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Article Publish Status: FREE
Abstract Title:

The anticancer effect of fucoidan in PC-3 prostate cancer cells.

Abstract Source:

Mar Drugs. 2013 Aug 19 ;11(8):2982-99. Epub 2013 Aug 19. PMID: 23966032

Abstract Author(s):

Hye-Jin Boo, Ji-Young Hong, Sang-Cheol Kim, Jung-Il Kang, Min-Kyoung Kim, Eun-Ji Kim, Jin-Won Hyun, Young-Sang Koh, Eun-Sook Yoo, Jung-Mi Kwon, Hee-Kyoung Kang

Article Affiliation:

Hye-Jin Boo

Abstract:

Fucoidan, a sulfated polysaccharide, has a variety of biological activities, such as anti-cancer, anti-angiogenic and anti-inflammatory. However, the mechanisms of action of fucoidan as an anti-cancer agent have not been fully elucidated. The present study examined the anti-cancer effect of fucoidan obtained from Undaria pinnatifida in PC-3 cells, human prostate cancer cells. Fucoidan induced the apoptosis of PC-3 cells by activating both intrinsic and extrinsic pathways. The induction of apoptosis was accompanied by the activation of extracellular signal-regulated kinase mitogen-activated protein kinase (ERK1/2 MAPK) and the inactivation of p38 MAPK and phosphatidylinositol 3-kinase (PI3K)/Akt. In addition, fucoidan also induced the up-regulation of p21Cip1/Waf and down-regulation of E2F-1 cell-cycle-related proteins. Furthermore, in the Wnt/β-catenin pathway, fucoidan activated GSK-3β that resulted in the decrease of β-catenin level, followed by the decrease of c-myc and cyclin D1 expressions, target genes of β-catenin in PC-3 cells. These results suggested that fucoidan treatment could induce intrinsic and extrinsic apoptosis pathways via the activation of ERK1/2 MAPK, the inactivation of p38 MAPK and PI3K/Akt signaling pathway, and the down-regulation of Wnt/β-catenin signaling pathway in PC-3 prostate cancer cells. These data support that fucoidan might have potential for the treatment of prostate cancer.

Study Type : In Vitro Study

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Sayer Ji
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