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Article Publish Status: FREE
Abstract Title:

Triclosan causes spontaneous abortion accompanied by decline of estrogen sulfotransferase activity in humans and mice.

Abstract Source:

Sci Rep. 2015 ;5:18252. Epub 2015 Dec 15. PMID: 26666354

Abstract Author(s):

Xiaoli Wang, Xiaojiao Chen, Xuejiao Feng, Fei Chang, Minjian Chen, Yankai Xia, Ling Chen

Article Affiliation:

Xiaoli Wang

Abstract:

Triclosan (TCS), an antibacterial agent, is identified in serum and urine of humans. Here, we show that the level of urinary TCS in 28.3% patients who had spontaneous abortion in mid-gestation were increased by 11.3-fold (high-TCS) compared with normal pregnancies. Oral administration of TCS (10 mg/kg/day) in mice (TCS mice) caused an equivalent urinary TCS level as those in the high-TCS abortion patients. The TCS-exposure from gestation day (GD) 5.5 caused dose-dependently fetal death during GD12.5-16.5 with decline of live fetal weight. GD15.5 TCS mice appeared placental thrombus and tissue necrosis with enhancement of platelet aggregation. The levels of placenta and plasma estrogen sulfotransferase (EST) mRNA and protein in TCS mice or high-TCS abortion patients were not altered, but their EST activities were significantly reduced compared to controls. Although the levels of serum estrogen (E2) in TCS mice and high-TCS abortion patients had no difference from controls, their ratio of sulfo-conjugated E2 and unconjugated E2 was reduced. The estrogen receptor antagonist ICI-182,780 prevented the enhanced platelet aggregation and placental thrombosis and attenuated the fetaldeath in TCS mice. The findings indicate that TCS-exposure might cause spontaneous abortion probably through inhibition of EST activity to produce placental thrombosis.

Study Type : Animal Study, Human Study
Additional Links
Additional Keywords : Risk Factors : CK(3057) : AC(392)
Problem Substances : Triclosan : CK(13) : AC(8)
Adverse Pharmacological Actions : Abortive : CK(22) : AC(3)

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Sayer Ji
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