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Abstract Title:

The inhibitory effects of xanthohumol, a prenylated chalcone derived from hops, on cell growth and tumorigenesis in human pancreatic cancer.

Abstract Source:

Biomed Pharmacother. 2015 Jul ;73:40-7. Epub 2015 Jun 4. PMID: 26211581

Abstract Author(s):

Weiliang Jiang, Senlin Zhao, Ling Xu, Yingying Lu, Zhanjun Lu, Congying Chen, Jianbo Ni, Rong Wan, Lijuan Yang

Article Affiliation:

Weiliang Jiang

Abstract:

Pancreatic cancer (PC) is one of the most lethal human malignancies worldwide. Here, we demonstrated that xanthohumol (XN), the most abundant prenylated chalcone isolated from hops, inhibited the growth of cultured PC cells and their subcutaneous xenograft tumors. XN treatment was found to induce cell cycle arrest and apoptosis of PC cells (PANC-1, BxPC-3) by inhibiting phosphorylation of signal transducer and activator of transcription 3 (STAT3) and expression of its downstream targeted genes cyclinD1, survivin, and Bcl-xL at the messenger RNA level, which involved in regulation of apoptosis and the cell cycle. Overall, our results suggested that XN presents a promising candidate therapeutic agent against human PC and the STAT3 signaling pathway is its key molecular target.

Study Type : Animal Study, In Vitro Study

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Sayer Ji
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