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Abstract Title:

Puerarin attenuates amyloid-beta-induced cognitive impairment through suppression of apoptosis in rat hippocampus in vivo.

Abstract Source:

Eur J Pharmacol. 2010 Dec 15 ;649(1-3):195-201. Epub 2010 Sep 22. PMID: 20868658

Abstract Author(s):

Jiaming Li, Gang Wang, Jicheng Liu, Li Zhou, Miaoxian Dong, Rui Wang, Xueyan Li, Xiaoming Li, Chunrong Lin, Yingcai Niu

Article Affiliation:

Jiaming Li

Abstract:

Elevated levels ofβ-amyloid (Aβ) in the brains being a hallmark of Alzheimer's disease have been believed to play a critical role in the cognitive dysfunction that occurs in Alzheimer's disease. Recent evidence suggests that Aβ induces neuronal apoptosis in the brain and in primary neuronal cultures. In this study, we investigated the effects of puerarin, a phytoestrogen isolated from Pueraria lobata, on cognitive function and neuronal apoptosis in the intrahippocampal injection of Aβ rats and its mechanism of action. The results show the intrahippocampal injection of Aβ induced a spatial memory deficit, apoptosis, and caspase-9 activation in hippocampal neurons. Puerarin treatment ameliorated Aβ(1-42)-induced cognitive impairment and reversed the increase of apoptosis in the hippocampus. The attenuation is associated with the activation of Akt and phosphorylation of Bad. These results suggest thatpuerarin may be an anti-Alzheimer's disease candidate drug to suppress both Alzheimer's disease-related neuronal cell apoptosis and dysfunction of the memory system.

Study Type : Animal Study

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Sayer Ji
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