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Abstract Title:

Nobiletin protects dopaminergic neurons in the 1-methyl-4-phenylpyridinium-treated rat model of Parkinson's disease.

Abstract Source:

J Med Food. 2015 Apr ;18(4):409-14. Epub 2014 Oct 17. PMID: 25325362

Abstract Author(s):

Kyoung Hoon Jeong, Min-Tae Jeon, Heung Deok Kim, Un Ju Jung, Min Cheol Jang, Jin Woo Chu, Seung Jun Yang, Il Yoon Choi, Myung-Sook Choi, Sang Ryong Kim

Article Affiliation:

Kyoung Hoon Jeong

Abstract:

This study investigated the effect of nobiletin, a flavonoid found in citrus fruits, on the degeneration of dopaminergic (DA) neurons in a neurotoxin model of Parkinson's disease (PD). 1-Methyl-4-phenylpyridinium (MPP(+)) was unilaterally injected into the median forebrain bundle of rat brains (to generate a neurotoxin model of PD) with or without daily intraperitoneal injection of nobiletin. Our results showed that nobiletin treatment at 10 mg/kg bw, but not at 1 or 20 mg/kg bw, significantly protected DA neurons in the substantia nigra (SN) of MPP(+)-treated rats. In parallel to the neuroprotection, nobiletin treatment at 10 mg/kg inhibited microglial activation and preserved the expression of the glial cell line-derived neurotrophic factor, which is a therapeutic agent against PD, in the SN. These results suggest that the proper supplementation with nobiletin may protect against the neurodegeneration involved in PD.

Study Type : Animal Study

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Sayer Ji
Founder of GreenMedInfo.com

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