Liver Damage

Name	AC	CK
Curcumin	59	121
Silymarin	9	26
Ginsenosides	14	25
Milk Thistle	3	24
Nigella sativa (aka Black Seed)	12	22
Polyphenols	12	22
Puerarin	11	21
Thymoquinone	11	20
Resveratrol	8	18
Vitamin C	10	18
Anthocyanins	8	16
Flavonoids	9	16
Melatonin	5	16
Silibinin	4	15
Turmeric	7	14
Dandelion	6	12
Ginger	6	12
Turmeric: Fermented	2	12
Phyllanthus urinaria	2	11
Rose	6	11
Black Tea	5	10
Fermented Foods and Beverages	5	10
Grape Seed Extract	5	10
Sesamol	3	10
Naringenin	5	9
Olive leaf extract	5	9
Sulforaphane	6	9
Alpha-Lipoic Acid	4	8
Asiatic Acid	4	8
Bael	4	8
Beet	4	8
Blueberry	4	8
Camel Milk	4	8
Diallyl sulfide	4	8
Ellagic Acid	4	8
Garlic	4	8
Geraniol	4	8
Honey	4	8
Lycopene	4	8
Mangiferin	3	8
Radish	5	8
Reishi Mushroom	4	8
Sweet Potato: Purple	4	8
Vitamin D	4	8
Astaxanthin	4	7
Fucoidan	4	7
Carrot	3	6
Carvacrol	3	6
Catechin	3	6
Chlorella (Algae)	2	6
Date Seeds	2	6
Dates	3	6
Diosmin	3	6
Fenugreek	3	6
Genistein	3	6
Gingerol	3	6
Ginkgo biloba	2	6
Green Tea	3	6
Jujube	3	6
Lactobacillus plantarum	3	6
Olive Oil	3	6
Pomegranate	3	6
Quercetin	3	6
Royal Jelly	2	6
Sea buckthorn	3	6
Shikonin	3	6
Solanum nigrum (black nightshade)	3	6
Vitamin E	3	6
Yellow Tea	3	6
Zataria multiflora	3	6
Artichoke	3	5
Citrus naringin	3	5
EGCG (Epigallocatechin gallate)	3	5
Fig	3	5
Genipin	3	5
Indole-3-Carbinol	3	5
NAC (N-acetyl-L-cysteine)	3	5
Rosemary	3	5
Apple Polyphenols	2	4
Apricot	2	4
Artesunate	1	4
Ayurvedic formulation: Liv52	2	4
Beeswax	2	4
Berberine	2	4
Berries: All	2	4
Blue Honeysuckle	2	4
Caffeic acid phenethyl ester	2	4
Chlorogenic Acid	2	4
Choline	2	4
Citrus Peel	2	4
Cranberry	2	4
Crocin	2	4
DHA (Docosahexaenoic Acid)	2	4
Dill	2	4
EPA (Eicosapentaenoic Acid)	2	4
Embelia ribes	2	4
Garlic: Aged	2	4
Henna	2	4
Hesperidin	2	4
Hibiscus sabdariffa	2	4
Hu Zhang (Polygonum cuspidatum)	1	4
Hydrogen Water	2	4
Hydroxytyrosol	2	4
Isoliquiritigenin	2	4
Juniper	2	4
Kombucha Tea	3	4
Lactobacillus casei	2	4
Litchi	2	4
Lotus	3	4
Luteolin	2	4
Lychee	2	4
Myricetin	2	4
Noni	2	4
Onion	2	4
Papaya	2	4
Passion Flower	2	4
Phloretin	3	4
Piceatannol	2	4
Pomegranate Peel	2	4
Pomegranate Seed	2	4
Potato	2	4
Propolis: Bee	2	4
Rooibos	2	4
Saffron	2	4
Selenium	2	4
Shiitake Mushroom	2	4
Stevia	2	4
Verbascoside	2	4
White Tea	2	4
Xanthohumol	2	4
Yeast	2	4
Zinc	2	4
Amygdalin (laetrile)	2	3
Chaga Mushroom (Inonotus obliquus)	2	3
D-Limonene	2	3
Lactobacillus fermentum	2	3
Lignans	2	3
Mulberry	2	3
Oleanolic acid	2	3
Thistle	2	3
Ursolic Acid	2	3
Ajwain	1	2
Almond	1	2
Andrographis	1	2
Anise	1	2
Antrodia camphorata	1	2
Apigenin	1	2
Apocynin	1	2
Apples	1	2
Apricot Kernel	1	2
Arginine	1	2
Ashwagandha	1	2
Baccharis trimera	1	2
Bacopa	1	2
Bamboo	1	2
Banana Peel	1	2
Banana Stem	1	2
Barberry	1	2
Barley	1	2
Beta-Caryophyllene	1	2
Bilberry	1	2
Bile salts	1	2
Bitter Apple	1	2
Bitter Melon	1	2
Black Currant	1	2
Black Raspberry	1	2
Black Tea Theaflavins	1	2
Broccoli Sprouts	1	2
Bromelain	1	2
Burdock	1	2
Butterbur	1	2
Cabbage	1	2
Caffeine	1	2
Cannabidiol	1	2
Capsaicin	1	2
Carotenoids	1	2
Celery	1	2
Celosia cristata (cockscomb)	1	2
Centella asiatica	1	2
Chamomile	1	2
Chickpea	1	2
Chicory	1	2
Chrysanthemum Indicum	1	2
Chrysin	1	2
Cinnamon	1	2
Cissus quadrangularis	1	2
Coconut Oil	1	2
Coconut Water	1	2
Coenzyme Q10	1	2
Coffee: Green/Unroasted	1	2
Cordyceps sinensis	1	2
Coriandrum sativum	1	2
Cucurbitacin B	1	2
Cumin	1	2
Cysteine (see N-Acetylcysteine)	1	2
Dibenzoylmethane (DBM)	1	2
Earthworms	1	2
Echinacea	1	2
Eggplant	1	2
Elderberry	1	2
Emodin	1	2
Eriodictyol	1	2
Feverfew	1	2
Fisetin	1	2
Fish Oil	1	2
Flaxseed	1	2
Folic Acid	1	2
Gallic Acid	1	2
Garden Cress (Lepidium sativum)	1	2
Geranium	1	2
Ginseng	1	2
Glycyrrhizin	1	2
Goat Milk	1	2
Goji	1	2
Gold (nanoparticles)	1	2
Goldenseal	1	2
Gotu Kola	1	2
Grape	1	2
Guava	1	2
Guduchi	1	2
Hibiscus rosa-sinensis	1	2
Hops	1	2
Horehound	1	2
Kimchi	1	2
Lactobacillus probiotics	1	2
Lactobacillus reuteri	1	2
Lactobacillus rhamnosus GG	1	2
Lactobacillus salivarius	1	2
Ligustrazine	1	2
Long Pepper	1	2
Loquat Seeds	1	2
Lutein	1	2
Magnesium	1	2
Mango	1	2
Medicinal Mushrooms	1	2
Mint	1	2
Miso	1	2
Modified Arabinoxylan Rice Bran (MGN-3)	1	2
Mucuna pruriens (aka Velvet Beans)	1	2
Myrica rubra	1	2
Nettle	1	2
Nicotinamide adenine dinucleotide (NADH)	1	2
Nobiletin	1	2
Nutmeg	1	2
Oak	1	2
Okra	1	2
Oleuropein	1	2
Olive	1	2
Orange	1	2
Oregano	1	2
Oyster Mushroom	1	2
Paeoniflorin	1	2
Palash	1	2
Palmitoylethanolamide	1	2
Panax Notoginseng	1	2
Peppermint	1	2
Phosphatidylcholine	1	2
Pine Bark Extract	1	2
Piper cubeba (Cubeb)	1	2
Piperine	1	2
Plant Stem Cells	1	2
Proanthocyanidins	1	2
Probiotics	1	2
Prunella vulgaris	1	2
Pterocarpus marsupium	1	2
Pterostilbene	1	2
Pumpkin Seed Oil/Meal	1	2
Purslane	1	2
Raspberry	1	2
Red Cabbage	1	2
Rice Bran	1	2
Rice: Brown	1	2
Rice: Parboiled	1	2
Rosemaric Acid	1	2
Sage	1	2
Saikosaponin	1	2
Salvia miltiorrhiza	1	2
Semecarpus anacardium	1	2
Sesame Seed Oil	1	2
Sessile Joyweed	1	2
Silica Hydride	1	2
Soy	1	2
Spirulina	1	2
Stilbenes	1	2
Strawberry	1	2
Tannic Acid	1	2
Taro	1	2
Taurine	1	2
Thymol	1	2
Tyrosine	1	2
Urine	1	2
Urine: Cow	1	2
Vanillin	1	2
Vitexins	1	2
Walnut	1	2
Water: Deuterium Depleted	1	2
Water: Electrolyzed Reduced	1	2
Yoghurt	1	2
Agrimony	1	1
Allicin	1	1
Astragaloside	1	1
Blackberry	1	1
Caraway	1	1
Coffee	1	1
Coriandor	1	1
Curcuminoids	1	1
Cyperus longus	1	1
Gynostemma	1	1
Haritaki (Terminalia chebula)	1	1
Honokiol	1	1
Kudzu	1	1
Lavender	1	1
Licorice	1	1
Lupeol	1	1
Prickly Pear Cactus	1	1
Rice: Black	1	1
Tanshinone IIA	1	1
Tetrahydrocurcumin	1	1
Vitex negundo	1	1
Wheat Grass	1	1
White Mulberry	1	1

Name	AC	CK
Statin Drugs	22	124
Paracetamol	51	95
Acetaminophen	49	91
Simvastatin	9	77
Atorvastatin	12	69
Isoniazid	4	62
Pravastatin	5	45
Bisphenol A	14	41
Fluvastatin	3	40
Lovastatin	7	36
Aflatoxin	10	27
High Fructose Corn Syrup	5	18
Rosuvastatin	4	17
Concanavalin A	7	16
Cadmium	9	15
Tylenol	2	14
Perfluorooctanoic acid (PFOA)	2	12
Tamoxifen	3	12
Fluoroquinolone Antibiotic	1	10
Proton-Pump Inhibitors	1	10
Fluoxetine (trade name Prozac)	4	9
Mercury	3	9
Pesticides	5	9
Morphine	4	8
Tertiary butyl hydroperoxide	6	7
2-chlorobenzylidene malononitrile (CS)	1	6
Arsenic	4	6
Aspartame	3	6
Glyphosate	4	6
Quizalofop-P-ethyl	1	6
Bisphenol S	3	5
Aluminum	2	4
Arsenite	2	4
Benzo(a)pyrene	2	4
Butylated Hydroxytoluene (BHT)	2	4
Cisplatin	2	4
Dichlorvos	2	4
Electronic Cigarettes	2	4
Formaldehyde	2	4
Fructose	2	4
Lead	2	4
Monosodium Glutamate (MSG)	2	4
N-nitrosodiethylamine	2	4
Nanoparticles	2	4
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	2	4
Organophosphate Pesticides	2	4
Perfluorooctane sulfonate (PFOS)	2	4
Rosiglitazone (trade name Avandia)	2	4
Sodium Fluoride	2	4
Acrylamide	2	3
Cerivastatin	1	3
Cholesterol Lowering Drugs	1	3
Fenofibrates	1	3
Fluconazole	1	3
Zinc Oxide	2	3
Aluminum Hydroxide	1	2
Antibiotics	1	2
Arsenic Trioxide	1	2
Brilliant Blue FCF	1	2
Chlorpyrifos	1	2
Cypermethrin	1	2
Dexamethasone	1	2
Diclofenac	1	2
Erythrosine	1	2
Ethylene Glycol	1	2
FD&C Red #40	1	2
Food Colorings	1	2
Insulin	1	2
Metanil-Yellow Dye	1	2
N-nitrosodimethylamine	1	2
Organophosphates	1	2
Paclitaxel	1	2
Ponceau 4R (New Coccine)	1	2
Selective Serotonin Reuptake Inhibitors (SSRIs)	1	2
Sucralose (aka Splenda)	1	2
Sucrose	1	2
Sugar Sweetened Beverages	1	2
Tartrazine (Yellow Food Dye)	1	2
Thiazolidinediones	1	2
Titanium Dioxide	1	2
Titanium Nanoparticles	1	2
Toluene	1	2
Trans Fatty Acids	1	2
Vaccine Adjuvants	1	2
Zoledronic Acid	1	2
Amiodarone	1	1
Dimethoate	1	1
Irinotecan	1	1
Methotrexate	1	1
Parabens	1	1
Triclosan	1	1
Zineb	1	1

Name	AC	CK
Western Diet	2	4
Electromagnetic Fields	1	2
Mobile Phone Radiation	1	2
Vaccination: All	1	2
Vaccination: Hepatitis B	1	2
Nanotechnology	1	1

[+]

Prophylactic therapy of milk thistle on anti-tuberculosis drug-induced liver injury.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2013 ;13:58. Epub 2013 Mar 8. PMID: 23497020

Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy.Oct 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Environ Toxicol. 2017 Feb ;32(2):630-644. Epub 2016 Mar 28. PMID: 28071871

Article Published Date : Jan 31, 2017

Study Type : Human In Vitro

Additional Links

Substances : Mangiferin

Diseases : Chemically-Induced Liver Damage, Mercury Poisoning, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective

Additional Keywords : Methylmercury

Problem Substances : Mercury

[+]

A case of hepatitis caused by simvastatin has been reported. Jan 01, 1991

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Pubmed Data : Gastroenterol Clin Biol. 1991 ;15(1):94-5. PMID: 2010080

Click here to read the entire abstract

Pubmed Data : Med Clin (Barc). 2002 May 18 ;118(18):717. PMID: 12042141

Article Published Date : May 18, 2002

Study Type : Human: Case Report

Additional Links

Diseases : Chemically-Induced Liver Damage, Cholestasis, Hepatitis: Cholestatic, Statin-Induced Pathologies

Problem Substances : Cerivastatin, Statin Drugs

Adverse Pharmacological Actions : Hepatotoxic

[+]

Acute cholestatic hepatitis induced by fenofibrate has been reported.Oct 01, 2009

Click here to read the entire abstract

Pubmed Data : J Clin Pharm Ther. 2009 Oct;34(5):599-602. PMID: 19744016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : Recenti Prog Med. 1991 Apr ;82(4):233-5. PMID: 1857844

Click here to read the entire abstract

Pubmed Data : Drug Dev Res. 2015 Aug ;76(5):251-8. Epub 2015 Aug 7. PMID: 26250417

Article Published Date : Jul 31, 2015

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

F. religisoa protects against isoniazid, rifampicin and paracetamol induced oxidative liver injury in rats.Sep 30, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacognosy Res. 2013 Oct ;5(4):271-6. PMID: 24174821

Article Published Date : Sep 30, 2013

A water extract of the leaves of Z. jujuba is efficacious for prevention and treatment of carbon tetrachloride induced hepatic injury in mice.Feb 21, 2017

Click here to read the entire abstract

Pubmed Data : Food Funct. 2017 Feb 22 ;8(2):816-822. PMID: 28124048

Click here to read the entire abstract

Pubmed Data : Am J Chin Med. 2000 ;28(2):163-73. PMID: 10999435

Article Published Date : Dec 31, 1999

Study Type : Animal Study

Additional Links

Substances : Burdock

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

A. marmelos attenuates carbon tetrachloride-mediated hepatic oxidative stress, toxicity, tumor promotion.Mar 31, 2009

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Pubmed Data : J Enzyme Inhib Med Chem. 2009 Apr ;24(2):320-7. PMID: 18830880

Article Published Date : Mar 31, 2009

Study Type : Animal Study

Additional Links

Substances : Bael

Diseases : Chemically-Induced Liver Damage, Lipid Peroxidation, Liver Cancer, Oxidative Stress

Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Antiproliferative

Additional Keywords : Plant Extracts

[+]

A. sessilis has hepatoprotective activity against carbon tetrachloride liver damage.Mar 31, 2018

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Pubmed Data : Indian J Clin Biochem. 2018 Apr ;33(2):190-195. Epub 2017 May 18. PMID: 29651210

Pubmed Data : Molecules. 2014 ;19(10):15440-51. Epub 2014 Sep 26. PMID: 25264831

Article Published Date : Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Basic Med Sci. 2015 Feb ;18(2):205-11. PMID: 25825639

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2017 Aug ;92:421-428. Epub 2017 May 27. PMID: 28558355

Article Published Date : Jul 31, 2017

Study Type : Animal Study

Additional Links

Substances : Apocynin

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

[+]

[+]

Aqueous extracts of Rosa damascene may prevent hepatic damage from acetaminophen induced toxicity in rats.Dec 31, 2011

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Pubmed Data : J Environ Pathol Toxicol Oncol. 2012 ;31(3):193-201. PMID: 23339694

Article Published Date : Dec 31, 2011

Study Type : Animal Study

Additional Links

Substances : Rose

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Arctium lappa root extract prevents lead-induced liver injury.Nov 23, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antioxidants (Basel). 2019 Nov 24 ;8(12). Epub 2019 Nov 24. PMID: 31771282

Article Published Date : Nov 23, 2019

Study Type : Animal Study

Additional Links

Substances : Burdock

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Lead

[+]

Artichoke extract ameliorates carbon tetrachloride-induced liver damage and oxidative stress in rats. Sep 01, 2008

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Pubmed Data : Exp Toxicol Pathol. 2008 Sep;60(6):475-80. Epub 2008 Jun 25. PMID: 18583118

Article Published Date : Sep 01, 2008

Study Type : Animal Study

Additional Links

Substances : Artichoke

Diseases : Chemically-Induced Liver Damage

[+]

Artichoke leaf extract has liver protective effects and causes downregulation of oxidative stress in acute diazinon-induced liver injury.Aug 29, 2019

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Pubmed Data : J Basic Clin Physiol Pharmacol. 2019 Aug 30 ;30(5). Epub 2019 Aug 30. PMID: 31469651

Article Published Date : Aug 29, 2019

Study Type : Animal Study

Additional Links

Substances : Artichoke

Diseases : Chemically-Induced Liver Damage, Pesticide-Induced Toxicity: Organophosphates

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Organophosphate Pesticides

[+]

Artichoke leaf extract may be used as a pharmaceutical phytomedicine in the treatment of liver diseases.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Springerplus. 2016 ;5:216. Epub 2016 Feb 29. PMID: 27026910

Article Published Date : Dec 31, 2015

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Pubmed Data : Mutat Res. 2010 Feb ;696(1):69-80. Epub 2009 Dec 28. PMID: 20038455

Article Published Date : Feb 01, 2010

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, DNA damage, Liver Damage, Oxidative Stress

Pharmacological Actions : Chemopreventive, Tumor Suppressor Protein p53 Upregulation

[+]

Problem Substances : Acetaminophen, Paracetamol

[+]

Bacopa monnieri may provide a beneficial herbal remedy for the efficient management of opioid related hepatotoxicity and nephrotoxicity.Jan 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:614580. Epub 2013 Jun 3. PMID: 23818929

Article Published Date : Dec 31, 2012

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2012 Jun ;50(6):2027-33. Epub 2012 Mar 24. PMID: 22465004

Article Published Date : May 31, 2012

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:1319-1326. Epub 2018 May 7. PMID: 29864914

Article Published Date : Jun 30, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Berberine protects against the hepatic damage induced by ParacetamolFeb 01, 2000

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Pubmed Data : Fitoterapia. 2000 Feb ;71(1):25-33. PMID: 11449466

Pubmed Data : Environ Pollut. 2019 Mar ;246:963-971. Epub 2018 Dec 24. PMID: 31159146

Article Published Date : Feb 28, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Diseases : Bisphenol Toxicity, Inflammation, Liver Damage, Oxidative Stress

Problem Substances : Bisphenol S

[+]

Bitter apple fruit possess significant hepatoprotective and antioxidant activity.Apr 30, 2015

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Pubmed Data : Pak J Pharm Sci. 2015 May ;28(3):951-7. PMID: 26004728

Pubmed Data : World J Gastroenterol. 2010 Jun 7;16(21):2657-63. PMID: 20518088

Article Published Date : Jun 07, 2010

Study Type : Animal Study

Additional Links

Substances : Blueberry

Diseases : Chemically-Induced Liver Damage, Liver Fibrosis

[+]

Both Nigella sativa and date reduce the toxic effects of aflatoxin-B1 in liver and kidney.Jun 30, 2008

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Health Sci (Qassim). 2008 Jul ;2(2):26-44. PMID: 21475486

Article Published Date : Jun 30, 2008

Study Type : Animal Study

Additional Links

Substances : Dates, Nigella sativa (aka Black Seed)

Diseases : Liver Damage: Aflatoxin-Induced

Pharmacological Actions : Hepatoprotective, Renoprotective

Problem Substances : Aflatoxin

[+]

Boysenberry anthocyanins is a food component available to prevent liver injury.Dec 31, 2003

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Pubmed Data : Biofactors. 2004 ;21(1-4):259-61. PMID: 15630207

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Toxicol Pathol. 2018 Oct ;31(4):275-282. Epub 2018 Jul 1. PMID: 30393431

Article Published Date : Sep 30, 2018

Study Type : Animal Study

Additional Links

Substances : Propolis: Brazillian

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Brewer's yeast (S. cerevisiae) has a protective effect against chemically-induced liver damage in rats. Jun 01, 2009

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Pubmed Data : Clin Nutr. 2009 Jun;28(3):338-45. Epub 2009 Feb 23. PMID: 19233522

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Yeast

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

[+]

Broccoli sprout extract protected the liver from various types of xenobiotic substances through induction of detoxification enzymes and glutathione synthesis.Sep 20, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : World J Gastroenterol. 2015 Sep 21 ;21(35):10091-103. PMID: 26401074

Article Published Date : Sep 20, 2015

Study Type : Animal Study

Additional Links

Substances : Broccoli Sprouts

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective, Phase I Detoxification Enzyme Inducer, Phase II Detoxification Enzyme Inducer

Additional Keywords : Gene Expression Regulation, Plant Extracts

Problem Substances : Acetaminophen

[+]

Bromelain ameliorates hepatic microcirculation after warm ischemia indicating it may have liver protective effects after injury. May 01, 2007

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Pubmed Data : J Surg Res. 2007 May 1;139(1):88-96. Epub 2007 Feb 8. PMID: 17292418

Article Published Date : May 01, 2007

Study Type : Animal Study

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Substances : Bromelain

Diseases : Liver Damage

Pharmacological Actions : Hepatoprotective

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Butterbur extract improves lipid profiles and antioxidant activities in monosodium L-glutamate-challenged mice.Sep 30, 2010

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Pubmed Data : J Med Food. 2010 Oct ;13(5):1216-23. PMID: 20828319

Article Published Date : Sep 30, 2010

Study Type : Animal Study

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Pubmed Data : Biotech Histochem. 2016 Jan 21:1-12. Epub 2016 Jan 21. PMID: 26796199

Article Published Date : Jan 20, 2016

Study Type : Animal Study

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Substances : Turmeric

Diseases : Cadmium Poisoning , Chemically-Induced Liver Damage, Liver Fibrosis

Pharmacological Actions : Hepatoprotective

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Caffeic acid phenethyl ester should be considered in the prevention of oxidative stress in diabetic liver.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:1421438. Epub 2018 May 2. PMID: 29854073

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Celosia cristata extract prevented oxidative stress-induced liver injury by enhancing hepatocyte antioxidant abilities.Jan 31, 2015

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Pubmed Data : Food Chem. 2015 Feb 1 ;168:572-9. Epub 2014 Jul 31. PMID: 25172750

Chlorella has hepatoprotective properties against tetrachloride-induced oxidative damage in rats.Sep 01, 2009

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Pubmed Data : In Vivo. 2009 Sep-Oct;23(5):747-54. PMID: 19779110

Cloudy apple juice potentiates hepatoprotection during experimental liver injury.Aug 20, 2019

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Pubmed Data : Int J Biol Macromol. 2019 Aug 21 ;140:1006-1017. Epub 2019 Aug 21. PMID: 31445146

Article Published Date : Aug 20, 2019

Study Type : Animal Study

Additional Links

Substances : Apple

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective

[+]

Coconut water vinegar ameliorates recovery of acetaminophen induced liver damage in mice.Jun 24, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2018 Jun 25 ;18(1):195. Epub 2018 Jun 25. PMID: 29940935

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Res Pharm Sci. 2016 Mar-Apr;11(2):120-9. PMID: 27168751

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Pubmed Data : Chem Biol Drug Des. 2017 Dec 17. Epub 2017 Dec 17. PMID: 29250925

Article Published Date : Dec 16, 2017

Study Type : Animal Study

Additional Links

Substances : Cucurbitacin B

Diseases : Chemically-Induced Liver Damage, Liver Fibrosis

Pharmacological Actions : Hepatoprotective, STAT3 Inhibitor

[+]

Curcuma longa extract or curcumin has the ability to alleviate the hepatotoxic effects caused by mercuric chloride in rats.Mar 19, 2017

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Pubmed Data : Exp Toxicol Pathol. 2017 Mar 20. Epub 2017 Mar 20. PMID: 28336172

Article Published Date : Mar 19, 2017

Study Type : Animal Study

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Substances : Curcumin, Turmeric

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Mercury

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Curcumin administration ameliorated the induced effects of aflatoxin B1.Dec 31, 2014

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Pubmed Data : Biomolecules. 2019 Nov 5 ;9(11). Epub 2019 Nov 5. PMID: 31694300

Article Published Date : Nov 04, 2019

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Chemically-Induced Liver Damage, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Lead

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Curcumin and capsaicin individually are protective to LDL oxidation both in vivo and in vitro, to iron-induced hepatotoxicity and to carrageenan-induced inflammation.Aug 26, 2009

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Pubmed Data : J Agric Food Chem. 2009 Aug 26;57(16):7401-8. PMID: 16956363

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Pubmed Data : Biol Trace Elem Res. 2019 Oct 25. Epub 2019 Oct 25. PMID: 31654258

Article Published Date : Oct 24, 2019

Study Type : Animal Study

Additional Links

Substances : Curcumin, Selenium

Diseases : Chemically-Induced Liver Damage, Lipopolysaccharide-Induced Toxicity, Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Diclofenac

[+]

Curcumin and turmeric extract might be recommendable to recover liver activity.Jul 25, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Balkan Med J. 2016 May ;33(3):252-7. Epub 2016 May 1. PMID: 27308068

Article Published Date : Apr 30, 2016

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

Problem Substances : Nanoparticles

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Curcumin has a liver protecting effect against aflatoxin B(1)-induced liver injury.May 01, 2010

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Pubmed Data : Arch Toxicol. 2010 May;84(5):389-96. Epub 2010 Jan 30. PMID: 20112103

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Trop Biomed. 2012 May ;2(5):385-8. PMID: 23569935

Dietary supplementation of vitamin D prevents the development of western diet-induced metabolic, hepatic and cardiovascular abnormalities.Jul 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : United European Gastroenterol J. 2018 Aug ;6(7):1056-1064. Epub 2018 May 17. PMID: 30228894

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Pubmed Data : J Pharm (Cairo). 2017 ;2017:6081374. Epub 2017 Jan 15. PMID: 28182107

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Dill

Diseases : Advanced Glycation End products (AGE), Chemically-Induced Liver Damage, Diabetic Complications

Pharmacological Actions : Anti-Glycation Agents, Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

[+]

Docosahexaenoic acid attenuates carbon tetrachloride-induced hepatic fibrosis in rats.Oct 12, 2017

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Pubmed Data : Int Immunopharmacol. 2017 Oct 13 ;53:56-62. Epub 2017 Oct 13. PMID: 29035816

Article Published Date : Oct 12, 2017

Study Type : Animal Study

Additional Links

Substances : DHA (Docosahexaenoic Acid)

Diseases : Chemically-Induced Liver Damage, Fibrosis: Liver

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective

[+]

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The Following are Sub-Topics of Liver Damage

View the Evidence: 834 Abstracts with Liver Damage Research

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Prophylactic therapy of milk thistle on anti-tuberculosis drug-induced liver injury.Dec 31, 2018

The use of statins for LDL suppression is associated with increased risk for cancer.Jul 31, 2007

Atorvastatin-induced acute pancreatitis has been reported.Jan 01, 2011

Autoimmune hepatitis associated with atorvastatin use has been reported.Aug 01, 2003

Bisphenol A was detected above the detection limit in all samples in individuals affected by non-alcoholic fatty liver disease.Jun 04, 2017

Combined treatment including melatonin resulted in the improvement of general conditions in 81.7% of the patientsDec 31, 2012

Drug-induced liver toxicity (particularly acetaminophen-induced liver toxicity) has replaced viral hepatitis as the most single frequent cause of acute liver failutre in ubran Sep 01, 2009

Exposure of children to even low doses of BPA may adversely affect later liver function.Nov 16, 2017

Fermented turmeric powder is well-tolerated and effective in subjects with elevated alanine transaminase levels.Dec 31, 2012

Fluoroquinolone therapy and idiosyncratic acute liver injury: a population-based study.Aug 12, 2012

Fluvastatin has been linked to adverse hepatic reactions.Jan 01, 2006

Fructose-associated hepatotoxicity indexed by the lactate dehydrogenase isoenzyme LDH-5.Feb 28, 2019

Isoniazid has been associated with grade 3 or 4 liver failure in 1.4%-5.2% of patients being treated for latent tuberculosis infection.Dec 15, 2009

Isoniazid treatment in latent tuberculosis infection may be associated with moderate-to-severe liver damage without symptoms. Jul 01, 2005

Liver failure and damage are rare but severe unintended consequences of statin drug use.Aug 31, 2011

More than half of patients who present at the hospital with acetaminophen-induced liver damage or liver failure have undetectable levels of acetaminophen.Feb 04, 2019

Perfluorooctanoic acid has hepatotoxic effects.Jul 31, 2016

Phyllanthus Urinaria is useful in preventing or delaying the development of HBV-associated cirrhosis to hepatocellular carcinoma.Mar 24, 2013

Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy.Oct 31, 2017

Severe liver toxicity requiring discontinuation occurs in 5% of simvastatin-treated patients and 4.5% of pravastatin-treated patients. Jan 01, 1992

Severe, even fatal liver injuries have resulted as a consequence of isoniazid treatment in individuals with latent tuberculosis.Mar 05, 2010

Silibinin could be beneficial in preventing drug-induced liver injury in tuberculosis treatments. Dec 31, 2014

Silymarin has an efficacy to prevent liver injury from standard combined antituberculosis drugs without significant adverse effects.Dec 31, 2014

Tamoxifen treatment for breast cancer may result in fatty liver.Nov 01, 2000

There is evidence that aflatoxin exposure plays a role in the pathogenesis of liver cancer in the US population. Jan 01, 1999

Treatment with proton pump inhibitors is associated with increased mortality in patients with pyogenic liver abscess.Feb 28, 2018

Unintended consequences of statin drug use are increased risk of esophageal cancer, kidney failure, cataract, liver dysfunction and myopathies.Jan 01, 2010

Acetaminophen toxicity induces mitochondrial complex I inhibition in human liver tissue.Aug 11, 2019

Curcumin could modulate hepatocyte epithelial-mesenchymal transition implicated in treatment of liver fibrosis.Aug 23, 2015

Mangiferin could ameliorate methylmercury mediated mitochondrial dysfunction in human hepatic cells in vitro.Jan 31, 2017

A case of hepatitis caused by simvastatin has been reported. Jan 01, 1991

A case report of fluoxetine-induced Stevens-Johnson syndrome and liver injury.Jan 31, 2019

Acute cholestatic hepatitis associated with atorvastatin use has been reported. Jan 01, 2006

Acute cholestatic hepatitis associated with pravastatin has been reported. May 01, 1999

Acute cholestatic hepatitis induced by cerivastatin has been reported. May 18, 2002

Acute cholestatic hepatitis induced by fenofibrate has been reported.Oct 01, 2009

Acute exposure to CS tear gas has been reported to cause several health problems in an individual.Dec 26, 1981

Acute hepatitis induced by lovastatin has been reported. Sep 01, 1994

After taking 30 mg artichoke leaf extract tea 3 times a day, patients bilirubin levels significantly declined at the end of the first week and all liver function tests were normalized within 2 months. Dec 31, 2013

Atorvastatin has been reported to have caused severe acute hepatitis with symptomatic cholestasis for more than 3 months and bile duct injury. Jul 01, 2008

Atorvastatin-induced cholestatic hepatitis in a young woman with systemic lupus erythematosus has been reported.Aug 09, 1999

Cholestatic jaundice during lovastatin medication has been reported. May 10, 1991

Cholestatic jaundice induced by atorvastatin has been observed. Jul 01, 2009

Hepatitis associated with treatment with lovastatin has been reported. Mar 01, 1998

Liver fibrosis has been attributed to lipid lowering medications.Sep 01, 2001

Lovastatin monotherapy has been reported to have been a cause of rhabdomyolysis, acute renal failure and hepatopathy.Jul 01, 1997

Mixed cholestatic/hepatocellular liver injury induced by the herbicide quizalofop-p-ethyl has been reported. Oct 01, 2007

Reversible acute hepatitis induced by rosuvastatin has been reported.Jul 01, 2008

Rosuvastatin-associated hepatitis with autoimmune features has been reported. May 01, 2005

Simvastatin has been reported to cause cholestatic hepatitis. Apr 01, 1991

Simvastatin has been reported to cause liver lesions.Apr 13, 1996

Simvastatin-ezetimibe-induced hepatic failure necessitating liver transplantation has been reported. Sep 01, 2008

Co-administration of N-Acetylcysteine and Acetaminophen efficiently blocks Acetaminophen toxicity.Jul 31, 2015

F. religisoa protects against isoniazid, rifampicin and paracetamol induced oxidative liver injury in rats.Sep 30, 2013

"Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury."Oct 01, 2012

"Vitamin E protects against oxidative damage caused by formaldehyde in the liver and plasma of rats."Oct 01, 2006

6-gingerol, an active ingredient of ginger, protects acetaminophen-induced liver damage in mice.Nov 01, 2011

A curcumin-phospholipid complex works synergistically to protect the livers of rats following chemical exposure. Feb 07, 2007

A new possible mechanism by which punicalagin protects against liver injury induced by type 2 diabetes mellitus.Nov 06, 2019

A phenolics rich extract of ginger had protective effects against Aflatoxin B1-induced oxidative stress and hepatotoxicity.May 01, 2017

A water extract of the leaves of Z. jujuba is efficacious for prevention and treatment of carbon tetrachloride induced hepatic injury in mice.Feb 21, 2017

A. cerana honey can prevent bromobenzene-induced hepatic damage in mice. Jan 15, 2018

A. graveolens extract showed an ameliorative effect against liver oxidative stress in adjuvant-induced arthritis.May 31, 2016

A. lappa could protect the liver cells from carbon tetrachloride or acetaminophen-induced liver damages.Dec 31, 1999

A. marmelos attenuates carbon tetrachloride-mediated hepatic oxidative stress, toxicity, tumor promotion.Mar 31, 2009

A. sessilis has hepatoprotective activity against carbon tetrachloride liver damage.Mar 31, 2018

Accumulation of polystyrene microplastics in juvenile Chinese mitten crab and oxidative stress effects in the liver.Jun 30, 2018

Acetaminophen could cause transient mitochondrial dysfunction that may synergize with other stresses to promote liver damage and steatosis.Dec 30, 2015

Acteoside has a protective and therapeutic effect on LPS-induced immunological liver injury in mice.Oct 31, 2009

Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury.Dec 31, 2017

Acute treatment with Mangifera indica L. leaf extract attenuates liver inflammation in rats fed a cafeteria diet.Jul 22, 2019

Administration of silymarin significantly prevented acute liver injury induced by restraint stress.Dec 31, 2015

Liver Damage

View the Evidence:
834 Abstracts with Liver Damage Research