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Article Publish Status: FREE
Abstract Title:

Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-α/β at the Initial Stage of Influenza A Virus (H3N2) Infection.

Abstract Source:

Immune Netw. 2013 Apr ;13(2):70-4. Epub 2013 Apr 30. PMID: 23700397

Abstract Author(s):

Yejin Kim, Hyemin Kim, Seyeon Bae, Jiwon Choi, Sun Young Lim, Naeun Lee, Joo Myung Kong, Young-Il Hwang, Jae Seung Kang, Wang Jae Lee

Article Affiliation:

Yejin Kim

Abstract:

L-ascorbic acid (vitamin C) is one of the well-known anti-viral agents, especially to influenza virus. Since the in vivo anti-viral effect is still controversial, we investigated whether vitamin C could regulate influenza virus infection in vivo by using Gulo (-/-) mice, which cannot synthesize vitamin C like humans. First, we found that vitamin C-insufficient Gulo (-/-) mice expired within 1 week after intranasal inoculation of influenza virus (H3N2/Hongkong). Viral titers in the lung of vitamin C-insufficient Gulo (-/-) mice were definitely increased but production of anti-viral cytokine, interferon (IFN)-α/β, was decreased. On the contrary, the infiltration of inflammatory cells into the lung and production of pro-inflammatory cytokines, tumor necrosis factor (TNF)-α and interleukin (IL)-α/β, were increased in the lung. Taken together, vitamin C shows in vivo anti-viral immune responses at theearly time of infection, especially against influenza virus, through increased production of IFN-α/β.

Study Type : Animal Study

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