Theaflavins
1
1
Thymol
1
1
Trichosanthes Kirilowii
1
1
Vitamin E: Gamma-tocotrienol
1
1
Vitamin E: alpha tocopherol
1
1
Vitamin K2
1
1
Walnut
1
1
Water: Deep Sea
1
1
Xanthohumol
1
1
Xanthones
1
1
8 Therapeutic Actions Researched for Dose Response
Name
AC
CK
Focus
Yoga
1
20
Exercise
3
14
Light-Emitting Diodes (LEDs) Therapy
2
11
Dietary Modification: Mediterranean Diet
1
10
Exercise: Cycling
1
10
Exercise: Green
1
10
Integrative Medicine
2
2
Laser Treatment: Low-Level
1
1
146 Pharmacological Actions Researched for Dose Response
Name
AC
CK
Focus
Antiproliferative
195
275
Apoptotic
177
275
Anti-Inflammatory Agents
72
172
Chemopreventive
41
137
Antioxidants
62
129
Cell cycle arrest
60
93
Anti-metastatic
49
75
Cardioprotective
7
73
Neuroprotective Agents
31
62
NF-kappaB Inhibitor
30
56
Hypoglycemic Agents
12
47
Bcl-2 protein down-regulation
24
41
Interleukin-1 beta downregulation
14
41
Tumor Necrosis Factor (TNF) Alpha Inhibitor
23
41
Antihypertensive Agents
7
37
Interleukin-6 Downregulation
13
35
Tumor Suppressor Protein p53 Upregulation
18
34
Anticholesteremic Agents
4
29
Cyclooxygenase 2 Inhibitors
18
29
Anticarcinogenic Agents
17
28
Hypolipidemic
4
26
Immunomodulatory
8
26
MicroRNA modulator
20
26
Analgesics
9
25
Chemosensitizer
12
25
Caspase-3 Activation
15
23
Malondialdehyde Down-regulation
8
23
Antiviral Agents
11
22
Cardiovascular Agents
2
22
Anti-Anxiety Agents
1
20
Hepatoprotective
11
20
Antinoceceptive
10
19
Matrix metalloproteinase-9 (MMP-9) inhibitor
16
19
Alpha-glucosidase inhibitor
5
18
Nrf2 activation
11
18
Antineoplastic Agents
12
17
Matrix metalloproteinase-2 (MMP-2) inhibitor
14
16
P21 Activation
7
16
Alpha-amylase inhibitor
4
14
Caspase-9 Activation
10
14
Superoxide Dismutase Up-regulation
9
14
Angiogenesis Inhibitors
7
13
Anti-Apoptotic
9
13
Chemotherapeutic
11
13
Prophylactic Agents
4
13
Anti-Glycation Agents
3
12
Anti-Tumor
3
12
Nitric Oxide Inhibitor
6
12
Prostaglandin PGE2 downregulation
6
12
Renoprotective
6
12
Immunostimulatory
2
11
Osteogenic
2
11
Anti-Bacterial Agents
6
10
Anti-collagenase
1
10
Autophagy Up-regulation
8
10
Chemoprotective Agents
5
10
Cytoprotective
6
10
Estrogen Receptor Modulators
1
10
Insulin-Like Growth Factor Inhibition/Downregulation
1
10
PER2 Protein Expression Up-regulation
1
10
Vascular Cell Adhesion Molecule-1 Inhibitor
1
10
Antimicrobial
8
9
Cyclin D1 Down-Regulation
7
9
Cytotoxic
7
9
Enzyme Inhibitors
6
9
Vascular Endothelial Growth Factor Inhibitors
6
9
Antidepressive Agents
4
8
Gastroprotective
4
8
Genoprotective
4
8
Pancreato Protective Agents
5
8
Radioprotective
3
8
Caspase-8 activation
6
7
Multidrug Resistance Gene Modulators
3
7
Neuritogenic
2
7
Acetylcholinesterase Inhibitor
2
6
Histone deacetylase inhibitor
2
6
Vasodilator Agents
3
6
Wnt/β-catenin pathway down-regulation
5
6
Anti-Angiogenic
3
5
Bax/Bcl2 ratio: Increase
4
5
Epidermal growth factor receptor (EGFR) inhibitor
3
5
Heme oxygenase-1 up-regulation
4
5
Photoprotective
1
5
Anti-Ulcer Agents
2
4
Anti-pyretic
2
4
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
2
4
Neuromodulatory
2
4
Radiosensitizer
2
4
Bax/Bcl2 Ratio: Decrease
2
3
Catalase Up-Regulation
2
3
Glutathione Upregulation
2
3
Heat Shock Protein Down-Regulation
2
3
Interleukin-10 upregulation
2
3
Redox Modulator
2
3
Topoisomerase I inhibitor
2
3
Topoisomerase II Inhibitor
2
3
Tumor Suppressor Protein p73 Upregulation
2
3
5-alpha reductase inhibitor
1
2
Anti-Fibrotic
1
2
Antidiarrheals
1
2
Antifungal Agents
2
2
Antiprotozoal Agents
1
2
Antitussive Agents
1
2
Antiurolithiatic
1
2
Autophagy Inhibitors
1
2
Bcl-xL down-regulation
1
2
Cyclooxygenase Inhibitors
1
2
Cytotoxicity
2
2
Fertility Agents
1
2
Gastrointestinal Agents
1
2
Heme oxygenase-1 inducer
1
2
Immunomodulatory: Th17 downregulation
1
2
Immunosuppressive Agents
1
2
Insulin-releasing
1
2
Lipoxygenase Inhibitors
1
2
Malonaldehyde (MDA) Down-Regulation
1
2
Matrix Metalloproteinase-7 (MMP-7) Inhibitor
2
2
Matrix Metalloproteinases Inhibitors
1
2
Neurogenesis
1
2
Postaglandin PGE2 downregulation
2
2
Proteasome Inhibitors
1
2
STAT3 Inhibitor
2
2
Survivin Down-Regulation
1
2
5-Lipoxygenase Inhibitor
1
1
Adiponectin upregulation
1
1
Angiotensin-Converting Enzyme Inhibitors
1
1
Anti-Allergic Agents
1
1
Caspase-7 Activation
1
1
Chelating Agents
1
1
Enzyme Activators
1
1
HIV Protease Inhibitors
1
1
Interferon Gamma Reducer
1
1
Interleukin-10 downregulation
1
1
Interleukin-18 down-regulation
1
1
Leishmanicidal
1
1
Matrix Metalloproteinase-13 (MMP-13) Inhibitor
1
1
Nitric Oxide Enhancer
1
1
Osteoprotective
1
1
PI3K/Akt/signaling suppression
1
1
Paraptosis
1
1
Phosphodiesterase Inhibitors
1
1
Reverse Transcriptase Inhibitors
1
1
Scolicidal
1
1
Telomerase Inhibitor
1
1
Trypsin Inhibitors
1
1
Wnt/β-catenin signaling pathway modulation
1
1
Research Articles
574
Cumulative Knowledge Score
928
Overall Research Rating
EXCELLENT
View the Evidence:
643 Abstracts with Dose Response Research
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[+]
Coffee consumption is inversely associated with all cause and cardiovascular disease mortality.
Oct 14, 2014
Click here to read the entire abstract
Pubmed Data
: Am J Epidemiol. 2014 Oct 15 ;180(8):763-75. Epub 2014 Aug 24. PMID:
25156996
Article Published Date
: Oct 14, 2014
Study Type
: Meta Analysis
Additional Links
Substances
:
Coffee
Diseases
:
All-Cause Mortality
,
Cardiac Mortality
,
Cardiovascular Diseases
Pharmacological Actions
:
Cardioprotective
Additional Keywords
:
Dose Response
,
Risk Reduction
[+]
Coffee consumption is inversely associated with liver cancer risk.
Dec 01, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2016 Dec 2 ;6:37488. Epub 2016 Dec 2. PMID:
27910873
Article Published Date
: Dec 01, 2016
Study Type
: Meta Analysis
Additional Links
Substances
:
Coffee
Diseases
:
Liver Cancer
Additional Keywords
:
Dose Response
,
Risk Reduction
[+]
Consumption of dietary fiber is inversely associated with risk of coronary heart disease, especially for fiber from cereals and fruits.
Jul 31, 2015
Click here to read the entire abstract
Pubmed Data
: Clin Nutr. 2015 Aug ;34(4):603-11. Epub 2014 May 28. PMID:
24929874
Article Published Date
: Jul 31, 2015
Study Type
: Meta Analysis
Additional Links
Substances
:
Fiber
Diseases
:
Cardiac Mortality
,
Heart Disease
Pharmacological Actions
:
Cardioprotective
Additional Keywords
:
Dose Response
,
Risk Reduction
[+]
Dietary fiber intake, especially vegetable and legume fiber, may be associated with reduced renal cell carcinoma risk.
Jul 31, 2014
Click here to read the entire abstract
Pubmed Data
: Med Oncol. 2014 Aug ;31(8):125. Epub 2014 Jul 20. PMID:
25038944
Article Published Date
: Jul 31, 2014
Study Type
: Meta Analysis
Additional Links
Substances
:
Fiber
,
Legumes
,
Vegetables: All
Diseases
:
Kidney Cancer
,
Kidney Cancer: Prevention
Additional Keywords
:
Dose Response
[+]
Hatha yoga is a promising method for treating anxiety.
May 19, 2016
Click here to read the entire abstract
Pubmed Data
: J Evid Based Med. 2016 May 20. Epub 2016 May 20. PMID:
27203378
Article Published Date
: May 19, 2016
Study Type
: Meta Analysis
Additional Links
Diseases
:
Anxiety Disorders
Therapeutic Actions
:
Yoga
Pharmacological Actions
:
Anti-Anxiety Agents
Additional Keywords
:
Dose Response
[+]
High intake of total red or total processed meat is associated with a significantly increased risk of nasopharyngeal carcinoma.
Jul 31, 2016
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2016 Aug-Sep;68(6):1034-43. Epub 2016 Jul 1. PMID:
27367552
Article Published Date
: Jul 31, 2016
Study Type
: Meta Analysis
Additional Links
Diseases
:
Nasopharyngeal Cancer
Additional Keywords
:
Dose Response
,
Increased Risk
Problem Substances
:
Meat
[+]
Higher consumption of fruit and vegetables is associated with a lower risk of all cause mortality, particularly cardiovascular mortality.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMJ. 2014 ;349:g4490. Epub 2014 Jul 29. PMID:
25073782
Article Published Date
: Dec 31, 2013
Study Type
: Meta Analysis
Additional Links
Diseases
:
All-Cause Mortality
,
Cancers: All
,
Cardiovascular Diseases
Pharmacological Actions
:
Cardiovascular Agents
Additional Keywords
:
Dose Response
,
Risk Reduction
[+]
Higher fruit or green leafy vegetables intake is associated with a significantly reduced risk of type 2 diabetes.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMJ Open. 2014 ;4(11):e005497. Epub 2014 Nov 5. PMID:
25377009
Article Published Date
: Dec 31, 2013
Study Type
: Meta Analysis
Additional Links
Substances
:
Fruit: All
,
Green Leafy Vegetables
Diseases
:
Diabetes Mellitus: Type 2
,
Diabetes Mellitus: Type 2: Prevention
Additional Keywords
:
Dose Response
,
Risk Reduction
[+]
Higher level of yogurt consumption was associated with a lower incident risk of cardiovascular disease in the dose-response analysis.
Mar 21, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2017 Mar 22 ;9(3). Epub 2017 Mar 22. PMID:
28327514
Article Published Date
: Mar 21, 2017
Study Type
: Meta Analysis
Additional Links
Substances
:
Yoghurt
Diseases
:
Cardiovascular Diseases
Additional Keywords
:
Cardiovascular Diseases
,
Dose Response
,
Risk Reduction
,
Yoghurt
[+]
Increased consumption of fruit and vegetables could be beneficial in preventing the risk of developing hypertension.
Sep 30, 2016
Click here to read the entire abstract
Pubmed Data
: J Hum Hypertens. 2016 Oct ;30(10):573-80. Epub 2016 Jun 16. PMID:
27306085
Article Published Date
: Sep 30, 2016
Study Type
: Meta Analysis
Additional Links
Substances
:
Fruit: All
,
Vegetables: All
Diseases
:
Hypertension
Additional Keywords
:
Dose Response
,
Risk Reduction
[+]
Light alcohol intake may protect against dementia, while excessive drinking may instead increase the risk.
Jan 16, 2017
Click here to read the entire abstract
Pubmed Data
: Eur J Epidemiol. 2017 Jan 17. Epub 2017 Jan 17. PMID:
28097521
Article Published Date
: Jan 16, 2017
Study Type
: Meta Analysis
Additional Links
Diseases
:
Alcohol Toxicity
,
Dementia
Additional Keywords
:
Dose Response
,
Increased Risk
,
Risk Reduction
[+]
Tea consumption could lower the risk associated with CVD mortality and for all cause mortality.
Jul 22, 2015
Click here to read the entire abstract
Pubmed Data
: Br J Nutr. 2015 Jul 23:1-11. Epub 2015 Jul 23. PMID:
26202661
Article Published Date
: Jul 22, 2015
Study Type
: Meta Analysis
Additional Links
Substances
:
Black Tea
,
Green Tea
Diseases
:
All-Cause Mortality
,
Cancer Mortality
,
Cardiac Mortality
Pharmacological Actions
:
Cardioprotective
,
Chemopreventive
Additional Keywords
:
Dose Response
,
Risk Reduction
[+]
The present meta-analysis showed that intake of vitamin C from food was inversely associated with prostate cancer risk.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Cancer. 2015 ;6(9):913-21. Epub 2015 Jul 28. PMID:
26284143
Article Published Date
: Dec 31, 2014
Study Type
: Meta Analysis
Additional Links
Substances
:
Vitamin C
Diseases
:
Prostate Cancer
,
Prostate Cancer: Prevention
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Dose Response
,
Risk Reduction
[+]
There is a highly significant linear dose-response relationship between circulating 25-OH-D levels and overall survival in patients with breast cancer.
Apr 30, 2017
Click here to read the entire abstract
Pubmed Data
: Integr Cancer Ther. 2017 May 1:1534735417712007. Epub 2017 May 1. PMID:
28589744
Article Published Date
: Apr 30, 2017
Study Type
: Meta Analysis
Additional Links
Substances
:
Vitamin D
Diseases
:
Breast Cancer
Additional Keywords
:
Dose Response
[+]
This meta-analysis indicated that the intake of dietary fiber was significantly associated with a decreased risk of inflammatory bowel disease.
Aug 31, 2015
Click here to read the entire abstract
Pubmed Data
: Nutr Res. 2015 Sep ;35(9):753-8. Epub 2015 Jun 3. PMID:
26126709
Article Published Date
: Aug 31, 2015
Study Type
: Meta Analysis
Additional Links
Substances
:
Fiber
Diseases
:
Inflammatory Bowel Diseases
Additional Keywords
:
Dose Response
,
Risk Reduction
[+]
This meta-analysis suggested that caffeinated coffee might have chemopreventive effects against basal cell carcinoma.
Nov 28, 2016
Click here to read the entire abstract
Pubmed Data
: Eur J Cancer Prev. 2016 Nov 29. Epub 2016 Nov 29. PMID:
27902644
Article Published Date
: Nov 28, 2016
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Coffee
Diseases
:
Basal Cell Carcinoma
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Dose Response
,
Risk Reduction
[+]
This meta-analysis suggests that processed meat may be associated with bladder cancer risk.
Dec 21, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Eur J Nutr. 2016 Dec 22. Epub 2016 Dec 22. PMID:
28070638
Article Published Date
: Dec 21, 2016
Study Type
: Meta Analysis
Additional Links
Diseases
:
Bladder Cancer
Additional Keywords
:
bladder cancer
,
Cancer
,
Dose Response
,
Meat
,
red meat
,
Risk Factors
Problem Substances
:
Meat
[+]
Tree nut intake lowers total cholesterol, LDL cholesterol, apolipoprotein B, and triglycerides.
Nov 30, 2015
Click here to read the entire abstract
Pubmed Data
: Am J Clin Nutr. 2015 Dec ;102(6):1347-56. Epub 2015 Nov 11. PMID:
26561616
Article Published Date
: Nov 30, 2015
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Nuts
Diseases
:
Hypercholesterolemia
,
Triglycerides: Elevated
Pharmacological Actions
:
Anticholesteremic Agents
,
Hypolipidemic
Additional Keywords
:
Dose Response
[+]
A diet that includes cruciferous vegetables could be an important modifiable risk factor for ovarian cancer.
Apr 24, 2018
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2018 Apr 25:1-6. Epub 2018 Apr 25. PMID:
29693426
Article Published Date
: Apr 24, 2018
Study Type
: Human Study
Additional Links
Substances
:
Cruciferous Vegetables
Diseases
:
Ovarian Cancer
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Dose Response
[+]
A dose-response relationship was found between sugar-sweetened beverages intake and ADHD.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Environ Res Public Health. 2016 ;13(7). Epub 2016 Jul 4. PMID:
27384573
Article Published Date
: Dec 31, 2015
Study Type
: Human Study
Additional Links
Diseases
:
Attention Deficit Disorder with Hyperactivity
Additional Keywords
:
Dose Response
,
Increased Risk
Problem Substances
:
Sugar Sweetened Beverages
[+]
An anthocyanin mixture reduced the inflammatory response in hypercholesterolemic subjects.
Aug 31, 2013
Click here to read the entire abstract
Pubmed Data
: Nutr Metab Cardiovasc Dis. 2013 Sep ;23(9):843-9. Epub 2012 Aug 17. PMID:
22906565
Article Published Date
: Aug 31, 2013
Study Type
: Human Study
Additional Links
Substances
:
Anthocyanins
,
Cyanidin 3-glucoside
,
Delphinidin
Diseases
:
Atherosclerosis
,
C-Reactive Protein
,
High Cholesterol
,
Hypercholesterolemia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Vascular Cell Adhesion Molecule-1 Inhibitor
Additional Keywords
:
Dose Response
,
Natural Substance Synergy
[+]
Application of melatonin cream 12.5% protects against natural sunlight induced erythema.
Aug 08, 2016
Click here to read the entire abstract
Pubmed Data
: J Dermatol Sci. 2016 Aug 9. Epub 2016 Aug 9. PMID:
27543364
Article Published Date
: Aug 08, 2016
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Erythema
,
Skin Diseases
,
Skin Diseases: Photo-Aging
Additional Keywords
:
Dose Response
[+]
Broccoli sprouts powder led to a significant decrease in oxidative stress and oxidized low density lipoprotein cholesterol in type 2 diabetes patients.
Jul 31, 2011
Click here to read the entire abstract
Pubmed Data
: Eur J Clin Nutr. 2011 Aug ;65(8):972-7. Epub 2011 May 11. PMID:
21559038
Article Published Date
: Jul 31, 2011
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
Diseases
:
Cholesterol: Oxidation
,
Diabetes Mellitus: Type 2
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Malondialdehyde Down-regulation
Additional Keywords
:
Dose Response
,
Phytotherapy
[+]
Caffeine given at breakfast significantly stimulated ketone production in a dose-dependent manner.
Nov 24, 2016
Click here to read the entire abstract
Pubmed Data
: Can J Physiol Pharmacol. 2016 Nov 25. Epub 2016 Nov 25. PMID:
28177691
Article Published Date
: Nov 24, 2016
Study Type
: Human Study
Additional Links
Substances
:
Caffeine
Diseases
:
Alzheimer's Disease
Additional Keywords
:
Dose Response
[+]
Coffee consumption was associated with 26% lower odds of developing colorectal cancer.
Mar 31, 2016
Click here to read the entire abstract
Pubmed Data
: Cancer Epidemiol Biomarkers Prev. 2016 Apr ;25(4):634-9. PMID:
27196095
Article Published Date
: Mar 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Coffee
Diseases
:
Colon Cancer
,
Rectal Cancer
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Dose Response
,
Risk Reduction
[+]
Cranberry fruit powder showed a clinically relevant, dose-dependent, and significant reduction in lower urinary tract symptoms in men over 45.
Jun 06, 2015
Click here to read the entire abstract
Pubmed Data
: World J Urol. 2015 Jun 7. Epub 2015 Jun 7. PMID:
26049866
Article Published Date
: Jun 06, 2015
Study Type
: Human Study
Additional Links
Substances
:
Cranberry
Diseases
:
Lower Urinary Tract Symptoms
Additional Keywords
:
Dose Response
,
Significant Treatment Outcome
[+]
Delphinol significantly and dose-dependently lowered basal glycemia and insulinemia.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Res Int. 2016 ;2016:9070537. Epub 2016 Nov 29. PMID:
28025651
Article Published Date
: Dec 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Delphinidin
,
Maqui
Diseases
:
Prediabetes
Pharmacological Actions
:
Alpha-amylase inhibitor
,
Alpha-glucosidase inhibitor
,
Hypoglycemic Agents
Additional Keywords
:
Alpha-amylase inhibitor
,
Alpha-Glucosidase Inhibitor
,
Delphinidin
,
Dose Response
,
Hypoglycemic Agents
,
Maqui
,
Plant Extracts
,
Prediabetes
[+]
Drinking cocoa could activate natural immunity.
Feb 29, 2016
Click here to read the entire abstract
Pubmed Data
: J Sci Food Agric. 2016 Mar ;96(4):1150-8. Epub 2015 Apr 27. PMID:
25847473
Article Published Date
: Feb 29, 2016
Study Type
: Animal Study, Human Study, In Vitro Study
Additional Links
Substances
:
Cocoa
Diseases
:
Influenza A
,
Influenza B
Pharmacological Actions
:
Antiviral Agents
,
Immunostimulatory
Additional Keywords
:
Dose Response
[+]
Drinking either black or green tea was associated with a dose-dependent reduction in tuberculosis risk.
May 24, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2017 May 25 ;9(6). Epub 2017 May 25. PMID:
28587081
Article Published Date
: May 24, 2017
Study Type
: Human Study
Additional Links
Substances
:
Black Tea
,
Green Tea
Diseases
:
Mycobacterium tuberculosis
Pharmacological Actions
:
Prophylactic Agents
Additional Keywords
:
Dose Response
,
Risk Reduction
[+]
Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans.
Jan 31, 2006
Click here to read the entire abstract
Pubmed Data
: Eur J Neurosci. 2006 Feb ;23(4):1082-6. PMID:
16519674
Article Published Date
: Jan 31, 2006
Study Type
: Human Study
Additional Links
Therapeutic Actions
:
Light-Emitting Diodes (LEDs) Therapy
Pharmacological Actions
:
PER2 Protein Expression Up-regulation
Additional Keywords
:
Circadian Rhythm
,
Dose Response
,
PER2 Protein
[+]
Evening primrose oil might be effective in treating atopic dermatitis.
Jul 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Ann Dermatol. 2013 Aug ;25(3):285-91. Epub 2013 Aug 13. PMID:
24003269
Article Published Date
: Jul 31, 2013
Study Type
: Human Study
Additional Links
Substances
:
Evening Primrose Oil
Diseases
:
Atopic Dermatitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Immunomodulatory
Additional Keywords
:
Dose Response
[+]
Exercise reduced neuropsychiatric symptoms in patients with mild Alzheimer's disease.
Dec 09, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Alzheimers Dis. 2015 Dec 10 ;50(2):443-53. PMID:
26682695
Article Published Date
: Dec 09, 2015
Study Type
: Human Study
Additional Links
Diseases
:
Alzheimer's Disease
Therapeutic Actions
:
Exercise
Additional Keywords
:
Dose Response
,
Risk Reduction
[+]
Fig fruit extracts is a possible adjunctive treatment for glycemic management of chronic metabolic disorders.
Jul 30, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2019 Jul 31 ;11(8). Epub 2019 Jul 31. PMID:
31370154
Article Published Date
: Jul 30, 2019
Study Type
: Human Study
Additional Links
Substances
:
Fig
Diseases
:
Diabetes Mellitus: Type 2
,
Prediabetes
Pharmacological Actions
:
Hypoglycemic Agents
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
Fried food consumption has a positive, dose-dependent association with coronary artery disease.
Jun 04, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Clin Nutr. 2019 Jun 5. Epub 2019 Jun 5. PMID:
31279615
Article Published Date
: Jun 04, 2019
Study Type
: Human Study
Additional Links
Diseases
:
Coronary Artery Disease
Additional Keywords
:
Dose Response
,
Increased Risk
Problem Substances
:
Fried Foods
[+]
Habitual tea consumption is associated with a reduced risk of type 2 diabetes among Vietnamese adults.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Asia Pac J Clin Nutr. 2018 ;27(3):701-706. PMID:
29737820
Article Published Date
: Dec 31, 2017
Study Type
: Human Study
Additional Links
Substances
:
Black Tea
,
Green Tea
Diseases
:
Diabetes Mellitus: Type 2: Prevention
Additional Keywords
:
Dose Response
,
Risk Reduction
[+]
High sugar intakes leads to high levels of caries in adults even in those with widespread water fluoridation and the use of fluoridated toothpastes.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Public Health. 2014 ;14:863. Epub 2014 Sep 16. PMID:
25228012
Article Published Date
: Dec 31, 2013
Study Type
: Human Study
Additional Links
Diseases
:
Dental Caries
Additional Keywords
:
Dose Response
Problem Substances
:
Fluoride
,
Sugar
[+]
Increases in dietary polyphenols are associated with decreased inflammatory biomarkers.
Apr 20, 2016
Click here to read the entire abstract
Pubmed Data
: Br J Clin Pharmacol. 2016 Apr 21. Epub 2016 Apr 21. PMID:
27100393
Article Published Date
: Apr 20, 2016
Study Type
: Human Study
Additional Links
Substances
:
Polyphenols
Diseases
:
Cardiovascular Diseases
,
Hypertension
,
Inflammation
Therapeutic Actions
:
Dietary Modification: Mediterranean Diet
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antihypertensive Agents
Additional Keywords
:
Dose Response
,
Risk Reduction
[+]
Inhaled cannabis demonstrated a dose dependent reduction in diabetic peripheral neuropathy pain in patients with treatment refractory pain.
Jun 30, 2015
Click here to read the entire abstract
Pubmed Data
: J Pain. 2015 Jul ;16(7):616-27. Epub 2015 Apr 3. PMID:
25843054
Article Published Date
: Jun 30, 2015
Study Type
: Human Study
Additional Links
Substances
:
Cannabis
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Diabetic Neuropathies
Pharmacological Actions
:
Analgesics
Additional Keywords
:
Dose Response
,
Significant Treatment Outcome
[+]
Lemon balm has the potential to provide health benefits with regard to glycation-associated tissue damage in blood vessels and skin of healthy adults.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Nutr Sci Vitaminol (Tokyo). 2017 ;63(1):59-68. PMID:
28367927
Article Published Date
: Dec 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Lemon Balm
Diseases
:
Advanced Glycation End products (AGE)
Pharmacological Actions
:
Anti-Glycation Agents
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
Lutein exerts anti-inflammatory effects in patients with coronary artery disease.
May 05, 2017
Click here to read the entire abstract
Pubmed Data
: Atherosclerosis. 2017 May 6 ;262:87-93. Epub 2017 May 6. PMID:
28527371
Article Published Date
: May 05, 2017
Study Type
: Human Study
Additional Links
Substances
:
Lutein
Diseases
:
Coronary Artery Disease
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
Additional Keywords
:
Dose Response
[+]
Moderate coffee intake was associated with smaller invasive primary tumors and lower proportions of ER positive tumors compared with patients with low consumption.
Feb 16, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Clin Cancer Res. 2015 Feb 17. Epub 2015 Feb 17. PMID:
25691730
Article Published Date
: Feb 16, 2015
Study Type
: Human Study
Additional Links
Substances
:
Caffeic Acid
,
Caffeine
Diseases
:
Breast Cancer
,
Breast Cancer: Estrogen
Pharmacological Actions
:
Anti-Tumor
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemopreventive
,
Estrogen Receptor Modulators
,
Insulin-Like Growth Factor Inhibition/Downregulation
Additional Keywords
:
Dose Response
,
Risk Reduction
Problem Substances
:
Tamoxifen
[+]
one-year treatment with melatonin increased bone mineral density at femoral neck in a dose-dependent manner, while high dose melatonin increased vBMD in the spine.
Jun 02, 2015
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2015 Jun 3. Epub 2015 Jun 3. PMID:
26036434
Article Published Date
: Jun 02, 2015
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Bone Fractures
,
Osteopenia
,
Osteoporosis
Pharmacological Actions
:
Osteogenic
Additional Keywords
:
Dose Response
,
Significant Treatment Outcome
[+]
Resveratrol supplementation increased PTX3 and TAS levels in a dose-dependent manner in T2DM patients.
Feb 24, 2017
Click here to read the entire abstract
Pubmed Data
: Acta Diabetol. 2017 Feb 25. Epub 2017 Feb 25. PMID:
28238190
Article Published Date
: Feb 24, 2017
Study Type
: Human Study
Additional Links
Substances
:
Resveratrol
Diseases
:
Diabetes Mellitus: Type 2
Additional Keywords
:
Diabetes mellitus: Type 2
,
Dose Response
,
RESVERATROL
[+]
Sulforaphane detoxifies benzene, an air pollutant, in a dose-dependent manner and may attentuate attenuate associated long-term health risks of air pollution.
Jul 03, 2019
Click here to read the entire abstract
Pubmed Data
: Am J Clin Nutr. 2019 Jul 3. Epub 2019 Jul 3. PMID:
31268126
Article Published Date
: Jul 03, 2019
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Air Pollution Linked Toxicity
,
Benzene Toxicity
Pharmacological Actions
:
Antioxidant Effects
,
Detoxifier
Additional Keywords
:
Airborne Pollution
,
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Dose Response
,
Environmental Pollutant
,
Environmental Pollution
Problem Substances
:
Airborne Pollution
,
Benzene
[+]
The combined formulation of fruit extracts showed excellent antioxidative and anti-collagenase activity as well as a significant effect on anti-wrinkle activity on human skin.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Clin Cosmet Investig Dermatol. 2015 ;8:389-96. Epub 2015 Jul 16. PMID:
26203268
Article Published Date
: Dec 31, 2014
Study Type
: Human Study, In Vitro Study
Additional Links
Substances
:
Fig
,
Ginkgo biloba
,
Pomegranate
,
White Mulberry
Diseases
:
Aging Skin
,
Wrinkles
Pharmacological Actions
:
Anti-collagenase
,
Antioxidants
Additional Keywords
:
Dose Response
,
Natural Substances Versus Drugs
,
Plant Extracts
[+]
The present study identifies an augmented post-exercise hypotensive effect for children following green exercise compared to exercise alone.
Mar 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Environ Res Public Health. 2014 Apr ;11(4):3678-88. Epub 2014 Apr 2. PMID:
24699030
Article Published Date
: Mar 31, 2014
Study Type
: Human Study
Additional Links
Diseases
:
Hypertension
Therapeutic Actions
:
Exercise: Green
Pharmacological Actions
:
Antihypertensive Agents
Additional Keywords
:
Dose Response
[+]
The results from a population sample of cyclists suggest that additional cardiovascular health benefits can be achieved beyond the current minimum physical activity recommendation.
Mar 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Hum Hypertens. 2015 Apr ;29(4):219-23. Epub 2014 Oct 2. PMID:
25273856
Article Published Date
: Mar 31, 2015
Study Type
: Human Study
Additional Links
Diseases
:
Cardiovascular Disease: Prevention
,
Cardiovascular Diseases
,
Hypercholesterolemia
,
Hypertension
Therapeutic Actions
:
Exercise: Cycling
Pharmacological Actions
:
Antihypertensive Agents
,
Cardioprotective
Additional Keywords
:
Dose Response
,
Risk Reduction
[+]
The study suggests that regular tea consumption may reduce the risk of de novo myelodysplastic syndromes.
Jan 31, 2015
Click here to read the entire abstract
Pubmed Data
: Leuk Res. 2015 Feb ;39(2):164-9. Epub 2014 Dec 2. PMID:
25529769
Article Published Date
: Jan 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Tea
Diseases
:
Myelodysplastic Syndromes
Additional Keywords
:
Dose Response
,
Risk Reduction
[+]
These results elucidated that apple pectin immediately enhanced quercetin absorption in human subjects.
May 27, 2015
Click here to read the entire abstract
Pubmed Data
: Br J Nutr. 2015 May 28 ;113(10):1531-8. Epub 2015 Apr 13. PMID:
25865751
Article Published Date
: May 27, 2015
Study Type
: Human Study
Additional Links
Substances
:
Apple Pectin
,
Quercetin
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Dose Response
[+]
These results support the beneficial effects of black raspberry on the control of glycemia and vascular inflammation in prediabetic patients.
Jun 08, 2016
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2016 Jun 9. Epub 2016 Jun 9. PMID:
27279471
Article Published Date
: Jun 08, 2016
Study Type
: Human Study
Additional Links
Substances
:
Black Raspberry
Diseases
:
Prediabetes
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hypoglycemic Agents
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
These results support the beneficial effects of black raspberry on the control of glycemia and vascular inflammation in prediabetic patients.
Jun 08, 2016
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2016 Jun 9. Epub 2016 Jun 9. PMID:
27279471
Article Published Date
: Jun 08, 2016
Study Type
: Human Study
Additional Links
Substances
:
Black Raspberry
Diseases
:
Prediabetes
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hypoglycemic Agents
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
This study demonstrates the feasibility for development of high dose EPA and DHA ethyl esters for primary prevention of breast cancer.
Aug 13, 2015
Click here to read the entire abstract
Pubmed Data
: Cancer Prev Res (Phila). 2015 Aug 14. Epub 2015 Aug 14. PMID:
26276744
Article Published Date
: Aug 13, 2015
Study Type
: Human Study
Additional Links
Substances
:
DHA (Docosahexaenoic Acid)
,
EPA (Eicosapentaenoic Acid)
,
Omega-3 Fatty Acids
Diseases
:
Breast Cancer
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Dose Response
[+]
This study found that plain water intake had a significant negative correlation with T2D risk score; and regression analysis suggested that water may have a role in reducing T2D risk.
Jul 01, 2015
Click here to read the entire abstract
Pubmed Data
: Nutr Res. 2015 Jul 2. Epub 2015 Jul 2. PMID:
26255759
Article Published Date
: Jul 01, 2015
Study Type
: Human Study
Additional Links
Substances
:
Water
Diseases
:
Diabetes Mellitus: Type 2: Prevention
Additional Keywords
:
Dose Response
,
Risk Reduction
[+]
This study may support the experimental and biological evidence for a neuroprotective effect by the endocannabinoid system in MS.
Dec 23, 2014
Click here to read the entire abstract
Pubmed Data
: J Neuroimmune Pharmacol. 2014 Dec 24. Epub 2014 Dec 24. PMID:
25537576
Article Published Date
: Dec 23, 2014
Study Type
: Human Study
Additional Links
Substances
:
Cannabinoids: Synthetic
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Multiple Sclerosis
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Dose Response
[+]
Zolpidem use might be associated with increased risk for dementia in elderly population.
Apr 30, 2015
Click here to read the entire abstract
Pubmed Data
: Medicine (Baltimore). 2015 May ;94(17):e809. PMID:
25929937
Article Published Date
: Apr 30, 2015
Study Type
: Human Study
Additional Links
Diseases
:
Dementia
Additional Keywords
:
Dose Response
,
Increased Risk
Problem Substances
:
Zolpidem (trade name Ambien)
[+]
A water extract of Withania somnifera has potent cytotoxic effect on human malignant melanoma A375 cells.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(9):e0137498. Epub 2015 Sep 3. PMID:
26334881
Article Published Date
: Dec 31, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Ashwagandha
Diseases
:
Malignant Melanoma
Pharmacological Actions
:
Apoptotic
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
An extract of Rosmarinus officinals L. was able to efficiently reduce the proliferation of the human melanoma A375 cells.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(7):e0132439. Epub 2015 Jul 15. PMID:
26176704
Article Published Date
: Dec 31, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Rosemary
Diseases
:
Melanoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
Anandamide is a potent and selective inhibitor of the proliferation of breast cancer cells.
Jul 06, 1998
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Proc Natl Acad Sci U S A. 1998 Jul 7 ;95(14):8375-80. PMID:
9653194
Article Published Date
: Jul 06, 1998
Study Type
: Human In Vitro
Additional Links
Substances
:
Anandamide
,
Cannabinoids
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
Additional Keywords
:
Cannabinoid Receptors
,
Dose Response
[+]
Apigenin could be a useful compound to prevent proliferation and migration of cancer cells as well as cancer stem cells.
Aug 24, 2016
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2016 Aug 25. Epub 2016 Aug 25. PMID:
27569589
Article Published Date
: Aug 24, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
Apigenin
Diseases
:
Prostate Cancer
,
Prostate Cancer Stem Cells
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
NF-kappaB Inhibitor
Additional Keywords
:
Dose Response
[+]
Curcumin and citral in combination may be a useful therapeutic intervention for breast cancer.
Aug 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Breast Cancer. 2015 Sep ;18(3):225-34. Epub 2015 Sep 24. PMID:
26472972
Article Published Date
: Aug 31, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Citral
,
Curcumin
,
Lemongrass
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Dose Response
,
Natural Substance Synergy
,
Selective Cytotoxicity
[+]
Curcumin inhibits Aβ-induced neuronal damage and cell death involving the prevention from intracellular Ca2+ elevation mediated by the NMDA receptor.
Jun 07, 2015
Click here to read the entire abstract
Pubmed Data
: J Recept Signal Transduct Res. 2015 Jun 8:1-8. Epub 2015 Jun 8. PMID:
26053510
Article Published Date
: Jun 07, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Curcumin
Diseases
:
Alzheimer's Disease
,
Neurodegenerative Diseases
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Dose Response
[+]
Curcumin reduced Akt expression, cell proliferation, and migration in MDA-MB-231 breast cancer cells.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2016 ;11(1):e0146553. Epub 2016 Jan 11. PMID:
26752181
Article Published Date
: Dec 31, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Curcumin
Diseases
:
Breast Cancer: Triple Negative
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
Additional Keywords
:
Dose Response
[+]
Extracts of Yarrow can contribute to reduce genotoxicity induced by ionizing radiation in human lymphocytes.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Dose Response. 2015 Jan-Mar;13(1):1559325815583761. Epub 2015 Apr 29. PMID:
26675116
Article Published Date
: Dec 31, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Yarrow
Diseases
:
Radiotherapy
Pharmacological Actions
:
Antioxidants
,
Genoprotective
,
Radioprotective
Additional Keywords
:
Dose Response
,
Plant Extracts
Anti Therapeutic Actions
:
Low Dose Ionizing Radiation
[+]
Fennel is a potential botanical agent for the treatment of skin damage induced by UV irradiation.
Nov 14, 2016
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2016 Nov 15 ;23(12):1273-1284. Epub 2016 Jun 16. PMID:
27765346
Article Published Date
: Nov 14, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
Fennel
Diseases
:
Aging Skin
,
Ultraviolet Radiation Induced Damage
Pharmacological Actions
:
Antioxidants
,
Nrf2 activation
,
Photoprotective
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
Glycyrrhizic acid may be a promising novel therapeutic agent against neuromyelitis optica.
Jul 24, 2016
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2016 Jul 25. Epub 2016 Jul 25. PMID:
27462020
Article Published Date
: Jul 24, 2016
Study Type
: Human In Vitro
Additional Links
Diseases
:
Neuromyelitis Optica
Pharmacological Actions
:
Immunomodulatory
Additional Keywords
:
Dose Response
[+]
Goji berry extracts have chemopreventive potential in breast cancer treatment.
Nov 01, 2015
Click here to read the entire abstract
Pubmed Data
: Nat Prod Res. 2015 Nov 2:1-4. Epub 2015 Nov 2. PMID:
26525080
Article Published Date
: Nov 01, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Goji
Diseases
:
Breast Cancer
Pharmacological Actions
:
Apoptotic
,
Chemopreventive
Additional Keywords
:
Dose Response
,
Plant Extracts
,
Selective Cytotoxicity
[+]
Makgeolli reduced the tumor size and volume in gastric adenocarcinoma tumor xenografts.
Aug 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Microbiol Biotechnol. 2015 Sep ;25(9):1485-92. PMID:
26017227
Article Published Date
: Aug 31, 2015
Study Type
: Animal Study, Human In Vitro
Additional Links
Substances
:
Rice
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Apoptotic
Additional Keywords
:
Dose Response
[+]
Malaysian and Brazilian red propolis show potential to assist in wound healing.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2015 ;15:294. Epub 2015 Aug 25. PMID:
26303848
Article Published Date
: Dec 31, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Propolis: Bee
,
Propolis: Brazillian
Diseases
:
Wound Healing
Additional Keywords
:
Dose Response
,
Gene Expression Regulation
[+]
Melatonin in combination with sorafenib synergistically inhibits proliferation and induces apoptosis in human liver cancer cells.
Feb 07, 2017
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2017 Feb 8. Epub 2017 Feb 8. PMID:
28178378
Article Published Date
: Feb 07, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Chemosensitizer
Additional Keywords
:
Chemothapeutic Synergy: Sorafenib
,
Dose Response
[+]
Melatonin is a potential candidate compound for the treatment of proinflammatory disorders.
Aug 31, 2012
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2012 Sep ;53(2):154-65. Epub 2012 Feb 21. PMID:
22348531
Article Published Date
: Aug 31, 2012
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
NF-kappaB Inhibitor
,
Nitric Oxide Inhibitor
,
Prostaglandin PGE2 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Dose Response
[+]
Morus alba flavonoid extract and doxorubicin induce a dose dependent cell death in HT-29 cell line.
Mar 30, 2016
Click here to read the entire abstract
Pubmed Data
: Cell Mol Biol (Noisy-le-grand). 2016 Mar 31 ;62(3):72-7. Epub 2016 Mar 31. PMID:
27064876
Article Published Date
: Mar 30, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
White Mulberry
Diseases
:
Colon Cancer
Pharmacological Actions
:
Apoptotic
,
Chemosensitizer
Additional Keywords
:
Chemotherapeutic Synergy: Doxorubicin
,
COLON CANCER
,
Dose Response
,
Plant Extracts
,
White Mulberry
[+]
N. sativa oil could be used against multi-drug resistant S. aureus in the treatment of diabetic wounds.
Oct 31, 2015
Click here to read the entire abstract
Pubmed Data
: Pak J Pharm Sci. 2015 Nov ;28(6):1985-90. PMID:
26639493
Article Published Date
: Oct 31, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions
:
Anti-Bacterial Agents
Additional Keywords
:
Dose Response
[+]
Neem leaf extract exhibits anti-leukemic properties in patient primary chronic lymphocytic leukemia cells.
Feb 28, 2014
Click here to read the entire abstract
Pubmed Data
: Leuk Lymphoma. 2014 Mar ;55(3):652-61. Epub 2013 Jul 1. PMID:
23721511
Article Published Date
: Feb 28, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Neem
Diseases
:
Leukemia: Chronic Lymphocytic Leukemia (CLL)
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
Oligonol has strong preventative potential in diabetes mellitus and in Alzheimer's disease.
Feb 29, 2016
Click here to read the entire abstract
Pubmed Data
: Arch Pharm Res. 2016 Mar ;39(3):409-20. Epub 2016 Jan 2. PMID:
26724817
Article Published Date
: Feb 29, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
Lychee
Diseases
:
Alzheimer's Disease
,
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Acetylcholinesterase Inhibitor
,
Alpha-glucosidase inhibitor
Additional Keywords
:
Dose Response
,
Proanthocyanidins
[+]
P. sulcata inhibited the growth in a dose-dependent manner and induced caspase-independent apoptosis at low doses.
Apr 30, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cytotechnology. 2015 May ;67(3):531-43. Epub 2014 Mar 28. PMID:
24676908
Article Published Date
: Apr 30, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Lichens
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Apoptotic
,
Caspase-3 Activation
Additional Keywords
:
Apoptotic
,
Breast Cancer
,
Breast Cancer: Triple Negative
,
Caspase-3 Activation
,
Dose Response
,
Lichens
[+]
Piperlongumine could reverse chemotherapy resistance of retinoblastoma cancer cells in a dose-dependent manner.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Clin Exp Pathol. 2015 ;8(3):2525-34. Epub 2015 Mar 1. PMID:
26045758
Article Published Date
: Dec 31, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Piperlongumine
Diseases
:
Retinoblastoma
Pharmacological Actions
:
Multidrug Resistance Gene Modulators
Additional Keywords
:
Dose Response
[+]
Sea buckthorn procyanidins were promising FAS inhibitors which could induce the apoptosis of MDA-MB-231 cells.
Sep 30, 2014
Click here to read the entire abstract
Pubmed Data
: Tumour Biol. 2014 Oct ;35(10):9563-9. Epub 2014 Jun 24. PMID:
24957042
Article Published Date
: Sep 30, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Sea buckthorn
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Apoptotic
Additional Keywords
:
Dose Response
,
Phytotherapy
[+]
Shikonin induces apoptosis in HL-60 cells without significant effect on primary cells from healthy volunteers.
Jul 14, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Physiol Biochem. 2016 Jul 15 ;39(2):604-616. Epub 2016 Jul 15. PMID:
27415599
Article Published Date
: Jul 14, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
Shikonin
Diseases
:
Acute Myeloid Leukemia
Pharmacological Actions
:
Apoptotic
Additional Keywords
:
Dose Response
[+]
THC inhibited cell proliferation, migration and invasion, and induced cell apoptosis in cholangiocarcinoma cells.
Apr 30, 2010
Click here to read the entire abstract
Pubmed Data
: Cancer Invest. 2010 May ;28(4):357-63. PMID:
19916793.
Article Published Date
: Apr 30, 2010
Study Type
: Human In Vitro
Additional Links
Substances
:
Delta-tetrahydrocannabinol (THC)
Diseases
:
Cancer Metastasis
,
Cholangiocarcinoma
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
Additional Keywords
:
Dose Response
[+]
The present study results indicated that human bladder cancer T-24 cells are highly sensitive to growth inhibition by apigenin.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Cell Int. 2015 ;15:33. Epub 2015 Mar 29. PMID:
25859163
Article Published Date
: Dec 31, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Apigenin
Diseases
:
Bladder Cancer
,
Bladder Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Cell cycle arrest
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Dose Response
[+]
The results suggest that overexposure to fluoride (160-320 μM) can induce cytotoxicity and regulate relevant genes expression.
Feb 28, 2015
Click here to read the entire abstract
Pubmed Data
: Biol Trace Elem Res. 2015 Mar 1. Epub 2015 Mar 1. PMID:
25726004
Article Published Date
: Feb 28, 2015
Study Type
: Human In Vitro
Additional Links
Diseases
:
Fluoride Toxicity
Additional Keywords
:
Dose Response
,
Gene Expression
Problem Substances
:
Sodium Fluoride
[+]
These results indicate the potential for açai polyphenolics in the prevention of intestinal inflammation.
Oct 06, 2015
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2015 Oct 7 ;6(10):3249-56. PMID:
26243669
Article Published Date
: Oct 06, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Acai
Diseases
:
Gastrointestinal Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Dose Response
[+]
These results proposed the benefits of jujube in regulating expressions of neurotrophic factors and anti-oxidant enzymes in cultured astrocytes.
Oct 31, 2014
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2014 Nov ;28(11):1727-30. Epub 2014 Jul 28. PMID:
25066116
Article Published Date
: Oct 31, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Jujube
Pharmacological Actions
:
Antioxidants
,
Neuritogenic
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
This study provides the first evidence that lycopene inhibits cholesterol absorption in the intestinal cells.
Aug 11, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2015 Aug 12. Epub 2015 Aug 12. PMID:
26264562
Article Published Date
: Aug 11, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Lycopene
Diseases
:
High Cholesterol
Pharmacological Actions
:
Anticholesteremic Agents
Additional Keywords
:
Dose Response
[+]
Thymoquinone inhibited IL-1β-induced inflammatory mediator production by inhibition of NF-κB and MAPKs signaling pathways in osteoarthritis chondrocytes.
Jul 08, 2015
Click here to read the entire abstract
Pubmed Data
: Inflammation. 2015 Jul 9. Epub 2015 Jul 9. PMID:
26156811
Article Published Date
: Jul 08, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Thymoquinone
Diseases
:
Inflammation
,
Osteoarthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
NF-kappaB Inhibitor
Additional Keywords
:
Dose Response
[+]
Thymoquinone promotes pancreatic cancer cell death and reduction of tumor size.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Adv Prev Med. 2016 ;2016:1407840. Epub 2016 Dec 26. PMID:
28105374
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study, Human In Vitro
Additional Links
Substances
:
Thymoquinone
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Cell cycle arrest
,
Histone deacetylase inhibitor
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Dose Response
[+]
Wogonin could increase doxorubicin sensitivity in human breast cancer cells.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Cell Mol Biol (Noisy-le-grand). 2015 ;61(7):123-7. Epub 2015 Nov 30. PMID:
26638893
Article Published Date
: Dec 31, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Wogonin
Diseases
:
Breast Cancer
Pharmacological Actions
:
Chemosensitizer
Additional Keywords
:
Chemotherapeutic Synergy: Doxorubicin
,
Dose Response
[+]
α-mangostin induces the apoptosis of YD-15 tongue carcinoma cells through the ERK1/2 and p38 MAPK signaling pathways.
Mar 03, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Med. 2016 Mar 4. Epub 2016 Mar 4. PMID:
26951885
Article Published Date
: Mar 03, 2016
Study Type
: Animal Study, Human In Vitro
Additional Links
Substances
:
Garcinia Mangostana
Diseases
:
Tongue Cancer
Pharmacological Actions
:
Apoptotic
Additional Keywords
:
Dose Response
[+]
Treatment of Nonclassic 11-Hydroxylase deficiency with Ashwagandha root.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Case Rep Endocrinol. 2017 ;2017:1869560. Epub 2017 Jun 20. PMID:
28713602
Article Published Date
: Dec 31, 2016
Study Type
: Human: Case Report
Additional Links
Substances
:
Ashwagandha
Diseases
:
Adrenal Hyperplasia: Congenital
Additional Keywords
:
Dose Response
[+]
P. densiflora bark extract dose-dependently prevented cataract formation.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Vis. 2017 ;23:638-648. Epub 2017 Sep 11. PMID:
28943754
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Pine Bark Extract
Diseases
:
Cataract
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
4-hydroxyisoleucine showed significant and dose-dependent antidepressant effects.
Sep 30, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pharmacogn Mag. 2015 Oct ;11(Suppl 3):S388-96. PMID:
26929572
Article Published Date
: Sep 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Fenugreek
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
Additional Keywords
:
Dose Response
[+]
A botanical extract of turmeric and white mulberry acted as a bradykinin receptor B1 and B2 antagonist.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: J Integr Med. 2016 Jan ;14(1):60-68. PMID:
26778230
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Turmeric
,
White Mulberry
Pharmacological Actions
:
Analgesics
,
Anti-Inflammatory Agents
,
Cyclooxygenase Inhibitors
,
Lipoxygenase Inhibitors
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
A enriched extract of blueberry anthocyanins protected against cyclophosphamide induced lung damage.
Oct 15, 2014
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2014 Oct 16 ;222C:106-111. Epub 2014 Oct 16. PMID:
25451569
Article Published Date
: Oct 15, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Anthocyanins
,
Blueberry
Diseases
:
Chemotherapy-Induced Toxicity: Cyclophosphamide
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
Additional Keywords
:
Dose Response
[+]
A Huaier polysaccharide reduced metastasis of human hepatocellular carcinoma.
Jul 31, 2015
Click here to read the entire abstract
Pubmed Data
: Tumour Biol. 2015 Aug ;36(8):6285-93. Epub 2015 Mar 19. PMID:
25787750
Article Published Date
: Jul 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Huaier (Trametes robiniophila murr)
Diseases
:
Cancer Metastasis
,
Liver Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Chemopreventive
Additional Keywords
:
Dose Response
[+]
A lipid-soluble ginseng extract potently inhibited invasion and migration of B16F10 mouse melanoma cells in a dose-dependent manner.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2015 Jan ;18(1):102-8. PMID:
25354136
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Ginseng
Diseases
:
Melanoma
,
Melanoma: Metastasis
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Dose Response
[+]
A methanol extract of Musa sapientum leaves have anti-diabetic properties.
Jun 29, 2013
Click here to read the entire abstract
Pubmed Data
: Niger J Physiol Sci. 2013 Jun 30 ;28(1):91-7. Epub 2013 Jun 30. PMID:
23955414
Article Published Date
: Jun 29, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Banana Leaf
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Alpha-amylase inhibitor
,
Hypoglycemic Agents
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
A methanolic extract of Chaga mushroom led to a significant enhancement of cognitive abilities in the observed mice.
May 31, 2011
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2011 Jun ;2(6):320-7. Epub 2011 Jun 6. PMID:
21779570
Article Published Date
: May 31, 2011
Study Type
: Animal Study
Additional Links
Diseases
:
Amnesia: Drug-Induced
,
Cognitive Decline/Dysfunction
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Malondialdehyde Down-regulation
,
Neuroprotective Agents
,
Superoxide Dismutase Up-regulation
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
A polyphenol-rich strawberry extract exerts important biological activities against a highly invasive breast cancer cell line.
Aug 07, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2016 Aug 8 ;6:30917. Epub 2016 Aug 8. PMID:
27498973
Article Published Date
: Aug 07, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Polyphenols
,
Strawberry
Diseases
:
Breast Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Cell cycle arrest
,
Chemopreventive
Additional Keywords
:
Dose Response
[+]
A polysaccharide from Sophora flavescens roots could be used safely to attenuate both inflammatory and peripheral neuropathic pain.
Aug 22, 2016
Click here to read the entire abstract
Pubmed Data
: Int J Biol Macromol. 2016 Aug 23. Epub 2016 Aug 23. PMID:
27565290
Article Published Date
: Aug 22, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Sophora Flavescens
Diseases
:
Neuropathic Pain
,
Peripheral Neuropathies
Pharmacological Actions
:
Antinoceceptive
Additional Keywords
:
Dose Response
[+]
Acacia Arabica extract has hypoglycemic, hypolipidemic, and antioxidant properties, therefore, it can be investigated for its efficacy in the treatment of diabetes in humans.
Jun 30, 2013
Click here to read the entire abstract
Pubmed Data
: Saudi Med J. 2013 Jul ;34(7):727-33. PMID:
23860893
Article Published Date
: Jun 30, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Acacia arabica
Diseases
:
Diabetes
Pharmacological Actions
:
Antioxidants
,
Hypoglycemic Agents
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
AGE and RGE significantly reduced the level of TNF-α and interleukin-6 in serum and completely protected against LPS-induced lethal shock in C57BL/6 mice.
Sep 30, 2014
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2014 Oct ;17(10):1057-63. Epub 2014 Sep 19. PMID:
25238199
Article Published Date
: Sep 30, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Garlic
Diseases
:
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
NF-kappaB Inhibitor
,
Nitric Oxide Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
AGE exhibits a dose-dependent ameliorative action on indicators of diabetes in STZ-induced diabetic rats.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2016 ;16(1):17. Epub 2016 Jan 19. PMID:
26786785
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Garlic: Aged
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Antioxidants
,
Hypoglycemic Agents
Additional Keywords
:
Dose Response
[+]
Amla extract may prove useful as an alternative or adjunct therapeutic approach in helping to fight ovarian cancer.
Dec 31, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2013 ;8(8):e72748. Epub 2013 Aug 15. PMID:
24133573
Article Published Date
: Dec 31, 2012
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Amla Fruit
Diseases
:
Ovarian Cancer
Pharmacological Actions
:
Anti-Angiogenic
,
Antineoplastic Agents
,
Antiproliferative
Additional Keywords
:
Chemotherapeutic Synergy: Cisplatin
,
Dose Response
,
Plant Extracts
[+]
An extract from roots of Pelargonium sidoides could be beneficial in respiratory tract infections.
Apr 14, 2015
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2015 Apr 15 ;22(4):504-9. Epub 2015 Mar 20. PMID:
25925973
Article Published Date
: Apr 14, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Pelargonium sidoides
Diseases
:
Cough
,
Respiratory Tract Infections
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Antitussive Agents
,
Malondialdehyde Down-regulation
,
Superoxide Dismutase Up-regulation
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
An extract of Curcuma purpurascens suppressed the proliferation of HT-29 colon cancer cells and triggered the induction of apoptosis through mitochondrial-dependent pathway.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2015 ;15:15. Epub 2015 Feb 5. PMID:
25652758
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Curcuma Purpurascens
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Caspase-3 Activation
,
Caspase-9 Activation
Additional Keywords
:
Dose Response
[+]
Apigenin reduces paraquat induced acute lung injury by inhibition of inflammation and oxidative stress.
Jan 18, 2016
Click here to read the entire abstract
Pubmed Data
: Inflammation. 2016 Jan 19. Epub 2016 Jan 19. PMID:
26782361
Article Published Date
: Jan 18, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Apigenin
Diseases
:
Herbicide Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
NF-kappaB Inhibitor
Additional Keywords
:
Dose Response
[+]
Apple total triterpenoid content induced apoptosis in MDA-MB-231 cells.
Sep 18, 2012
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2012 Sep 19 ;60(37):9430-6. Epub 2012 Sep 6. PMID:
22924395
Article Published Date
: Sep 18, 2012
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Apples
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
,
Colon Cancer
,
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
NF-kappaB Inhibitor
Additional Keywords
:
Dose Response
[+]
Aromatic turmerone constitutes a promising candidate to support regeneration in neurologic disease.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Stem Cell Res Ther. 2014 ;5(4):100. Epub 2014 Sep 26. PMID:
25928248
Article Published Date
: Dec 31, 2013
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Turmeric
,
Turmerones
Diseases
:
Neurodegenerative Diseases
,
Neurologic Disorders
Pharmacological Actions
:
Neurogenesis
,
Neuroprotective Agents
Additional Keywords
:
Dose Response
,
Neural Stem Cell
[+]
Artemisia extracts were mucoprotective by attenuating stress related mucosal damages.
Feb 28, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Clin Biochem Nutr. 2015 Mar ;56(2):132-42. Epub 2014 Nov 28. PMID:
25759519
Article Published Date
: Feb 28, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Artemisia asiatica
Diseases
:
Gastrointestinal Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Gastroprotective
,
Nrf2 activation
Additional Keywords
:
Dose Response
[+]
Bacopa Monniera extract alleviates depression induced by chronic unpredictable stress.
Jun 30, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Psychiatry Investig. 2014 Jul ;11(3):297-306. Epub 2014 Jul 21. PMID:
25110503
Article Published Date
: Jun 30, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Bacopa
Diseases
:
Depression
,
Stress
Pharmacological Actions
:
Antidepressive Agents
Additional Keywords
:
Dose Response
[+]
Bacopa monnieri extracts have significant anti-hyperglycemic and anti-nociceptive potential.
Oct 31, 2015
Click here to read the entire abstract
Pubmed Data
: Pak J Pharm Sci. 2015 Nov ;28(6):2135-9. PMID:
26639482
Article Published Date
: Oct 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Bacopa
Diseases
:
Chronic Pain
,
Hyperglycemia
Pharmacological Actions
:
Antinoceceptive
,
Hypoglycemic Agents
Additional Keywords
:
Dose Response
,
Superiority of Natural Substances versus Drugs
[+]
Baicalein significantly improved the biochemical and histopathological condition of Alzheimer's disease in rats.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Neuropsychiatr Dis Treat. 2016 ;12:3145-3152. Epub 2016 Dec 9. PMID:
28003750
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Baicalein
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Alzheimer's disease
,
Baicalein
,
Dose Response
,
Neuroprotective Agents
[+]
Bee venom is a potentially potent 5α-reductase inhibitor and hair growth promoter.
Apr 01, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biol Pharm Bull. 2016 Apr 2. Epub 2016 Apr 2. PMID:
27040904
Article Published Date
: Apr 01, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Bee Venom
Diseases
:
Hair Loss
Pharmacological Actions
:
5-alpha reductase inhibitor
Additional Keywords
:
Dose Response
[+]
Berberine significantly reduces tumor growth in vivo.
Aug 18, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2016 Aug 19. Epub 2016 Aug 19. PMID:
27557493
Article Published Date
: Aug 18, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Glioblastoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Autophagy Up-regulation
Additional Keywords
:
Dose Response
[+]
Berberis vulgaris fruit has beneficial effects in rat pulmonary fibrosis induced by paraquat.
Jun 30, 2016
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2016 Jul ;81:329-36. Epub 2016 Apr 26. PMID:
27261610
Article Published Date
: Jun 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Barberry
Diseases
:
Fibrosis
,
Pesticide Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Dose Response
Problem Substances
:
Paraquat
[+]
Betulinic acid can be the potential therapeutic agent for virus infection via anti-inflammatory activity.
Jun 30, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomol Ther (Seoul). 2015 Jul ;23(4):345-9. Epub 2015 Jul 1. PMID:
26157551
Article Published Date
: Jun 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Betulinic acid
Diseases
:
Influenza A
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antiviral Agents
Additional Keywords
:
Dose Response
[+]
Betulinic acid was able to mitigate dexamethasone -induced oxidative stress and might play an important role in repairs of oxidative damage in immunological system.
Jun 30, 2015
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2015 Jul ;27(1):85-94. Epub 2015 May 7. PMID:
25959028
Article Published Date
: Jun 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Betulinic acid
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Dose Response
Problem Substances
:
Dexamethasone
[+]
Bisdemethoxycurcumin attenuated gastric adenocarcinoma growth by inducing mitochondrial dysfunction.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2015 Jan ;9(1):270-274. Epub 2014 Nov 7. PMID:
25435973
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Bisdemethoxycurcumin
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Apoptotic
Additional Keywords
:
Dose Response
[+]
BPA concentration was associated with increased circulating inflammatory factors.
May 31, 2016
Click here to read the entire abstract
Pubmed Data
: Endocrinology. 2016 Jun ;157(6):2333-45. Epub 2016 May 4. PMID:
27145005
Article Published Date
: May 31, 2016
Study Type
: Animal Study
Additional Links
Diseases
:
Bisphenol Toxicity
,
Inflammation
,
Obesity
Additional Keywords
:
Dose Response
Problem Substances
:
Bisphenol A
[+]
BPA might penetrate the placental barrier and perturb the fetal thyroid adipokine axis to influence fat metabolism and the endocrine system.
Jun 16, 2016
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2016 Jun 17. Epub 2016 Jun 17. PMID:
27326465
Article Published Date
: Jun 16, 2016
Study Type
: Animal Study
Additional Links
Diseases
:
Bisphenol Toxicity
,
Fetal Origin of Adult Disease
,
Prenatal Chemical Exposures
Additional Keywords
:
Dose Response
Problem Substances
:
Bisphenol A
[+]
Cannabidiol is a potential therapeutic for the affective-motivational dimension of incision pain in rats.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2017 ;8:391. Epub 2017 Jun 21. PMID:
28680401
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Allodynia
Pharmacological Actions
:
Analgesics
Additional Keywords
:
Dose Response
[+]
Cannabinoids can prime glioma cells to respond better to ionizing radiation and suggest a potential clinical benefit for glioma patients by using these two treatment modalities.
Nov 30, 2014
Click here to read the entire abstract
Pubmed Data
: Mol Cancer Ther. 2014 Dec ;13(12):2955-67. Epub 2014 Nov 14. PMID:
25398831
Article Published Date
: Nov 30, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabidiol
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Glioma
Pharmacological Actions
:
Radiosensitizer
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
Carnosol and carnosic acid displayed significant and dose-dependent anti-inflammatory and anti-nociceptive effects.
Jul 26, 2016
Click here to read the entire abstract
Pubmed Data
: Br J Pharmacol. 2016 Jul 27. Epub 2016 Jul 27. PMID:
27464306
Article Published Date
: Jul 26, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Carnosic Acid
,
Carnosol
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antinoceceptive
Additional Keywords
:
Dose Response
[+]
Carrot showed a significant nephroprotective effect in a dose-dependent manner by ameliorating the gentamicin-induced nephrotoxicity.
Feb 29, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Indian J Pharmacol. 2016 Mar-Apr;48(2):122-7. PMID:
27127313
Article Published Date
: Feb 29, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Carrot
Diseases
:
Chemotherapy-Induced Toxicity: Gentamicin
Pharmacological Actions
:
Chemoprotective Agents
,
Renoprotective
Additional Keywords
:
Dose Response
[+]
CCGG stimulated lipid metabolism in HED-induced obese rats, which is attributable to fat mobilization from adipose tissue.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2016 ;16(1):100. Epub 2016 Mar 12. PMID:
26968378
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cocoa
,
Coffee
,
Garcinia Mangostana
,
Green Tea
Diseases
:
Obesity
Pharmacological Actions
:
Anticholesteremic Agents
Additional Keywords
:
Anti-Obesity Agents
,
Dose Response
[+]
Celery extracts were found to have vasorelaxant and antihypertensive effects.
Sep 30, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Asian Pac J Trop Biomed. 2013 Oct ;3(10):776-9. Epub 2013 Sep 4. PMID:
24075341
Article Published Date
: Sep 30, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Celery
Diseases
:
Hypertension
Pharmacological Actions
:
Antihypertensive Agents
,
Vasodilator Agents
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
Chamomile decoction extract can be used as functional beverage against obesity, hyperglycemia and hyperlipidemia.
Jan 01, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Jan 2 ;87:153-159. Epub 2017 Jan 2. PMID:
28056419
Article Published Date
: Jan 01, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Chamomile
Diseases
:
High Fat Diet
,
Obesity
Pharmacological Actions
:
Antioxidants
,
Hypoglycemic Agents
,
Hypolipidemic
,
Renoprotective
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
Chronic curcumin ameliorates AD-related cognitive deficits and that upregulated BDNF-ERK signaling in the hippocampus.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(6):e0131525. Epub 2015 Jun 26. PMID:
26114940
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Diseases
:
Alzheimer's Disease
,
Cognitive Decline/Dysfunction
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Dose Response
[+]
Chrysin mitigated side effects of acute Paracetamol toxicity in male reproductive system proportionally in a dose-dependent manner.
Feb 23, 2016
Click here to read the entire abstract
Pubmed Data
: Andrologia. 2016 Feb 24. Epub 2016 Feb 24. PMID:
26914515
Article Published Date
: Feb 23, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Chrysin
Diseases
:
Acetaminophen (Tylenol) Toxicity
Pharmacological Actions
:
Cytoprotective
Additional Keywords
:
Dose Response
Problem Substances
:
Acetaminophen
,
Paracetamol
[+]
Chrysin protects against cell injury induced by ammonia intoxication in a dose-response manner.
Jul 31, 2016
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2016 Aug ;82:345-54. Epub 2016 May 24. PMID:
27470372
Article Published Date
: Jul 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Chrysin
Diseases
:
Hyperammonemia
Pharmacological Actions
:
Antioxidants
,
Cytoprotective
Additional Keywords
:
Dose Response
[+]
Chrysin treatment improves diabetes and its complications in liver, brain, and pancreas
May 12, 2015
Click here to read the entire abstract
Pubmed Data
: Can J Physiol Pharmacol. 2015 May 13:1-6. Epub 2015 May 13. PMID:
26863330
Article Published Date
: May 12, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Chrysin
Diseases
:
Diabetes Mellitus: Type 1
,
Diabetic Complications
Pharmacological Actions
:
Hepatoprotective
,
Neuroprotective Agents
,
Pancreato Protective Agents
Additional Keywords
:
Dose Response
[+]
Coenzyme Q10 has a coloprotective effect against experimentally induced ulcerative colitis.
Jan 02, 2017
Click here to read the entire abstract
Pubmed Data
: Inflammopharmacology. 2017 Jan 3. Epub 2017 Jan 3. PMID:
28050757
Article Published Date
: Jan 02, 2017
Study Type
: Animal Study
Additional Links
Substances
: