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Abstract Title:

Sustained Cytotoxicity of Wogonin on Breast Cancer Cells by Encapsulation in Solid Lipid Nanoparticles.

Abstract Source:

Nanomaterials (Basel). 2018 Mar 13 ;8(3). Epub 2018 Mar 13. PMID: 29533979

Abstract Author(s):

Jong-Suep Baek, Young-Guk Na, Cheong-Weon Cho

Article Affiliation:

Jong-Suep Baek

Abstract:

While wogonin has been known to have cytotoxicity against various cancer cells, its bioavailability and cytotoxicity are low due to its low water solubility. Therefore, wogonin-loaded solid lipid nanoparticles were fabricated using a hot-melted evaporation technique. The highest solubility of wogonin was observed in stearic acid. Hence, wogonin-loaded solid lipid nanoparticles were composed of stearic acid as the lipid matrix. The physicochemical properties of the wogonin-loaded solid lipid nanoparticles were evaluated by dynamic laser scattering and scanning electron microscopy. The wogonin-loaded solid lipid nanoparticles exhibited sustained and controlled release up to 72 h. In addition, it was observed that the wogonin-loaded solid lipid nanoparticles exhibited enhanced cytotoxicity and inhibited poly (ADP-ribose) polymerase in MCF-7 breast cancer cells. Overall, the results indicate that wogonin-loaded solid lipid nanoparticles could be an efficient delivery system for the treatment of breast cancer.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Cytotoxic : CK(76) : AC(60)

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Sayer Ji
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