Tanshinone IIA promotes non-amyloidogenic processing of amyloid precursor protein in platelets via estrogen receptor signaling to phosphatidylinositol 3-kinase/Akt.
Biomed Rep. 2014 Jul ;2(4):500-504. Epub 2014 Mar 24. PMID: 24944795
Amyloidβ peptide (Aβ) is a proteolytic product of amyloid precursor protein (APP). Recent findings suggested that platelet-derived Aβ is closely associated with the pathogenesis of atherosclerosis (AS). Tanshinone IIA (Tan IIA), a pharmacologically active component of the Chinese herbBunge, has long been used to treat AS and was also identified as a phytoestrogen. However, it has not been elucidated whether Tan IIA intervenes with platelet APP processing and whether such an intervention is associated with its estrogenic activity. Using human platelets, this study demonstrated that Tan IIA promoted the non-amyloidogenic cleavage of APP via estrogenic activity. The phosphatidylinositol 3-kinase/Akt pathway may be involved in this effect of Tan IIA on platelet APP metabolism as a downstream effector of estrogen receptor signaling. This study aimed to extend the existing data and provide new insights into the mechanism underlying the vasoprotective effect of Tan IIA.