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Abstract Title:

Could 25-OH vitamin D deficiency be a reason for HPV infection persistence in cervical premalignant lesions?

Abstract Source:

J Exp Ther Oncol. 2016 Jul ;11(3):177-180. PMID: 28471122

Abstract Author(s):

Emre Özgü, Nafiye Yılmaz, Eralp Başer, Tayfun Güngör, Salim Erkaya, Halilİbrahim Yakut

Article Affiliation:

Emre Özgü

Abstract:

Vitamin D is an essential precursor to the steroid hormone calcitriol which mainly regulates calcium homeostasis. Moreover anti- proliferative, pro- apoptotic, anti- angiogenic effects of Vitamin D support the ideas of preventive role in various cancer. This study aimed to determine if there is a relationship between HPVDNA infection and cervical intraepithelial neoplasia and Vitamin D deficiency. As a result of the study the difference of 25-OH Vitamin D3 levels between HPVDNA positive group and the control group were statistically significant (p=0,009). According to results of our study, with the proven anti-inflammatory functions of Vitamin D, the deficiency of these molecule and its metabolites can be a possible reason for HPVDNA persistence and related cervical intraepithelial neoplasia.

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Sayer Ji
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