[Observation on clinical efficacy of combined therapy of zinc supplement and jinye baidu granule in treating human cytomegalovirus infection].
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005 May;25(5):449-51. PMID: 15957842
OBJECTIVE: To explore the clinical efficacy of the combined therapy of zinc supplement and Jinye Baidu granule (JBG) on human cytomegalovirus (HCMV) infection. METHODS: One hundred and forty patients with positive HCMV-IgM were randomly divided into four groups, with 35 cases in each group, that is, the control group (only medicated with JBG), the high-, moderate- and low-dose zinc combined groups (treated with JBG combined with zinc gluconate tablet at dose of 30 mg, 20 mg, 10 mg every day respectively). The negative conversion rate of HCMV-IgM was observed. RESULTS: Insignificant difference in the negative conversion rate was shown in comparison of the control group with the low dose group (P>0.05), and in comparison of the high dose with the moderate dose group (P>0.05); however, the rate was significantly lower in the control group than that in the moderate dose and high dose group (P<0.05). CONCLUSION: Combined therapy of zinc supplement and JBG can significantly increase the negative conversion rate of HCMV-IgM. The optimal dosage of zinc gluconate tablet was 20 mg once a day.