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Article Publish Status: FREE
Abstract Title:

Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism.

Abstract Source:

Nat Commun. 2014 Dec 10 ;5:5748. Epub 2014 Dec 10. PMID: 25494366

Abstract Author(s):

Simone Gupta, Shannon E Ellis, Foram N Ashar, Anna Moes, Joel S Bader, Jianan Zhan, Andrew B West, Dan E Arking

Article Affiliation:

Simone Gupta

Abstract:

Recent studies of genomic variation associated with autism have suggested the existence of extreme heterogeneity. Large-scale transcriptomics should complement these results to identify core molecular pathways underlying autism. Here we report results from a large-scale RNA sequencing effort, utilizing region-matched autism and control brains to identify neuronal and microglial genes robustly dysregulated in autism cortical brain. Remarkably, we note that a gene expression module corresponding to M2-activation states in microglia is negatively correlated with a differentially expressed neuronal module, implicating dysregulated microglial responses in concert with altered neuronal activity-dependent genes in autism brains. These observations provide pathways and candidate genes that highlight the interplay between innate immunity and neuronal activity in the aetiology of autism.

Study Type : Human In Vitro

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Sayer Ji
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