Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

n/a
Abstract Title:

Vitamin D administration, cognitive function, BBB permeability and neuro-inflammatory factors in high-fat diet induced obese rats.

Abstract Source:

Int J Obes (Lond). 2017 Jan 17. Epub 2017 Jan 17. PMID: 28093570

Abstract Author(s):

G Hajiluian, G Nameni, P Shahabi, M Mesgari-Abbasi, S Sadigh-Eteghad, M A Farhangi

Article Affiliation:

G Hajiluian

Abstract:

OBJECTIVES: The purpose of this research is to investigate the effects of vitamin D administration on cognitive function, nuclear factor Kappa-B (NF-kB), brain derived neurotrophic factor (BDNF) concentration in the hippocampus and blood-brain barrier (BBB) permeability in high-fat diet (HFD) induced obese rats.

METHODS: Male Wistar rats were fed either a control diet or HFD for 16 weeks (n=20); then each group was randomized into two subgroups supplemented orally with 500 IU/kg vitamin D for 5 weeks. A Morris Water Maze (MWM) test was performed at the 21st week to examine cognitive function. BBB permeability was characterized by Evans blue dye in the hippocampus. BDNF and NF-κB concentrations in the hippocampus and serum vitamin D concentrations were also measured.

RESULTS: HFD led to a significant delay in escape latency time and reduced time of MWM probe test due to increased NF-kB and decreased BDNF concentrations in the hippocampus. Vitamin D supplementation in the HFD group significantly reduced body weight, NF-κB concentrations, BBB permeability, and increased BDNF concentrations in the hippocampus.

CONCLUSIONS: Vitamin D reversed HFD-induced cognitive impairments by reduction of the NF-kB and elevation of BDNF concentrations and modulation of the BBB permeability in rats' hippocampus.International Journal of Obesity accepted article preview online, 17 January 2017. doi:10.1038/ijo.2017.10.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.