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Abstract Title:

Tanshinone IIA protects against lipopolysaccharide-induced lung injury through targeting Sirt1.

Abstract Source:

J Pharm Pharmacol. 2019 Mar 13. Epub 2019 Mar 13. PMID: 30868609

Abstract Author(s):

Minxue Quan, Yanni Lv, Yang Dai, Biying Qi, Longsheng Fu, Xuanying Chen, Yisong Qian

Article Affiliation:

Minxue Quan

Abstract:

OBJECTIVES: This study was designed to investigate the effects and the mechanism of Tanshinone IIA (TIIA) on endotoxic shock-induced lung injury in a mouse model.

METHODS: Mice were administered intraperitoneally with TIIA (10 mg/kg) 0.5 h before lipopolysaccharide (LPS) challenge and then received additional injections every 24 h during the 3-day experimental period. The physiological indexes, the survival rate and the parameters for lung injury were examined. The protein levels of Sirt1, and the acetylation and activation of NF-κB p65 were determined. The expression and secretion of pro-inflammatory factors were evaluated, respectively.

KEY FINDINGS: Treatment with TIIA significantly improved physiological indexes and increased the survival rate of mice in response to LPS challenge. TIIA treatment displayed an obvious up-regulation of Sirt1 protein, in accompany with reduced acetylation and activation of NF-κB p65 following LPS stimulation. In addition, TIIA attenuated LPS-induced lung injury and prevented the expression and secretion of pro-inflammatory factors. However, the protective effects of TIIA were abolished by Sirt1 inhibitor.

CONCLUSIONS: Tanshinone IIA prevents LPS-induced secretion of pro-inflammatory cytokines thus exerts protective effects against acute lung injury, probably via modulation of Sirt1/NF-κB signalling pathway.

Study Type : Animal Study

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