Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

n/a
Abstract Title:

Tanshinone IIA sensitizes oral squamous cell carcinoma to radiation due to an enhanced autophagy.

Abstract Source:

Environ Toxicol Pharmacol. 2016 Sep ;46:264-269. Epub 2016 Jul 30. PMID: 27521571

Abstract Author(s):

Lijuan Ding, Shudong Wang, Xiaozhang Qu, Jiafeng Wang

Article Affiliation:

Lijuan Ding

Abstract:

PURPOSE: Tanshinone IIA (TanIIA), which is derived from the roots of Salvia miltiorrhiza (Danshen), has multiple pharmacological activities. However, the radiosensitivezing activity of TanIIA in oral cancer cells has not been studied extensively. The purpose of this study is to investigate the radiosensitizing effects of TanIIA in human oral squamous cell carcinoma SCC090 and examined the underlying mechanisms.

METHODS: Clonogenic assay was used to investigate the radiosensitizing effect of TanIIA on SCC090. And then, apoptosis and reactive oxygen species (ROS) induced by the combination of TanIIA with radiation were analyzed by Flow cytometry. Finally, autophagy was detected by monodansylcadervarine (MDC) staining.

RESULTS: TanIIA could significantly sensitize SCC090 to radiation. Meanwhile, an increase ROS generation after exposed to the combination treatment was found. In addition, the protein levels of Beclin 1, Atg5 and LC3-II, three important proteins involved in autophagy were increased in cells.

CONCLUSIONS: TanIIA exerted a strong radiosensitizing effect on SCC090 comparing with the simple drug or single radiation treatment, which was due to an enhanced ROS generation and autophagy.

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.