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Article Publish Status: FREE
Abstract Title:

Interleukin-6 suppression reduces tumour self-seeding by circulating tumour cells in a human osteosarcoma nude mouse model.

Abstract Source:

Oncotarget. 2015 Nov 9. Epub 2015 Nov 9. PMID: 26623559

Abstract Author(s):

Yinglong Zhang, Qiong Ma, Tao Liu, Guofeng Guan, Kailiang Zhang, Jiayan Chen, Nan Jia, Shiju Yan, Guanyin Chen, Shiluan Liu, Kuo Jiang, Yao Lu, Yanhua Wen, Haien Zhao, Yong Zhou, Qingyu Fan, Xiuchun Qiu

Article Affiliation:

Yinglong Zhang

Abstract:

Tumour self-seeding by circulating tumour cells (CTCs) enhances tumour progression and recurrence. Previously, we demonstrated that tumour self-seeding by CTCs occurs in osteosarcoma and revealed that interleukin-6 (IL-6) may promote CTC attraction. Here, we investigated the underlying mechanisms of IL-6 in tumour self-seeding by CTCs. IL-6 suppression inhibited in vitro cell proliferation, migration, and invasion. In addition, rhIL-6 activated the Janus-activated kinase/signal transducers and activators of transcription 3 (JAK/STAT3) and mitogen-activated protein kinase/extracellular-signal regulated kinase1/2 (MAPK/ERK1/2) pathways in vitro. Both pathways increased cell proliferation, but only the JAK/STAT3 pathway promoted migration. Suppressing IL-6 inhibited in vivo tumour growth and metastasis. IL-6 suppression or JAK/STAT3 pathway inhibition reduced CTC seeding in primary tumours. Collectively, IL-6 promotes tumour self-seeding by CTCs in a nude mouse model. This finding may provide a novel strategy for future therapeutic interventions to prevent osteosarcoma progression and recurrence.

Study Type : Animal Study

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Sayer Ji
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