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Abstract Title:

[The effect of tanshinoneⅡA potentiates the effects of Cisplatin in Fadu cells in vitro through downregulation of survivin].

Abstract Source:

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 May 20 ;31(10):781-784. PMID: 29771043

Abstract Author(s):

Y X Zhao, D Luo, Y H Zhang, B Shen, B X Wang, Z F Sun

Article Affiliation:

Y X Zhao

Abstract:

The aim of this study is to investigate the inhibitory effect and mechanism of tanshinoneⅡA combined with cisplatin on tumor Fadu cells in pharyngeal squamous cell carcinoma.Cytotoxicity was determined by CCK8 assay. Flow cytometry was used to detect apoptosis and cell cycle distribution. Western blotting was used to assess the protein expression of related signaling proteins.Compared with the two single drug groups treated with TanⅡA and DDP respectively, the combination group showed significantly higher anti-proliferative rate (<0.01), arrested cell cycle at S phase, and resulted in observably higher apoptotic cell fractions in human hypopharyngeal squamous cell carcinomas Fadu cells; Western blotting showed that the protein expression of cleaved caspase 3 and cleaved PARP increased ,while survivin significantly decreased in the cells treated with the combination of tanshinoneⅡA and cisplatin.TanshinoneⅡA potentiates the efficacy of Cisplatin in Fadu cells, which may be attributed to the downregulation of survivin protein expression.

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