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Abstract Title:

Kanuka honey versus aciclovir for the topical treatment of herpes simplex labialis: a randomised controlled trial.

Abstract Source:

BMJ Open. 2019 May 14 ;9(5):e026201. Epub 2019 May 14. PMID: 31092654

Abstract Author(s):

Alex Semprini, Joseph Singer, Irene Braithwaite, Nick Shortt, Darmiga Thayabaran, Melanie McConnell, Mark Weatherall, Richard Beasley

Article Affiliation:

Alex Semprini

Abstract:

OBJECTIVE: To compare New Zealand medical grade kanuka honey with topical aciclovir for the treatment of herpes simplex labialis.

DESIGN: Prospective parallel randomised controlled open-label superiority trial.

SETTING: 76 community pharmacies across New Zealand between 10 September 2015 and 13 December 2017.

PARTICIPANTS: 952 adults randomised within the first 72 hours of a herpes simplex labialis episode.

INTERVENTIONS: Random assignment 1:1 to either 5% aciclovir cream or medical grade kanuka honey (90%)/glycerine (10%) cream, both applied five times daily.

OUTCOME MEASURES: The primary outcome was time from randomisation to return to normal skin (stage 7). Secondary outcomes included time from randomisation to stage 4 (open wound), time from stage 4 to 7, maximal pain, time to pain resolution and treatment acceptability.

RESULTS: Primary outcome variable: Kaplan-Meier-based estimates (95% CI) for the median time in days for return to normal skin were 8 (8 to 9) days for aciclovir and 9 (8 to 9) for honey; HR (95% CI) 1.06 (0.92 to 1.22), p=0.56. There were no statistically significant differences between treatments for all secondary outcome variables. No related serious adverseevents were reported.

CONCLUSION: There was no evidence of a difference in efficacy between topical medical grade kanuka honey and 5% aciclovir in the pharmacy-based treatment of herpes simplex labialis.

TRIAL REGISTRATION NUMBER: ACTRN12615000648527;Post-results.

Study Type : Human Study

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Sayer Ji
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