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Article Publish Status: FREE
Abstract Title:

Chamaecyparis obtusa Suppresses Virulence Genes in Streptococcus mutans.

Abstract Source:

Evid Based Complement Alternat Med. 2016 ;2016:2396404. Epub 2016 May 11. PMID: 27293453

Abstract Author(s):

Eun-Hee Kim, Sun-Young Kang, Bog-Im Park, Young-Hoi Kim, Young-Rae Lee, Jin-Hee Hoe, Na-Young Choi, Ji-Young Ra, So-Youn An, Yong-Ouk You

Article Affiliation:

Eun-Hee Kim

Abstract:

Chamaecyparis obtusa (C. obtusa) is known to have antimicrobial effects and has been used as a medicinal plant and in forest bathing. This study aimed to evaluate the anticariogenic activity of essential oil of C. obtusa on Streptococcus mutans, which is one of the most important bacterial causes of dental caries and dental biofilm formation. Essential oil from C. obtusa was extracted, and its effect on bacterial growth, acid production, and biofilm formation was evaluated. C. obtusa essential oil exhibited concentration-dependent inhibition of bacterial growth over 0.025 mg/mL, with 99% inhibition at a concentration of 0.2 mg/mL. The bacterial biofilm formation and acid production were also significantly inhibited at the concentration greater than 0.025 mg/mL. The result of LIVE/DEAD® BacLight™ Bacterial Viability Kit showed a concentration-dependent bactericidal effect on S. mutans and almost all bacteria were dead over 0.8 mg/mL. Real-time PCR analysis showed that gene expression of some virulence factors such as brpA, gbpB, gtfC, and gtfD was also inhibited. In GC and GC-MS analysis, the major components were found to be α-terpinene (40.60%), bornyl acetate (12.45%), α-pinene (11.38%), β-pinene (7.22%), β-phellandrene (3.45%), and α-terpinolene (3.40%). These results show that C. obtusa essential oil has anticariogenic effect on S. mutans.

Study Type : In Vitro Study

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Sayer Ji
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