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Article Publish Status: FREE
Abstract Title:

Phytochemical analysis ofL. active compounds possessing anticonvulsant activity.

Abstract Source:

J Tradit Complement Med. 2019 Oct ;9(4):263-270. Epub 2018 Sep 28. PMID: 31453121

Abstract Author(s):

K Raafat, M Wurglics

Article Affiliation:

K Raafat

Abstract:

The anticonvulsant potential ofmethanol-extract (Fc) has been studied. It was found that Fc most active fraction is rich in oligosaccharides (OFG).H,C NMR and Nano-ESI, MALDI MS, and LC-MS techniques proved that OFG contains alpha-glucopyranoside oligomer in high amounts. Both Fc and OFG reduced strychnine (STR) convulsion-action. Fc and OFG fully protected the experimental-animals from STR-lethality. The intracerebroventricular-administration (ICV) of Fc or OFG in combination with glycine in ethanol-treated mice caused a dose-dependent returning to a 2nd-loss of righting-reflex (LORR), and was antagonized by STR. FC and OFG ICV injection counteracted STR-inhibition, confirming that Fc/OFG anticonvulsant mechanism of action was mediated by potentiation of glycine receptor. These results support Fc and OFG potential anticonvulsant-activity with good safety-profile.

Study Type : Animal Study

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Sayer Ji
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