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Abstract Title:

Induction of apoptosis by puerarin in colon cancer HT-29 cells.

Abstract Source:

Cancer Lett. 2006 Jul 8 ;238(1):53-60. Epub 2005 Aug 1. PMID: 16055262

Abstract Author(s):

Zengli Yu, Wenjie Li

Article Affiliation:

Zengli Yu

Abstract:

Puerarin was isolated from Pueraria radix and has beneficial effects on cardiovascular, neurological, and hyperglycemic disorders. The current study showed that puerarin also possessed anti-cancer properties. Methyl thiazolyl tetrazolium assay (MTT) assay revealed a dose-dependent reduction of HT-29 cellular growth in response to puerarin treatment. Apoptosis was observed following treatments ;with>or=25 microM puerarin, as reflected by the appearance of the subdiploid fraction and NDA fragmentations. We then investigated effects of puerarin on expression of apoptosis-associated genes and the results revealed an increase of bax and decreases of c-myc and bcl-2. Finally, puerarin treatment significantly increased the activation of caspase-3, a key executioner of apoptosis. These findings indicate that puerarin may act as a chemopreventive and/or chemotherapeutic agent in colon cancer cells by reducing cell viability and inducing apoptosis.

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Sayer Ji
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