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Abstract Title:

Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis.

Abstract Source:

Planta Med. 2000 Dec ;66(8):694-8. PMID: 11199123

Abstract Author(s):

R L Huang, C C Chen, H L Huang, C G Chang, C F Chen, C Chang, M T Hsieh

Article Affiliation:

R L Huang

Abstract:

By using an HBV-producing cell line (MS-G2) in vitro culture system, we found that wogonin isolated from Scutellaria baicalensis can suppress HBV surface antigen production (P<0.001) without evidence of cytotoxicity. By assaying the endogenous HBV DNA polymerase activity, we found that both the relaxed circular and the linear forms of HBV DNA are significantly reduced in the wogonin-treated group. Wogonin deserves to be further evaluated for the treatment of human HBV infection.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antiviral Agents : CK(1307) : AC(596)

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