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Abstract Title:

Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities.

Abstract Source:

Arch Pharm Res. 2015 Aug ;38(8):1443-8. Epub 2015 Jan 29. PMID: 25630793

Abstract Author(s):

Chau Van Minh, Nguyen Xuan Nhiem, Hoang Thi Yen, Phan Van Kiem, Bui Huu Tai, Hoang Le Tuan Anh, Truong Thi Thu Hien, SeonJu Park, Nanyoung Kim, Seung Hyun Kim

Article Affiliation:

Chau Van Minh

Abstract:

One new lignan, trichobenzolignan (1), and seven known compounds, ligballinol (2), (-)-pinoresinol (3), ehletianol C (4), luteolin 7-O-β-D-glucopyranoside (5), chrysoeriol-7- O-β-D-glucopyranoside (6), 10α-cucurbita-5,24-dien-3β-ol (7), and arvenin I (8). Their structures were established on the basis of spectral and chemical evidence, which were in agreement with those reported in literature. The cytotoxic activities of thesecompounds were evaluated on four cancer cell lines such as A-549 (human lung cancer), HT-29 (human colon adenocarcinoma), OVCAR (human ovarian carcinoma), and MCF-7 (human breast cancer). As the results, compound 7 showed significant activity on HT-29 and OVCAR cancer cell lines with IC50 of 4.1 and6.5 µM, respectively. Compounds 1, 5, 6, and 8 exhibited moderate activities in all cancer cell lines with IC50 ranging from 11.3 to 42.8 µM.

Study Type : In Vitro Study

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