Metabolic Diseases

Name	AC	CK
Polyphenols	6	35
Vitamin D	3	30
Coffee	1	20
Lutein	1	20
Magnesium	1	20
Tea: Black	1	20
Tea: Green	1	20
Zinc	1	20
Curcumin	4	16
Hibiscus sabdariffa	2	12
Nigella sativa (aka Black Seed)	2	12
Turmeric	2	12
Black Raspberry	1	10
Cannabis	1	10
Coenzyme Q10	1	10
Curcuminoids	1	10
DHEA (Dehydroepiandrosterone)	1	10
Grape	1	10
Omega-3 Fatty Acids	1	10
Piperine	1	10
Pomegranate	1	10
Vitamin C	3	7
Green Tea	2	4
Melatonin	2	4
Resveratrol	3	4
Vitamin E	2	4
Kaempferia parviflora	2	3
Raspberry	2	3
Alpha-Lipoic Acid	1	2
Berberine	1	2
Black Currant	1	2
Cannabinoids	1	2
Carnitine	1	2
Ellagic Acid	1	2
Ferulic acid	1	2
Glycyrrhizin	1	2
Grapefruit peel extract	1	2
Peach	1	2
Plum	1	2
Probiotics	2	2
Quercetin	1	2
Rutin	1	2
Tetrahydrocurcumin	1	2
Thymoquinone	1	2
Xanthohumol	1	2
EGCG (Epigallocatechin gallate)	1	1
Lemon Verbena	1	1
Prebiotics	1	1

Name	AC	CK
Antipsychotic Drugs	2	21
Polychlorinated biphenyls (PCBs)	2	20
Risperidone	1	20
Sugar Sweetened Beverages	2	20
Dichlorodiphenyldichloroethylene (DDE)	1	10
Organochlorine compounds	1	10
Organochlorine pesticides	1	10
Bisphenol A	4	7
Aspartame	2	3
Artificial Sweeteners	2	2
Carboxymethyl Cellulose	1	2
Fluoxetine (trade name Prozac)	1	2
Pioglitazone (trade Name Actos)	1	2
Polysorbate 80	1	2
Selective Serotonin Reuptake Inhibitors (SSRIs)	1	2
Sucrose	1	2
High Fructose Corn Syrup	1	1
Saccharin	1	1
Sucralose (aka Splenda)	1	1

Name	AC	CK
Exercise	4	14
Dietary Modification: Low Carbohydrate/Ketogenic	1	10
Dietary Modification: Mediterranean Diet	1	10
Fasting/Caloric Restriction	1	2

Name	AC	CK
Shift Work	1	10
Urbanization	1	10
Western Diet	1	2

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Alpha-lipoic acid administration may lead to an improvement in glucose homeostasis parameters and lipid profiles except HDL-cholesterol levels.Jul 06, 2018

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Pubmed Data : Metabolism. 2018 Jul 7. Epub 2018 Jul 7. PMID: 29990473

Article Published Date : Jul 06, 2018

Study Type : Meta Analysis, Review

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Metabolic Diseases

Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic

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Zinc may contribute to the management of hyperglycemia in individuals with chronic metabolic disease.Nov 04, 2012

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Pubmed Data : J Trace Elem Med Biol. 2012 Nov 5. Epub 2012 Nov 5. PMID: 23137858

Article Published Date : Nov 04, 2012

Study Type : Meta Analysis

Additional Links

Substances : Zinc

Diseases : A1C, Hyperglycemia, Metabolic Diseases

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A Western dietary pattern is prospectively associated with cardio-metabolic traits and incidence of the metabolic syndrome.Apr 30, 2018

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Pubmed Data : Br J Nutr. 2018 May ;119(10):1168-1176. PMID: 29759108

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Pubmed Data : Eur J Nutr. 2015 Sep 18. Epub 2015 Sep 18. PMID: 26385228

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Pubmed Data : J Phys Ther Sci. 2016 Mar ;28(3):983-91. Epub 2016 Mar 31. PMID: 27134398

Article Published Date : Feb 29, 2016

Study Type : Human Study

Additional Links

Diseases : Metabolic Diseases, Smoking: Pulmonary, Smoking Cessation: Nicotine Addiction

Therapeutic Actions : Exercise

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Glucose homeostasis may worsen after decades of exposure to PCBs and OCPs at background environmental levels, independent of BMI.Jan 31, 2015

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Pubmed Data : Environ Res. 2015 Feb ;137:485-94. Epub 2015 Feb 23. PMID: 25706918

Article Published Date : Jan 31, 2015

Study Type : Human Study

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Diseases : Diabetes Mellitus: Type 2, Insulin Resistance, Metabolic Diseases

Additional Keywords : Risk Factors

Problem Substances : Organochlorine pesticides, Polychlorinated biphenyls (PCBs)

Adverse Pharmacological Actions : Diabetogenic

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H. sabdariffa extract improved metabolism, displayed potent anti-inflammatory and antioxidant activities, and significantly reduced blood pressure.May 31, 2014

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Pubmed Data : Mol Nutr Food Res. 2014 Jun ;58(6):1374-8. Epub 2014 Feb 24. PMID: 24668839

Article Published Date : May 31, 2014

Study Type : Human Study

Additional Links

Substances : Hibiscus sabdariffa , Polyphenols

Diseases : Cardiovascular Diseases, Endothelial Dysfunction, Hypertension, Metabolic Diseases, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antihypertensive Agents, Antioxidants

Additional Keywords : Plant Extracts, Significant Treatment Outcome

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Improvement of vitamin D status may help reduce the public health burden of metabolic syndrome, and potential subsequent health conditions including type 2 diabetes and cardiovascular disease.Dec 31, 2014

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Pubmed Data : Diabetes Care. 2013 Jun ;36(6):1454-61. Epub 2012 Dec 28. PMID: 23275372

Article Published Date : May 31, 2013

Study Type : Human Study

Additional Links

Substances : Grape, Polyphenols

Diseases : Diabetes Mellitus: Type 2, Insulin Resistance, Metabolic Diseases, Oxidative Stress

Pharmacological Actions : Antioxidants

Additional Keywords : High-fructose Corn Syrup

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The combined application of berberine in patients with metabolic syndrome can effectively regulate blood glucose and blood lipid of patients.Mar 31, 2019

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Pubmed Data : Metab Syndr Relat Disord. 2018 Sep ;16(7):350-357. Epub 2018 Jul 10. PMID: 29989845

Article Published Date : Aug 31, 2018

Study Type : Animal Study

Additional Links

Diseases : High Fructose Diet, Liver Damage, Metabolic Diseases

[+]

Berberine ameliorates non alcoholic fatty liver disease and related metabolic disorders.Dec 31, 2014

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Pubmed Data : PLoS One. 2015 ;10(8):e0134172. Epub 2015 Aug 7. PMID: 26252777

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Metabolic Diseases, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

Additional Keywords : Gene Expression Regulation

[+]

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Pubmed Data : Redox Biol. 2015 Jun 26 ;6:206-217. Epub 2015 Jun 26. PMID: 26262997

Article Published Date : Jun 25, 2015

Study Type : Animal Study

Additional Links

Substances : Grapefruit peel extract, Green Tea, Polyphenols, Vitamin C, Vitamin E

Diseases : Metabolic Diseases, Obesity, Oxidative Stress

Pharmacological Actions : Anti-Glycation Agents, Antioxidants, Malondialdehyde Down-regulation

Additional Keywords : Risk Reduction

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Curcumin treatment can partially recover the metabolism disorders induced by high-fat diet.Dec 31, 2014

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Pubmed Data : Nutrients. 2019 Feb 27 ;11(3). Epub 2019 Feb 27. PMID: 30818779

Article Published Date : Feb 26, 2019

Study Type : Animal Study

Additional Links

Substances : Coffee: Green/Unroasted

Diseases : Liver Damage, Metabolic Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents, Hepatoprotective, Interleukin-6 Downregulation

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GTE+Ex function in part by inducing the conversion of WAT to BLAT and provides novel mechanistic insight into this combination.Mar 31, 2015

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Pubmed Data : J Funct Foods. 2015 Apr 1 ;14:210-214. PMID: 25844091

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Pubmed Data : J Pharmacol Exp Ther. 2018 May ;365(2):281-290. Epub 2018 Feb 22. PMID: 29472517

Article Published Date : Apr 30, 2018

Study Type : Animal Study

Additional Links

Substances : Nordihydroguaiaretic acid (NDGA)

Diseases : Metabolic Diseases

Pharmacological Actions : Antioxidants, MicroRNA modulator

Anti Therapeutic Actions : Western Diet

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Protective effects of Bacillus probiotics against high-fat diet-induced metabolic disorders in mice.Dec 31, 2017

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Pubmed Data : PLoS One. 2018 ;13(12):e0210120. Epub 2018 Dec 31. PMID: 30596786

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Probiotics

Diseases : High Fat Diet, Metabolic Diseases

Pharmacological Actions : Gastrointestinal Agents, Hypolipidemic

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Additional Keywords : Risk Reduction

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Supplementation of Lactobacillus plantarum improves markers of metabolic dysfunction induced by a high fat diet.Jul 05, 2018

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Pubmed Data : J Proteome Res. 2018 Jul 6. Epub 2018 Jul 6. PMID: 29931981

Article Published Date : Jul 05, 2018

Study Type : Animal Study

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Substances : Lactobacillus plantarum

Diseases : High Fat Diet, Metabolic Diseases, Obesity

[+]

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Pubmed Data : Nutrients. 2019 Jan 25 ;11(2). Epub 2019 Jan 25. PMID: 30691017

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Pubmed Data : J Nutr Biochem. 2015 Jun ;26(6):633-41. Epub 2015 Feb 26. PMID: 25801980

Article Published Date : May 31, 2015

Study Type : Animal Study

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Substances : Peach, Plum

Diseases : Cardiovascular Diseases, Metabolic Diseases, Obesity

Pharmacological Actions : Cardioprotective

Additional Keywords : Juice

[+]

This study demonstrates protective effect of thymoquinone against HFD-induced MetS on rats which might have been mediated via PPAR mechanism.Sep 30, 2015

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Pubmed Data : Eur J Nutr. 2015 Oct ;54(7):1117-27. Epub 2014 Oct 28. PMID: 25347965

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Pubmed Data : Nutrients. 2018 Jan 12 ;10(1). Epub 2018 Jan 12. PMID: 29329215

Article Published Date : Jan 11, 2018

Study Type : Animal Study

Additional Links

Substances : Yellow Tea

Diseases : Diabetes Mellitus: Type 2, Hepatic Steatosis, Metabolic Diseases

Pharmacological Actions : Hepatoprotective, Hypoglycemic Agents

Additional Keywords : Plant Extracts

[+]

A review of berberine in cardiovascular and metabolic diseases.Dec 31, 2018

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[+]

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Pubmed Data : Rev Diabet Stud. 2019 ;15:35-48. Epub 2019 Aug 4. PMID: 31380886

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Pubmed Data : Nat Rev Endocrinol. 2013 Aug ;9(8):494-500. Epub 2013 Jun 4. PMID: 23732284

Article Published Date : Jul 31, 2013

Study Type : Review

Additional Links

Diseases : Fetal Origin of Adult Disease, Metabolic Diseases, Obesity

Additional Keywords : Increased Risk, Prenatal Epigenetic Programming

Problem Substances : High Fructose Corn Syrup

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In the absence or dysfunction of normal gut flora, a multitude of diseases may occur, shedding light on the important role maintained by the gut–brain axis.Dec 31, 2014

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Pubmed Data : Nutrients. 2017 May 25 ;9(6). Epub 2017 May 25. PMID: 28587078

Article Published Date : May 24, 2017

Study Type : Review

Additional Links

Substances : Noni

Diseases : Metabolic Diseases, Obesity

Additional Keywords : Anti-Obesity Agents

[+]

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Pubmed Data : Obes Rev. 2017 Feb ;18 Suppl 1:15-24. PMID: 28164449

Article Published Date : Jan 31, 2017

Study Type : Review

Additional Links

Diseases : Circadian Dysregulation, Metabolic Diseases, Obesity, Sleep Disorders

Additional Keywords : Risk Factors

Anti Therapeutic Actions : Shift Work

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Stevia can serve as a natural and alternative treatment for diseases that are associated with metabolic syndrome.Aug 08, 2017

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Pubmed Data : J Med Food. 2017 Aug 9. Epub 2017 Aug 9. PMID: 28792778

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Pubmed Data : Nutrients. 2015 Jul ;7(7):5443-68. Epub 2015 Jul 7. PMID: 26198245

Article Published Date : Jun 30, 2015

Study Type : Review

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Metabolic Diseases

Pharmacological Actions : Antioxidants

[+]

This review details potential mechanisms linking gut dysbiosis to metabolic dysfunction.Mar 02, 2016

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Pubmed Data : J Clin Endocrinol Metab. 2016 Mar 3:jc20154251. Epub 2016 Mar 3. PMID: 26938201

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View the Evidence: 141 Abstracts with Metabolic Diseases Research

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Alpha-lipoic acid administration may lead to an improvement in glucose homeostasis parameters and lipid profiles except HDL-cholesterol levels.Jul 06, 2018

Higher blood concentrations of lutein are generally associated with better cardiometabolic health.Jan 12, 2016

Inositol supplementation may result in reduction in triglycerides, total and LDL-cholesterol levels.May 23, 2018

Studies on coffee and NAFLD suggest that coffee consumption could have a protective role on fibrosis.Mar 29, 2016

The present meta-analysis suggests that dietary magnesium intake is inversely associated with the prevalence of metabolic syndrome.Oct 31, 2014

There is good evidence to support the existence of both metabolic and neurological adverse effects in children treated with second-generation antipsychotics.Jul 31, 2011

This meta-analysis suggests that pycnogenol may have a role in preventing cardiometabolic disease.Sep 30, 2019

Zinc may contribute to the management of hyperglycemia in individuals with chronic metabolic disease.Nov 04, 2012

A Western dietary pattern is prospectively associated with cardio-metabolic traits and incidence of the metabolic syndrome.Apr 30, 2018

Almond consumption during energy restriction lowers truncal fat and blood pressure in compliant overweight or obese adults.Nov 01, 2016

An early Mediterranean diet-based nutritional intervention in pregnancy is associated with reductions in postpartum rates of metabolic syndrome.Sep 18, 2019

Betatrophin levels were increased with vitamin D deficiency. Oct 05, 2016

Bisphenol A may increase the risk of metabolic syndrome.Aug 21, 2019

Children and adolescents with high intakes of carbonated beverages could be at increased risk of MetS, abdominal obesity, and hypertension.Dec 31, 2014

Coffee consumption might be associated with reduction of metabolic syndrome in Korean women.Dec 31, 2015

Consumption of sweetened soft drinks is associated with metabolic syndrome.Oct 30, 2016

Consumption was associated with a better weight/adiposity and CVRF profile than seen in non-consumers.Dec 31, 2014

CoQ10 supplements in patients with metabolic syndrome for 8 weeks had beneficial effects on serum insulin levels, HOMA-IR, HOMA-B and plasma TAC concentrations.Sep 17, 2015

Curcumin supplementation significantly decreases serum concentrations of pro-inflammatory cytokines in subjects with MetS.Jun 05, 2016

Current cannabis use is associated with lower odds of metabolic syndrome across emerging and middle-aged US adults.Nov 04, 2015

Dehydroepiandrosterone supplementation results in stabilization of BMI, waist circumference and fasting glycaemia values in schizophrenic patients treated with olanzapine.Dec 31, 2014

Exercise interventions may be used as nicotine replacement therapy or protective aids against smoking-related cardiopulmonary disorders.Feb 29, 2016

Glucose homeostasis may worsen after decades of exposure to PCBs and OCPs at background environmental levels, independent of BMI.Jan 31, 2015

H. sabdariffa extract improved metabolism, displayed potent anti-inflammatory and antioxidant activities, and significantly reduced blood pressure.May 31, 2014

Improvement of vitamin D status may help reduce the public health burden of metabolic syndrome, and potential subsequent health conditions including type 2 diabetes and cardiovascular disease.Dec 31, 2014

In persons without MetS a relationship was detected between vitamin D concentration and exponents of metabolic syndrome.May 31, 2015

Individuals with both H pylori infection and vitamin D deficiency had greater risk of developing metabolic syndrome.Apr 30, 2016

Insulin sensitivity improvement with exercise training is mediated by body weight loss in subjects with metabolic syndrome.May 30, 2019

Long-term consumption of Mediterranean diet partially restores the population of gut microbiota that were found to be lower in patients with MetS.Dec 31, 2015

Metabolic syndrome increases dietary α-tocopherol requirements.Jan 10, 2017

Nut consumption is independently associated with lower odds for metabolic syndrome in US adolescents.Sep 03, 2018

Nutritional doses of grape polyphenols protects against fructose induced oxidative stress and insulin resistance.May 31, 2013

Pomegranate juice consumption has potential anti-inflammatory and cardio-protective effects.Jul 31, 2016

Preliminary results revealed Yoga led to significantly larger improvements in two quality of life domains in those at risk of metabolic syndrome.Dec 31, 2015

Regular cycling to school may to be associated with better physical fitness and a lower incidence of metabolic syndrome.Dec 31, 2016

Sedentary behaviour increased metabolic syndrome risk.May 21, 2018

Short term supplementation with curcuminoid and piperine combination significantly improves oxidative and inflammatory status in patients with MetS.Jan 06, 2015

The combination of black seeds and turmeric can be recommended with lifestyle modification as a starting point for patients with MetS to halt its future complications and progression.Mar 31, 2015

The combined application of berberine in patients with metabolic syndrome can effectively regulate blood glucose and blood lipid of patients.Mar 31, 2019

The ketogenic diet was beneficial for patients with GLUT-1 deficiency syndrome.Jan 13, 2016

The use of black raspberry improved cardiovascular risks in patients with metabolic syndrome during the 12-week follow-up.Mar 31, 2016

There is inadequacy of water and high sugar beverage intake among the shift workers which is a potential risk of some chronic diseases.Jun 07, 2016

These findings suggest that for girls, prenatal exposure to POPs may play a role for later development of metabolic diseases by affecting the level of insulin.Jul 28, 2015

These results suggest that higher egg consumption may be associated with a reduction in the odds for metabolic syndrome.Jul 01, 2017

This study shows direct and indirect associations with lipid molecular species and clinical variables of interest in the evaluation of the metabolic syndrome after diets naturally rich in polyphenols.Aug 31, 2014

Unhealthy levels of phthalates and bisphenol A in mexican pregnant women with gestational diabetes. Jul 06, 2019

Urbanization of the Ovahimba people is associated with an increasing prevalence of disorders of glucose metabolism and other unfavorable metabolic parameters.Feb 28, 2015

Vitamin D deficiency may contribute to common obesity, metabolic syndrome and a reduction in thermogenic activity.Mar 01, 2009

Vitamin D deficiency was associated with a 2.07-fold higher risk of elevated fasting blood glucose.Dec 02, 2017

A case report suggests that mild vitamin C deficiency associated with metabolic syndrome and severe periodontal infection may be associated with the pathogenesis of severe gingival overgrowth.Nov 30, 2014

A combination of black seeds and turmeric at low doses showed enhanced efficacy in preventing metabolic syndrome in fructose fed rats.Jan 31, 2015

Administration of rutin could effectively improve aging-related metabolic dysfunction.Jan 24, 2016

Alpha-lipoic acid and carnitine had a beneficial role in the prevention of MS associated with development of type 2 diabetes.Aug 04, 2016

An aqueous extract of Hibiscus sabdariffa palliates insulin resistance, hyperglycemia, dyslipidemia and oxidative rout in high-fructose induced metabolic syndrome rats.May 11, 2015

Aspartame influenced the gut microbial composition which could lead to the development of metabolic disease.Dec 31, 2013

Association between serum CK-18 levels and the degree of liver damage in fructose-induced metabolic syndrome.Aug 31, 2018

Berberine ameliorates non alcoholic fatty liver disease and related metabolic disorders.Dec 31, 2014

Berberine attenuates olanzapine induced-metabolic syndrome.Jul 31, 2019

Black ginger extract has a preventive effect on obesity and various metabolic diseases.Nov 30, 2011

BlaG improves metabolic disorders by modulating gut microbiota.Mar 01, 2017

BPA contributes to glucose metabolic disorders, and that HFD aggravates these adverse effects in paternal rats. Mar 31, 2014

Chronic organochlorine pesticides exposure could modulate bile acid metabolism that might cause metabolic disorders.Jun 30, 2017

Chronic particulate matter exposure during perinatal life in rats leads to glucose dyshomeostasis in male offspring both in early and later life.Dec 31, 2017

Combinations of natural anti-oxidants prevents metabolic syndrome by reducing oxidative stress.Jun 25, 2015

Curcumin treatment can partially recover the metabolism disorders induced by high-fat diet.Dec 31, 2014

Dietary royal jelly ameliorates diet-induced obesity, hyperglycemia, and hepatic steatosis by promoting metabolic thermogenesis in BAT in mice.Jan 10, 2017

Dietary XN suppressed SREBP-1 target gene expression in the liver accompanied by a reduction of the mature form of hepatic SREBP-1, inhibiting the development of obesity and hepatic steatosis.Jul 02, 2015

Early dietary supplementation with n-6 and n-3 PUFAs can be powerfully used for protection against metabolic dysfunctions.Dec 31, 2015

Early life BPA exposure at representative human exposure levels can perturb metabolic health across multiple generations in the mouse through stable inheritance of DNA methylation changes.May 31, 2015

Ellagic acid in diets may normalize metabolic insults triggered by high sucrose consumption.Mar 11, 2016

Fasting-induced liver GADD45β restrains hepatic fatty acid uptake and improves metabolic health.Dec 31, 2015

Fermented red ginseng might be a beneficial therapeutic approach for metabolic syndrome.Jun 15, 2016

Metabolic Diseases

View the Evidence:
141 Abstracts with Metabolic Diseases Research