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Abstract Title:

Shikonin alleviates hepatic fibrosis and autophagy via inhibition of TGF-β1/Smads pathway.

Abstract Source:

J Gastroenterol Hepatol. 2018 Jun 4. Epub 2018 Jun 4. PMID: 29864192

Abstract Author(s):

Tong Liu, Ling Xu, Chengfen Wang, Kan Chen, Yujing Xia, Jingjing Li, Sainan Li, Liwei Wu, Jiao Feng, Shizan Xu, Wenwen Wang, Xiya Lu, Xiaoming Fan, Wenhui Mo, Yingqun Zhou, Yan Zhao, Chuanyong Guo

Article Affiliation:

Tong Liu

Abstract:

BACKGROUND AND AIM: Liver fibrosis is a worldwide clinical challenge during the progression of chronic liver disease to liver cirrhosis. Shikonin is extracted from the root of Lithospermum erythrorhizon with antioxidant, anti-inflammatory, anticancer, and wound healing properties. The study aim to investigate the protective effect of shikonin on liver fibrosis and its underlying mechanism.

METHODS: Two liver fibrosis models were established in male C57 mice by intraperitoneal injection of CClor bile duct ligation (BDL). Shikonin was administered orally three times weekly at a dosage of 2.5 or 5 mg/kg. Protein and mRNA expression were assayed by quantitative real-time polymerase chain reaction (qPCR), western blotting, and immunohistochemical staining.

RESULTS: Shikonin significantly inhibited activation of hepatic stellate cells (HSCs) and extracellular matrix (ECM) formation by downregulating the TGF-β1 expression and maintaining the normal balance between MMP2 and TIMP1. Shikonin also decreased HSCs energy production by inhibiting autophagy.

CONCLUSIONS: The results confirmed that shikonin attenuated liver fibrosis by downregulating the TGF-β1/Smads pathway and inhibiting autophagy.

Study Type : Animal Study

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