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Article Publish Status: FREE
Abstract Title:

Murr: a traditional Chinese medicine with potent anti-tumor effects.

Abstract Source:

Cancer Manag Res. 2019 ;11:1541-1549. Epub 2019 Feb 14. PMID: 30863164

Abstract Author(s):

Jun Pan, Chenghui Yang, Zhou Jiang, Jian Huang

Article Affiliation:

Jun Pan

Abstract:

Murr also known as Huaier, one of the traditional Chinese medicines, has been shown an effective adjuvant of cancer therapy. Accumulating evidence suggests that the anti-cancer effects of Huaier can be briefly divided into two aspects: the direct effects on tumor cells and the indirect effects on immune cells. In vitro and in vivo experiment showed Huaier directly inhibited tumor cell proliferation, induced tumor cell death, prevented metastasis and interfered with angiogenesis via various signaling pathways. The immunomodulatory effect of Huaier is associated with enhancement of the number and function of CD4T cells and NK cells, regulation of the polarization and function of macrophages, and elevated secretion of immune stimulatory cytokines. In this review, the anti-cancer effects and combined treatments of Huaier with other anti-cancer therapies, and the underlying mechanisms are summarized and discussed.

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Sayer Ji
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