Tetrahydroxystilbene glucoside effectively prevents apoptosis induced hair loss. - GreenMedInfo Summary
Tetrahydroxystilbene Glucoside Effectively Prevents Apoptosis Induced Hair Loss.
Biomed Res Int. 2018 ;2018:1380146. Epub 2018 Apr 2. PMID: 29808162
The effect ofagainst hair loss has been widely recognized. 2,3,5,4'-Tetrahydroxystilbene-2-O--D-glucoside (TSG) is the main component of; however, its role in hair regeneration has not been established. To evaluate the hair growth-promoting activity of TSG, depilated C57BL/6J mice were topically treated with normal saline, TSG, Pifithrin-, Minoxidil for 2 weeks. In this study, we identified that p53, Caspase-3, Active Caspase-3, and Caspase-9 were obviously upregulated in the skin of human and mice with hair loss by western blot analysis. Depilated mice treated with TSG showed markedly hair regrowth. TUNELcells were also reduced in mice with TSG. These changes were accompanied with inhibition of Fas, p53, Bax, Active Caspase-3, and Procaspase-9 activities. These results demonstrated that TSG exerts great hair regrowth effect on hair loss, which was probably mediated by inhibition of p53, Fas, and Bax induced apoptosis.