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Abstract Title:

Mobile phone (1800MHz) radiation impairs female reproduction in mice, Mus musculus, through stress induced inhibition of ovarian and uterine activity.

Abstract Source:

Reprod Toxicol. 2017 Oct ;73:41-60. Epub 2017 Aug 2. PMID: 28780396

Abstract Author(s):

Saba Shahin, Surya Pal Singh, Chandra Mohini Chaturvedi

Article Affiliation:

Saba Shahin

Abstract:

Present study investigated the long-term effects of mobile phone (1800MHz) radiation in stand-by, dialing and receiving modes on the female reproductive function (ovarian and uterine histo-architecture, and steroidogenesis) and stress responses (oxidative and nitrosative stress). We observed that mobile phone radiation induces significant elevation in ROS, NO, lipid peroxidation, total carbonyl content and serum corticosterone coupled with significant decrease in antioxidant enzymes in hypothalamus, ovary and uterus of mice. Compared to control group, exposed mice exhibited reduced number of developing and mature follicles as well as corpus lutea. Significantly decreased serum levels of pituitary gonadotrophins (LH, FSH), sex steroids (E2 and P4) and expression of SF-1, StAR, P-450scc, 3β-HSD, 17β-HSD, cytochrome P-450 aromatase, ER-α and ER-β were observed in all the exposed groups of mice, compared to control. These findings suggest that mobile phone radiation induces oxidative and nitrosative stress, which affects the reproductive performance of female mice.

Study Type : Animal Study
Additional Links
Additional Keywords : Risk Factors : CK(3057) : AC(392)
Anti Therapeutic Actions : Mobile Phone Radiation : CK(64) : AC(13)
Adverse Pharmacological Actions : Oxidant : CK(122) : AC(48)

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