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Abstract Title:

A new phenanthrene derivative and two diarylheptanoids from the roots of Brassica rapa ssp. campestris inhibit the growth of cancer cell lines and LDL-oxidation.

Abstract Source:

Arch Pharm Res. 2013 Apr ;36(4):423-9. Epub 2013 Feb 24. PMID: 23435947

Abstract Author(s):

Qian Wu, Jin-Gyeong Cho, Ki-Hyun Yoo, Tae-Sook Jeong, Ji-Hae Park, Su-Yeon Kim, Ji-Hyun Kang, In-Sik Chung, Myung-Sook Choi, Kyung-Tae Lee, Hae-Gon Chung, Myun-Ho Bang, Nam-In Baek

Article Affiliation:

Qian Wu

Abstract:

Brassica rapa ssp. campestris (Brassicaceae) is a conical, deep purple, edible root vegetable commonly known as a turnip. We initiated phytochemical and pharmacological studies to search for biological active compounds from the roots of B. rapa ssp. campestris. We isolated a novel phenanthrene derivative, 6-methoxy-1-[10-methoxy-7-(3-methylbut-2-enyl)phenanthren-3-yl]undecane-2,4-dione, named brassicaphenanthrene A (3) along with two known diarylheptanoid compounds, 6-paradol (1) and trans-6-shogaol (2), through the repeated silica gel (SiO2), octadecyl silica gel, and Sephadex LH-20 column chromatography. The chemical structures of the compounds were determined by spectroscopic data analyses including nuclear magnetic resonance, mass spectrometry, ultraviolet spectroscopy, and infra-red spectroscopy. All compounds exhibited high inhibitory activity against the growth of human cancer lines, HCT-116, MCF-7, and HeLa, with IC50 values ranging from 15.0 to 35.0μM and against LDL-oxidation with IC50 values ranging from 2.9 to 7.1 μM.

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Sayer Ji
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