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Article Publish Status: FREE
Abstract Title:

Tuscan Varieties of Sweet Cherry Are Rich Sources of Ursolic and Oleanolic Acid: Protein Modeling Coupled to Targeted Gene Expression and Metabolite Analyses.

Abstract Source:

Molecules. 2019 Apr 22 ;24(8). Epub 2019 Apr 22. PMID: 31013661

Abstract Author(s):

Roberto Berni, Mubasher Zahir Hoque, Sylvain Legay, Giampiero Cai, Khawar Sohail Siddiqui, Jean-Francois Hausman, Christelle M Andre, Gea Guerriero

Article Affiliation:

Roberto Berni

Abstract:

The potential of six ancient Tuscan sweet cherry (L.) varieties as a source of health-promoting pentacyclic triterpenes is here evaluated by means of a targeted gene expression and metabolite analysis. By using a sequence homology criterion, we identify five oxidosqualene cyclase genes (s) and three cytochrome P450s (s) that are putatively involved in the triterpene production pathway in sweet cherries. We performed 3D structure prediction and induced-fit docking using cation intermediates and reaction products for some OSCs to predict their function. We show that the Tuscan varieties have different amounts of ursolic and oleanolic acids and that these variations are related to different gene expression profiles. This study stresses the interest of valorizing ancient fruits as alternative sources of functional molecules with nutraceutical value. It also provides information on sweet cherry triterpene biosynthetic genes, which could be the object of follow-up functional studies.

Study Type : In Vitro Study

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Sayer Ji
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