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Abstract Title:

TanshinoneⅡA inhibits human esophageal cancer cell growth through miR-122-mediated PKM2 down-regulation.

Abstract Source:

Arch Biochem Biophys. 2016 05 15 ;598:50-6. Epub 2016 Mar 31. PMID: 27040384

Abstract Author(s):

Hong-Sheng Zhang, Feng-Juan Zhang, Hu Li, Yang Liu, Guang-Yuan Du, Ying-Hui Huang

Article Affiliation:

Hong-Sheng Zhang

Abstract:

Pyruvate kinase M2 (PKM2) plays a pivotal role in the growth, survival and metabolic reprogramming of cancer cells. Here, we presented for the first time that tanshinoneⅡA inhibited human esophagus cancer cell growth through miR-122-mediated PKM2 down-regulation pathway. Tanshinone ⅡA inhibited cell proliferation and induced cell cycle arrest in S phase in human Ec109 cells. As expected, tanshinone ⅡA down-regulated PKM2 mRNA and protein expression in Ec109 cells. Given these findings, we further investigated microRNAs regulation of PKM2 and confirmed miR-122 for targeting PKM2. Moreover, we found that tanshinone ⅡA-induced up-regulation of miR-122 expression inhibited PKM2 expression in Ec109 cells. Meanwhile, tanshinone ⅡA inhibited proliferation through miR122-medated PKM2 down-regulation. It was demonstrated that the anticancer activity of tanshinone ⅡA was targeted at metabolic regulation of miR-122/PKM2 in human esophagus cancer cells. Taken together, our results revealed tanshinone ⅡA targeting at PKM2-mediated metabolic reprogramming play an important role in inhibition of esophageal cancer cell growth.

Study Type : In Vitro Study

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