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Article Publish Status: FREE
Abstract Title:

The Citrus Flavanone Naringenin Protects Myocardial Cells against Age-Associated Damage.

Abstract Source:

Oxid Med Cell Longev. 2017 ;2017:9536148. Epub 2017 Mar 12. PMID: 28386313

Abstract Author(s):

Eleonora Da Pozzo, Barbara Costa, Chiara Cavallini, Lara Testai, Alma Martelli, Vincenzo Calderone, Claudia Martini

Article Affiliation:

Eleonora Da Pozzo

Abstract:

In recent years, the health-promoting effects of the citrus flavanone naringenin have been examined. The results have provided evidence for the modulation of some key mechanisms involved in cellular damage by this compound. In particular, naringenin has been revealed to have protective properties such as an antioxidant effect in cardiometabolic disorders. Very recently, beneficial effects of naringenin have been demonstrated in old rats. Because aging has been demonstrated to be directly related to the occurrence of cardiac disorders, in the present study, the ability of naringenin to prevent cardiac cell senescence was investigated. For this purpose, a cellular model of senescent myocardial cells was set up and evaluated using colorimetric, fluorimetric, and immunometric techniques. Relevant cellular senescence markers, such as X-gal staining, cell cycle regulator levels, and the percentage of cell cycle-arrested cells, were found to be reduced in the presence of naringenin. In addition, cardiac markers of aging-induced damage, including radical oxidative species levels, mitochondrial metabolic activity, mitochondrial calcium buffer capacity, and estrogenic signaling functions, were also modulated by the compound. These results suggested that naringenin has antiaging effects on myocardial cells.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Cardioprotective : CK(3412) : AC(1032)

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