These results support Ficus carica and oligosaccharides potential anticonvulsant-activity. - GreenMedInfo Summary
Phytochemical analysis ofL. active compounds possessing anticonvulsant activity.
J Tradit Complement Med. 2019 Oct ;9(4):263-270. Epub 2018 Sep 28. PMID: 31453121
The anticonvulsant potential ofmethanol-extract (Fc) has been studied. It was found that Fc most active fraction is rich in oligosaccharides (OFG).H,C NMR and Nano-ESI, MALDI MS, and LC-MS techniques proved that OFG contains alpha-glucopyranoside oligomer in high amounts. Both Fc and OFG reduced strychnine (STR) convulsion-action. Fc and OFG fully protected the experimental-animals from STR-lethality. The intracerebroventricular-administration (ICV) of Fc or OFG in combination with glycine in ethanol-treated mice caused a dose-dependent returning to a 2nd-loss of righting-reflex (LORR), and was antagonized by STR. FC and OFG ICV injection counteracted STR-inhibition, confirming that Fc/OFG anticonvulsant mechanism of action was mediated by potentiation of glycine receptor. These results support Fc and OFG potential anticonvulsant-activity with good safety-profile.