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Article Publish Status: FREE
Abstract Title:

Wogonin inhibits multiple myeloma-stimulated angiogenesis via c-Myc/VHL/HIF-1α signaling axis.

Abstract Source:

Oncotarget. 2015 Dec 30. Epub 2015 Dec 30. PMID: 26735336

Abstract Author(s):

Rong Fu, Yan Chen, Xiao-Ping Wang, Teng An, Lei Tao, Yu-Xin Zhou, Yu-Jie Huang, Bao-An Chen, Zhi-Yu Li, Qi-Dong You, Qing-Long Guo, Zhao-Qiu Wu

Article Affiliation:

Rong Fu

Abstract:

Angiogenesis is associated with the progression of multiple myeloma (MM). Wogonin is an active mono-flavonoid with remarkable antitumor activity. However, its impact on MM-stimulated angiogenesis remains largely unknown. Here, we demonstrated that wogonin decreased expression and secretion of pro-angiogenic factors in MM cells via c-Myc/HIF-1α signaling axis, reducing MM-stimulated angiogenesis and MM cell proliferation in vivo. Overexpression of c-Myc in MM cells disrupted the balance between VHL SUMOylation and ubiquitination, and thus inhibited proteasome-mediated HIF-1α degradation. Impaired function of VHL ubiquitination complexin c-Myc-overexpressing cells was fully reversed by wogonin treatment via increasing HIF-1α-VHL interaction and promoting HIF-1α degradation. Collectively, our in vitro and in vivo studies reveal for the first time that wogonin represses MM-stimulated angiogenesis and tumor progression via c-Myc/VHL/HIF-1α signaling axis.

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Sayer Ji
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