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Abstract Title:

Total glucosides of peony attenuates experimental autoimmune encephalomyelitis in C57BL/6 mice.

Abstract Source:

J Neuroimmunol. 2015 Jul 15 ;284:67-73. Epub 2015 May 12. PMID: 26025060

Abstract Author(s):

Qiling Huang, Xiaomeng Ma, Dong Liang Zhu, Li Chen, Ying Jiang, Linli Zhou, Lei Cen, Rongbiao Pi, Xiaohong Chen

Article Affiliation:

Qiling Huang

Abstract:

Total glucosides of peony (TGP), an active compound extracted from the roots of Paeonia lactiflora Pall, has wide pharmacological effects on nervous system. Here we examined the effects of TGP on experimental autoimmune encephalomyelitis (EAE), an established model of multiple sclerosis (MS). The results showed that TGP can reduce the severity and progression of EAE in C57 BL/6 mice. In addition, TGP also down-regulated the Th1/Th17 inflammatory response and prevented the reduced expression of brain-derived neurotrophic factor and 2',3'-cyclic nucleotide 3'-phosphodiesterase of EAE. These findings suggest that TGP could be a potential therapeutic agent for MS.

Study Type : Animal Study

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Sayer Ji
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