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Article Publish Status: FREE
Abstract Title:

Withania somnifera Root Extract Enhances Chemotherapy through 'Priming'.

Abstract Source:

PLoS One. 2017 ;12(1):e0170917. Epub 2017 Jan 27. PMID: 28129345

Abstract Author(s):

Aine Brigette Henley, Ling Yang, Kun-Lin Chuang, Meliz Sahuri-Arisoylu, Li-Hong Wu, S W Annie Bligh, Jimmy David Bell

Article Affiliation:

Aine Brigette Henley

Abstract:

Withania somnifera extracts are known for their anti-cancerous, anti-inflammatory and antioxidative properties. One of their mechanisms of actions is to modulate mitochondrial function through increasing oxidative stress. Recently 'priming' has been suggested as a potential mechanism for enhancing cancer cell death. In this study we demonstrate that 'priming', in HT-29 colon cells, with W. somnifera root extract increased the potency of the chemotherapeutic agent cisplatin. We have also showed the W. somnifera root extract enhanced mitochondrial dysfunction and that the underlying mechanism of 'priming' was selectively through increased ROS. Moreover, we showed that this effect was not seen in non-cancerous cells.

Study Type : In Vitro Study

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Sayer Ji
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