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Abstract Title:

Prenatal exposure to organomercury, thimerosal, persistently impairs the serotonergic and dopaminergic systems in the rat brain: implications for association with developmental disorders.

Abstract Source:

Brain Dev. 2013 Mar ;35(3):261-4. Epub 2012 Jun 1. PMID: 22658806

Abstract Author(s):

Michiru Ida-Eto, Akiko Oyabu, Takeshi Ohkawara, Yasura Tashiro, Naoko Narita, Masaaki Narita

Article Affiliation:

Michiru Ida-Eto

Abstract:

Thimerosal, an organomercury compound, has been widely used as a preservative. Therefore, concerns have been raised about its neurotoxicity. We recently demonstrated perturbation of early serotonergic development by prenatal exposure to thimerosal (Ida-Eto et al. (2011) [11]). Here, we investigated whether prenatal thimerosal exposure causes persistent impairment after birth. Analysis on postnatal day 50 showed significant increase in hippocampal serotonin following thimerosal administration on embryonic day 9. Furthermore, not only serotonin, striatal dopamine was significantly increased. These results indicate that embryonic exposure to thimerosal produces lasting impairment of brain monoaminergic system, and thus every effort should be made to avoid the use of thimerosal.

Study Type : Animal Study
Additional Links
Problem Substances : Thimerosal : CK(618) : AC(151)
Adverse Pharmacological Actions : Neurotoxic : CK(1458) : AC(323)

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Sayer Ji
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